Comparison of 99mTc-methoxyisobutylisonitrile myocardial single-photon emission computed tomography and electron beam computed tomography for detecting coronary artery disease in patients with no myocardial infarction

Background Previous studies have compared single-photon emission computed tomography (SPECT) and electron beam computed tomography (EBCT) in detection of coronary artery disease (CAD) in patients with myocardial infarction (MI). The purpose of this study was to compare SPECT with EBCT in detection of CAD in patients with no MI.Methods One hundred and forty-seven patients with suspected CAD underwent stress-rest 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) myocardial SPECT, cardiac EBCT and coronary angiography (CAG) within one month. Of them, 73 patients (aged 52.6±10.6 years old) with no history of MI were included in this study. Coronary artery calcium (CAC) was defined as a CT value ≥130 HU within the boundary of coronary artery on EBCT. Results There were 35 and 38 patients with or without CAD according to CAG. Ninety-six percent of the patients with abnormal SPECT and CAC had a coronary arteries stenosis ≥50%, and 90.9% patients with normal SPECT and EBCT showed no CAD. The sensitivity of SPECT and EBCT in detection of CAD was comparable, and the specificity of SPECT (92.1%) was significantly higher than that of EBCT (55.3%) (P<0.005). For the detection of individual coronary artery stenosis, both sensitivity and specificity of SPECT (75.0% and 93.7%) were significantly higher than those of EBCT (53.3% and 76.7%) (P<0.025 and P<0.005, respectively). In patients without chest pain, the sensitivity and specificity of SPECT (76.9% and 91.4%) were significantly higher than those of EBCT (23.1% and 69.0%) in detection of a coronary artery stenosis of ≥50% (P<0.01 and P<0.005, respectively). However, in patients with chest pain, both sensitivity and specificity of SPECT were comparable to those of EBCT. In patients ≤45 years old, the sensitivity of SPECT (77.8%) was significantly higher than that of EBCT (27.8%) in assessing a coronary artery stenosis of ≥50% (P<0.005), and the specificity of SPECT was comparable to that of EBCT. In patients >45 years old, the specificity of SPECT (94.3%) was significantly higher than that of EBCT (70.5%) (P<0.005), and the sensitivity of SPECT was comparable to that of EBCT. Conclusion 99mTc-MIBI myocardial perfusion SPECT has higher accuracy than that of EBCT in detection of CAD in patients without MI.     

Assessment of coronary artery disease with second harmonic myocardial perfusion contrast echocardiography

Objectives To assess the relationship between myocardial regional perfusion using second harmonic myocardial contrast echocardiography (MCE) by venous injection of Levovist and coronary artery stenosis detected by coronary angiography to determine whether MCE can be used to detect coronary artery disease (CAD) and its sensitivity and specificity for detecting CAD.Methods Thirty-six patients who underwent coronary artery angiography and MCE formed the study groups.Ten myocardial segments (5 each in the apical two- and four-chamber views) from the images were scored for detecting myocardial perfusion as follows: 1, normal perfusion; 2, decreased perfusion; and 3, perfusion defect.The arteries were classified as normal or diseased.The diseased arteries were classified into three groups according to the perfusion scores.Results There were significant differences in coronary diameter stenosis among the different perfusion score groups (P<0.001).There were 10 total occluded arteries, and the myocardial perfusion scores were different because of different collateral circulation.In the normal perfusion group (Group A), the coronary diameter stenosis was 65%±12%, and the myocardial perfusion score index was 1±0.00.In the decreased perfusion group (Group B), the average coronary diameter stenosis was 82%±8%, and the myocardial perfusion score was 1.93±0.16.The diameter stenosis was less than 85% in 63 % of the coronary arteries (including diameter stenosis ≤75% in 12% of the vessels).The diameter stenosis was 85%-90% in 22% of the coronary arteries and >90% in 15% of the arteries.In the perfusion defect group (Group C), the average diameter stenosis was 90%±6%, and the myocardial perfusion score index was 2.89±0.24.The diameter stenosis was　≥85% in 94% of the coronary arteries, and the diameter stenosis was <85% and >75% only in 6% of the coronary arteries.The overall sensitivity and specificity of MCE in identifying angiographic coronary diameter stenosis was 67% and 100%, respectively.The false negative rate was 32.6% for the 108 coronary arteries.Further subdivided analysis showed the sensitivities in Groups A, B and C were 0, 100%, and 100%, respectively.The sensitivity increased with increased lumen diameter stenosis of coronary arteries.Conclusions There is a close relationship between coronary artery stenosis and MCE perfusion scores.MCE with venous injection of new generation contrast can define the presence of CAD and lesion graded classifications.Some disagreements between perfusion score and coronary diameter of stenosis may indicate other factors such as different collateral circulation, which should be further investigated.As artery stenosis increases, the sensitivity of MCE is increased.     

