A high circulating copy number of HHV‐6 due to chromosomal integration in a child with acute lymphoblastic leukemia

We report a case of a 3.5‐year‐old female with a very high copy number of human herpesvirus 6 (HHV‐6) detected by PCR in blood during acute lymphoblastic leukemia induction therapy. The patient was unsuccessfully treated with antiviral drugs. HHV‐6 genome was shown to be constitutively integrated into chromosome 22q‐tel, likely to be inherited from the mother who was found to carry high HHV‐6 copy number. This case highlights the importance of excluding HHV‐6 chromosomal integration before diagnosing HHV‐6 infection or reactivation in immunocompromised patients. Pediatr Blood Cancer. 2010;55:1236–1238. © 2010 Wiley‐Liss, Inc.     

Hemothorax due to hemorrhagic disease of the newborn

A three day old male, term infant with hemothorax due to hemorrhagic disease of the newborn was treated successfully with vitamin K and thoracocentesis. Exclusive breast feeding and absence of vitamin K prophylaxis were important diagnostic clues, although hemothorax as a sole manifestation of hemorrhagic disease of the newborn is rare. This case highlighted the good prognosis of an uncommon complication when prompt diagnosis and appropriate treatment are instituted. The importance of vitamin K prophylaxis to all newborns is emphasized.     

医学论文文题翻译中的常见问题

在一篇由文题、摘要、引言、方法、结果、结论和参考文献组成的医学论文中,文题往往是读者最先浏览的部分,有时甚至是唯一浏览的部分.因此,准确、完整、简洁、有效地译好论文文题十分重要.医学论文文题汉译英中有以下一些常见问题,需要引起我们的注意.     

Adolescents who use the emergency department as their usual source of care

OBJECTIVE: To examine the factors associated with use of the emergency department (ED) as the only source of health care among adolescents. DESIGN: Analyses of the 1997 Commonwealth Fund Survey of the Health of Adolescent Girls, a nationally representative sample of 6748 in-school male and female adolescents in 5th through 12th grade. The X2 statistics and logistic regression analyses were computed with the use of SUDAAN. RESULTS: Overall, 4.6% of the adolescents in the survey, or 1.5 million adolescents in the United States, reported that the ED was their usual source of health care. In multivariate models, factors associated with the use of the ED included male sex, African American ethnicity, fewer financial resources, and living in a rural area. Adolescents with higher levels of risky behaviors, a history of physical or sexual abuse, and higher depression scores were all more likely to use the ED as their usual source of care. Adolescents who reported using the ED as their usual care source were also less likely to have had regular well visits and were more likely to report having missed needed care than those with other sources of primary care. CONCLUSIONS: Adolescents who use the ED as their usual source of care are often from vulnerable populations. Many have special mental or physical needs that are unlikely to be met with ED visits only, and they are likely to have missed care they needed. Creating linkages between EDs and other services could help at-risk adolescents identify and use more appropriate sources of primary care.