非瓣膜病心房颤动患者血浆D-二聚体与左房功能异常的关联性及对其诊断价值

目的:以经食道心脏超声(transesophageal echocardiography,TEE)为判断标准,分析非瓣膜病持续性心房颤动患者血浆D-二聚体水平与左房功能异常的关联性及其对左房功能异常的诊断价值。方法:52例持续性心房颤动患者,病因排除瓣膜性心脏病。依据TEE结果分为两组:左房功能异常组(栓塞高危组,n=17);其余患者为左房功能正常(对照组,n=35)。单因素分析比较两组间基础临床资料、经胸超声(TTE)结果和凝血指标,多因素Logistics回归分析栓塞高危患者的危险因素并按诊断试验评价方法计算真实性指标。结果:栓塞高危组和对照组在年龄、既往栓塞史、左房内径、左室射血分数、血浆D-二聚体水平方面差异具有显著性(均P0.05)。Logistics回归分析,仅左室射血分数(P0.05)和血浆D-二聚体浓度(P0.01)是栓塞高危状态的相关因素。以300μg/L为阈值,D-二聚体诊断左心房功能异常的灵敏度为88%,特异度为83%,准确度为85%。结论:非瓣膜病持续性心房颤动患者外周血液D-二聚体水平与左房功能异常(栓塞高危状态)有关联,它对左房功能异常有一定诊断价值。     

不同抗凝强度华法林对非瓣膜病性房颤患者出血发生率及D-二聚体浓度的影响

目的探讨不同抗凝强度华法林对非瓣膜病性房颤患者出血发生率及D-二聚体浓度的影响。方法选取我院2012年2月~2014年3月收治的非瓣膜病性房颤患者150例,将其随机分为三组,即标准抗凝强度A组(2.0INR3.0)、低抗凝强度B组(1.5INR1.9)、阿司匹林C组,各50例,观察三组患者血栓栓塞并发症、出血发生率以及D-二聚体浓度的变化。结果经治疗后,A组患者血栓栓塞发生率明显低于B组与C组,但总体来说不同强度华法林抗凝的三组患者血栓栓塞率比较,差异无统计学意义(P0.05);治疗后三组患者的D-二聚体浓度明显比治疗之前低,治疗前与治疗后的D-二聚体浓度比较,差异有统计学意义(P0.05),其中B组患者的D-二聚体浓度明显低于C组患者,差异有统计学意义(P0.05),A组患者的D-二聚体浓度明显要低于其他两组患者,差异有统计学意义(P0.05)。结论 A组患者的抗栓疗效比B组与C组患者的疗效要好,且华法林抗凝维持INR值在2.0~3.0时,能够降低非瓣膜病性房颤患者的血栓栓塞出血发生率,具有一定的有效性与安全性。     

不同血栓栓塞风险心房颤动患者微栓子及D-二聚体水平观察

目的 观察不同血栓栓塞风险心房颤动(房颤)患者微栓子及D-二聚体水平,明确其与房颤栓塞风险的关系。方法 观察2020年2月至2021年11月我院门诊及病区首诊的持续性房颤患者206例,常规检测血浆D-二聚体水平并经颅多普勒监测大脑中动脉微栓子,使用CHA2DS2-VASc评分系统评估患者栓塞风险,按≥2分高危组和<2分低中危组分组,根据指南建议预防性抗凝治疗,其中48例患者应用达比加群,1月后复查D-二聚体水平并再次监测微栓子。结果 68例低中危组房颤患者微栓子阳性5例,138例高危组房颤患者微栓子阳性28例,高危组微栓子阳性率显著高于低中危组,两组差异有统计学意义(χ²=5.67,P<0.05);48例房颤患者抗凝治疗前微栓子阳性18例,抗凝治疗后微栓子阳性5例,微栓子阳性率显著降低(χ²=9.66,P<0.05);低中危组D-二聚体水平(286±67)μg/L,高危组D-二聚体水平为(426±79)μg/L,两组差异有统计学意义(P<0.05);48例患者抗凝治疗前D-二聚体水平为(412±58)μg/L,抗凝治疗...     

