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1.
Rong Tian Minggang Su Ye Tian Fanglan Li Lin Li Anren Kuang Jiancheng Zeng 《Skeletal radiology》2009,38(5):451-458
Purpose The purpose of the present study was to evaluate whether 2-fluoro[fluorine-18]-2-deoxy-d-glucose (F-18 FDG) positron emission tomography (PET) could differentiate malignant and benign bone lesions and whether obtaining
delayed F-18 FDG PET images could improve the accuracy of the technique.
Methods In a prospective study, 67 patients with bone lesions detected by computed tomography (CT) or magnetic resonance imaging were
included. Whole body PET/CT imaging was performed at 1 h (early) after the F-18 FDG injection and delayed imaging at 2 h post
injection was performed only in the abnormal region. Semiquantitative analysis was performed using maximum standardized uptake
value (SUVmax), obtained from early and delayed images (SUVmaxE and SUVmaxD, respectively). The retention index (RI) was calculated according to the equation: RI = (SUVmaxD − SUVmaxE) × 100/SUVmaxE. Histopathology of surgical specimens and follow-up data were used as reference criteria. The SUVmaxE and RI were compared between benign and malignant lesions.
Results The final diagnoses revealed 53 malignant bone lesions in 37 patients and 45 benign lesions in 30 patients. There were statistically
significant differences in the SUVmaxE between the malignant and benign lesions (P = 0.03). The mean SUVmaxE was 6.8 ± 4.7 for malignant lesions and 4.5 ± 3.3 for benign lesions. However, a considerable overlap in the SUVmaxE was observed between some benign and malignant tumors. With a cutoff value of 2.5 for the SUVmaxE, the sensitivity, specificity, and accuracy were 96.0%, 44.0%, and 72.4%, respectively. The positive predictive value (PPV)
and negative predictive value (NPV) were 67.1% and 90.9%, respectively. There were significant differences in the RI between
the malignant and benign lesions (P = 0.004). But there was overlap between the two groups. The mean RI was 7 ± 11 for the benign lesions and 18 ± 11 for the
malignant lesions. When an RI of 10 was used as the cutoff point, the sensitivity, specificity, and accuracy were 90.6%, 76.0%,
and 83.7.0%, respectively. The PPV and NPV were 81.4% and 87.1%, respectively.
Conclusions The results of this study indicate that dual-time point F-18 FDG PET may provide more help in the differentiation of malignant
tumors from benign ones. 相似文献
2.
Shuichi Monzawa Shuji Adachi Kayo Suzuki Koichi Hirokaga Shintaro Takao Toshiko Sakuma Keisuke Hanioka 《Annals of nuclear medicine》2009,23(10):855-861
Purpose
The purpose of this retrospective study was to evaluate the diagnostic performance of positron emission tomography/computed tomography (PET/CT) with fluorine-18–labeled 2-fluoro-2-deoxy-d-glucose (FDG) in comparison with that of ultrasonography and contrast-enhanced computed tomography (CT) in detecting axillary lymph node metastasis in patients with breast cancer. 相似文献3.
Hongzan Sun Jun Xin Shaomin Zhang Qiyong Guo Yueyue Lu Wei Zhai Long Zhao Weiai Peng Baijun Wang 《European journal of nuclear medicine and molecular imaging》2014,41(5):898-905
Purpose
To evaluate the concordance among 18F-FDG PET imaging, MR T2-weighted (T2-W) imaging and apparent diffusion coefficient (ADC) maps with diffusion-weighted (DW) imaging in cervical cancer using hybrid whole-body PET/MR.Methods
This study prospectively included 35 patients with cervical cancer who underwent pretreatment 18F-FDG PET/MR imaging. 18F-FDG PET and MR images were fused using standard software. The percent of the maximum standardized uptake values (SUVmax) was used to contour tumours on PET images, and volumes were calculated automatically. Tumour volumes measured on T2-W and DW images were calculated with standard techniques of tumour area multiplied by the slice profile. Parametric statistics were used for data analysis.Results
FDG PET tumour volumes calculated using SUVmax (14.30?±?4.70) and T2-W imaging volume (33.81?±?27.32 cm3) were similar (P?>?0.05) at 35 % and 40 % of SUVmax (32.91?±?18.90 cm3 and 27.56?±?17.19 cm3 respectively) and significantly correlated (P?<?0.001; r?=?0.735 and 0.766). The mean DW volume was 30.48?±?22.41 cm3. DW volumes were not significantly different from FDG PET volumes at either 35 % SUVmax or 40 % SUVmax or from T2-W imaging volumes (P?>?0.05). PET subvolumes with increasing SUVmax cut-off percentage showed an inverse change in mean ADC values on DW imaging (P?<?0.001, ANOVA).Conclusion
Hybrid PET/MR showed strong volume concordance between FDG PET, and T2-W and DW imaging in cervical cancer. Cut-off at 35 % or 40 % of SUVmax is recommended for 18F-FDG PET/MR SUV-based tumour volume estimation. The linear tumour subvolume concordance between FDG PET and DW imaging demonstrates individual regional concordance of metabolic activity and cell density. 相似文献4.
