角膜像差与角膜前表面Q值对角膜塑形术近视控制的影响

目的探讨角膜像差与角膜前表面Q值改变对角膜塑形术控制近视效果的影响。方法前瞻性临床研究。对配戴角膜塑形镜治疗的8~16岁青少年儿童中低度近视患者85例（85眼）,分别进行配戴前及配戴1年后的眼轴和角膜像差、角膜前表面Q值测量。眼轴由IOLMaster测得,角膜像差和Q值由角膜地形图仪测得,角膜像差取6 mm瞳孔直径下的数据。采用logistic回归分析、独立样本t检验、配对t检验对数据进行分析。结果73例受检者完成1年的随访检查。初始眼轴长度和配戴1年后眼轴长度分别为（25.17±0.88）mm和（25.42±0.83）mm,差异具有统计学意义（t=8.387,P<0.01）。眼轴年增长幅度低于均值组和高于均值组间差异具有统计学意义的因素有初始戴镜年龄、角膜前表面Q值差值、初始角膜球差、初始水平角膜彗差、初始近视程度。行logistic回归分析,角膜塑形镜控制眼轴增长幅度主要的影响因素有：初始近视程度（?茁=3.709,P<0.01）、初始角膜球差（?茁=-12.881,P<0.01）、角膜前表面Q值差值（?茁=-4.349,P<0.01）。影响近视程度的主要因素有初始戴镜年龄（?茁=0.441,P<0.05）和初始角膜球差（?茁=8.762,P<0.05）。结论年龄和角膜球差影响近视进展。随访1年,角膜塑形镜对中度近视的眼轴控制效果优于低度近视,角膜塑形镜通过改变角膜前表面Q值及角膜球差影响近视控制效果。     

调节放松及调节状态人眼波前像差的研究

目的研究正视眼、低中度近视眼的调节作用对波前像差的影响。方法采用Hartmann—Shack原理的WASCA波前像差仪．分别测量64例正视眼和中低度近视眼（其中正视组9眼．低度近视组21眼，中度近视组34眼）在调节放松和调节状态的波前像差。结果调节放松状态各组间的总高阶像差、彗差、球差差异均无显著性，水平彗差和球差与总高阶像差存在线性相关（P值分别为0．0019和0．0008）;左右眼别的高阶像差差异无显著性。调节状态各组间总高阶像差、彗差、球差差异均无显著性。调节前后进行配对t检验．结果示调节导致球镜度增加（P〈0．01），球差减小（P〈0．01），并有向负值方向改变的趋势，调节作用能够产生明显的彗差和总高阶像差的改变。结论近视屈光度的增加并不会引起高阶像差的改变，两者无相关性。水平彗差、球差与总高阶像差存在线性相关性．正常人眼高阶像差主要由彗差和球差决定。人眼调节时，高阶像差发生改变，尤其球差的改变有统计学意义，人眼可能通过球差的负向改变来完成视近。     

FS-LASIK矫正不同程度近视术后角膜高阶像差的早期变化

目的:探究轻中度和高度近视患者飞秒激光制瓣准分子激光原位角膜磨镶术(FS-LASIK)术后角膜前后表面和整体角膜高阶像差的变化。方法:对2018-12/2019-12在我院行FS-LASIK手术的近视患者129例129眼进行回顾性病例研究,按术前等效球镜度(SE)分为轻中度近视组(SE<-6.00D,76眼)和高度近视组(SE≥-6.00D,53眼)。分别于术前和术后6mo用Pentacam眼前节分析系统测量角膜前后表面和整体角膜的高阶像差。结果:术后6mo,两组角膜前表面和整体角膜的总高阶像差、球差和水平彗差较术前增加,且高度近视组高于轻中度近视组(均P<0.01);两组角膜后表面的水平彗差较术前有差异(均P<0.01),且高度近视组高于轻中度近视组(P<0.01)。两组患者角膜前表面和整体角膜的术源性总高阶像差、球差和水平彗差与术前SE有明显相关性(均P<0.01)。结论:FS-LASIK术后6mo角膜前表面及整体角膜的总高阶像差、球差和水平彗差均较术前增加,且与术前SE明显相关;角膜后表面高阶像差除水平彗差外无明显变化,其远期变化有待进一步研究。     