Comparative study on 16-slice CT coronary angiography vs conventional coronary angiography—A report of 38 cases

The clinical application of 16-slice CT coronary angiography （CTCA） and the impact of plaques differently characterized on assessing coronary artery stenosis were evaluated. Thirty-eight patients with coronary artery disease diagnosed by conventional coronary angiography （CAG） underwent 16-slice CTCA （collimation： 16×0.75 mm; rotation time： 420 msec; kernel： 35f; effective current： 500 mAs; tube voltage： 120 kV）. The interval between CTCA and CAG was within one month. CTCA was evaluated by consensus of two independent experienced radiologists unknowing CAG findings. Original images, maximum intensity projections and multiplanar reconstructions were used to assess coronary artery stenosis. For a determined plaque an attenuation value ≥ 130 HU was considered as calcified, and 〈130 HU noncalcified. The plaques were then classified into significant calcification （extensive calcification）, medium calcification （small isolated calcification） and noncalcification. The diagnostic accuracy of 16-slice CTCA findings as well as to detect ≥50% stenoses caused by plaques was evaluated respectively regarding CAG as the standard of reference. In comparison with CAG findings, the sensitivity, specificity, positive and negative predictive value derived from CTCA for mild stenosis （〈50%） were 72.7%, 38.5%, 50%, 62.5%, respectively; for moderate stenosis （50%-75%） 82.4%, 72.7%, 70%, 84.2%, resepctively; and for severe coronary stenosis （〉75%） 85%, 90.5%, 81%, 92.7% respectively. With the increase of stenoses degree, the value of CTCA was greater. For the classification of the plaque calcification with ≥50% stenosis CTCA attained the sensitivity, specificity, positive and negative predictive value for severe calcificatoin 73.3% 22.2%, 61.1% and 33.3%, respectively; for moderate calcification 70%, 55.6%, 63.6% and 62,5%, respectively; for noncalcification 93.8%, 85.7%, 93.8% and 85.7% respectively. CTCA was restricted in assessing coronary artery stenosis in the presence of calci     

Evaluating non-invasive medical imaging for diagnosis of carotid artery stenosis with ischemic cerebrovascular disease

Objectives To assess the value of non-invasive medical imaging for diagnosis of carotid artery stenosis and to study the relationship between stenosis and brain infarction.Methods Thirty-one patients with a total of 62 carotid arteries were studied using Doppler ultrasound (DUS)and magnetic resonance angiography(MRA),Eleven of the 31 patients were studied using CT angiography(CTA).CT and MRI of the brain were also done in all patients.The imaging results in 5 patients were compared with those of digital subtraction angiography(DSA).Eight patients with severe stenosis received carotid endarterectomy.The comparisons between the imaging results and pathological data were conducted in 2 patients. Results Of the 62 carotid arteries,mild stenosis was seen in 11,moderate in 14,severe in 21,obstructed in 4 and normal in 12.In 25 patients with severe stenosis or occlusion of carotid arteries,there were a total of 35 focal or multifocal infarcts on the ipsilateral cerebral hemisphere,and 15 infarcts on the contrary side.Compared with the results of the operations,DUS correctly diagnosed 6 stenoses,while MRA identified 7 correctly and CTA 8.Agreement on location of stenosis as performed by endarterectomy,DUS,MRA and CTA occurred in all patients.Histologically,areas of calcification and fibrousness were related to high densities on CTA,strong echoes on DUS,and low signal intensities on MRA.Relatively large amounts of necrotic material and foam cells filled with lipolytic materials on the intimal surface of arteries were observed during pathologically,corresponding to low and iso-densities of CTA.low echoes on DUS,and inhomogeneous signal intensities on MRA.Conclusions A strong link exists between carotid stenosis and brain infarction.The combined use of DUS,MRA and CTA can improve diagnostic accuracy for the assessment of carotid artery stenosis,as well as assist in ascertaining the nature of the plaque.     

