良性急性胃十二指肠溃疡穿孔两种手术方式的疗效比较

目的探讨良性急性胃十二指肠溃疡穿孔两种不同手术方式治疗的临床效果。方法对本院132例良性急性胃十二指肠溃疡穿孔病例,A组90例为单纯穿孔修补术加抑酸、根除幽门螺杆菌;B组42例胃大部切除进行疗效比较。结果所有病例治愈出院,随访3-120个月．两组的疗效按改良Visick分级评分标准I、II级分别为84．4％、76．1％,溃疡复发率分别为5．5％、7．1％,术后再次穿}L率均为零,两组比较差异均无统计学意义（P〈0．05）。B组切口感染发生率高于A组,差异有统计学意义（P〉O．05）。结论消化性溃疡穿孔修补加抑酸、根除幽门螺杆菌治疗,操作简单、创伤小、并发症少、远期疗效好,可作为良性急性胃十二指肠溃疡穿孔治疗的首选方式。     

单纯缝合修补十二指肠球部溃疡穿孔84例的治疗体会

84例十二指肠球部溃疡穿孔单纯缝合修补病例中，急性溃疡穿孔46例，慢性溃疡穿孔38例。术后进行抗幽门螺杆菌及抑酸治疗三月。本组死亡1例，术后三月溃疡愈合率为96．4％，五年复发率30．1％，病残率3．6％，急性和慢性溃疡有一定的差别（P＜0．05）。溃疡大小对术后溃疡复发率和再手术率影响不大（P＞0．05）。因此，十二指肠球部溃疡穿孔单纯缝合修补术后结合正规有效的内科治疗，预后良好。单线缝合修补仍可作为处理十二指肠球部溃疡穿孔的主要手段。     

幽门螺杆菌对消化性溃疡穿孔修补后的影响

目的:了解幽门螺杆菌对十二指肠溃疡穿孔单纯修补后溃疡愈合的影响.方法:收集120例穿孔性胃十二指肠溃疡,其中99例(82.5%)为幽门螺杆菌阳性,其中51例为抗HP治疗组,用次橼酸铋120 mg、阿莫西林500 mg和甲硝唑300 mg治疗.48例为单用雷尼替丁治疗组.结果:胃十二指肠穿孔单纯修补后只要消除感染,溃疡复发率就降低.结论:幽门螺杆菌是影响胃十二指肠溃疡穿孔修补后复发的主要因素.     

单纯修补或加PCV后清除Hp治疗十二指肠溃疡穿孔

目的：评估十二指肠溃疡穿孔行单纯修补或加行壁细胞迷切（ＰＣＶ）术后常规清除幽门螺杆菌（Ｈｐ）的疗效。方法：１９９４年来,我院收治十二指肠溃疡穿孔５１例,其中单纯修补４１例,修补加ＰＣＶ１０例。术后均常规予清除Ｈｐ治疗,并对术后恢复及溃疡复发情况作一回顾性分析。结果：经２年以上随访,单纯修补或加ＰＣＶ术后再常规清除Ｈｐ,溃疡复发率和再手术率均明显降低。修补加ＰＣＶ组疗效显著优于单纯修补组（Ｐ＜０．０５）;单纯修补组中,急性溃疡穿孔病例的疗效显著优于慢性溃疡穿孔（Ｐ＜０．０５）。结论：单纯修补术后再清除Ｈｐ可作为急性溃疡穿孔的理想治疗方案;修补加ＰＣＶ术后再清除Ｈｐ治疗慢性溃疡穿孔可获良好根治溃疡效果。     

青少年十二指肠溃疡穿孔的处理

目的：探讨青少年十二指肠溃疡急性穿孔的治疗方法。方法：回顾性分析45例青少年十二指肠溃疡急性穿孔的治疗，其中行单纯修补术24例，胃大部切除术13例，迷走神经切除加胃部分切除3例，修补加高选择性迷走神经切除5例。单纯修补组术后国洛赛克治疗3个月。结果：随讠年，全组无死亡。单纯修补组并发症发生率（8％）与手术切除组（38％）相比差异有显著意义（P＜0．05）；修补组治愈率明显高于手术切除组（P＜0．05）；2组溃疡复发率相比差异无意义（P＞0．05）；修补组体重增加较手术切除组差异有显著意义（P＜0．05）。结论：应用单纯修补加洛赛克治疗青少年十二指肠溃疡穿孔是一种既符合青少年生理特征又有效和可靠的方法。     