经食管超声心动图联合增强在诊断老年非瓣膜性心房颤动患者血栓形成中的价值

目的研究经食管超声心动图(TEE)联合增强检出老年非瓣膜性心房颤动(房颤)患者左心耳血栓形成中的价值。方法选取2017年12月～2020年10月内蒙古医科大学附属医院行经TEE检查的老年非瓣膜性房颤患者145例,根据TEE联合增强检查结果分为血栓形成组52例和非血栓组93例。先后行经胸超声心动图(TTE)及TEE检查。并对疑似血栓形成又不能排除的12例患者完成TEE联合增强检查。对比TTE与TEE对左心房及左心耳不同血流状态的检出情况。比较2组一般临床资料,并进行多因素logistic回归分析。结果 TEE联合增强血栓检出率明显高于TTE,差异有统计学意义(35.9%vs 5.5%,P0.01)。与非血栓组比较,血栓形成组左心房内径(LAD)、同型半胱氨酸、C反应蛋白和D-二聚体水平明显升高,左心耳流速和LVEF明显降低,差异有统计学意义(P0.05,P0.01)。多因素logistic回归分析显示,LAD及D-二聚体是老年非瓣膜性房颤患者血栓形成的独立危险因素(OR=1.14,95%CI:1.03～1.25,P=0.027;OR=4.79,95%CI:1.40～16.70,P=0.012),左心耳流速为保护因素(OR=0.84,95%CI:0.78～0.90,P=0.001)。结论 TEE可以直观显示心房及心耳的血流状态,准确测量左心耳流速,联合增强更有助于鉴别诊断。     

老年非瓣膜性房颤病人血浆BNP水平及其对左房附壁血栓的预测价值研究

目的分析老年非瓣膜性房颤(NVAF)病人血浆B型脑利钠肽(BNP)水平与左房附壁血栓形成的相关性及其预测价值。方法选取在沈阳医学院附属第二医院心内科和老年病科住院的老年非瓣膜性房颤病人204例,男144例,女60例,年龄65～83(72.76±11.13)岁。根据经食管超声心动图(TEE)检测有无左心房附壁血栓分为血栓阳性组与血栓阴性组。比较两组病人血浆BNP、C反应蛋白(CRP)、D-二聚体、左房内径(LAD)、左室舒张末期内径(LVEDd)、左室射血分数(LVEF)等。通过多因素Logistics回归分析老年非瓣膜性房颤病人左房附壁血栓形成的危险因子,并绘制ROC曲线研究各指标对左房血栓形成的预测价值。结果两组病人中,充血性心力衰竭病人比例、CHA2DS2-VASc评分、血浆BNP、D-二聚体水平和LAD左房血栓阳性组均显著大于血栓阴性组(P0.05),LVEF左房血栓阳性组小于血栓阴性组(P0.05)。多因素Logistics逐步回归分析显示,血浆BNP(OR=1.16,95%CI 1.05～4.24,P0.05)和CHA2DS2-VASc评分(OR=2.19,95%CI 1.55～6.45,P0.01)是左房附壁血栓形成的危险因素。ROC曲线显示,血浆BNP ROC曲线下面积为0.801(95%CI 0.731～0.871,P0.01),最佳临界值为307.5pg/mL。结论血浆BNP水平是老年非瓣膜性房颤病人左房附壁血栓形成的风险因素,并且BNP可以作为老年非瓣膜性房颤病人发生左房附壁血栓预测指标。     

血小板激活及内皮损伤血液标志物对心房颤动血栓栓塞危险性的评价

目的:研究心房颤动(Af)患者是否存在血小板激活和内皮损伤,探讨其对评价Af血栓栓塞危险性的价值。方法:Af患者共89例,按是否接受了经食管超声心动图(TEE)检查分为两个亚组:①TEE检查亚组:35例,发现左心房和(或)左心耳有血栓者10例,有明确外周动脉血栓栓塞并发症者8例,无血栓者17例;②未检查亚组:54例。另选33例非Af者为对照组。用ELISA法测定两组的血浆可溶性P选择素(sP选择素)、血管性血友病因子(vWF)、D二聚体(DD)水平,用全自动生化分析仪测定平均血小板体积(MPV),对其结果进行对照分析。结果:Af患者血浆sP选择素、vWF、MPV、DD水平显著升高(P<0.05),其中血浆sP选择素、DD、MPV水平在血栓和无血栓者中差异有统计学意义(P<0.05)。且sP选择素与DD水平呈正相关(r=0.311,P<0.05)。结论:Af患者存在有血小板激活及内皮损伤,与其血栓形成及栓塞并发症有一定关系。     