Preliminary clinical application of contrast-enhanced MR angiography using 3D time-resolved imaging of contrast kinetics (3D-TRICKS)

Objective:To introduce a new better contrast-enhanced MR angiographic method, named 3D time-resolved imaging of contrast kinetics (3D-TRICKS). Methods: TRICKS is a high temporal resolution (2-6 s) MR angiographic technique using a short TR(4 ms) and TE(1. 5 ms), partial echo sampling, in which central part of k-space is updated more frequently than the peripheral part. TRICKS pre-contrast mask 3D images are firstly scanned, and then the bolus injecting of Gd-DTPA. 15-20 sequential 3D images are acquired. The reconstructed 3D images, subtraction of contrast 3D images with mask images, are conceptually similar to a catheter-based intra-arterial digital subtraction angiographic series (DSA). Thirty patients underwent contrast-enhanced MR angiography using 3D-TRICKS. Results: Totally 12 vertebral arteries were well displayed on TRICKS, in which 7 were normal, 1 demonstrated bilateral vertebral artery stenosis, 4 had unilateral vertebral artery stenosis and 1 was accompanied with the same lateral carotid artery bifurcation stenosis. Four cases of bilateral renal arteries were normal, 1 transplanted kidney artery showed as normal and 1 transplanted kidney artery showed stenosis. 2 cerebral arteries were normal, 1 had sagittal sinus thrombosis and 1 displayed intracranial arteriovenous malformation. 3 pulmonary arteries were normal, 1 showed pulmonary artery thrombosis and 1 revealed pulmonary sequestration's abnormal feeding artery and draining vein. One left lower limb fibrolipoma showed feeding artery. One displayed radial-ulnar artery artificial fistula stenosis. One revealed left antebrachium heman-gioma. Conclusion: TRICKS can clearly delineate most body vascular system and reveal most vascular abnormality. It possesses convenience and high successful rate, which make it the first choice of displaying most vascular abnormality.     

Assessment of Coronary Stents by 64-slice Computed Tomography： In-stent Lumen Visibility and Patency

Objective To assess lumen visibility of coronary stents by 64-slice computed tomography （CT） coronary angiography, and determine the value of 64-slice CT in non-invasive detecting of in-stent restenosis after coronary artery stent implantation. Methods Totally, 60 patients （54 males, aged 57.0±12.7 years） and /05 stents were investigated by 64-slice CT at a mean interval of 20.0±16.6 months after coronary stents implantation. Axial multi-planar reconstruction images of the stents and curved-planar reconstruction images through the median of the stents were reconstructed for evaluating stent image quality on a 5-point scale （1=excellent, 5=nonassessable）, and stent lumen diameter was detected. Conventional coronary angiography was performed in 18 patients, and 32 stents were evaluated. Results Image quality was good to excellent on average （score 1.71±0.76）. Stent image quality score was correlated to heart rate （r=0. 281, P〈0.01） and stent diameter （r=-0.480, P〈0.001）. All the stents were assessable in lumen visibility with an average visible lumen diameter percentage of 60.7%±13.6%. Visible lumen diameter percentage was correlated to heart rate （r=-0.193, P〈0.05）, stent diameter （r=0.403, P〈0.001）, and stent image quality score （r=-0.500, P〈0.001）. Visible lumen diameter percentage also varied depending on the stent type. In comparison with the conventional coronary angiography, 4 of 6 in-stent stenoses were correctly detected. The sensitivity and specificity for the detection of in-stent stenosis were 66.7% and 84.6%, respectively. Conclusions Using a 64-slice CT, the stent lumen is partly visible in most of the stents. And 64-slice CT may be useful in the assessment of stent patency.     

