中国新型冠状病毒疫苗犹豫影响因素比较分析

因新型冠状病毒感染引起的疫情暴发后三年期间,许多国家和地区出现疫情大流行和感染高风险状态,人民群众健康和生命安全面临严重威胁。接种疫苗是防控新冠病毒感染最经济、最有效的手段,广泛和快速接种新型冠状病毒疫苗对于战胜疫情至关重要,然而疫苗犹豫却严重影响了疫苗接种工作的顺利实施。文章对新冠病毒疫情期间我国两岸四地疫苗犹豫人群的特征进行系统的综述,对四地疫苗接种的主要影响因素进行比较。分析显示,两岸四地新冠疫苗接种率均达到90%以上,年龄和接受教育水平对四地疫苗犹豫的影响程度相似,均为女性大于男性,接受高等教育人群的疫苗犹豫更低,年龄和婚姻状况的影响程度有较大不同。     

关于准备妊娠和辅助生殖技术助孕人群新型冠状病毒疫苗接种的专家建议

新型冠状病毒疫情暴发以来,世界各国加快新型冠病毒疫苗（简称新冠疫苗）的研发。已有多个候选疫苗进入Ⅲ期临床试验或附条件上市及紧急使用。虽然所有年龄段人群均对新型冠状病毒易感,但孕妇仍被排除在新冠疫苗Ⅲ期临床试验之外,因此无法确定新冠疫苗对妊娠期妇女及其子代的安全性,也缺乏孕期及准备妊娠人群新冠疫苗有效性和安全性的数据。本...     

新型冠状病毒肺炎疫苗上市前疫苗犹豫情况及相关影响因素研究

目的 了解新型冠状病毒肺炎(简称新冠肺炎)疫苗上市前的疫苗犹豫发生情况及相关影响因素,为在疫苗上市早期采取针对性的干预措施提供科学依据.方法 自行设计调查问卷并通过网络发放,比较疫苗犹豫者和接受者在社会人口学信息、对新冠肺炎的认知情况、对疫苗的一般性认知情况,以及信心、自满和便利性等维度的差异.采用单因素和多因素log...     

全球疫苗犹豫现状及影响因素研究进展

疫苗犹豫在全球范围内普遍存在,降低了疫苗覆盖率和及时率,成为了 2019年全球卫生10项威胁之一.本研究对疫苗犹豫现状、影响因素、2019新型冠状病毒肺炎疫情(新冠疫情)的疫苗犹豫影响及预测、正面的网络媒体信息可改善疫苗犹豫四个方面进行了综述.疫苗犹豫的影响因素可用决定因素矩阵归类,包括疫苗或免疫规划影响、个人/群体影...     

新型冠状病毒疫苗研发进展与挑战

新型冠状病毒(2019-nCoV)感染暴发流行对全球公众健康构成了严重威胁,疫苗接种是有效预防病毒感染流行的手段。2019-nCoV与急性呼吸综合征冠状病毒(SARS-CoV)和中东呼吸综合征冠状病毒(MERS-CoV)同属于β-冠状病毒。基于对SARS-CoV和MERS-CoV的了解,科学家对2019-nCoV病毒特征的研究、候选抗原及表位的鉴定、动物模型的建立、免疫应答的检测,疫苗的设计等工作取得了快速进展。新型冠状病毒疫苗(新冠疫苗)的研发也取得了快速进展,新冠疫苗类型几乎涵盖了目前疫苗研究的所有形式,包括灭活疫苗、重组蛋白疫苗、病毒载体疫苗、核酸疫苗(mRNA疫苗与DNA疫苗)等。至2020年3月,已有2项新冠疫苗进入了Ⅰ期临床试验,分别为我国军事医学科学院联合天津康希诺生物股份公司研发的基于腺病毒载体的重组新冠疫苗和美国Moderna公司的mRNA 疫苗,两种疫苗均以2019-nCoV的刺突蛋白为抗原靶标。同时,新冠疫苗研发仍面临着许多未知的挑战,如2019-nCoV病毒抗原特征、抗原变异、机体的保护性免疫应答特征以及对老年及基础病人群是否具有保护,新冠疫苗量产的生产工艺等方...     