不同程度近视患者行SMILE术后的有效光学区及角膜高阶像差比较

目的：比较低、中、高度近视患者行飞秒激光小切口基质透镜取出术(SMILE)后的有效光学区和角膜高阶像差。

方法：收集2019-02/2021-02在我院行SMILE手术的患者134例,均取右眼入组,按等效球镜度(SE)分为低度近视组SE>-3.00 D,中度近视组-6.00 D结果：SMILE术后1 mo,三组术后有效光学区均小于预设光学区,随着屈光度数增加,有效光学区越小(P<0.05); 术后1 mo角膜总高阶像差、球差、彗差均高于术前,除低近视度组球差术前与术后1 mo无差异(P>0.05),其余组别均有差异(P<0.05); 角膜总高阶像差、球差和彗差随着屈光度数增加而增加,三组角膜总高阶像差和球差有差异(均P<0.05),高度近视组与中度近视组、低度近视组彗差结果均有差异(P<0.05),中度近视组与低度近视组彗差结果无差异(P>0.05)。

结论：随着手术矫正的屈光度数增加,术后有效光学区减少越多,角膜高阶像差增加越明显; SMILE术后1 mo角膜高阶像差较术前增加。     

角膜波前引导的LASIK治疗低中度近视角膜高阶像差的临床观察

目的:比较角膜波前像差引导下的准分子激光原位角膜磨镶术(laser in situkeratomileusi,LASIK)和常规的LASIK对低中度近视角膜高阶像差的影响。方法:采用前瞻性非随机对比研究,选取6mo内连续的低中度近视患者32例58眼实施常规LASIK(A组,其中低度近视24眼,中度近视34眼),34例52眼实施角膜波前引导下的个性化LASIK(B组,其中低度近视23眼,中度近视29眼)。所有手术均使用德国Schwind公司Esiris第九代准分子激光治疗仪和Carriazo Pendular钟摆式角膜板层刀,使用4.2.0版本的Optikon keratron Scout2000角膜地形图对两组患者在术前和术后3mo进行6mm瞳孔直径时角膜高阶像差检查。结果:两组病例角膜球差和均方根均高于术前。A组低度近视术后高阶像差增加量依次为均方根0.236μm、彗差0.146μm、球差0.139μm和三叶差0.054μm,中度近视高阶像差增加量依次为均方根0.367μm、球差0.284μm、彗差0.177μm和三叶差0.021μm。B组低度近视高阶像差增加量依次为球差0.127μm、均方根0.088μm、三叶差0.051μm、和彗差0.042μm,中度近视高阶像差增加量依次为均方根0.175μm、球差0.162μm、彗差0.027μm和三叶差0.024μm;两组病例术后3mo裸眼视力非常接近.同样条件下低中度近视角膜波前像差引导下的个性化LASIK切削的深度较常规LASIK深。结论:角膜波前像差引导下的低中度近视LASIK较常规LASIK角膜高阶像差影响少。     

ORK-CAM引导的非球面切削不同近视组间屈光参数比较

目的:研究ORK-CAM引导的非球面切削个体化手术不同程度近视组间手术前后的角膜总体像差、球差、彗差和Q值的变化特点,并进行对比分析。方法:选取2010年在眼科激光中心行ORK-CAM引导的非球面切削个体化手术的250例500眼近视病例,其中低中度近视组有125例250眼,高度近视组有125例250眼。分别对两组病例手术前后的裸眼视力、等效球镜度、角膜总体像差RMS、球差、彗差和Q值的变化进行比较,随访6mo,所有数据采用SPSS 17.0进行统计分析,P<0.05有统计学差异。结果:两组术后裸眼视力分别为1.15±0.16和1.13±0.14,无统计学差异。两组术后残余等效球镜度均减少,但无统计学差异。术后角膜总体像差RMS、球差、彗差和Q值均增加,但高度近视组的增幅大于低中度近视组(P<0.05)。结论:ORK-CAM引导的非球面切削个性化手术对低中高度近视的治疗都是有效和安全的。但如要进一步减少高度近视术后角膜总体像差、球差、彗差和Q值的增加仍需深入探索。     