4排螺旋CT对冠状动脉粥样硬化性心脏病的临床价值

目的 探讨4排螺旋CT冠状造影在诊断冠状动脉粥样硬化性心脏病(简称冠心病)中的价值.方法 收集临床上初步拟诊为冠心病的35例患者的93支血管并进行螺旋CT冠状造影和常规冠状动脉造影检查,对比分析螺旋CT冠状造影的准确性.结果 螺旋CT冠状造影发现47支冠状动脉狭窄,常规冠状动脉造影检查发现51支冠状动脉狭窄.螺旋CT冠状造影发现的44支血管狭窄与冠状动脉造影结果一致,敏感性为86.3%,特异性为100%.螺旋CT冠状造影和常规冠状动脉造影检查结果大体一致.结论 4排螺旋CT冠状造影可作为诊断冠心病的一种无创筛选检查方法,提高了冠状动脉造影诊断冠心病的符合率. Abstract： Objective To explore the diagnosticclinical value of 4 -detector row spiral CT with coronary artery disease. Methods Spiral CT coronary angiography (CTCA) and conventionalcoronary angiography(CAG) were used in 93 arteries of 35 coronary artery disease patients. To analysis the precise level of CTCA through contrasting. Results CTCA showed the angiostegnosis with 47coronary arteries,CAG showed theangiostegnosis with 51coronary arteries. The angiostegnosis results of 44 coronary arteries were same with CTCA and CAG. The total sensitivity of CTCA was 86.3% , and specificity was 100%.The results of CTCA and CCA were coincidentalin general. Conclusions 4 - detector row spiral CT can be used as a noninvasive screening method for the patients with suspected coronary artery disease, and the coincidence ratewasincreased ofcoronary angiography with coronary artery disease.     

Compensatory enlargement in transplant coronary artery disease: an intravascular ultrasound study

Background It is unclear to what extent the “Glagov phenomenon” occurs in transplant coronary artery disease (TCAD). The objective of this study was to evaluate the relationship between intimal hyperplasia and compensatory enlargement in TCAD. Methods Intravascular ultrasound imaging was performed on 190 cardiac transplant recipients at (1.4±0.6) months and again (12.1±0.7) months after cardiac transplantation. Studies 1 year apart were matched at 625 sites. There were 345 coronary artery sites that had an increase in intimal area >10% from baseline to one year, and this comprised the data set of the present study. Results At the first year, 91% of coronary artery sites with intimal growth had a total cross-sectional area stenosis ≤40%, but 38% of the sites showed a decrease of >10% in lumen area. Receiver operating characteristic curve demonstrated that the change in cross-sectional area stenosis cut-off level at year 1 was 8% with a sensitivity of 75% and a specificity of 82% in predicting lumen loss. At a total cross-sectional area stenosis of 20%, sensitivity was 65% with a specificity of 81% in predicting lumen loss. Conclusions In TCAD, vessel enlargement as a compensatory mechanism for plaque growth is generally inadequate. Instead of continued vessel expansion, luminal narrowing develops when there is more than 8% cross-sectional area filled with intimal hyperplasia. In distinction to native coronary artery atherosclerotic disease, the transition point in transplant vasculopathy where the lumen is diminished by increasing intimal growth, occurs at a lower threshold, 20% vs 40% of vessel cross-sectional area.     

Preliminary clinical application using 3D time-resolved imaging of contrast-enhanced MR angiography of contrast kinetics （3D-TRICKS）i

Objective：To introduce a new better contrast-enhanced MR angiographic metnod, named 3D time-resolved imaging of contrast kinetics （3D-TRICKS）. Methods： TRICKS is a high temporal resolution （2-6 s） MR angiographic technique using a short TR（4 ms） and TE（1.5 ms）, partial echo sampling, in which central part of k-space is updated more frequently than the peripheral part. TRICKS pre-contrast mask 3D images are firstly scanned, and then the bolus injecting of Gd-DTPA, 15-20 sequential 3D images are acquired. The reconstructed 3D images, subtraction of contrast 3D images with mask images, are conceptually similar to a catheter-based intra-arterial digital subtraction angiographic series （DSA）. Thirty patients underwent contrast-enhanced MR angiography using 3D-TRICKS. Results： Totally 12 vertebral arteries were well displayed on TRICKS, in which 7 were normal, 1 demonstrated bilateral vertebral artery stenosis, 4 had unilateral vertebral artery stenosis and 1 was accompanied with the same lateral carotid artery bifurcation stenosis. Four cases of bilateral renal arteries were normal, 1 transplanted kidney artery showed as normal and 1 transplanted kidney artery showed stenosis. 2 cerebral arteries were normal, 1 had sagittal sinus thrombosis and 1 displayed intracranial arteriovenous malformation. 3 pulmonary arteries were normal, 1 showed pulmonary artery thrombosis and 1 revealed pulmonary sequestration＇s abnormal feeding artery and draining vein. One left lower limb fibrolipoma showed feeding artery. One displayed radial-ulnar artery artificial fistula stenosis. One revealed left antebrachium hemangioma. Conclusion： TRICKS can clearly delineate most body vascular system and reveal most vascular abnormality. It possesses convenience and high successful rate, which make it the first choice of displaying most vascular abnormality.     