新型冠状病毒疫苗:现状与展望

新型冠状病毒肺炎的大流行严重威胁人类健康和发展,为应对这一全球性公共卫生事件,多种技术路线的新型冠状病毒疫苗(新冠疫苗)被投入紧急使用.本文介绍了新冠疫苗技术路线,并就新冠疫苗应对多种突变毒株的效力和在高危人群中的使用进行了梳理,发现现有疫苗对突变毒株效力出现了不同程度的下降,提示应关注突变毒株的影响.现有疫苗对高龄,...     

新型冠状病毒疫苗接种意愿影响因素及犹豫原因分析

目的 了解乌鲁木齐市人群对新型冠状病毒疫苗的接种意愿,分析影响因素及犹豫原因。方法 于2021年2-3月在乌鲁木齐市常住居民中通过便利抽样的方法抽取不同年龄段、不同文化程度的人群,通过微信等自媒体平台以二维码或链接的形式发布问卷,调查居民的新冠疫苗接种意愿影响因素和接种犹豫原因。结果 共回收问卷335份,有效问卷327份（97.60%）。愿意接种新冠疫苗人群占63.30%(207/327),单因素分析显示性别、文化程度、月收入、是否患病、是否认为疫苗是预防新冠的重要手段、是否听从家人朋友建议影响新冠疫苗接种意愿（P<0.05）。多因素Logistic回归分析结果显示,性别为男性（OR=2.160）、认为疫苗是预防新冠肺炎的重要手段（OR=2.935）、听从家人朋友建议（OR=4.426）的人群更愿意接种新冠疫苗。犹豫接种新冠疫苗的主要原因为担心疫苗不安全或担心接种疫苗后的副作用（31.80%）。结论 乌鲁木齐市人群对新冠疫苗的接种意愿程度中等,可加强对女性、患病人群开展疫苗相关知识科普。     

孕妇新型冠状病毒肺炎及疫苗的流行病学研究进展

新型冠状病毒肺炎（COVID-19）是一种由新型冠状病毒（新冠病毒）引起的急性呼吸道传染性疾病。由于妊娠期间的生理变化,孕妇易感COVID-19,尤其是新冠病毒变异株流行期间,孕妇不良妊娠结局的发生风险可能更高。目前尚缺乏孕妇接种新冠病毒疫苗（新冠疫苗）的随机临床试验证据,各国关于孕妇接种新冠疫苗的推荐存在差异,这给孕妇COVID-19的防控带来了一定挑战。本文回顾了国内外妊娠期感染新冠病毒的重要研究进展,论述了妊娠期患COVID-19对孕妇、胎儿及婴儿的危害,以及真实世界研究中妊娠期接种新冠疫苗的有效性和安全性等,以期为今后开展孕妇相关研究,制定防控措施提供参考。     

新型冠状病毒疫苗对新型冠状病毒德尔塔变异株预防效果的Meta分析

目的 运用循证医学Meta分析方法,探究和评价新型冠状病毒疫苗对新型冠状病毒德尔塔变异株的预防效果,为新冠肺炎的防控提供循证支持。方法 以新型冠状病毒德尔塔毒株、疫苗及其同义词、近义词作为检索词,系统检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、PubMed、考科蓝图书馆、Web of Science、BioRxiv、MedRxiv和Europe PMC关于新型冠状病毒疫苗保护效果(Vaccine Effectiveness,VE)的文献,使用纽卡斯尔-渥太华风险评分量表对纳入的队列研究和病例对照研究文献进行质量评价,对纳入的随机对照试验则使用Jadad评分进行质量评价,运用Stata 12.0进行异质性检验、总效应值和发表性偏倚估计。结果 共纳入文献14篇,其中病例对照研究文献5篇,队列研究文献8篇,随机对照实验1篇。Meta分析显示,接种一剂新冠疫苗的合并VE(95%CI)为34.57%(95%CI:21.70%～47.44%),接种两剂新型冠状病毒疫苗的合并VE(95%CI)为70.56%(95%CI: 64.29%～76.82%)。漏斗图分析表明存在发表偏倚风险。结论 接种新型冠状病毒疫苗对预防新型冠状病毒德尔塔变异株有保护作用,且2剂疫苗保护作用明显比1剂疫苗强。后续仍需要收集更多的疫苗保护率研究,提供发表性偏倚风险小的证据。     

新型冠状病毒肺炎疫苗有效性评价中的相关问题探讨

新型冠状病毒肺炎出现以来,席卷了全球各个国家和地区,安全且有效的新型冠状病毒肺炎疫苗是控制新型冠状病毒肺炎疫情最有效手段之一。新型冠状病毒肺炎疫苗的关键性临床研究通常采用安慰剂对照的保护效力试验,以观察疫苗是否可以有效降低疾病的发病率。本文即将对新冠疫苗保护效力临床试验中研究设计和研究终点的考量、统计学评价方法、主要估...     

