Onychotillomania: 2 case reports

Onychotillomania is an uncommon condition characterized by self-destruction of the fingernails and/or toenails by compulsive manipulation. We report 2 cases of onychotillomania with differing presentations in a young man and in an older man. Onychotillomania may be a form of obsessive-compulsive disorder (OCD), and we discuss the psychologic factors and current treatments for this condition.     

乳腺癌术后丹毒12例分析

目的 分析12例乳腺癌术后丹毒住院患者的临床特点、细菌学特点及治疗方法。 方法 回顾性分析宁波市三家三级甲等医院确诊的12例乳腺癌术后丹毒患者的临床资料。 结果 8例患者行乳腺癌改良根治术 + 腋窝淋巴结清扫术,3例患者行乳腺癌根治术 + 腋窝淋巴结清扫术,1例患者行乳腺切除术,12例患者均有术后患侧的淋巴水肿。丹毒发生于乳腺癌手术治疗后1 ~ 18年（平均8.0年）,4例患者存在复发。8例患者感染部位为手术同侧上肢,1例患者为手术侧胸壁,另1例患者为手术侧下肢,多部位感染者有2例。5例患者行血培养,2例阳性,1例为似马链球菌,另1例为肺炎克雷伯菌。6例患者使用青霉素类抗生素,其中2例初始治疗失败,更换抗生素后,12例患者均好转出院。 结论 乳腺癌术后淋巴水肿的上肢及胸壁容易发生丹毒,病原学上需警惕革兰阴性菌,在抗生素治疗的同时需注重淋巴水肿的治疗。     

Onychotillomania. 2 case reports

2 interesting cases of onychotillomania associated with depressive neurosis and delusion of infestation, respectively, are reported with a brief review of the literature.     

Nail unit blue melanocyte nevi: 2 case reports

INTRODUCTION: Nail unit blue nevus is a rare and benign melanocyte proliferation of the nail unit matrix. OBSERVATIONS: We report two cases of nail matrix blue nevi with a blue-black spot of the lunular area associated in the first case with a longitudinal nail groove. COMMENTS: The analysis of our cases and of the previously reported cases give us the opportunity to describe different clinical and histological presentations.     

Kimura disease: 2 case reports and a literature review

Kimura disease (KD) is a chronic inflammatory soft-tissue disorder often presenting as swollen soft tissue or enlarged lymph nodes. KD is rare, and most reported cases have involved Asians. The pathogenesis is poorly understood, and treatments are unsatisfactory. KD is associated with allergic conditions such as asthma, rhinitis, and eczema. We present the cases of 2 patients treated for chronic endogenous eczema and KD in our dermatology clinic.     

Granulomatous rosacea associated with ulcerative colitis: 2 case reports

Inflammatory gastrointestinal disorders (ulcerative colitis and Crohn's disease) are often associated with cutaneous disorders, which occasionally may even precede the internal symptoms. Aside from the specific skin diseases, such as erythema nodosum or pyoderma gangraenosum, a number of unspecific skin eruptions may be found in both disorders. Here we report on 2 cases of ulcerative colitis associated with granulomatous rosacea.     

Male genital dyskeratotic tumor. 2 case reports

Two cases of genital vegetant tumors are described associated with lichen sclerous in male patients. Clinically they were very close to giant condyloma acuminatum. This diagnosis was rejected after histological examination of the tumors. The pathological changes consisted of epithelial hyperplasia, dyskeratosis, epidermal dysplasia and presence of some vacuolated keratinocytes. After surgical excision, the relapses are frequent. Etr etinate or local 5-fluorouracil seemed to prevent these relapses.     

色素性神经纤维瘤六例

6例色素性神经纤维瘤中男3例,女3例,年龄8～55岁.6例患者的皮损均表现为褐色斑片或斑块,3例皮损位于左颈部及躯干、四肢,1例皮损位于右腋窝及左上臂,1例皮损位于左前臂伸侧,1例皮损位于腰臀部,皮损2 cm×3 cm至30 cm×40 cm.3例合并Ⅰ型神经纤维瘤病.皮损组织病理主要表现为表皮轻度角化过度,基底层色素增加,真皮和皮下脂肪组织内可见肿瘤细胞呈弥漫性分布,肿瘤组织无包膜,主要由大量的梭形细胞构成.肿瘤组织中散在或簇集状分布黑素细胞,胞质内可见黑素颗粒.免疫组化显示S100(+)和波形蛋白(+).6例患者均未治疗.色素性神经纤维瘤少见,临床和组织病理上,需与Becker痣、先天性黑素细胞痣、色素性隆突性皮肤纤维肉瘤等鉴别.     

Proteus syndrome: 2 case reports and a review of the literature

Proteus syndrome is a rare condition that has a variable clinical presentation. The syndrome is characterized by asymmetric disproportionate enlargement of the limbs, skull, or vertebrae, associated with a number of cutaneous lesions. Herein, the clinical findings of 2 patients with Proteus syndrome are presented and the current clinical diagnostic criteria are reviewed.     