不同屈光度近视SMILE术后1个月角膜屈光力分布及角膜高阶像差研究

目的比较低、中、高度近视患者飞秒激光小切口角膜基质透镜取出术(SMILE)术后1个月的角膜屈光力分布与角膜高阶像差。方法采用系列病例观察研究方法。选取209例SMILE患者的右眼入组,根据手术矫正等效球镜度(SE)分为低(SE<-3.0 D)、中(-3.0 D≤SE<-6.0 D)、高(SE≥-6.0 D)度近视3组,使用Pentacam眼前节分析系统测量与角膜中央直径4 mm环的平均屈光力相差0.5 D以内(△0.5 D)的角膜区域最大环直径及角膜高阶像差,分析不同近视分组术后角膜屈光力分布及其与角膜高阶像差变化的相关关系。结果低、中、高度近视组患者微透镜直径差异无统计学意义,矫正近视度数越高,△0.5 D分布最大环直径越小。术后角膜总高阶像差、球差和彗差较术前增加,术后球差在高度近视组明显增加,矫正近视度数越高,增加程度越大;术后三叶草差及变化值在3组患者中差异无统计学意义。△0.5 D分布最大环直径与手术前后角膜总高阶像差、球差、彗差的变化值呈显著负相关。结论SMILE矫正近视度数越高,术后产生良好视力的角膜范围越小,而术后角膜高阶像差越大,提示在矫正中高度近视时,确保安全前提下应设计较大直径微透镜,提高患者术后视觉质量。     

不同屈光度近视SMILE术后1个月角膜屈光力分布及角膜高阶像差研究

目的 比较低、中、高度近视患者飞秒激光小切口角膜基质透镜取出术(SMILE)术后1个月的角膜屈光力分布与角膜高阶像差。方法 采用系列病例观察研究方法。选取209例SMILE患者的右眼入组,根据手术矫正等效球镜度(SE)分为低(SE<-3.0 D)、中(-3.0 D≤SE<-6.0 D)、高(SE≥-6.0 D)度近视3组,使用Pentacam眼前节分析系统测量与角膜中央直径 4 mm环的平均屈光力相差0.5 D以内(△0.5 D)的角膜区域最大环直径及角膜高阶像差,分析不同近视分组术后角膜屈光力分布及其与角膜高阶像差变化的相关关系。结果 低、中、高度近视组患者微透镜直径差异无统计学意义,矫正近视度数越高,△0.5 D分布最大环直径越小。术后角膜总高阶像差、球差和彗差较术前增加,术后球差在高度近视组明显增加,矫正近视度数越高,增加程度越大;术后三叶草差及变化值在3组患者中差异无统计学意义。△0.5 D分布最大环直径与手术前后角膜总高阶像差、球差、彗差的变化值呈显著负相关。结论 SMILE矫正近视度数越高,术后产生良好视力的角膜范围越小,而术后角膜高阶像差越大,提示在矫正中高度近视时,确保安全前提下应设计较大直径微透镜,提高患者术后视觉质量。     

LASIK手术前后屈光状态和角膜形态对高阶像差的影响

目的 分析近视散光患者行准分子激光原位角膜磨镶术(LASIK)手术前后屈光状态和角膜形态对高阶像差的影响.方法 在LASIK术前和术后6个月,分别对患者69例108眼进行角膜地形图和波前像差检查,屈光矫正范围(-1.25～-9.00)D,切削直径为6.0 mm或6.5 mm.结果 LASIK手术前后在6.0 mm瞳孔直径下最主要的高阶像差是3阶彗差、4阶球差和三叶草散光,术后总高阶像差的均方根(RMSh)增加1.82倍.术后RMSh变化与近视度的矫正量呈正相关,主要表现为3阶彗差和4阶球差的变化.术后角膜表面不对称指数(SAI)显著增加,RMSh的变化与其增加量呈正相关,特别是3阶彗差.角膜形态术前为不规则型及术后为半环型和中央岛型时SAI增大,高阶像差增大.结论 LASIK手术前后的主要高阶像差均为3阶彗差和4阶球差.术后总高阶像差增大,主要表现为慧差增大,可能为角膜表面的不对称性增大引起.     