Reasons for COVID-19 Vaccine Hesitancy Among Chinese People Living With HIV/AIDS: Structural Equation Modeling Analysis

BackgroundMany countries and organizations recommended people living with HIV/AIDS (PLWHA) receive the COVID-19 vaccine. However, vaccine hesitancy still exists and becomes a barrier for promoting COVID-19 vaccination among PLWHA.ObjectiveThis study aims to investigate factors that contributed to COVID-19 vaccine hesitancy among PLWHA.MethodsThe study used a multicenter cross-sectional design and an online survey mode. We recruited PLWHA aged 18-65 years from 5 metropolitan cities in China between January 2021 and February 2021. Participants completed an online survey through Golden Data, a widely used encrypted web-based survey platform. Multiple linear regression models were used to assess the background characteristics in relation to COVID-19 vaccine hesitancy, and structural equation modeling was performed to assess the relationships among perceived benefits, perceived risks, self-efficacy, subjective norms, and COVID-19 vaccine hesitancy.ResultsAmong 1735 participants, 41.61% (722/1735) reported COVID-19 vaccine hesitancy. Older age, no other vaccinations in the past 3 years, and having chronic disease history were positively associated with COVID-19 vaccine hesitancy. Structural equation modeling revealed a direct relationship of perceived benefits, perceived risks, and subjective norms with self-efficacy and vaccine hesitancy and an indirect relationship of perceived benefits, perceived risks, and subjective norms with vaccine hesitancy. Moreover, self-efficacy toward COVID-19 vaccination was low. PLWHA had concerns of HIV disclosure during COVID-19 vaccination. Family member support could have an impact on COVID-19 vaccination decision-making.ConclusionsCOVID-19 vaccine hesitancy was high among PLWHA in China. To reduce COVID-19 vaccine hesitancy, programs and strategies should be adopted to eliminate the concerns for COVID-19 vaccination, disseminate accurate information on the safety and efficacy of the COVID-19 vaccine, encourage family member support for COVID-19 vaccination, and improve PLWHA’s trust of medical professionals.     

Vaccine hesitancy against COVID-19 vaccine over time in Nigeria

IntroductionWhile COVID-19 pandemic is an ongoing threat for our lives, the rapid development of effective vaccines against COVID-19 provided us hopes for manageable disease control. However, vaccine hesitancy across the globe is a concern which could attenuate efforts of disease control. This study examined the extent and trend of vaccine hesitancy in Nigeria.MethodsThe COVID-19 National Longitudinal Phone Survey conducted between 2020 and 2021 was used for the analysis. The extent and trend of vaccine hesitancy across different zones within Nigeria, over time, as well as reasons of the hesitancy were evaluated.ResultsVaccine hesitancy was more prevalent in southern zones, which on average have better socioeconomic status than northern zones. Overtime, vaccine hesitancy became more prevalent, and respondents became more resistant to the COVID-19 vaccine across the country.ConclusionWhile the nature of interventions to improve the uptake of COVID-19 vaccine should differ by regions due to differential barriers to vaccination, it might be important to prebunk and debunk any misinformation related to COVID-19 vaccine to mitigate the vaccine hesitancy across the country.     

Vaccination willingness,vaccine hesitancy,and estimated coverage at the first round of COVID-19 vaccination in China: A national cross-sectional study