Correlation of apparent diffusion coefficients measured by 3T diffusion-weighted MRI and SUV from FDG PET/CT in primary cervical cancer 总被引:1,自引:0,他引:1
Ho KC Lin G Wang JJ Lai CH Chang CJ Yen TC 《European journal of nuclear medicine and molecular imaging》2009,36(2):200-208
Purpose Diffusion-weighted magnetic resonance imaging (DWI) and fluorodeoxyglucose positron emission tomography/computed tomography
(FDG PET/CT) are oncological feasible techniques. Currently, apparent diffusion coefficient (ADC) measured by DWI and standard
uptake value (SUV) from FDG PET/CT have similar applications in clinical oncology. The aim of this study was to assess the
correlation between ADC and SUV in primary cervical cancer.
Materials and methods Patients with documented primary cervical cancer were recruited. All participants underwent abdominopelvic DWI at 3T and FDG
PET/CT within 2 weeks. For the primary tumor, ADC was measured as minimum ADC (ADCmin) and mean ADC (ADCmean) within the whole tumor by DWI. Maximum SUV (SUVmax) and mean SUV (SUVmean) were measured by FDG PET/CT.
Results A total of 33 patients were included. There was no significant correlation either between ADCmin and SUVmax or between ADCmean and SUVmean. The relative ADCmin (rADCmin) defined as ADCmin/ADCmean ratio was significantly inversely correlated with the relative SUVmax (rSUVmax) defined as SUVmax/SUVmean ratio (r = –0.526, P = 0.0017) in all study patients. A significantly inverse correlation between rADCmin and rSUVmax was observed in patients with adenocarcinoma/adenosquamous carcinoma (r = –0.685, P = 0.0012) and those with well-to-moderate differentiated tumor (r = –0.631, P = 0.0050). No significant correlation was demonstrated in patients with squamous cell carcinoma or poorly differentiated
tumor.
Conclusions The significantly inverse correlation between rADCmin and rSUVmax in primary cervical tumor suggests that DWI and FDG PET/CT might play a complementary role for the clinical assessment of
this cancer type. 相似文献
5.
Byun BH Jeong UG Hong SP Min JJ Chong A Song HC Bom HS 《Annals of nuclear medicine》2012,26(6):471-477
Purpose
The presence of central lymph node (LN) metastasis increases the risk of cervical LN recurrence or distant metastasis in patients with papillary thyroid microcarcinoma (PTMC). We investigated the value of preoperative 18F-fluoro-2-deoxy-d-glucose-positron emission tomography (FDG PET)?Ccomputerized tomography (CT) and ultrasonography (US) to predict central LN metastasis from PTMC.Patients and methods
Two hundred patients with newly diagnosed unifocal PTMC were enrolled. Preoperative FDG PET?CCT was performed, and the highest SUV (SUVmax) of focally increased uptake at thyroid was measured. Tumor size was measured using preoperative US. Uni- and multivariate analyses were performed using the presence of focally increased uptake at thyroid (FDG positivity), SUVmax, tumor size, and clinical risk factor for central LN metastasis. ROC curves for risk factors were then analyzed. These analyses were undertaken in two groups: the all patients group and the FDG-positive group. Finally, we combined risk factors associated with central LN metastasis to improve predictive accuracy.Results
Tumor size >6?mm was associated with central LN metastasis. FDG positivity was identified in 110 patients (55.0?%) and the SUVmax ranged from 1.8 to 12.8 (median 3.0). In FDG-positive group, SUVmax >2.8 was associated with central LN metastasis. Addition of SUVmax >2.8 to size >6?mm of PTMC improved sensitivity of predicting central LN metastasis from 55.0 to 67.5?%, while specificity remained at 70.6?%.Conclusion
Both FDG PET?CCT and US are valuable for preoperative prediction of central LN metastasis from PTMC. Combined use of SUVmax and tumor size improves sensitivity without changing specificity. 相似文献6.