炎症与非瓣膜性心房颤动血栓形成的关系

目的:通过观察非瓣膜性心房颤动患者血浆C反应蛋白(CRP)、D-二聚体的浓度及左心房直径、射血分数的水平,研究CRP与其左心房内血栓形成的关系.方法:将经食管超声心动图(TEE)检查的非瓣膜性心房颤动患者(107例)分为:左心房血栓形成组31例(血栓组)、无左心房血栓形成组76例(非血栓组).检测血浆中CRP、D-二聚体的浓度及经胸超声心动图检测左心房直径、缩短分数、射血分数.结果:血栓组与非血栓组CRP浓度(中位数1.65 mg/L:0.80 mg/L,P＜0.01)、D-二聚体浓度(中位数188.00 μg/L:92.00 μg/L,P＜0.01)、左心房直径[(54.68±12.44):(46.77±12.31)mm,P＜0.05]、射血分数[(58.20±9.42):(62.81±8.67)%,P＜0.05]、缩短分数[(30.46±5.75):(35.24±5.41)%,P＜0.01].Logistic回归发现CRP、左心房直径与非瓣膜性心房颤动并发血栓形成独立相关(P＜0.05),而D-二聚体、射血分数、缩短分数与非瓣膜性心房颤动并发血栓形成无显著相关.结论:CRP增高、左心房直径扩大是非瓣膜性心房颤动并发血栓形成的高危因素,炎症反应可能参与了心房内血栓形成.     

老年非瓣膜病心房颤动患者左心房血栓的影响因素

目的探讨老年非瓣膜病心房颤动(房颤)患者左心房血栓的影响因素。方法选择本院2011年4月~2015年10月收治的116例老年非瓣膜病房颤、食管超声发现左心房/左心耳血栓的患者作为血栓组,以同期收治的116例未发现左心房/左心耳血栓的老年非瓣膜病房颤患者作为对照组,分析2组患者基本指标差异,采用多因素logistic回归分析左心房/左心耳血栓形成的高危因素。结果血栓组较对照组高血压、脑卒中比例增高(65.52%vs 51.72%,13.79%vs 5.17%,P<0.05),2组慢性心力衰竭比例、左心房内径(LAD)、左心室舒张末内径、LVEF、N末端B型脑钠肽前体(NT-proBNP)水平、持续性/永久性房颤比例、CHA2DS2-VASc评分有统计学差异(P<0.01)。多因素logistic回归分析显示,持续性/永久性房颤(OR=5.721,95%CI:2.069~15.820,P=0.001)、NT-proBNP(OR=1.001,95%CI:1.000~1.002,P=0.002)、CHA2DS2-VASc评分(OR=2.021,95%CI:1.316~3.103,P=0.001),LAD(OR=1.104,95%CI:1.002~1.216,P=0.046)是老年非瓣膜病房颤患者左心房血栓形成的独立影响因素。结论持续性/永久性房颤、LAD扩大、NT-proBNP水平高、CHA2DS2-VASc评分高为老年非瓣膜病房颤患者左心房血栓形成的高危因素。     

血源性组织因子和D-二聚体在老年患者动静脉血栓中的研究

目的研究血源性组织因子(TF)的表达和D-二聚体与老年患者下肢动静脉血栓的关系。方法选取100例经下肢动静脉造影确诊为动静脉血栓的老年患者,分为动脉血栓组50例,静脉血栓组50例;另选择同期健康体检者50例为对照组。检测3组血浆D-二聚体值和TF水平,同时采用半定量RT-PCR法检测3组外周血细胞TF mRNA表达水平,并进行比较。结果与对照组比较,动脉血栓组和静脉血栓组D-二聚体、TF和TF mRNA表达明显升高,差异有统计学意义(P<0.05);与静脉血栓组比较,动脉血栓组D-二聚体、TF和TF mRNA虽有升高趋势,但差异无统计学意义(P>0.05)。相关分析显示,动脉血栓组和静脉血栓组TF mRNA与TF呈正相关(r=0.91,r=0.94,P<0.05)。结论血细胞中TF的表达是外周血TF的主要来源,在老年人动静脉血栓启动、形成、延续阶段起重要作用。     

慢性非瓣膜病房颤患者血浆TM、D-D水平及意义

慢性心房颤动（AF）引起血栓前状态,促进左心房（LA）和／或左心耳（LAA）的血栓形成,由此引起的血栓栓塞并发症（尤其是脑卒中）是房颤致死致残的重要原因。2005年2月～2006年2月,我们检测了AF患者血浆血栓调节蛋白（TM）、D-二聚体（D—D）水平变化,旨在探讨房颤患者内皮损害及其对评估AF患者血栓栓塞危险性的价值。     

Plasma brain natriuretic peptide levels indicating thromboembolism in very elderly patients with non-valvular atrial fibrillation.