BackgroundVaccination against coronavirus disease 2019 (COVID-19) has become an important public health solution. To date, there has been a lack of data on COVID-19 vaccination willingness, vaccine hesitancy, and vaccination coverage in China since the vaccine has become available.MethodsWe designed and implemented a cross-sectional, population-based online survey to evaluate the willingness, hesitancy, and coverage of the COVID-19 vaccine among the Chinese population. 8742 valid samples were recruited and classified as the vaccine-priority group (n = 3902; 44.6%) and the non-priority group (n = 4840; 55.4%).ResultsThe proportion of people’s trust in the vaccine, delivery system, and government were 69.0%, 78.0% and 81.3%, respectively. 67.1% of the participants were reportedly willing to accept the COVID-19 vaccination, while 9.0% refused it. 834 (35.5%) reported vaccine hesitancy, including acceptors with doubts (48.8%), refusers (39.4%), and delayers (11.8%). The current coverage was 34.4%, far from reaching the requirements of herd immunity. The predicted rate of COVID-19 vaccination was 64.9%, 68.9% and 81.1% based on the rates of vaccine hesitancy, willingness, and refusal, respectively.ConclusionsThe COVID-19 vaccine rate is far from reaching the requirements of herd immunity, which will require more flexible and comprehensive efforts to improve the population’s confidence and willingness to vaccinate. It should be highlighted that vaccination alone is insufficient to stop the pandemic; further efforts are needed not only to increase vaccination coverage but also to maintain non-specific prevention strategies.     

新冠肺炎疫苗研发与公共卫生安全

  目的  通过对某医科大学大学生关于愿意接种和拒绝接种新冠病毒疫苗的原因进行质性文本分析,最终构建公众视角下的“疫苗接种决策过程模型”,进一步探讨公众在疫苗决策产生过程中的促进与阻碍因素,为新冠病毒疫苗接种的推进提供理论依据,从而为其他疫苗的接种推动提供理论指导。   方法  本研究于2021年3月27 — 29日对某医科大学347名学生进行了新冠病毒疫苗接种的开放性访谈式问卷调查。通过NVivo 12进行词频分析、节点分析等质性分析后,结合相关文献和扎根理论研究,构建“疫苗接种决策过程模型”的理论框架。   结果  通过词云图得出：新冠病毒疫苗接种原因中,出现频率较高的词汇为：新冠、预防、接种、免费等;新冠病毒疫苗犹豫的原因中,出现频率较高的词汇为：安全性、疫苗、有效性、不良反应等词。通过NVivo12Plus软件,对样本问卷中的文本进行节点编码,最终得到3个父节点、9个子节点,基于生物 – 心理 – 社会医学模式、“防护行为决策”模型以及疫苗犹豫或疫苗接种相关模型等理论,结合本课题组的前期相关研究,将公众是否接种新冠病毒疫苗的原因总结为3个层面、9个维度,分别为：客观生物层面（包括：病毒与药物因素,生理与病理因素）、主观心理层面（包括个人风险与利益判断、疫苗安全性、疫苗有效性、社会责任感）、社会因素层面（包括服务可及性、信息可及性、社会情境影响）,构建了公众视角下“疫苗接种决策过程模型”的理论框架。   结论  基于公众“疫苗接种决策过程模型”,推动我国公众新冠病毒疫苗接种的意愿和行为产生,保证群体免疫屏障的有效形成,降低我国疫情防控成本,同时为公众接种流感疫苗等其他疫苗的推动提供理论支撑与参考。     

Patterns and influencing factors of COVID-19 vaccination willingness among college students in China

BackgroundVaccination is an important preventive measure against the coronavirus disease 19 (COVID-19) pandemic. We aimed to examine the willingness to vaccination and influencing factors among college students in China.MethodsFrom March 18 to April 26, 2021, we conducted a cross-sectional online survey among college students from 30 universities in Wuhan, Hubei Province, China. The survey was composed of the sociodemographic information, psychological status, experience during pandemic, the willingness of vaccination and related information. Students’ attitudes towards vaccination were classified as ‘vaccine acceptance’, ‘vaccine hesitancy’, and ‘vaccine resistance’. Multinomial logistic regression analyses were performed to identify the influencing factors associated with vaccine hesitancy and resistance.ResultsAmong 23,143 students who completed the survey, a total of 22,660 participants were included in the final analysis with an effective rate of 97.9% after excluding invalid questionnaires. A total of 60.6% of participants would be willing to receive COVID-19 vaccine, 33.4% were hesitant to vaccination, and 6.0% were resistant to vaccination. Social media platforms and government agencies were the main sources of information vaccination. Worry about the efficacy and adverse effects of vaccine were the top two common reason of vaccine hesitancy and resistance. Multiple multinomial logistic regression analysis identified that participants who worried about the adverse effects of vaccination were more likely to be vaccine hesitancy (aOR = 2.44, 95% CI = 2.30, 2.58) and resistance (aOR = 2.71, 95% CI = 2.40, 3.05).ConclusionMore than half of college students are willing to receive the COVID-19 vaccine, whereas nearly one-third college students are still hesitant or resistant. It is crucial to provide sufficient and scientific information on the efficacy and safety of vaccine through social media and government agencies platforms to promote vaccine progress against COVID-19 and control the pandemic in China.     

