多发性簇集性皮肤纤维瘤1例

患者男,55岁,因左上肢丘疹、结节28年,背部丘疹、结节4年于2009年2月8只来我院就诊.患者28年前左上肢伸侧出现数个淡红色绿豆大丘疹、结节,质较硬,无明显自觉症状,未治疗,以后皮损逐渐增多、增大,颜色渐变成暗红,部分皮损融合.7年前皮损出现轻度瘙痒,4年前背部出现相同性质的丘疹、结节.     

皮肤Rosai-Dorfman病

<正>1 病历摘要 患者女，16岁。因右大腿伸侧皮肤丘疹、结节2年，背部皮肤丘疹、结节1年半，于2020年4月21日来临沂市人民医院皮肤科就诊。患者自诉2年前无明显诱因右大腿伸侧皮肤出现约一元硬币大暗红斑，局部有灼热感，无明显痒痛感；暗红斑逐渐增大，其上毛发增多，并且出现绿豆大丘疹及结节，皮下可触及质地稍硬的结节，并散在色素沉着；丘疹及结节逐渐增多、     

毛发上皮瘤一家系报告

先证者女,22岁。面部丘疹,结节14年,于2006年3月5日就诊。患者7岁时鼻根部出现一粟粒大肤色丘疹,并逐渐在鼻部两侧、额头、上唇等处出现多个类似丘疹和结节,无明显自觉症状。体格检查：一般情况好,智力正常,系统检查无明显异常。皮肤科检查：鼻唇沟、上唇、鼻根、鼻翼两侧密集肤色粟粒至绿豆大的丘疹和结节,呈半球形,质韧,有透明感,部分丘疹表面有粟丘疹（图1）。[第一段]     

外观类似结节性痒疹的瘤型麻风1例

<正>1 临床资料患者男,33岁,贵州籍,头面、躯干丘疹、结节伴瘙痒,并手部、足部麻木3年。3年前患者因双下肢丘疹、结节伴瘙痒1个月就诊于本院皮肤科门诊,根据患者病史及查体,考虑诊断结节性痒疹,并予以对症止痒、抗过敏等治疗。后双下肢丘疹逐渐消失,伴头面、躯干部出现多发丘疹、结节伴轻度瘙痒,遂就诊于当地镇医院,镇医院诊断结节性痒疹并对症止痒至今,未返本院随诊。现因镇医院对症治疗效果不佳,头皮、躯干丘疹、结节增多并手部、足部麻木感加重就诊本院     

“巨大型”老年皮脂腺过度增生

报告1例患巨大的老年皮脂腺过度增生的75岁男性患者。8年前其右颊有一肤色无症状的丘疹,用电凝法去除。数年后在同一部位又长出圆顶形的肤色结节,表面出现多个小脐凹,结节渐增至10mm 直径大小。随之颊部又起数个黄色小丘疹,中央也有脐凹,其中一个正位于原结节下方。(?)及家族史无异常。将结节及周围丘疹(?)梭形切口切除,术后10月无复发。组织学检查结节与丘疹病变基本相同,在扁平的表皮下有特大而多的皮脂腺小叶。丘疹的组织学改变是     

丘疹结节型色素性基底细胞癌的电子皮镜所见

目的　探讨丘疹结节型色素性基底细胞癌的电子皮镜所见及其在临床诊断中的意义。方法　利用电子皮镜观察丘疹结节型色素性基底细胞癌 6例 8个病灶 ,术后做组织病理确认。结果　丘疹结节型色素性基底细胞癌在电子皮镜下所见具有特征性 ,术后病理均诊断为基底细胞癌。结论　电子皮镜检查可以为丘疹结节型色素性基底细胞癌的诊断及鉴别诊断提供依据 ,具有重要意义。     

Ⅱ型麻风反应1例

正1临床资料患者男,40岁,江西吉安人。面部反复暗红色丘疹和结节1年,泛发全身伴瘙痒并乏力1个月,伴寒战、发热和关节疼痛7d。1年前,无明显诱因额面部出现少量散在的暗红色丘疹和结节,无自觉症状。1个月前,皮损泛发至耳部、躯干及四肢,伴疼痛、瘙痒、乏力。外院以"血管炎"予静滴药物治疗(药名不详),乏力消失,丘疹、结节消退。7d前受凉后皮疹加重,全身再次发生丘疹、结节,伴寒战、发热、关节痛。既往史、个人史、家     