Shiiba M Ishihara K Kimura G Kuwako T Yoshihara H Yoshihara N Sato H Kondo Y Tsuchiya S Kumita S 《Annals of nuclear medicine》2012,26(2):138-145
Objective
The objective of this study was to evaluate the capability of 11C-methionine (MET)-PET/CT and 18F-2-deoxy-2-fluoro-d-glucose (FDG)-PET/CT to diagnose primary prostate cancer using recently developed Gemini TF PET/CT (Philips Healthcare, Cleveland, OH). 相似文献7.
Objective
Langerhans cell histiocytosis (LCH) has a wide spectrum of clinical manifestations, ranging from spontaneous resolution to rapid progression or death, with the risk of permanent consequences. F-18 FDG PET/CT has been used for assessment of LCH patients. However, its clinical implication has not been well elucidated, mainly due to very low incidence of LCH. The aim of this study was to evaluate the clinical usefulness of F-18 FDG PET/CT in LCH patients.Methods
A database of 12 patients (mean age 17.8?±?17.9?years; 7 children, 5 adults) who were diagnosed histopathologically as LCH was retrospectively reviewed. Two patients underwent F-18 FDG PET/CT before and after therapy, 6 patients underwent only before therapy and 4 patients underwent only after therapy.Results
Nine (75.0?%) and 3 patients (25.0?%) had single-system (single site and multiple sites) and multisystem involvements, respectively. Pretreatment SUVmax of patients with multisystem or multiple site involvement of a single-system was significantly higher than that of patients with single site involvement of a single-system (3.29?±?2.52 vs. 1.63?±?0.52, p?=?0.025). One patient showed multisystem risk organs (lung and bone marrow) involvement. In 2 patients, F-18 FDG PET/CT detected additional active LCH lesions not identified on conventional imaging modalities. In follow-up F-18 FDG PET/CT scans, complete resolution was identified in 2 patients and reactivation in another 2 patients.Conclusions
Results of this study suggest that F-18 FDG PET/CT is useful for identification of active lesions, stratification of disease stages, monitoring of therapeutic response, and detection of reactivation in LCH patients. 相似文献8.
Takayoshi Shinya Soichiro Fujii Shoji Asakura Toshitaka Taniguchi Kotaro Yoshio Aierken Alafate Shuhei Sato Tadashi Yoshino Susumu Kanazawa 《Annals of nuclear medicine》2012,26(8):616-621
Objective
The aim of this study was to evaluate the usefulness of F-18 fluorodeoxyglucose (FDG) dual-time-point (DTP) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for the initial staging in patients with malignant lymphoma.Methods
Forty-three patients had DTP PET/CT, with 60-min and 2-h scan [n?=?8, Hodgkin??s lymphoma (HL); n?=?12, indolent non-Hodgkin lymphoma (NHL); n?=?23, aggressive NHL].Results
A total of 524 lesions were evaluated (406 lymph nodes and 118 extra-nodal lesions). The maximum standardized uptake value (SUVmax) on 2-h delayed scan (SUV2) was significantly higher than those on 1-h early scan (SUV1) for all groups (P?<?0.0001 for HL; P?<?0.0001 for indolent NHL; P?<?0.0001 for aggressive NHL). Significant differences were detected between HL and indolent NHL, between indolent NHL and the aggressive NHL for both SUV1 and SUV2 (each P?<?0.0001). No significant differences were detected between HL and aggressive NHL for both SUV1 and SUV2 (P?=?0.6891 for SUV1; P?=?0.8828 for SUV2); however, significant differences were detected for the retention index of SUVmax between these groups (P?=?0.0238).Conclusions
DTP F-18 FDG PET/CT with a semiquantitative technique may have the potential to provide the more accurate diagnoses for the staging of malignant lymphoma and the more important role in predicting the histological grades of malignancy compared with single-time-point F-18 FDG-PET scan. 相似文献9.