胃十二指肠溃疡急性穿孔急诊治疗策略

目的探讨胃十二指肠溃疡急性穿孔的急诊治疗策略。方法回顾分析我院2003年3月～2007年8月62例胃十二指肠溃疡急性穿孔的临床资料。其中非手术治疗8例,急诊胃大部切除术7例,腹腔镜穿孔修补术（腹腔镜组）22例,开腹穿孔修补术（开腹组）25例,比较各方法的治疗效果。结果62例全部治愈出院,无死亡。非手术治疗8例中,无中转手术治疗,无并发症。急诊胃大部切除7例中,吻合口溃疡3例,胆汁反流性胃炎4例。在穿孔修补术47例中,腹腔镜组与开腹组手术时间分别为（71.1±15.0）min和（63.3±17.8）min（t=1.612,P=0.114）,术中出血量分别为（7.4±2.6）ml和（18.0±11.8）ml（t=-4.121,P=0.000）,并发症分别为0例和3例（P=0.237）,术后体温〉38℃分别为4例、12例（χ^2=4.634,P=0.031）,术后肛门排气时间分别为（35.7±6.8）h和（69.9±6.4）h（t=-17.754,P=0.000）,术后住院时间分别为（6.3±0.7）d和（9.5±1.6）d（t=-8.670,P=0.000）。结论胃十二指肠溃疡急性穿孔的急诊治疗中,腹腔镜下修补是安全有效的,应作为首选。而非手术治疗和急诊胃大部切除术是对胃十二指肠溃疡急性穿孔急诊治疗的有效补充。     

十二指肠溃疡急性穿孔218例治疗分析

目的探讨十二指肠溃疡急性穿孔行单纯修补及术后药物治疗的效果。方法对我院2001年1月~2005年12月收治的十二指肠球部溃疡急性穿孔218例实施单纯修补术208例,术后给予抗溃疡药物及根除幽门螺杆菌(helicobacetr pylori,HP)治疗;保守治疗10例。结果本组近期效果良好。术后随访190例,随访半年~4年,溃疡复发13例,复发率为6%。失访28例。结论十二指肠溃疡急性穿孔行单纯修补术疗效确切。术后行正规抗溃疡及根除HP治疗能有效降低溃疡的复发率和并发症的发生率。     

十二指肠溃疡急性穿孔不同手术方式疗效的比较研究

目的探讨十二指肠溃疡急性穿孔的不同外科手术方式的疗效。方法对120例十二指肠溃疡急性穿孔病人分别行开腹单纯穿孔修补术加用高选择性迷走神经切断术（Parietal Cell Vagotomy,以下简称PCV）、腹腔镜下穿孔修补加用PCV、开腹胃大部切除术。对其手术时间、住院时间、术后并发症、溃疡复发率进行比较观察。结果腹腔镜下十二指肠溃疡急性穿孔修补术＋PCV明显节省了手术时间、住院时间和减少了手术并发症,但与开腹胃大部切除术相比,溃疡复发率较高。结论腹腔镜下十二指肠溃疡急性穿孔修补加用PCV是较合理的选择,术后辅以制酸及抗Helicobacter pylori感染药物是必要的。开腹胃大部切除术已不再是治疗十二指肠溃疡急性穿孔的合理选择。     