黏液水肿性苔藓2例

报告2例黏液水肿性苔藓。例1.女,16岁。全身起丘疹、结节2个月,以手部结节损害为特征。例2．女,40岁。四肢、躯干丘疹3年,伴面部斑块1年,以眉间隆起的纵向斑块为特征。此2例患者的丘疹、结节组织病理检查均示真皮胶原纤维疏松,成纤维细胞增生,胶原纤维束间阿新蓝染色阳性。     

有皮肤损害的急性粒细胞白血病1例

患者女 ,30岁 ,病期2年。2年来四肢躯干反复出现丘疹、紫癜、结节 ,伴瘙痒 ,曾多次诊断为湿疹。检查可见周身散在淡红丘疹、结节、水疱及紫癜。左上肢丘疹组织病理检查符合皮肤白血病。骨髓检查及细胞免疫分型确诊急性粒细胞性白血病M2型。     

多发性化脓性肉芽肿1例

患者女,19岁。左膝丘疹、结节10余年。皮肤科情况:左膝内侧长约15cm条索状瘢痕,两侧见较多淡红、灰红色丘疹、结节。组织病理符合化脓性肉芽肿。诊断:多发性化脓性肉芽肿。     

A distinctive type of widespread congenital melanocytic nevus with large nodules

We report an unusual case of congenital melanocytic nevus presenting in a 19-year-old African woman as widespread papules and variably sized nodules and tumors affecting the entire body, including the palms, soles, and oral mucous membrane. Histopathologic examination of 3 representative skin lesions showed mainly dermal aggregations of round to oval, focally pigmented, monomorphous melanocytes, arranged in nodular and plexiform patterns. Scattered areas with spindle-shaped dendritic melanocytes surrounded by fibrosis were also noted in the center of the lesions. The clinical and histopathologic findings were similar to those in 2 other previously reported cases, except that in 1 of the earlier cases the skin nodules were composed of spindle-shaped cells, suggesting a type of blue nevus. The findings in our case indicate a broader spectrum of morphologic features in this condition, with dermal aggregations of melanocytes showing congenital features, representing a common histopathologic denominator. Based on this observation, we suggest the term "widespread congenital dermal nevus with large nodules" to be the most appropriate for this rare, but distinctive, type of congenital nevus.     

痒疹样营养不良型大疱性表皮松解症一家系调查

先证者女,18岁。躯干、四肢反复水疱、丘疹、结节伴痒6年。皮肤科情况:双下肢胫前多发密集米粒至花生米大小扁平丘疹、结节,色泽淡红至暗红,部分呈脐样凹陷,上覆白色糠状鳞屑,见点状糜烂、结痂;躯干及双上肢散在粟粒至黄豆大小淡白色、淡红色丘疹及萎缩性疤痕,部分皮损表面糜烂、结痂;指趾甲及黏膜未见受累。皮损组织病理示:角化过度,颗粒层、棘层中度不规则增厚,表皮下见裂隙及大疱,真皮浅层毛细血管扩张,血管内皮细胞及纤维组织明显增生,血管周围少许淋巴细胞浸润。诊断:痒疹样营养不良型大疱性表皮松解症。家系调查4代39人,共有24人患病,每代均有发病,其中男17人、女7人患病,符合常染色体显性遗传。     

皮内痣伴结缔组织增生性结节一例

患者男,28岁,因左侧胸部单发褐色肿物4年、多发小丘疹1年就诊。皮肤科检查：胸部左侧一1.2 cm × 1.1 cm × 1.0 cm褐色类圆形肿物,质韧,其右侧数个直径3 ~ 5 mm褐色丘疹,左侧腋下淋巴结未触及肿大。手术完整切除肿物后行组织病理检查：肿物和小丘疹内均可见真皮浅层痣细胞聚集成巢,考虑皮内痣;最大肿物...     

Linear epidermal nevus with acantholytic dyskeratosis in an infant

A 7-month-old boy came to use with flat papules and small erosions on the extensor aspect of his left forearm and a linear arrangement of verrucous papules on the dorsum of his left hand. Histological examination revealed hyperkeratosis, parakeratosis, irregular acanthosis, and marked acantholysis from suprabasal through upper epidermis. This is the first reported case of linear epidermal nevus with acantholytic dyskeratosis in Japan.     

