共查询到20条相似文献,搜索用时 15 毫秒
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S. Yu. Ryabova Yu. I. Trofimkin V. A. Azimov L. M. Alekseeva V. G. Granik 《Pharmaceutical Chemistry Journal》1995,29(2):127-131
The methylation of 2-formyl-3-hydroxyindole was studied, and the sequence of introduction the methyl groups was traced by1H NMR spectroscopy. The O-methyl, N-methyl, and N,O-methyl derivatives of 2-formylindole, and also the O-methyl and N-methyl derivatives of 2-methyl-3-ethoxycarbonyl-4-hydroxypyrrole were synthesized. Novel derivatives of indolyl- and pyrrolylacrylic acids were obtained on the basis of some O- and N,O-substituted aldehydes of the indole and pyrrole series. 相似文献
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P Giori M Guarneri D Mazzotta G Vertuani C Branca 《Il Farmaco; edizione scientifica》1979,34(4):277-283
4-Thiocyanato-5-amino or acylaminopyrazoles were prepared and their antifungal activity was tested against Candida albicans and Trichophyton mentagrophytes: the 4-thiocyanato-5-aminopyrazoles were the most effective in both tests. 相似文献
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The reaction of 1-benzoyl-2-oxo-4,6-dihydroxyazetino-[3,2-d] pyrimidine (III) with diethanolamine affords the amide (IV). Heating of the last with SOCl2 yields 2-beta-chloroethyl-8-hydroxy-9-benzoylamino-perhydropyrazino [1,2-c] pyrimidine-1,6-dione (VI). Reaction of compound (VI) with different amines gives the respective 2-beta-aminosubstituted derivatives (VII-XIII). Some of the obtained compounds showed central activity. 相似文献
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Ikhlass M. Abbass Mohyee A. F. Sharaf Alia A. El-damaty 《Archives of pharmacal research》1992,15(3):224-228
Arylhydrazones of diethylacetondicarboxylate3 was treated with formaldehyde to give 1-aryl-4,5,6-trihydropyridaine derivatives4a-f Cyclization of compound4a-f by hydroxylamine afforded [3,4d] 1,3,4,5-tetrahydropyridazine derivatives5a-f. Also cyclization of compound4c with semicarbazide gave 1-amidopyrazolo-5-one-1-aryl-3-carboxypyridazine6. On the other hand compound3 reacted with ethylorthoformate to give diethyl-1,4-dihydro-1-arylpyridazine-4-one-2,5 dicarboxylate7, which on treatment with hydrazine, semicarbazide and thiosemicarbazide gave pyridazine, amido and thioamido derivatives. The spectral and antimicrobial data of these compounds1–8 were studied. 相似文献
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J Marton M Kovács J Filep S Hosztafi S Garadnay S Makleit 《Acta pharmaceutica Hungarica》1999,69(4):218-223
The synthesis of the dansyl derivatives of the pharmacologically important 6,14-ethenomorphinans has not been reported. The authors realized the preparation of the dansyl derivatives (2a-i) of some 20-alkyl(aralkyl)-orvinols (1a-i). The authors unequivocally proved the structure of the parent compounds, and their dansyl derivatives. The authors also investigated certain analitical characteristics (thin-layer chromatography, UV-spectral data and reversed-phase HPLC purity tests) for the detection if necessary of these compound in biological fluid. Namely, due to the fluorescent properties of the dansyl derivatives, the sensitivity and selectivity of the analytical determinations of the parent compounds are significantly enhanced. 相似文献
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K Witkiewicz Z Machoń M Mordarski J Wieczorek 《Polish journal of pharmacology and pharmacy》1987,39(6):715-720
Several new 5-substituted 1-phenylpyrazole [3,4-d] pyrimidine derivatives were synthesized and tested for antitumor activity. Compound 17, which has 3,4-dichlorophenyl moiety at N5 of the pyrazole pyrimidine ring, shows a strong activity against L-1210 leukemia (152%). On the other hand, compounds 15, 17 and 21 were the most active against sarcoma Sa-180. It was observed that many derivatives of pyrazole [3,4-d] pyrimidine possess different biological, especially antitumor properties [1-6, 9, 10]. 相似文献