Factors influencing acceptance of the COVID-19 vaccine in Malaysia: a web-based survey

ObjectivesThe coronavirus disease 2019 (COVID-19) pandemic has set a precedent for the fastest-produced vaccine as a result of global collaboration and outreach. This study explored Malaysians’ acceptance of the COVID-19 vaccine and its associated factors.Methods A cross-sectional anonymous web-based survey was disseminated to Malaysian adults aged ≥18 years old via social media platforms between July 10, 2020 and August 31, 2020.Results In the analysis of 4,164 complete responses, 93.2% of participants indicated that they would accept the COVID-19 vaccine if it was offered for free by the Malaysian government. The median out-of-pocket cost that participants were willing to pay for a COVID-19 vaccine was Malaysian ringgit (MYR) 100 (interquartile range [IQR], 100) if it was readily available and MYR 150 (IQR, 200) if the supply was limited. Respondents with a low likelihood of vaccine hesitancy had 13 times higher odds of accepting the COVID-19 vaccine (95% confidence interval [CI], 8.69 to 19.13). High perceived risk and severity were also associated with willingness to be vaccinated, with adjusted odds ratios of 2.22 (95% CI, 1.44 to 3.41) and 2.76 (95% CI, 1.87 to 4.09), respectively. Age and ethnicity were the only independent demographic characteristics that predicted vaccine uptake.Conclusion Public health strategies targeting perceived risk, perceived susceptibility and vaccine hesitancy could be effective in enhancing vaccine uptake.     

Hesitancy to receive the novel coronavirus vaccine and potential influences on vaccination among a cohort of healthcare workers in the Democratic Republic of the Congo

Hesitancy to receive the COVID-19 vaccine among healthcare workers (HCWs) in low-resource settings, such as the Democratic Republic of the Congo (DRC), is a major global health challenge. This study identifies changes in willingness to receive vaccination among 588 HCWs in the DRC and reported influences on COVID-19 vaccination intentions. Up to 25 repeated measures were collected from participants between August 2020 to August 2021. Among the overall cohort, between August 2020 and mid-March 2021, the proportion of HCWs in each period of data collection reporting COVID-19 vaccine hesitancy ranged from 8.6% (95% CI: 5.97, 11.24) to 24.3% (95% CI: 20.12, 28.55). By early April 2021, the proportion reporting hesitancy more than doubled (52.0%; 95% CI: 46.22, 57.83). While hesitancy in the cohort began to decline by late-June 2021, 22.6% (95% CI: 18.05, 27.18) respondents indicated hesitancy in late-August 2021 which remains greater than the proportion of hesitancy at any time prior to early-March 2021. Patterns in reported influences on COVID-19 vaccination were varied with the proportion reporting some influences (e.g., no serious side effects, country of vaccine production) remaining stable throughout the year and other factors (e.g., recommendation of Ministry of Health, ease of vaccination) falling in popularity among respondents. Agreement that the national vaccination schedule should be followed apart from the COVID-19 vaccine remained high among respondents throughout the study period. This study shows that, among a cohort of HCWs in the DRC who have likely been influenced by regional, national, and global factors, COVID-19 vaccine hesitancy has fluctuated during the pandemic and should not be treated as a static factor. Additional research to determine which factors most influence HCWs’ willingness to receive the COVID-19 vaccine offers opportunities to reduce vaccine hesitancy among this important population through tailored public health messaging.     

Vaccine hesitancy and anti-vaccination in the time of COVID-19: A Google Trends analysis

The COVID-19 pandemic has produced many calls for a vaccine. There is growing concern that vaccine hesitancy and anti-vaccination presence will dampen the uptake of a coronavirus vaccine. There are many cited reasons for vaccine hesitancy. Mercury content, autism association, and vaccine danger have been commonly found in anti-vaccination messages. It is also mused that the reduced disease burden from infectious diseases has paradoxically reduced the perceived requirement for vaccine uptake. Our analysis using Google Trends has shown that throughout the pandemic the search interest in a coronavirus vaccine has increased and remained high throughout. Peaks are found when public declarations are made, the case number increases significantly, or when vaccine breakthroughs are announced. Anti-vaccine searches, in the context of COVID-19, have had a continued and growing presence during the pandemic. Contrary to what some may believe, the burden of coronavirus has not been enough to dissuade anti-vaccine searches entirely.     