修补术加PGV与修补术加奥美拉唑方案治疗十二指肠溃疡穿孔的疗效对比

目的研究十二指肠溃疡穿孔的两种不同疗法——穿孔修补术加近侧胃迷走神经切断术（ＰＧＶ）与穿孔修补术加奥美拉唑方案的临床疗效。方法将１９９４年１月－１９９６年１２月相继入院的４８例十二指肠溃疡穿孔患者随机分为Ａ、Ｂ两组。Ａ组（２１例）在穿孔修补术的基础上，加行ＰＧＶ。Ｂ组（２７例）仅作穿孔修补术，术后辅予奥美拉唑方案（即口服奥美拉唑加羟氨苄青霉素加灭滴灵）。术后定期随访。随访结果按Ｖｉｓｉｃｋ标准分级。结果Ａ组术后半年和２年疗效优良者（ＶｉｓｉｃｋⅠ加Ⅱ级）分别为１８例（８５．７％）和１７例（８１．０％），溃疡复发者（ＶｉｓｉｃｋⅣ级）分别为１例（４．８％半年）和２例（９．５％２年）。Ｂ组术后半年和２年疗效优良者分别为１９例（６６．７％）和１０例（３７．０％），溃疡复发者分别为５例（１８．５％）和１２例（４４．５％）。Ａ组疗效优于Ｂ组（Ｐ＜０．０１）。Ｈｐ检测，Ａ组术后半年和两年的Ｈｐ阳性率分别为８１．０％和８５．７％（Ｐ＞０．０５）；Ｂ组分别为１８．５％和５１．９％（Ｐ＜０．０１）。结论十二指肠溃疡穿孔在施行修补术后，应同时加行ＰＧＶ，以提高对溃疡病的根治效果     

修补术加PGV与修补术加奥美拉唑方案治疗十二指肠溃疡穿孔的疗效对比

目的 研究十二指肠溃疡穿孔的两种不同疗法——穿孔修补术加近侧胃迷走神经切断术(PCV)与穿孔修补术加奥美拉唑方案的临床疗效,方法 将1994年1月-1996年12月相继入院的48例十二指肠溃疡穿孔患随机分为A、B两组。A组（21例）在穿孔修补术的基础上．加行PGV。B组(27例)仅作穿孔修补术,术后辅予奥美拉唑方案(即口服奥美拉唑加羟氨苄青霉素加灭滴灵)。术后定期随访。随访结果按Visick标准分级。结果 A组术后半年和2年氨疗效优良（Visick Ⅰ加Ⅱ级)分别为18例（85.7％)和17例(81.0％),溃疡复发(Visick Ⅳ级)分别为1例(4．8%半年)和2例(9.5％2年).B维术后半年和2年疗效优良分别为19例(66．7％)和10例(37．0％),溃疡复发分别为5例（18.5％)和12例(44.5％)A组疗效优于B组(P＜0.01)。Hp检测,A组术后半年和两年的Hp阳性率分别为81.0％和85.7％(P＞0.05)：B组分别为18．5％和51．9％(P＜0．01)。结论 十二指肠溃疡穿孔在施行修补术后．应同时加行PCV,以提高时溃疡病的根治效果。     

Perforated gastroduodenal stress ulcer

Experimental and clinical data support the role of oxidative stress in the development of gastro-duodenal inflammatory lesions and peptic ulcer. Although quite common, stress ulcer remains a minor concern in the The authors review the literature data and perform a retrospective study on 205 personal cases of gastroduodenal ulcers, diagnosed and operated in the period 1986-2005. Of these, 58 (28.29%) were perforated ulcers, including 4 cases (6.8%) caused by various psychic traumas. All the patients presented symptoms and signs characteristic for perforated ulcer and were undoubtedly of psychogenic cause. The surgical treatment consisted in the closure of the perforation and peritoneal drainage. Besides medical treatment of peptic ulcer disease consisting of antisecretory drugs, antioxidants and sedatives were used. Postoperative follow-up showed a rapid and uneventful recovery in all cases. In conclusion, surgery is the mainstay of treatment in perforated ulcer, but additional stress therapy promotes healing and may reduce postoperative morbidity in cases with certain involvement of psychic trauma.     

Treatment of perforated gastroduodenal ulcer by simple suture followed by Helicobacter pylori eradication