BACKGROUND: Assessment of left atrial (LA) function by transesophageal echocardiography is useful for detecting patients with a high risk thromboembolism secondary to atrial fibrillation (AF). A recent study showed that the atrium is the main source of brain natriuretic peptide (BNP) in AF patients without overt heart failure. The purpose of this study was to assess the possible relationship between LA function and plasma BNP levels in very elderly patients with non-valvular AF. METHODS AND RESULTS: Seventy-four consecutive patients with chronic non-valvular AF (aged, 82+/-6 years) underwent transthoracic and transesophageal echocardiography and measurement of plasma BNP. Thirteen AF patients who had a history of cerebral embolism or echocardiographic evidence of thrombus (TE+ group) were compared with 61 AF patients who had no such complications (TE- group). The TE+ group demonstrated a lower LA appendage (LAA) velocity and higher plasma BNP level than the TE- group. Assessment of variables by multiple logistic regression analysis revealed that BNP was a significant predictor of thromboembolism. There was a significant negative correlation between the plasma BNP level and the LAA peak flow velocity. CONCLUSIONS: The present findings would suggest the usefulness of measuring plasma BNP to detect very elderly non-valvular AF patients at high risk for thromboembolism.     

Role of transoesophageal echocardiography in evaluation of cardiogenic embolism.

OBJECTIVE--To determine the value of transoesophageal echocardiography in the assessment of selected patients at risk of cardiogenic embolism or after it. DESIGN--Prospective comparison of the results of transoesophageal and transthoracic echocardiography. Transoesophageal echocardiography was performed with a 5 MHz single plane phased array transducer. SETTING--University teaching hospital. PATIENTS--100 patients referred for transoesophageal echocardiography after a cerebral ischaemic event or peripheral arterial embolism (n = 63), before percutaneous balloon dilatation of the mitral valve (n = 23), or before electrical cardioversion of atrial fibrillation (n = 14). RESULTS--Transthoracic echocardiography showed potential sources of embolism in four patients including left ventricular thrombus in two patients (with one false positive), left atrial appendage thrombus (n = 1), and patent foramen ovale (n = 1). Transoesophageal echocardiography showed 59 potential embolic sources in 45 patients including left atrial spontaneous echo contrast (n = 33), left atrial appendage thrombus (n = 13), left ventricular thrombus (n = 5), patent foramen ovale (n = 3), left ventricular spontaneous echo contrast (n = 2), mitral valve prosthesis thrombus (n = 1), mitral valve prolapse (n = 1), and pronounced aortic atheroma (n = 1). Transoesophagal echocardiography showed potential embolic sources in 36/53 (68%) patients with atrial fibrillation compared with 9/47 (19%) patients in sinus rhythm. Percutaneous balloon dilatation of the mitral valve was performed without embolic complications in 18 patients without left atrial thrombi and in three patients with small fixed thrombi in the left atrial appendage. It was cancelled in two patients with large thrombi in the left atrial appendage. Cardioversion was performed without embolic complications in 14 patients without left atrial thrombi. CONCLUSIONS--Transoesophageal echocardiography detects potential sources of embolism better than transthoracic echocardiography in selected patients at risk of cardiogenic embolism or after it.     

Role of transoesophageal echocardiography in evaluation of cardiogenic embolism.

OBJECTIVE--To determine the value of transoesophageal echocardiography in the assessment of selected patients at risk of cardiogenic embolism or after it. DESIGN--Prospective comparison of the results of transoesophageal and transthoracic echocardiography. Transoesophageal echocardiography was performed with a 5 MHz single plane phased array transducer. SETTING--University teaching hospital. PATIENTS--100 patients referred for transoesophageal echocardiography after a cerebral ischaemic event or peripheral arterial embolism (n = 63), before percutaneous balloon dilatation of the mitral valve (n = 23), or before electrical cardioversion of atrial fibrillation (n = 14). RESULTS--Transthoracic echocardiography showed potential sources of embolism in four patients including left ventricular thrombus in two patients (with one false positive), left atrial appendage thrombus (n = 1), and patent foramen ovale (n = 1). Transoesophageal echocardiography showed 59 potential embolic sources in 45 patients including left atrial spontaneous echo contrast (n = 33), left atrial appendage thrombus (n = 13), left ventricular thrombus (n = 5), patent foramen ovale (n = 3), left ventricular spontaneous echo contrast (n = 2), mitral valve prosthesis thrombus (n = 1), mitral valve prolapse (n = 1), and pronounced aortic atheroma (n = 1). Transoesophagal echocardiography showed potential embolic sources in 36/53 (68%) patients with atrial fibrillation compared with 9/47 (19%) patients in sinus rhythm. Percutaneous balloon dilatation of the mitral valve was performed without embolic complications in 18 patients without left atrial thrombi and in three patients with small fixed thrombi in the left atrial appendage. It was cancelled in two patients with large thrombi in the left atrial appendage. Cardioversion was performed without embolic complications in 14 patients without left atrial thrombi. CONCLUSIONS--Transoesophageal echocardiography detects potential sources of embolism better than transthoracic echocardiography in selected patients at risk of cardiogenic embolism or after it.     