Li Wang Hong-Xing Wei Min-Fu Yang Jin Guo Jian-Feng Wang Wei Fang Yue-Tao Wang 《Annals of nuclear medicine》2013,27(4):325-334
Purpose
To investigate the value of gated F-18 FDG PET/CT on left ventricular (LV) dyssynchrony assessment in comparison with gated Tc-99m sestamibi SPECT in patients with coronary artery disease (CAD).Methods
The data of 100 consecutive CAD patients who underwent both gated myocardial Tc-99m sestamibi SPECT and F-18 FDG PET/CT imaging were analyzed. Phase standard deviation (SD) and histogram bandwidth (BW) were derived from phase analysis using Cedars software package. The correlation and agreement of SD and BW between Tc-99m sestamibi SPECT and F-18 FDG PET/CT were examined. Myocardial viability and the site of latest activation assessed by the two imaging methods were compared as well.Results
A moderate correlation for SD (r = 0.58, p < 0.0001) and BW (r = 0.60, p < 0.0001) was found between gated SPECT and gated F-18 FDG PET/CT. Bland–Altman analysis revealed an overestimation of SD and BW (6.4° ± 14.3° and 22.0° ± 46.8°) by gated F-18 FDG PET/CT. Multivariate logistic regression analysis identified that significant LV remodeling on SPECT imaging, LV functional parameters and F-18 FDG uptake ratio of myocardium to blood pool (SUVM/B) were associated with the overestimation. Myocardial SPECT and F-18 FDG PET/CT had a 67.1 % identity in determining the latest activation site and 5.2 % more viable myocardium was detected by F-18 FDG PET/CT than SPECT.Conclusion
Gated F-18 FDG PET/CT moderately correlated with gated Tc-99m sestamibi SPECT in assessing LV dyssynchrony. Gated F-18 FDG PET/CT phase analysis should be cautiously applied in CAD patients with significant LV remodeling on SPECT imaging, severe LV functional impairment or poor myocardial F-18 FDG uptake. 相似文献10.
Cheebsumon P Velasquez LM Hoekstra CJ Hayes W Kloet RW Hoetjes NJ Smit EF Hoekstra OS Lammertsma AA Boellaard R 《European journal of nuclear medicine and molecular imaging》2011,38(5):832-842
Purpose
Imaging with positron emission tomography (PET) using 18F-2-fluoro-2-deoxy-D-glucose (FDG) plays an increasingly important role for response assessment in oncology. Several methods for quantifying FDG PET results exist. The goal of this study was to analyse and compare various semi-quantitative measures for response assessment with full kinetic analysis, specifically in assessment of novel therapies. 相似文献11.
Purpose
Using integrated PET/CT, we evaluated the prognostic value of [18F]FDG uptake ratio between pelvic lymph node (LN) and primary tumor in invasive squamous cell carcinoma (SCCA) of the uterine cervix.Methods
We retrospectively reviewed patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB to IIA cervical SCCA who underwent preoperative [18F]FDG PET/CT scans. PET/CT parameters such as maximum standardized uptake value (SUV) of the primary cervical cancer (SUVcervix) and LN (SUVLN), and the LN-to-cervical cancer SUV ratio (SUVLN/SUVcervix) were assessed. Prognostic values of PET/CT-derived metabolic and volumetric variables and clinicopathology parameters were analyzed to predict progression-free survival (PFS) in regression analyses.Results
Clinical data, treatment modalities, and results were reviewed for 103 eligible patients. Median post-surgical follow-up was 29 months (range, 6–89), and 19 (18.5%) patients experienced recurrence. Multivariate logistic regression analysis showed that SUVLN / SUVcervix > 0.1747(P = 0.048) was the independent risk factor of recurrence. Patient group categorized by SUVLN/SUVcervix showed significant difference in PFS (log-rank test, P < 0.001).Conclusions
Preoperative SUVLN/SUVcervix measured by [18F]FDG PET/CT was significantly associated with recurrence, and has an incremental prognostic value for PFS in patients with cervical SCCA.12.