进行性骨发育异常三例分析

目的 探讨进行性骨发育异常的临床病理特征、诊断及治疗.方法 分析3例进行性骨发育异常患儿的临床病理资料,并复习相关文献.结果 3例患儿均为女性,出生后数天至数月发病,临床表现为头皮、躯干、四肢质硬的淡红色或肤色丘疹、结节或斑块,无明显症状.组织病理学检查均显示真皮中深层成片的骨或骨样组织形成.3例患儿血清钙、磷及甲状旁腺激素水平均未见明显异常.例1口服碳酸氢钠片并切除右下腹皮疹,随访约7个月右下腹皮疹无复发,但其他皮疹较前凸出、增大、变硬,并出现新发皮疹;例2外用阿达帕林凝胶,皮疹未增多,但皮损增大,质地变硬;例3未治疗,已失访.结论 进行性骨发育异常临床表现为向深部进行性发展的质硬的斑丘疹、斑块,目前尚无有效方案预防或治疗.     

Artificial penile nodules: case reports.

An interesting cultural practice of implanting foreign bodies under the skin of the penis for enhancing sexual excitement in the man's sexual partner is described. Recognition of this is important to venereologists because of their primary concern with the genital area. The term artificial penile nodule has been suggested for the condition resulting from this practice.     

Late-onset hydroa vacciniforme: two case reports

Hydroa vacciniforme (HV) is a rare blistering photodermatosis that heals with vacciniform scarring, with onset usually in childhood and spontaneous resolution by early adulthood. We report two cases of HV seen at the National Skin Centre, Singapore, both with a late onset at 20 years of age, during compulsory military service, and one with a less typical non-vesicular presentation, that initially caused some diagnostic difficulties.     

肉芽肿性口周皮炎二例

报告2例肉芽肿性口周皮炎.例1男,6岁.面部红斑、丘疹5个月就诊.曾外用糖皮质激素软膏后皮疹渐增多.例2女,28岁.口周、鼻周红斑、小丘疹2个月余就诊.2例均表现为面部腔口周围直径1 ～3mm大小的淡红色坚实小丘疹,皮损组织病理检查:真皮毛囊周围上皮样细胞肉芽肿改变.结合临床表现及组织病理学检查,2例均确诊为肉芽肿性口周皮炎.例1口服琥乙红霉素颗粒200 mg/次,每日4次、1％克林霉素凝胶和0.03％他克莫司软膏外用,治疗2个月后皮疹完全消退,1个月后口周皮疹又复发.例2在行组织病理活检后皮疹自行消退,提示本病具有临床自愈倾向.     

Localized pemphigus herpetiformis: two case reports

Pemphigus herpetiformis (PHF) is a rare variant of pemphigus that combines the clinical features of dermatitis herpetiformis and immunopathological features of pemphigus. In previous case reports, distribution of lesions is usually generalized, involving trunk and limbs. We report two cases of localized PHF presenting with grouped pustules on bilateral dorsal feet and left preauricular area, respectively. Microscopic examination showed neutrophilic spongiosis, subcorneal pustules, and focal acantholysis. Both direct immunofluorescence of Case 1 and indirect immunofluorescence of Case 2 revealed moderate deposition of IgG in the intercellular space of upper epidermis. Based on the typical histologic features and immunopathological findings, diagnoses of PHF were made. However, the atypical and localized clinical presentation rendered the process of reaching a diagnosis more difficult. PHF should be added in the spectrum of differential diagnosis of localized pustular disorders.     

前额纤维化性脱发二例

例1女,44岁,额颞部发际线后移4年,面部多发性肤色小丘疹2年.皮肤科检查:额颞部发际线后移,局部皮肤光滑菲薄,可见残存的细小毛发;眉毛、腋毛和阴毛部分脱落;额颞部、双下颌角处可见弥漫性分布许多粟粒大小的肤色小丘疹.皮肤镜下可见毛囊开口数减少,毛发直径不一,瘢痕性白斑和毛囊周围红斑.例2女,55岁,额颞部毛发稀少2年.皮肤科检查:双侧额颞部发际线后移,眉毛、腋毛和阴毛部分脱落.2例患者的组织病理检查均可见毛囊周围以淋巴细胞为主的浸润,基底细胞液化变性,毛囊周围有板层状纤维化.2例患者的临床和组织病理表现均符合前额纤维化性脱发的诊断.     

Idiopathic oedema: case reports and review

Two cases of idiopathic oedema are reported and the literature is reviewed. The diagnosis of this disorder is made by exclusion of other known causes of oedema. In both our patients no abnormalities were detected other than increased daily fluctuation of body weight and increased capillary permeability.     

Pigmented epithelioid melanocytoma: two case reports

Because of indolent course without mortality, the term "pigmented epithelioid melanocytoma" has been suggested as a replacement for "equine" or "animal-type" melanoma and for the epithelioid blue nevus of the Carney type, from which they are histologically indistinguishable. This report reviews this concept and recounts in detail two of eighteen cases occurring in residents of the Central Coast of California. This paper also contains clinical photographs of pigmented epithelioid melanocytoma, unlike prior reports.     

未定类细胞组织细胞增生症三例分析

未定类细胞组织细胞增生症（indeterminate cell histiocytosis, ICH）较为少见,国内仅见数例个例报道［1-4］。现将我们诊治的3例报道如下,并对该病的临床及组织病理学特征进行分析……