脑梗死患者颅外段颈动脉及椎动脉的超声诊断价值

目的 探讨彩色多普勒超声对脑梗死患者颅外段颈动脉及椎动脉超声检查的临床价值.方法 对91例脑梗死住院患者行颅外段颈动脉、椎动脉彩色多普勒检查,观察其动脉壁的形态病变性质和动脉管腔的内径及椎动脉的最大流速(PSV)、阻力指数(RI).结果 91例脑梗死患者中,内径超过正常范围的颈总动脉最多,其中左侧17例,右侧22例.斑块生长部位以颈总动脉多见,类型以扁平斑最多,其次为硬斑.椎动脉PSV减低多见,其中左侧52例,右侧57例;RI超出正常范围的,左侧22例,右侧36例.结论 脑梗死患者颅外段颈动脉及椎动脉的彩色多普勒超声常规检查,提供了形态学及血流动力学改变,为临床诊断及治疗提供了重要的信息. Abstract： Objective To evaluate the clinical value of the color Doppler ultrasound for cerebral infarction in patients with extracranial carotid artery and vertebral artery. Methods Ninty-one cases of cerebral infarction patients in the hospital were examined of extracranial internal carotid artery, vertebral artery by color Doppler ultrasound. The pathological change patterns of arterial wall and the inner diameter of the arterial lumens and the peak flow rate (PSV), resistent index (RI)of the vertebral artery were observed.Results In the 91 cases of cerebral infarction patients, the inner diameter of carotid artery beyond the normal range, there were 17 cases in the left, 22 cases in the right.The most plaqueslie in carotid artery.The type of plaques was flat applanation spot at most, following was hard spot.Vertebral artery's peak flow rate was usually reduce, 52 cases in left, 57 cases in right. 22 patients' resistent index beyond the normal range in the left, and 36 cases in right.Conclusions The color Doppler ultrasound to extracranial carotid artery and vertebral artery provides the morphology and hemodynamics's change, offers important messages for the clinical diagnosis and treatment in the cerebral infarction.     

64层螺旋CTA评价颅颈部动脉狭窄的临床研究

目的以DSA结果为对照标准,评价64层螺旋头颈血管CTA判断不同程度狭窄的准确性。方法搜集临床怀疑颅颈部动脉狭窄性病变患者27例,均行头颈血管CTA检查,并在一周内行DSA检查,将CTA与DSA结果对照,评价64层CTA诊断头颈部动脉狭窄的准确性。结果以双侧颈、椎动脉为观察对象,共观察108支血管。CTA显示不同程度狭窄的血管段共115段;DSA显示不同程度狭窄的血管段共108段。64层CTA对颈、椎动脉狭窄总的诊断敏感度分别为97.70%、93.75%,特异度分别为99.51%、99.57%。结论64层螺旋CT头颈血管CTA无创,快捷,简单易行,能够清晰显示颅颈部动脉狭窄性病变,具有较高的敏感性与特异性。     

64排螺旋CT脑动脉成像CT血管造影技术的临床应用探讨

目的 探讨我科64排螺旋CT在脑动脉血管成像的临床应用价值.方法 回顾性分析64排螺旋CT脑血管造影的影像表现44例,由诊断医师 与数字减影血管造影（DSA）对比,进行图像综合评价.结果 64例患者中,60例图像显示成功,脑动脉狭窄38例（伴脑梗死12例）,脑动脉瘤14例（脑动脉 狭窄伴动脉瘤8例）,动静脉畸形8例.与DSA相比,CT血管造影（CTA）诊断脑血管疾病的敏感性为93.75%,特异性为100%.结论 CTA与DSA的敏感性与特 异性差异均无统计学意义,在临床普查、筛查上可以选用CTA成像技术.     