VisuMax飞秒激光准分子激光原位角膜磨镶术娇正高度近视术后角膜前后表面高阶像差变化

目的 探讨VisuMax飞秒激光准分子激光原位角膜磨镶术(LASIK)矫正高度近视术后角膜前后表面高阶像差的变化情况.方法 前瞻性连续病例研究.选择行LASIK矫正高度近视(等效球镜度数-6.38～-13.50 D)患者22例((41眼),其中使用Visumax飞秒激光制瓣11例(21眼),Moria M3旋转式微型角膜刀制瓣11例(20眼).采用Pentacam-HR眼前节分析系统,分别在术前、术后6个月对术眼进行眼前节三维图像采集,记录基于角膜前后表面高度图获取的分析直径为6 mm的角膜前后表面高阶像差均方根值及各阶像差的Zernike系数,计算彗差和初级球差,采用方差分析及t检验进行统计分析.结果 术后飞秒激光组和角膜刀组的角膜前表面总高阶像差均方根值、彗差、初级球差均较术前显著增加(P<0.05),其中角膜刀组的彗差增加量显著高于飞秒激光组[分别为(0.788±0.592)μm及(0.403±0.572)μm,P<0.05];术后飞秒激光组的角膜后表面总高阶像差均方根值、彗差、初级球差的绝对值均较术前增加(P<0.05),而角膜刀组的角膜后表面像差在手术前后差异无统计学意义(P>0.05);与角膜刀组相比,飞秒激光组术后角膜后表面的彗差增加量更显著[分别为(0.004±0.031)μm及(0.027土0.036)μm,P<0.05].结论 VisuMax飞秒激光LASIK矫正高度近视比角膜刀制瓣引起的角膜前表面彗差增加量较少;其角膜后表面像差亦存在轻微增加,且角膜后表面彗差增加较角膜刀显著,发生机制有待进一步探讨.     

Corneal changes and wavefront analysis after orthokeratology fitting test

PURPOSE: To evaluate corneal changes and ocular aberrations during an orthokeratology test. DESIGN: A prospective, nonrandomized cohort study. METHODS: Fourteen myopic patients (26 eyes) underwent an orthokeratology fitting test with the BE contact lens (Ultravision Pty, Ltd, Brisbane, Australia). Best spectacle-corrected visual acuity (BSCVA), uncorrected (Ultravision Pty, Ltd, Brisbane, Australia) visual acuity (UCVA), subjective cycloplegic refraction, biomicroscopy, corneal topography, optical pachymetry, and aberrometry were performed at baseline and one and eight nights orthokeratology. The short-term effect of orthokeratology using corneal topography, tomography, and ocular aberrations was evaluated. RESULTS: The mean spherical equivalent changed from -2.24 +/- 0.98 diopters (D) at baseline to 0.15 +/- 0.76 D after the eight nights of lens wear (P = .001). All patients had an UCVA of 20/30, 69.2% with 20/20. Changes in central corneal pachymetry were not observed. There was a statistically significant increase in the temporal corneal thickness from night one, without any difference between nights one and eight (P > .001). A significant increase of higher-order root mean square values was observed from baseline (0.42 +/- 0.16 mum), night one (0.81 +/- 0.24 mum), and night eight (1.04 +/- 0.24 mum). Increases in coma (Z7+Z8) and spherical aberration (Z12) were observed. Positive horizontal (Z8) coma increased in right eyes, and negative horizontal (Z8) coma increased in left eyes (P < .001). CONCLUSIONS: Myopia reduction resulting from rapid central corneal flattening and improvement of UCVA occurred after orthokeratology. Higher-order aberrations (HOAs), particularly spherical aberration and coma, increased significantly during the orthokeratology test. An increase of temporal pachymetry and differences in coma direction induced between the eyes may be related to the subclinical lens decentration temporally.     

Refractive error and monochromatic aberrations in Singaporean children

Higher order optical aberrations were measured in 273 cyclopleged Singaporean school children using a Bausch and Lomb Zywave aberrometer, with 268 of these subjects also undergoing corneal topography measurements (Tomey TMS 2 system). Subjects with low myopia (> -3.00 to -0.50 D) showed slightly, but significantly, less positive levels of spherical aberration than other refractive error groups. Chinese subjects also showed significantly higher amounts of aberrations than Malay subjects, particularly for vertical coma, but also for horizontal coma and spherical aberration. Anterior corneal spherical aberration (calculated from topography) was significantly correlated with whole eye spherical aberration, but did not vary significantly with refractive error or racial background. Residual spherical aberration (i.e. of posterior cornea and crystalline lens) did vary significantly with refractive error and race. Our results do not provide any evidence for aberration-driven form-deprivation as a major mechanism of myopia development.     