Parental attitudes in the pediatric emergency department about the COVID-19 vaccine

BackgroundCOVID-19 vaccinations are now recommended in the United States (U.S.) for children ≥ 6 months old. However, pediatric vaccination rates remain low, particularly in the Hispanic/Latinx population.ObjectiveUsing the 4C vaccine hesitancy framework (calculation, complacency, confidence, convenience), we examined parental attitudes in the emergency department (ED) towards COVID-19 vaccination, identified dimensions of parental vaccine hesitancy, and assessed parental willingness to have their child receive the COVID-19 vaccine.MethodsAs part of a larger multi-methods study examining influenza vaccine hesitancy, we conducted interviews that included questions about COVID-19 vaccine authorization for children. We used directed content analysis to extract qualitative themes from 3 groups of parents in the ED: Hispanic/Latinx Spanish speaking (HS), Hispanic/Latinx English speaking (HE), non-Hispanic/non-Latinx White English speaking (WE). Themes were triangulated with the Parent Attitudes about Childhood Vaccines (PACV) survey, where higher scores indicate increased vaccine hesitancy.ResultsFactors influencing vaccine hesitancy were mapped to the 4C framework from 58 sets of interviews and PACVs. HE and HS parents, compared to WE parents, had less knowledge about COVID-19 and its vaccine, and more beliefs in COVID-19 vaccine myths. However, both HS and HE parent groups were more inclined to endorse COVID-19 vaccine effectiveness as a reason to have their children vaccinated. HS parents felt that COVID-19 increased their fear of illnesses in general and were worried about confusing COVID-19 with other infections. Median PACV scores of HS (Mdn = 20) and HE (Mdn = 20) parent groups were higher than of WE parents (Mdn = 10), but parental willingness to have their child receive COVID-19 vaccination was similar across groups.ConclusionsHigher COVID-19 vaccine hesitancy among HS and HE parents compared to WE parents may be attributed to insufficient knowledge about COVID-19, its vaccine, along with COVID-19 vaccine myths. Efforts to provide targeted vaccine education to different populations is warranted.     

Changes in Parental Attitudes Toward COVID-19 Vaccination and Routine Childhood Vaccination During the COVID-19 Pandemic: Repeated Cross-sectional Survey Study

BackgroundIt was reported that one in four parents were hesitant about vaccinating their children in China. Previous studies have revealed a declining trend in the vaccine willingness rate in China. There is a need to monitor the level of parental vaccine hesitancy toward routine childhood vaccination and hesitancy toward the COVID-19 vaccine during the ongoing COVID-19 pandemic.ObjectiveThis study aims to assess changes in trends of parental attitudes toward routine childhood vaccines and COVID-19 vaccinations across different time periods in China.MethodsThree waves of cross-sectional surveys were conducted on parents residing in Wuxi City in Jiangsu Province, China from September to October 2020, February to March 2021, and May to June 2021. Participants were recruited from immunization clinics. Chi-square tests were used to compare the results of the three surveys, controlling for sociodemographic factors. Binary and multivariable logistic regression analysis was used to examine factors related to parental vaccine hesitancy and COVID-19 vaccine willingness.ResultsOverall, 2881, 1038, and 1183 participants were included in the survey’s three waves. Using the Vaccine Hesitancy Scale, 7.8% (225/2881), 15.1% (157/1038), and 5.5% (65/1183) of parents showed hesitancy to childhood vaccination (P<.001), and 59.3% (1709/2881), 64.6% (671/1038), and 92% (1088/1183) of parents agreed to receive a COVID-19 vaccine themselves in the first, second, and third surveys, respectively (P<.001). In all three surveys, “concerns about vaccine safety and side effects” was the most common reason for refusal.ConclusionsThere has been an increasing acceptance of COVID-19 vaccination in Wuxi City, China. Effective interventions are needed to mitigate public concerns about vaccine safety.