64层螺旋CTA与DSA在基底动脉狭窄研究中的应用

目的：探讨64层螺旋CTA与DSA在基底动脉狭窄的临床应用价值。方法：收集临床拟诊为脑梗死或TIA发作的患者152例,进行64层螺旋CTA检查并同时行DSA检查,将CTA与DSA结果相对照,分别计算出基底动脉狭窄程度的敏感性和特异性。结果：本组行CTA检查的152例患者中有88例患者基底动脉有不同程度的狭窄,同时行DSA检查判断基底动脉狭窄程度,计算出基底动脉狭窄CTA与DSA的敏感性和特异性为73．9％、85．4％。结论：64层螺旋CTA能够清晰地显示基底动脉系统的异常,在某些方面上可替代DSA检查。     

64层螺旋CT冠脉成像在冠心病诊断中的应用

目的:评价64层螺旋CT冠脉成像在冠心病诊断中的作用。方法:对86例疑诊冠心病患者(男40例,女46例)用64层螺旋CT进行冠脉成像,以选择性冠脉造影结果作为金标准,评价其对冠心病诊断的灵敏度和特异度。结果:86例患者共分析638个血管节段,其中64层螺旋CT冠脉成像对左冠主干诊断的灵敏度和特异度为100%,左前降支为97.9%和97.1%,右冠远端为84.5%和97.5%,对钙化的诊断优于冠脉造影。结论:64层螺旋CT冠脉成像对冠心病诊断有较高的准确性,可以作为冠心病诊断和筛查的主要检查方法。     

64层螺旋CT冠状动脉成像诊断冠状动脉狭窄价值

目的评价64层螺旋CT冠状动脉成像(CTA)诊断冠状动脉狭窄的准确性与可行性。方法 30例临床拟诊为冠心病的病人行64层螺旋CTA,以选择性冠状动脉DSA造影作为金标准,比较两种检查方法的结果。结果 120段冠状动脉在CTA图像上得到良好显示,达到分析要求。64层螺旋CT诊断冠状动脉狭窄(狭窄程度≥50%)的灵敏度、特异度、阳性预测值和阴性预测值分别为77.8%、85.3%、48.3%和95.6%。结论 64层螺旋CTA显示冠状动脉狭窄具有很高的阴性预测值,可作为一种无创检查技术对冠状动脉狭窄进行筛查。     

Diagnostic accuracy of coronary angiography using 64-slice computed tomography in coronary artery disease

Objectives:

To conduct a meta-analysis and investigate the diagnostic value of 64-slice computed tomography (CT) angiography for diagnosing coronary artery disease (CAD) in patients.

Methods:

A comprehensive literature search from March 2005 to August 2014 was performed on the following databases: Cochrane Library; Medline; EmBase; PubMed; and BioMed Central database. As a reference standard, studies that assessed 64-slice CT angiography in detecting coronary artery stenosis (CAS) with invasive coronary angiography were included. Coronary artery stenosis was defined as ≥50% diameter stenosis. Diagnostic value was determined by pooling sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) values at segment-level analysis. Diagnostic accuracy was undertaken using area under the curve (AUC) value and summary receiver operating characteristic (SROC) curves. Publication bias was examined by Deek’s funnel plot asymmetry test.

Results:

Eight studies were included in the analysis, enrolling a total of 579 patients (7,407 segment coronary vessels). At segment-level, pooled sensitivity value was 90% (95% confidence interval [CI]: 83-95%), specificity was 91% (95% CI: 61-98%), PLR value was 9.7 (95% CI: 1.8-53.3), and NLR value was 0.11 (95% CI: 0.05-0.22) for CAS. Optimal cut-off point of sensitivity was 90%, and specificity under the SROC curve was 91%. The AUC value was 0.94.

Conclusion:

The 64-slice CT angiography is a reliable tool for detection of CAD when using a cut-off of ≥50% diameter stenosis in elderly population.Coronary artery stenosis (CAS) is not only observed in coronary atherosclerotic heart diseases, but also in Kawasaki diseases associated with coronary damages.1,2 Conventional coronary angiography has been considered as the gold standard method for diagnosing coronary lesions. However, coronary angiography is unlikely to be accepted in the absence of significant lesions and risk of complications due to its invasive features.3 Therefore, an alternative noninvasive procedure for determining CAS is necessary. In recent decades, multi-slice spiral computed tomography (CT) coronary angiography has become one of the hot spots in cardiovascular imaging technology. This method has been applied for evaluating CAS, and was proposed as a potential alternative procedure for invasive coronary angiography.4 Multi-slice CT imaging technology advances have undergone 4-slice, 16-slice, 64-slice and 256-slice stages. Progress of multi-slice CT systems has allowed increased accuracy in quantifying obstructive lesions of coronary arteries.5 Many researchers have used multi-slice CT coronary angiography to determine CAS using invasive coronary angiography as a standard of reference.6,7 However, great variations in sensitivity, specificity, and diagnostic accuracy exist. The 64-slice CT scanner is widely used in current clinical practice due to its high temporal and spatial resolution. In order to assess the diagnostic accuracy of 64-slice CT in determining CAS, we conducted a meta-analysis of currently published studies that compared 64-slice CT angiography with conventional coronary angiography for diagnosing CAS.     