配戴散光设计型角膜塑形镜对人眼像差的影响

目的：通过观察散光设计型角膜塑形镜配戴后人眼高阶像差的变化,评价该角膜塑形镜对人眼视觉质量的影响。方法：回顾性研究。选取石迎辉眼科诊所门诊2015 年2 月至2016 年8 月期间配戴散光设计型角膜塑形镜患者25例（50眼）,测量配戴塑形镜前,戴镜后1个月、3个月、6个月、1年,在5、7 mm瞳孔直径下的高阶像差均方根（RMS）值。戴镜前后各像差值比较采用重复测量方差分析,各组间比较采用LSD检验,当校正系数Epsilon < 0.7 时,采用Bonferroni法进行两两比较。结果：戴镜 后在5 mm和7 mm瞳孔直径时像散、彗差、球差、剩余像差及总高阶像差较戴镜前均增加,差异有统计学意义（5 mm：F =5.15、11.11、10.73、6.95、11.18,均P < 0.05; 7 mm：F =2.93、4.71、9.34、5.01、5.70,均P < 0.05）。随着戴镜时间的延长,各像差值逐渐增大,戴镜3 个月时达到最大值,随后逐渐降低。结论：角膜散光较大患者配戴散光设计型角膜塑形镜后高阶像差增加,人眼视觉质量下降。     

角膜塑形术对角膜表面形态及角膜像差的影响

目的观察和分析角膜塑形术后角膜表面形态及角膜像差的变化,并评估角膜塑形偏心量对角膜像差的影响。方法前瞻性临床研究。对22例年龄为（24．4±2．2）岁的中低度近视[（-2．23±0．74）D1患者采用夜戴型角膜塑形镜矫治近视。分别在配戴角膜塑形镜前．戴镜后1周、1个月时用开视野红外验光仪（Grand Seiko 5500）测量中心近视度数：用Medmont E-300角膜地形图仪进行角膜地形检查,通过角膜地形图得到角膜塑形偏心数据（包括幅度和方向）、角膜曲率（K值）,用Matlab软件将角膜地形图数据转化成角膜像差数据,只取右眼数据进行研究。数据分别采用配对t检验、独立样本￡检验、单因素方差分析、Pearson相关进行分析。结果配戴角膜塑形镜后眼近视度数即开始有效减低,角膜中心表面曲率也同时开始降低,两者1周之后都趋于稳定。戴镜第1周时的平均偏心量是（0．49±0．24）mm。与1个月时的偏心量差异无统计学意义;偏心方向主要在颞侧,其次是下方。戴镜后角膜表面的总高阶像差、三阶像差、四阶像差均方根值相对戴镜前增加,1周之后趋于稳定。角膜三阶像差变化量与偏心幅度呈正相关（r=0.492,P〈0．05）;四阶像差变化量与偏心的相关性无统计学意义;角膜三阶像差中的一级彗差变化量与偏心在幅度和方向上都呈正相关（r=0．546,P〈0．05;r=0．710,P〈0．05）。初始散光较大者的偏心量并不比散光较小者大,差异无统计学意义。结论角膜塑形术在1周之内即可有效降低近视度数、角膜曲率;角膜总高阶像差及三阶、四阶像差均增大．其中三阶像差中的一级彗差增加量与角膜塑形偏心相关。角膜塑形术后的偏心量不取决于初始的散光度数。     

Third-order aberrations of pseudophakic eyes

The aberrations of pseudophakic eyes were analysed by third-order theory assuming thin intraocular lenses. Third-order aberrations with spherical surfaced lenses are quadratic functions of lens shape. Spherical aberration and coma are generally the most rapidly changing aberrations, at small field positions, with change in lens shape. Optimum designs probably lie within the shape factor range at which these attain minimum absolute values (+1.1, spherical aberration; -0.9 to -3.4, coma). The importance of spherical aberration declines relative to that of off-axis aberrations as pupil size decreases. The introduction of a level of corneal asphericity alters each aberration by a constant amount for any lens shape.     

中央孔型ICL V4c植入术矫正中高度近视的稳定性及高阶像差分析

目的：探讨中央孔型ICL V4c植入术矫正中高度近视的稳定性及对高阶像差的影响。

方法：观察采用ICL V4c人工晶状体植入术(研究组17例34眼)和全飞秒小切口基质透镜取出术(SMILE)(对照组18例34眼)治疗的高度近视患者术前、术后1d,1wk,1、3mo UCVA、BCVA、球镜(SE)、柱镜(CE)、IOP、角膜内皮细胞计数、总高阶像差(RMS)、球差、垂直彗差、水平彗差、彗差的差异。

结果：术后1、3mo研究组SE、CE高于对照组(P<0.05),术后1wk,1、3mo RMS、彗差低于对照组(P<0.05),术后3mo球差、水平彗差低于对照组(P<0.05)。