Importance of left atrial appendage flow as a predictor of thromboembolic events in patients with atrial fibrillation.

AIM: The purpose of this study was to investigate the role of transoesophageal echocardiography in predicting subsequent thromboembolic events in patients with atrial fibrillation. METHODS AND PATIENTS: Transoesophageal echocardiography was performed in 88 patients with documented paroxysmal (n=53) or chronic atrial fibrillation (n=35) to assess morphological and functional predictors of thromboembolic events. Prospective selection was from patients with non-valvular atrial fibrillation who had undergone transoesophageal echocardiography because of previous thromboembolism (n=30); prior to electrical cardioversion (n=31); or for other reasons (n=27). All patients were followed up for 1 year. RESULTS: During the period of follow-up new thromboembolic events occurred in 18 of 88 patients (20%/year); 16 of these patients had a stroke and two a peripheral embolism. Univariate analysis revealed that previous thromboembolism (P<0.005; odds ratio 5.3 [CI 1.9, 12. 1]), history of hypertension (P<0.01; odds ratio 4.0 [CI 1.4, 10.4), presence of left atrial spontaneous echo contrast (P<0.025; odds ratio 3.5 [CI 1.2, 10.0]), and presence of left atrial appendage peak velocity 相似文献   

High risk of cardiogenic cerebral embolism for very elderly patients in sinus rhythm with left atrial appendage flow velocity below 50 cm/s

Recent clinical trials have demonstrated that patients in sinus rhythm after cardioversion are still at risk of suffering from embolic events, but the precise mechanisms underlying the occurrence of cardiogenic cerebral embolism remain to be determined. All 72 patients aged 75 or over who were consecutively referred to our department between October 2003 and March 2006 were divided into three groups; these were: group 1, 17 patients in sinus rhythm after cardioversion; group 2, 18 patients without any history of atrial fibrillation; and group 3, 37 patients with chronic atrial fibrillation. Using transesophageal echocardiography, we evaluated the left atrial appendage flow velocity, left atrial appendage dimension, spontaneous echocardiographic contrast in the left atrium, and the presence of thrombus in the left atrial appendage. Left atrial appendage flow velocity was significantly lower in group 1 compared with group 2 (38.2 ± 6.1 vs 61.4 ± 7.4 cm/s, P  < 0.001), but was even lower in group 3 (25.1 ± 9.8 cm/s, P  < 0.001 vs group 1). Spontaneous echocardiographic contrast in the left atrium, thrombus in the left atrial appendage and cardiogenic cerebral embolism showed a close relationship with left atrial appendage flow velocity, and were more frequent when left atrial appendage flow velocity was less than 50 cm/s. Very elderly patients in long-term maintenance of sinus rhythm with an left atrial appendage flow velocity of less than 50 cm/s would have a high risk of cardiogenic cerebral embolism.     

Assessment of left atrial appendage function by biplane transesophageal echocardiography in patients with nonrheumatic atrial fibrillation: Identification of a subgroup of patients at increased embolic risk