Hyun Hoon Chung Gi Jeong Cheon Keon Wook Kang Jae Weon Kim Noh-Hyun Park Yong Sang Song 《European journal of nuclear medicine and molecular imaging》2014,41(4):674-681
Purpose
Using integrated PET/CT, we evaluated the prognostic relevance in uterine cervical cancer of preoperative pelvic lymph node (LN) [18F]FDG uptake.Methods
Patients with FIGO stage IB to IIA uterine cervical cancer were imaged with FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the FDG maximum standardized uptake value (SUVmax) in the pelvic LN (SUVLN) on PET/CT.Results
Clinical data, treatment modalities, and results in 130 eligible patients were reviewed. The median postsurgical follow-up was 34 months (range 6 to 109 months). Receiver operating characteristic analysis identified SUVLN 2.36 as the most significant cut-off value for predicting recurrence. SUVLN was correlated with SUVtumour (P?=?0.002), primary tumour size (P?=?0.004), and parametrial invasion (P?=?0.013). Univariate analyses showed significant associations between recurrence and SUVLN (P?=?0.001), SUVtumour (P?=?0.007), pelvic LN metastasis (P?=?0.002), parametrial invasion (P?<?0.001), primary tumour size (P?=?0.007), suspected LN metastasis on MRI (P?=?0.024), and FIGO stage (P?=?0.026). Multivariate analysis identified SUVLN (P?=?0.013, hazard ratio, HR, 4.447, 95 % confidence interval, CI, 1.379 – 14.343) and parametrial invasion (P?=?0.013, HR 6.728, 95 % CI 1.497 – 30.235) as independent risk factors for recurrence. Patients with SUVLN ≥2.36 and SUVLN <2.36 differed significantly in terms of recurrence (HR 15.20, P?<?0.001).Conclusion
Preoperative pelvic LN FDG uptake showed a strong significant association with uterine cervical cancer recurrence. 相似文献13.
Bong Joo Kang Joo Hyun O Jun Hyun Baik So Lyung Jung Young Ha Park Soo Kyo Chung 《Annals of nuclear medicine》2009,23(8):729-737
Purpose
To evaluate the usefulness of maximum standard uptake value (max SUV) calculated from F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examination and findings from ultrasonographic (US) examination on incidentally detected thyroid FDG uptake on FDG PET/CT. 相似文献14.
Kanegae K Nakano I Kimura K Kaji H Kuge Y Shiga T Zhao S Okamoto S Tamaki N 《Annals of nuclear medicine》2007,21(6):331-337
Objective The aim of this study was to evaluate and compare the ability of C-11-methionine (MET) and F-18 fluoro-deoxy-d-glucose positron emission tomography (FDG-PET) to diagnose lung cancer in patients with pneumoconiosis.
Methods Twenty-six subjects underwent both whole-body MET-PET and FDG-PET on the same day. The first group was a lung cancer group,
which consisted of 15 patients, and included those with pneumoconiosis with increased nodules (13 cases), hemoptysis (1 case),
and positive sputum cytology (1 case). The second group was a no-malignancy control group, consisting of 11 patients with
pneumoconiosis.
Results Significant correlations between nodule size and the maximum standardized uptake value (SUVmax) of the two PET tracers were observed in the control group. The larger the nodule size, the greater were the amounts of these
tracers accumulated (MET: r = 0.771, P < 0.0001; FDG: r = 0.903, P < 0.0001). The SUVmax of MET was significantly lower than that of FDG in the pneumoconiotic nodules (P < 0.0001). Lung cancer was found in 5 of 19 nodules (two with adenocarcinoma, one with squamous cell carcinoma, one with
small cell carcinoma, and one with large cell carcinoma) in the first group. As for nodules equal to or less than 3 cm in
diameter, the SUVmax of MET was significantly higher in the lung cancer than in the pneumoconiotic nodules, with 3.48 ± 1.18 (mean ± SE) for the
lung cancer and 1.48 ± 0.08 for the pneumoconiotic nodules (P < 0.01), similar to the SUVmax of FDG, with 7.12 ± 2.36 and 2.85 ± 0.24 (P < 0.05), respectively. On the basis of the criteria for the control group, FDG and MET identified lung cancer with sensitivities
of 60% and 80%, specificities of 100% and 93%, accuracies of 90% and 90%, positive predictive values of 100% and 80%, and
negative predictive values of 88% and 93%, respectively.
Conclusions Our results indicate that nodules with an intense uptake of MET and FDG relative to their size should be carefully observed
because of a high risk for lung cancer. 相似文献
15.