结论：ICL V4c植入术矫正中高度近视眼具有良好稳定性,对术眼高阶像差影响小。     

Age-related changes in corneal and ocular higher-order wavefront aberrations

PURPOSE: To investigate age-related changes in ocular and corneal higher-order wavefront aberrations and elucidate relative contributions of the cornea and the lens in the age-related changes. DESIGN: Observational case series. METHODS: Corneal and ocular higher-order wavefront aberrations in the central 6 mm diameter were measured with videokeratography and the Hartmann-Shack wavefront aberrometer in 75 normal eyes of 75 patients with a mean age of 43.5 +/- 11.7 years (range, 18-69 years). Higher-order wavefront aberrations were calculated with Zernike polynomials up to sixth order. From the Zernike coefficients, we calculated root mean square (RMS) of coma and spherical aberration. To examine age-related changes of the polarity of spherical aberration, the changes of the Zernike coefficient Z(4)(0) was also investigated. RESULTS: Both corneal (r =.307, P =.007) and ocular (r =.334, P =.0033) coma RMS showed positive correlations with age. There was a positive correlation between corneal and ocular coma RMS (r =.468, P <.0001). The RMS of corneal spherical aberration did not change with aging (r =.153, P =.1895), whereas the RMS of ocular spherical aberration had a positive correlation with aging (r =.308, P =.0068). CONCLUSIONS: These results suggest that the ocular coma increases with age, mainly because of the increase in the corneal coma, and the ocular spherical aberration increases with age, mainly because of the increase in the spherical aberration in the internal optics.     

Optical changes and visual performance with orthokeratology

Orthokeratology has undergone drastic changes since first described in the early 1960s. The original orthokeratology procedure involved a series of lenses to flatten the central cornea and was plagued by variable results. The introduction of highly oxygen-permeable lens materials that can be worn overnight, corneal topography, and reverse-geometry lens designs revolutionised this procedure. Modern overnight orthokeratology causes rapid, reliable, and reversible reductions in refractive error. With modern designs, patients can wear lenses overnight, remove them in the morning, and see clearly throughout the day without the need for daytime refractive correction. Modern reverse-geometry lens designs cause central corneal flattening and mid-peripheral corneal steepening that provides clear foveal vision while simultaneously causing a myopic shift in peripheral retinal defocus. The peripheral myopic retinal defocus caused by orthokeratology is hypothesised to be responsible for reductions in myopia progression in children fitted with these lenses. This paper reviews the changes in orthokeratology lens design that led to the reverse-geometry orthokeratology lenses that are used today and the optical changes these lenses produce. The optical changes reviewed include changes in refractive error and their time course, high- and low-contrast visual acuity changes, changes in higher-order aberrations and visual quality metrics, changes in accommodation, and changes in peripheral defocus caused by orthokeratology. The use of orthokeratology for myopia control in children is also reviewed, as are hypothesised connections between orthokeratology-induced myopic peripheral defocus and slowed myopia progression in children, and safety and complications associated with lens wear. A better understanding of the ocular and optical changes that occur with orthokeratology will be beneficial to both clinicians and patients in making informed decisions regarding the utilisation of orthokeratology. Future research directions with this lens modality are also discussed.     

LASIK术后眼高阶像差和角膜非球面系数Q值的变化

目的:观察2mm小光斑飞点扫描伴主动眼球跟踪系统的激光机行常规LASIK术后,眼高阶像差和角膜非球面系数Q值的改变,同时观察术后不同瞳孔直径下眼高阶像差的变化。方法:近视患者33例60眼均接受常规LASIK手术,术前和术后3mo分别检查记录5mm和6mm瞳孔直径下总高阶像差、三阶彗差、四阶球差和角膜前表面非球面系数Q值,并进行统计学分析。结果:LASIK术后,5mm和6mm瞳孔直径下各高阶像差均较术前显著增加,其中四阶球差增加最为显著;术后水平彗差比垂直彗差增加显著;术前术后6mm直径下高阶像差均较5mm直径下显著增大;LASIK术后角膜非球面系数Q值向正值方向明显变化,差异具有显著性。结论:近视眼常规LASIK术后,各项高阶像差明显增大,其中球差增大最为显著。手术前后6mm瞳孔直径下高阶像差均比5mm瞳孔直径下高阶像差明显增大。术后角膜表面非球面系数Q值由负值变为正值,且增大显著。