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Casey L. Ross Alina Shevchenko Nicholas K. Mollanazar Sylvia Hsu Kiran Motaparthi 《Dermatologic therapy》2018,31(4)
Acute generalized exanthematous pustulosis is a rare adverse cutaneous reaction characterized by the rapid appearance of numerous pustules arising on edematous, erythematous skin. It is commonly accompanied by fever and leukocytosis and usually resolves with discontinuation of the offending agent. Herein, acute generalized exanthematous pustulosis induced by terbinafine is described, followed by a brief review of the literature. 相似文献
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Acute generalized exanthematous pustulosis due to thallium 总被引:4,自引:0,他引:4
MH Aziz Jalali S Mirzazadeh Javaheri P Salehian 《Journal of the European Academy of Dermatology and Venereology》2004,18(3):321-323
Acute generalized exanthematous pustulosis (AGEP) is characterized clinically by fever, pruritus and acute pustular eruption. Usually a drug is found to be the responsible agent. We present a patient who experienced an acute generalized exanthematous pustulosis due to radioactive thallium. The eruption cleared rapidly after discontinuation of the drug and systemic corticosteroid therapy. 相似文献
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Acute generalized exanthematous pustulosis induced by oxacillin confirmed by patch testing 下载免费PDF全文
Rima Gammoudi Chaker Ben Salem Lobna Boussofara Neyla Fathallah Nejet Ghariani Raoudha Slim Badreddine Sriha Colandane Belajouza Rafiaa Nouira Mohamed Denguezli 《Contact dermatitis》2018,79(2):108-110
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Acute generalized exanthematous pustulosis (AGEP) presents with an abrupt onset of widespread pustules on erythematous base and rapid spontaneous healing. AGEP may have a variety of causative factors such as drugs, viral infection and exposure to mercury. We report a case of AGEP in a 6-year-old boy who presented with acute onset of fever and widespread pustular eruption on erythematous bases. Histologic examination showed neutrophilic subcorneal spongiform pustule. It is an uncommon condition in children. 相似文献
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C Galvão† Rfj Criado† Pr Criado‡ Nys Valente‡ Jf de Mello† Mfm Fernandes† 《Journal of the European Academy of Dermatology and Venereology》2002,16(6):634-637
We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline. To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of bamifylline in the medical literature. We, therefore, add this drug to the list of causes for AGEP. 相似文献
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本文分析了14例急性泛发性发疹性脓疱病的一般资料、临床表现和治疗情况。14例患者中11例有用药史,全部有发热,皮疹为弥漫性红斑、非毛囊性脓疱,予以糖皮质激素等对症治疗,所有患者2周内痊愈。 相似文献
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First case report of acute generalized exanthematous pustulosis (AGEP) caused by gadolinium confirmed by patch testing 下载免费PDF全文
M. Teresa Bordel Gómez Cristina Martín García Carmen Meseguer Yebra M. Isabel Zafra Cobo M. Esther Cardeñoso Álvarez Juan Sánchez Estella 《Contact dermatitis》2018,78(2):166-168
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Fernando SL 《The Australasian journal of dermatology》2012,53(2):87-92
Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is caused by drugs in >90% of cases. It is rare, with an incidence of 1-5 patients per million per year. The clinical manifestations are characterised by fever and the rapid appearance of disseminated sterile pustules 3-5 days after the commencement of treatment. It is accompanied by marked neutrophilia. Mucous membranes are not typically involved. The drugs conferring the highest risk of AGEP according to the EuroSCAR study are aminopenicillins, pristinamycin, hydroxychloroquine, antibacterial sulphonamides, terbinafine and diltiazem. The pathogenesis of AGEP involves the initial influx of CD8 cytotoxic T-cells resulting in the apoptosis of keratinocytes and formation of vesicles. Then CXCL-8-producing and granulocyte macrophage-colony stimulating factor-producing CD4 cells enter the epidermis, resulting in neutrophil mediated inflammation and the formation of pustules. As a result, the histology reveals intraepidermal, usually subcorneal, pustules and an accompanying neutrophilic and lymphocytic infiltrate. Epicutaneous patch testing may also support the diagnosis by causing a localised pustular reaction 48-96 h after the offending drug is applied. The condition usually resolves by 15 days after the causative drug is withdrawn but oral corticosteroid therapy may be necessary in some individuals. The mortality rate is up to 5% and mostly occurs in elderly people who have significant comorbidities. 相似文献