A case of nevus comedonicus syndrome associated with neurologic and skeletal abnormalities

A 12-year-old male was referred to us with recurrent pus discharge from tender nodules on the right axilla dating from the neonatal period. The nodules were black, characterized by scarring with dilated follicular openings and there were black papules filled with comedo-like keratin plugs in both axillae. Physical examination revealed a bowing deformity of the right third finger and retardation in language ability. The patient was referred to the Departments of Neurology and Orthopedics in Chungnam National University Hospital, Korea.
Histologic examination of one of the black comedo-like lesions showed a bulbous and dilated infundibulum that contained laminated keratin, indicating a diagnosis of nevus comedonicus. A CT scan of the brain revealed dysgenesis of the corpus callosum. The IQ (intelligence quotient) score of the patient, measured by the Korean Wechsler Intelligence Scale for Children-Revised, was 94. The only difficulty noted for ordinary life was learning language. A radiograph of the right hand revealed hyperextension and an ulnar drift deformity of the right middle finger. Corrective osteotomy with external fixation and an iliac bone autograft were performed. Intermittent neurologic follow-up visits were ordered for the noted language deficit. At present the patient only exhibits difficulty in calculation.
Oral antibiotics were administered to the skin lesions on occasion for secondary infections and inflammation of the cysts and comedones. Extraction of the comedones was performed as needed.     

肉芽肿性皮肤松弛症

报告1例肉芽肿性皮肤松弛症.患者男,56岁.全身皮肤出现丘疹、结节25年,皮肤松弛10年.皮肤科检查:以褶皱部位为主全身可见300余个丘疹、结节,皮肤松弛下垂,未见隆起性及浸润性斑块.组织病理检查示真皮内以淋巴细胞为主的浸润,可见多核巨细胞肉芽肿,弹性纤维缺失.免疫组化染色示CD3、CD68、CD45RO均( ),CD20、CD79a均(-),Ki-67阳性细胞的比率<10%.     

带状疱疹样皮肤转移癌1例

患者男,78岁。胸部丘疹、结节伴疼痛1月余。查体见以左胸部为主的散在或簇集的丘疹、结节,似带状分布,后背部未累及。皮损组织病理示:肿瘤组织位于真皮中上层,肿瘤细胞呈立方形,具异型性,可见病理性核分裂,呈灶状分布,有的细胞空泡化,有的肿瘤团块中腺样结构形成。CK7(+),CK20(-),AE1/AE3(+),CK5/6(-)。诊断:皮肤转移性腺样鳞癌。     

CD8~+的淋巴瘤样丘疹病1例

患者女,38岁。全身反复红斑、斑片8年,丘疹、结节1年。全身多处泛发色素沉着斑及红色小丘疹,左腰部有一直径1cm大小的斑块。斑块处组织病理示:真皮及皮下弥漫大细胞,有异形性;免疫组化:异形细胞LCA(+)、CD3(+)、CD4(+)、CD8(+)、CD30(+)、GranzymeB(+),诊断为淋巴瘤样丘疹病,A型。该患者以红斑起病之后出现丘疹,但从未出现溃疡坏死,丘疹的大小和可自行消退的特点符合淋巴瘤样丘疹病,CD8+是LyP较为少见的免疫表型。该病应与皮肤CD30(+)间变性大细胞淋巴瘤和蕈样肉芽肿鉴别,需监测其预后及转归。     

Disseminated Epidermolytic Acanthoma

A 65-year-old Japanese male suffered from numerous brownish papules on his back for 6 months. Clinical appearance resembled seborrheic keratosis, but light microscopic examination revealed epidermolytic hyperkeratosis. Electron findings were the same as those of epidermolytic hyperkeratosis and systemic nevus verrucosus. It may be concluded that this type of skin disease is an acquired epidermolytic hyperkeratosis.     

Eruptive collagenomas

A 24-year-old woman presented with hypopigmented papules of the abdomen that had been present for four years without a family history of similar cutaneous findings or associated medical problems. Histopathologic features confirmed the diagnosis of a connective-tissue nevus that was composed of collagen. Eruptive collagenomas are a rare form of acquired collagenomas, which are characterized by the sudden appearance of asymptomatic papules and nodules on the lower trunk and extremities; the lesions are composed of haphazardly arranged collagen fibers. The pathogenesis is unknown, lesions are persistent, and therapeutic options have not been reported.