Cheng G Chen W Chamroonrat W Torigian DA Zhuang H Alavi A 《European journal of nuclear medicine and molecular imaging》2011,38(8):1469-1476
Purpose
The objective is to assess the role of 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/CT versus bone marrow biopsy (BMB) in the initial evaluation of bone marrow (BM) involvement in pediatric lymphoma patients. 相似文献16.
Hyun Hoon Chung Gi Jeong Cheon Hee Seung Kim Jae Weon Kim Noh-Hyun Park Yong Sang Song 《European journal of nuclear medicine and molecular imaging》2014,41(9):1793-1799
Purpose
Using integrated PET/CT, we evaluated the prognostic relevance of preoperative pelvic lymph node (LN) 18F-FDG uptake in endometrioid endometrial cancer.Methods
We retrospectively reviewed patients with pathologically proven endometrial cancer who underwent preoperative 18F-FDG PET/CT scans to evaluate the prognostic significance of PET/CT parameters and other clinicopathological variables. We used Cox proportional hazards regression to examine the relationship between recurrence and the maximum standardized uptake value (SUVmax) in pelvic LNs (SUVLN) on FDG PET/CT.Results
Clinical data, treatment modalities and results were reviewed in 70 eligible patients. The median postsurgical follow-up was 29 months (range 6 to 95 months). Receiver-operating characteristic analysis identified the significant SUVLN cut-off value as 15. The SUVLN correlated with FIGO stage (P?<?0.001), LN metastasis (P?<?0.001), lymphovascular space invasion (P?<?0.001), SUVtumour (P?=?0.001), metastatic LN size (P?=?0.004), primary tumour size (P?=?0.012), tumour grade (P?=?0.015) and depth of tumour invasion (P?=?0.035). Regression analysis showed a statistically significant association between recurrence and SUVLN (P?=?0.002). Recurrence differed significantly (P?<?0.001) between patients with SUVLN >15 and those with SUVLN ≤15.Conclusion
Preoperative pelvic LN FDG uptake exhibited a strong significant association with recurrence of endometrioid endometrial cancer. 相似文献17.
Ningbo Liu Li Ma Qingsong Pang Fang Shi Minghuan Li Jinming Yu 《European journal of radiology》2010,74(1):231-235
Purpose
To evaluate the performance of F-18 FDG PET/CT in the detection of bone metastasis in non-small cell lung cancer (NSCLC) patients.Materials and methods
Three hundred and sixty-two consecutive NSCLC patients who underwent F-18 FDG PET/CT scanning were retrospectively analyzed. Each image of PET/CT, combined CT, and PET was performed at 10 separate areas and interpreted blindly and separately. The sensitivity, specificity and accuracy of F-18 FDG PET/CT, combined CT and F-18 FDG PET were calculated and the results were statistically analyzed.Results
Bone metastasis was confirmed in 82 patients with 331 positive segments based on the image findings and clinical follow-up. On patient-based analysis, the sensitivity of F-18 FDG PET/CT (93.9%) was significantly higher than those of combined CT (74.4%) and F-18 FDG PET (84.1%), respectively (p < 0.05). The overall specificity and accuracy of combined CT, F-18 FDG PET, and F-18 FDG PET/CT were 90.7%, 93.2%, 98.9% and 87.0%, 91.2%, and 97.8%, respectively (compared with PET/CT, p < 0.05). On segment-based analysis, the sensitivity of the three modalities were 79.5%, 94.3%, and 98.8%, respectively (compared with PET/CT, p < 0.05). The overall specificity and accuracy of the three modalities were 87.9%, 89.2%, 98.6% and 84.5%, 91.2%, 98.7%, respectively (compared with PET/CT, p < 0.05).Conclusion
F-18 FDG PET/CT is superior to F-18 FDG PET or combined CT in detecting bone metastasis of NSCLC patients because of the complementation of CT and PET. It is worth noting that the added value of F-18 FDG PET/CT may beneficially impact the clinical management of NSCLC. 相似文献18.