64层螺旋CT对冠状动脉疾病诊断的评价

目的探讨64层螺旋CT对冠状动脉疾病的诊断价值。方法对45例[男29例,女16例,年龄60～86（73．1±5．3）岁]冠心病疑似患者在7d内进行64层螺旋CT冠状动脉造影（CTA）及常规冠状动脉造影（CAG）,对冠状动脉的右冠状动脉、左主干、左前降支和回旋支进行检查。以CAG结果为金标准,分析64层螺旋CT诊断〉50％的冠状动脉狭窄的准确性。结果CTA评价〉50％冠状动脉狭窄的敏感性为94．0％,特异性为94．0％,阳性预测值为69．6％,阴性预测值为94．0％,符合率为78．8％。结论64层螺旋CT对老年冠状动脉疾病患者具有较高的诊断价值,可作为评价冠状动脉狭窄的一种无创检查。     

64层与16层螺旋CT冠状动脉成像比较

目的比较64层与16层螺旋CT冠状动脉成像的图像质量和分支显示率,评价64层螺旋CT诊断冠状动脉狭窄的准确性。方法对100例临床可疑冠心病患者(A组)行64层螺旋CT心电门控增强扫描,其中48例患者有常规冠状动脉造影做对照。对另外100例临床可疑冠心病患者(B组)行16层螺旋CT心电门控增强扫描。比较两组图像的质量评分和冠状动脉分支显示率。结果A组图像质量评分为(1.20±0.47)分,明显低于B组的(1.37±0.63)分(P<0.05)。两组冠状动脉近中段显示率差异无显著性(P>0.05),而远段和部分小分支显示率差异有显著性(P<0.05)。64层螺旋CT冠状动脉成像诊断冠状动脉≥50%狭窄的敏感性为94.9%(56/59),特异性为93.2%(124/133)。结论64层螺旋CT冠状动脉成像的图像质量和分支显示率较16层螺旋CT进一步提高,能够可靠诊断冠状动脉≥50%狭窄。     

64层螺旋CT诊断不同程度冠状动脉狭窄的临床价值

目的用传统的冠状动脉造影作对照,评价64层螺旋CT诊断冠状动脉不同程度狭窄的准确性。方法 116例患者临床怀疑冠状动脉粥样硬化性心脏病并同期接受64层螺旋CT冠状动脉造影及常规冠状动脉造影,计算冠状动脉不同程度狭窄的敏感性、特异性、准确性、阳性预测值、阴性预测值。结果 64层螺旋CT诊断可评估冠状动脉中度、重度及轻度狭窄的敏感性为95.73%、89.7%、70.0%,特异性为98.7%、95.7%、88.1%,准确性为98.7%、95.7%、88.1%,阳性预测值为83.0%、80.7%、36.3%,阴性预测值为99.7%、97.9%、96.8%。结论 64层螺旋CT是一种有效的无创性的检测冠状动脉狭窄的工具。     

64排螺旋CT冠状动脉成像对冠心病诊断的临床应用价值

目的探讨64排螺旋CT冠状动脉成像（64SCTCA）对冠心病诊断的临床应用价值。方法选取广东省清远市中医院2012年10月~2013年10月接诊的40例根据临床诊断为冠心病的患者,以冠状动脉造影（CAG）为参照标准,对40例患者行64排螺旋CT检查和冠状动脉造影检查。观察2组患者检测结果。结果 64SCTCA诊断冠状动脉≥50%狭窄性病变的敏感性为96.0%（96/100）,特异性为93.8%（392/418）,阳性预测值为78.7%（96/122）,阴性预测值为98.9%（392/396）,与CAG结果相比较,其差异无统计学意义。结论在对冠心病的诊断中,64SCTCA对诊断冠状动脉重度狭窄有着较高的准确性、敏感性和特异性。作为一种安全可靠、风险小、无创伤的筛检手段,64排螺旋CT冠状动脉成像有着重要的临床价值。