Objectives. This study was conducted to identify a subgroup of patients with nonrheumatic atrial fibrillation with an increased risk for cardiogenic embolism by assessing left atrial appendage function.Background. Patients with nonrheumatic atrial fibrillation have an increased risk for thromboembolic complications. The left atrial appendage is the most likely source for thrombus formation. It is likely that the appendage function (contraction, filling dynamics) is related to the pathogenesis of thrombus formation.Methods. Twenty-nine patients with nonrheumatic atrial fibrillation (group I) underwent biplane transesophageal echocardiography. The maximal and minimal areas during a cardiac cycle and the peak emptying and filling velocities of the appendage were measured in both scan planes. For comparison, two additional groups were also analyzed. Group II consisted of 12 patients with chronic atrial fibrillation due to significant mitral stenosis, and group III consisted of 30 patients who were in sinus rhythm.Results. Patients with nonrheumatic atrial fibrillation showed two distinct appendage flow patterns: either well defined peak filling and emptying waves (≥25 cm/s) with visible fibrillatory contractions of the appendage wall (“high flow profile”) or irregular, very low, peak filling and emptying waves (<25 cm/s) associated with almost no visible appendage contractions (“low flow profile”). The left atrial appendage function in the first subgroup resembles that seen in patients with sinus rhythm, whereas the appendage function in the latter subgroup resembles more the “static pouch” seen in patients with rheumatic atrial fibrillation. Events suggestive of cardiogenic embolism occurred in six patients from group I, five of whom were in the low flow profile subgroup (p < 0.05). The spontaneous echo contrast phenomenon was observed in 80% of the low flow profile subgroup but in only 5% in the high flow profile subgroup (p < 0.05). Three thrombi confined to the left atrial appendage were detected by transesophageal echocardiography in group I; all three of the patients were in the low flow profile subgroup.Conclusions. The assessment of left atrial appendage function by transesophageal echocardiography may be helpful to identify subgroups of patients with nonrheumatic atrial fibrilation with an increased risk of thrombus formation.     

压缩比偏大WATCHMAN左心耳封堵器的疗效与安全性

目的 观察压缩比偏大WATCHMAN左心耳封堵（left atrial appendage closure, LAAC）术后的短、中期疗效与安全性。 方法 选择2016年10月～2019年10月我中心实施WATCHMAN左心耳封堵治疗的患者（n=113）,按封堵器压缩比≥25%分为压缩比偏大组（n=23）和压缩比正常组(n=90),研究临床基线资料,统计围手术期并发症的发生情况,随访短、中期情况。 结果 两组间基线资料的差异无统计学意义。随访中位数14（3,39）月,压缩比偏大组无封堵器表面血栓形成、心脏压塞;无新发脑卒中、外周动脉栓塞;无消化道出血、泌尿系出血以及颅内出血。压缩比偏大组左心耳双叶式形态比例、术中封堵器露肩比例以及术后随访中残余分流比例较压缩比正常组显著增高（P<0.05, P<0.01）。 结论 压缩比偏大组WATCHMAN LAAC器的短、中期随访结果是安全有效的,但术后残余分流发生率较高。     

非瓣膜性心房颤动血栓形成的相关因素分析

目的通过观察非瓣膜性心房颤动患者血浆C反应蛋白、D-二聚体的浓度及左心房直径、射血分数的水平,研究C反应蛋白与非瓣膜性心房颤动患者左心房内血栓形成的关系。方法按照经食管超声心动图（TEE）检查结果将非瓣膜性心房颤动患者98名分为：左心房血栓形成组（血栓组）22例、无左心房血栓形成组（非血栓组）76例。检测血浆中C反应蛋白、D-二聚体的浓度及经胸超声心动图检测左心房直径、射血分数。结果血栓组在C反应蛋白浓度、D-二聚体浓度、左心房直径、射血分数、缩短分数方面与非血栓组差异有统计学意义,分别为C反应蛋白浓度（中位数1.60mg/L比0.80 mg/L,P=0.003）、D-二聚体浓度（中位数170.50μg/L比92.00μg/L,P=0.004）、左心房直径（55.20±12.94 mm比46.77±12.31 mm,P=0.002）、射血分数（57.46%±9.10%比62.81%±8.67%,P=0.006）、缩短分数（29.82%±5.26%比35.24%±5.41%,P〈0.001）。Logistic回归,发现C反应蛋白、左心房直径与非瓣膜性心房颤动合并血栓形成独立相关（P〈0.05）,而D-二聚体、射血分数、缩短分数与非瓣膜性心房颤动合并血栓形成无显著相关。结论CRP增高、左心房直径扩大是非瓣膜性心房颤动合并血栓形成的高危因素,炎症反应可能参与了心房内血栓的形成。     

造影增强经食道超声心动图评估射频消融术前房颤患者左心耳血栓及功能情况研究

目的 探讨造影增强经食道超声心动图(TEE)评估射频消融术前房颤患者的左心耳血栓及功能检出情况及应用价值.方法 选择2020年10月至2020年12月于四川大学华西医院就诊并拟行射频消融术的房颤患者20例,均行常规TEE及造影增强TEE检查.评估两种方法左心耳功能指标(左心耳排空、充盈速度)和左心耳血栓的检出情况.结果...