Stefan Adams Richard P Baum Tankred Stuckensen Klaus Bitter Gustav Hör 《European journal of nuclear medicine and molecular imaging》1998,25(9):1255-1260
The aims of this study were to investigate the detection of cervical lymph node metastases of head and neck cancer by positron
emission tomographic (PET) imaging with fluorine-18 fluorodeoxyglucose (FDG) and to perform a prospective comparison with
computed tomography (CT), magnetic resonance imaging (MRI), sonographic and histopathological findings. Sixty patients with
histologically proven squamous cell carcinoma were studied by PET imaging before surgery. Preoperative endoscopy (including
biopsy), CT, MRI and sonography of the cervical region were performed in all patients within 2 weeks preceding 18F-FDG whole-body PET. FDG PET images were analysed visually and quantitatively for objective assessment of regional tracer
uptake. Histopathology of the resected neck specimens revealed a total of 1284 lymph nodes, 117 of which showed metastatic
involvement. Based on histopathological findings, FDG PET correctly identified lymph node metastases with a sensitivity of
90% and a specificity of 94% (P<10–6). CT and MRI visualized histologically proven lymph node metastases with a sensitivity of 82% (specificity 85%) and 80% (specificity
79%), respectively (P<10–6). Sonography revealed a sensitivity of 72% (P<10–6). The comparison of 18F-FDG PET with conventional imaging modalities demonstrated statistically significant correlations (PET vs CT, P = 0.017; PET vs MRI, P = 0.012; PET vs sonography, P = 0.0001). Quantitative analysis of FDG uptake in lymph node metastases using body weight-based standardized uptake values
(SUVBW) showed no significant correlation between FDG uptake (3.7±2.0) and histological grading of tumour-involved lymph nodes (P = 0.9). Interestingly, benign lymph nodes had increased FDG uptake as a result of inflammatory reactions (SUVBW-range: 2–15.8). This prospective, histopathologically controlled study confirms FDG PET as the procedure with the highest
sensitivity and specificity for detecting lymph node metastases of head and neck cancer and has become a routine method in
our University Medical Center. Furthermore, the optimal diagnostic modality may be a fusion image showing the increased metabolism
of the tumour and the anatomical localization.
Received 17 February and in revised form 12 June 1998 相似文献
19.
Value of<Superscript> 18</Superscript>F-FDG PET in the detection of peritoneal carcinomatosis 总被引:2,自引:0,他引:2
Suzuki A Kawano T Takahashi N Lee J Nakagami Y Miyagi E Hirahara F Togo S Shimada H Inoue T 《European journal of nuclear medicine and molecular imaging》2004,31(10):1413-1420
Purpose Peritoneal carcinomatosis can be difficult to diagnose using computed tomography (CT). The purpose of this study was to evaluate the role of 2-(fluorine 18) fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the detection of peritoneal carcinomatosis.Methods We reviewed the CT and FDG PET radiological reports and clinical charts of 18 patients with peritoneal carcinomatosis and 17 cancer patients without peritoneal carcinomatosis. We also assessed FDG PET scans from 20 healthy volunteers as a baseline study. The maximum standardised uptake values (SUVmax) over peritoneal lesions in cancer patients and over the area of most intense intestinal uptake in healthy volunteers and cancer patients without peritoneal carcinomatosis were measured.Results The sensitivity and positive predictive value (PPV) of combined FDG PET and CT were superior to those of CT alone for the detection of peritoneal lesions (sensitivity: 66.7% vs 22.2%, p<0.025; PPV: 92.3% vs 50.0%, p<0.05). The most frequent pattern of FDG uptake in patients with peritoneal carcinomatosis was abnormally intense focal uptake near the abdominal wall. An SUVmax threshold of 5.1 produced a diagnostic accuracy of combined FDG PET and CT of 78%. The additional information provided by FDG PET allowed a more accurate diagnosis in 14 patients (40.0%), and led to alteration of the therapeutic strategy in five (14.3%) of the enrolled cancer patients.Conclusion We found that use of an intra-abdominal FDG uptake cut-off value for SUVmax of >5.1 assists in the diagnosis of peritoneal carcinomatosis. FDG PET may play an important role in the clinical management of patients with suspected peritoneal carcinomatosis. 相似文献
20.
Kobe C Scheffler M Holstein A Zander T Nogova L Lammertsma AA Boellaard R Neumaier B Ullrich RT Dietlein M Wolf J Kahraman D 《European journal of nuclear medicine and molecular imaging》2012,39(7):1117-1127