AIMS OF THE STUDY: To determine the prevalence of Helicobacter pylori (HP) infection in Vietnam in case of perforated gastro-duodenal ulcer and to evaluate efficiency of medical treatment to obtain eradication of HP and ulcer healing. PATIENTS AND METHODS: One hundred and eleven patients with perforated gastro-duodenal ulcer underwent surgical suture. HP infection was diagnosed by urease test and pathologic examination of peroperative antral biopsies, and by postoperative detection of HP-specific immunoglobulins G. HP infection was defined by positivity of at least one test. Medical treatment included omeprazole, clarithromycin, and amoxicillin for 7 days followed by omeprazole for 3 weeks for duodenal ulcer and 5 weeks for gastric ulcer. Follow-up endoscopy with biopsies was performed 4 to 6 weeks after treatment cessation. RESULTS: Among 111 patients, 107 (96%) were infected by HP. The 4 patients non-infected by HP were treated by omeprazole alone and excluded from the study. Ulcer healed in 99 patients (93%). HP eradication was obtained in 102 patients (95%). The 8 patients with a non-healed ulcer and the 5 patients in whom HP eradication was not obtained at the first endoscopic control received additional medical treatment. Ultimately HP eradication and ulcer healing were obtained in all cases. CONCLUSION: In a country in which prevalence of HP infection is high, acid-reduction surgery is unnecessary in case of perforated gastro-duodenal ulcer treated by simple surgical closure.     

Non-operative treatment for perforated gastro-duodenal peptic ulcer in Duchenne Muscular Dystrophy: a case report

Background  

Clinical characteristics and complications of Duchenne muscular dystrophy caused by skeletal and cardiac muscle degeneration are well known. Gastro-intestinal involvement has also been recognised in these patients. However an acute perforated gastro-duodenal peptic ulcer has not been documented up to now.     

基层医院胃十二指肠溃疡急性穿孔64例诊治体会

目的探讨基层医院胃十二指肠溃疡急性穿孔的诊断和治疗方法。方法对我院外科1996年1月到2006年12月收治的64例胃十二指肠溃疡急性穿孔患者的临床资料进行回顾性分析。结果6例保守治疗（其中的2例因治疗无效中转手术治疗）,60例行手术治疗。其中28例行单纯穿孔修补术,32例行胃大部分切除术。死亡1例。治愈率98.4%。结论胃大部切除术是基层医院常用治疗胃十二指肠溃疡穿孔的手术。然而,溃疡穿孔修补＋扩大壁细胞的迷走神经切除术术后疗效好,并发症少,手术操作易于掌握,值得在基层医院开展使用。     

Prevention of stress ulcer bleeding with cimetidine in severe burns

This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns. It shows that gastrointestinal bleeding after severe burn is significantly reduced, and the incidence of acute gastro-duodenal ulcer lowered by administration of cimetidine.     

胃十二指肠溃疡急性穿孔1226例临床分析

目的探讨急性胃十二指肠溃疡穿孔的诊断和治疗方法。方法对1980年至2002年期间，我院外科收治的1226例急性胃十二指肠穿孔病人的临床资料进行了回顾性的分析。结果122例保守治疗成功。1104例行手术治疗，其中行单纯穿孔修补术393例，围手术死亡率6．9％。行胃大部切除术和溃疡病局部切除术711例，围手术死亡率0．72％。结论胃大部切除术是胃十二指肠溃疡急性穿孔的主要治疗方法。在保守治疗过程中，应该掌握外科的手术适应证，以便提高治愈率，降低手术死亡率。     

腹腔镜胃十二指肠溃疡修补术治疗急性胃十二指肠溃疡穿孔

目的:总结腹腔镜胃十二指肠溃疡修补术治疗急性胃、十二指肠溃疡穿孔的临床经验。方法:1997年6月至2007年12月35例急性胃十二指肠溃疡穿孔患者施行腹腔镜消化性溃疡穿孔修补术。结果:35例中十二指肠球部溃疡穿孔28例,胃窦部溃疡穿孔7例,穿孔直径0.5～0.8cm,手术时间80～180min,手术均获成功,术后患者疼痛轻微,均未使用止痛剂。术后康复顺利,术后住院5～10d,平均6.5d,切口均甲级愈合,痊愈出院。出院后予以内科根除幽门螺杆菌、口服H2受体拮抗剂治疗。结论:腹腔镜手术治疗急性胃、十二指肠溃疡穿孔,与开腹手术同样安全有效。胃溃疡穿孔患者术中需快速病理检查,若为恶性病变应中转开腹。     

Spontaneously perforated pyometra. A differential diagnosis in acute abdomen

Spontaneously perforated pyometra is rare, but the condition must be born in mind in women with acute abdomen. Two cases are reported, one resembling perforated peptic ulcer, the other was mistaken for acute appendicitis.