Optimal incision sites to obtain an astigmatism-free cornea after cataract surgery with a 3.2 mm sutureless incision.

PURPOSE: To determine the optimal incision to eliminate astigmatism after cataract extraction. SETTING: Hara Eye Hospital, Utsunomiya, Japan. METHODS: Patients having cataract extraction through a 3.2 mm corneal limbal incision without limbal sutures were divided into 2 groups. Group 1 comprised 98 eyes of 80 patients without preoperative astigmatism and Group 2, 72 eyes of 62 patients with no astigmatism postoperatively. In Group 1, the incisions that caused postoperative corneal changes were retrospectively evaluated. In Group 2, the types of incisions that induced an astigmatism-free cornea postoperatively were retrospectively studied. Patients were examined preoperatively and 6 months postoperatively. RESULTS: In Group 1, 23 of 40 eyes (57.5%) with an incision between 9 and 12 o'clock (BENT incision) and 10 of 58 eyes (17.2%) with an incision at 12 o'clock remained astigmatism free postoperatively (P <.0001). One eye (2.5%) with a BENT incision and 17 (29.3%) with a 12 o'clock incision had astigmatism greater than 1.0 diopter (D) postoperatively (P <.001). In Group 2, 72 eyes had less than 1.2 D of preoperative astigmatism. No eye with more than 1.2 D of astigmatism was astigmatism free postoperatively, even when the incision was made at the steepest meridian. CONCLUSIONS: The results indicate that to reduce astigmatism in eyes with preoperative astigmatism of 0.5 D or more, a limbal 3.2 mm BENT incision should be placed at 10:30 o'clock. To prevent astigmatism postoperatively, the incision should be placed at the steepest meridian in eyes with preoperative astigmatism greater than 0.5 D; for preoperative astigmatism greater than 1.2 D, a 3.2 mm incision at the corneal limbus is insufficient and a wider incision or an additional incision is required.     

角膜地形图引导下白内障手术切口对角膜散光的矫正

目的:比较不同位置和形态的手术切口对白内障摘除术后角膜散光及裸眼视力的影响。方法:选取术前角膜散光值>1.00D的白内障患者43例52眼,将患者随机分成两组,A组患者采用超声乳化白内障吸除联合人工晶状体植入术,手术切口为位于上方10∶30～11∶30的透明角膜隧道切口。B组患者采用手法碎核白内障摘除联合人工晶状体植入术,其中角膜散光值为1.00～2.00D的患者,切口为位于角膜最大屈光度径线的直线形巩膜隧道切口,长度为6.0～7.0mm,角膜散光值>2.00D的患者,在上述直线形切口对侧角膜缘处,另作一弧形板层松解切口。分别于术后2wk,3mo随访患者,检查裸眼视力及行角膜地形图检查。结果:B组患者术后2wk,3mo裸眼视力好于A组。B组患者术后角膜散光度在术后2wk,3mo时均小于A组。结论:位于角膜最大屈光度径线的6.0～7.0mm直线形巩膜隧道切口,及此切口联合作对侧弧形板层松解切口均能有效矫正白内障术前存在的角膜散光,能够使患者获得更好的术后裸眼视力。     

Wound healing of scleral self-sealing incision: a comparison of ultrasound biomicroscopy and histology findings

· Purpose: The goal of this study was to compare the morphologic findings of wound healing in scleral self-sealing incisions using ultrasound biomicroscopy and histology. · Methods: Using a slit-knife, we made a scleral self-sealing incision in the rabbit eye. At various time points postoperatively, ultrasound biomicroscopy was performed to evaluate wound healing; the eyes then were enucleated and studied histologically. We also performed ultrasound biomicroscopy at various time points postoperatively in patients who received a scleral self-sealing incision during cataract surgery. · Results: In rabbit eyes, on days 1 and 2 postoperatively, we detected the scleral wound; thereafter, detection became increasingly difficult. On day 7 postoperatively, the wound was undetectable. By light-microscopic observation, the scleral wound was open at 1 day postoperatively. On day 2 postoperatively, fibrovascular tissue barely extended into the wound; on day 5 postoperatively, connective tissue extended through the full thickness of the wound. On day 7 postoperatively, the connective tissue became dense and aligned with the lamella. In human eyes, using ultrasound biomicroscopy, the scleral incision was detectable until 5 days postoperatively, but undetectable at 7 days postoperatively. · Conclusions: Ultrasound biomicroscopy demonstrates the stages of wound healing of scleral self-sealing incisions. We believe that careful observation is necessary for approximately 7 days following self-sealing incision cataract surgery. Received: 16 July 1997 Revised version received: 13 October 1997 Accepted: 9 February 1998     

Topical vitamin C,vitamin E,and acetylcysteine as corneal wound healing agents: A comparative study

Purpose:The purpose of this study was to evaluate wound healing abilities and efficacy of topical Vitamin C, Vitamin E, and acetylcysteine for their possible clinical use.Methods:The study was conducted on 36 eyes of 18 single-breed rabbits, Oryctolagus cuniculus, of both sexes. A 7.5 mm calibrated vacuum corneal trephine was used to induce a defect of 100 micron depth in center of both the corneas. The right eye of rabbits was selected as the control eye and the left eye as the trial eye, which received eyedrops as Group 1–10% Vitamin C eyedrops, Group 2–3% acetylcysteine eye drops, and Group 3–1% Vitamin E eye drops. Control eyes received ringer lactate. Evaluation was done for fluorescein stain positivity, epithelial defect size, and corneal haze on Day 2, Day 7, and Day 14 post induction of the epithelial defect.Results:On day 14, three eyes of control group, all Vitamin C and acetylcysteine treated eyes, and four Vitamin E treated eyes were fluorescein stain negative. The mean defect area on day 14 was 0, 0, 0.13, and 1.86 mm² in Vitamin C, Vitamin E, acetylcysteine, and control eyes, respectively. Vitamin C and Vitamin E control corneal haze better than acetylcysteine in experimentally induced corneal wounds in rabbits.Conclusion:The three trial drugs with different mechanism of action showed similar effect on healing of the experimentally created corneal wounds in rabbits, with comparison showing statistical insignificance.     

LASEK术后皮质类固醇使用时机的临床观察

目的:研究激光上皮下角膜磨镶术(laser epithelial keratomileusis,LASEK)后创面愈合过程及皮质类固醇的使用时机。方法:对218例患者400眼行LASEK治疗,按术后皮质类固醇的使用时间分为A组200眼(术后48h开始用典必殊滴眼液),B组200眼(术后3~5d取治疗片后开始用典必殊滴眼液),观察LASEK术后3~7d角膜创面愈合和患者术后疼痛以及术后1,3,6mo Haze发病率,分析皮质类固醇的使用时机。结果:LASEK术后3~7d角膜创面愈合,术后1,3,6moHaze发病率无显著差异。结论:LASEK术后早期使用皮质类固醇药物可以减轻术后反应,并不减慢角膜创面的愈合也没有增加Haze发生率。     

Therapeutic keratoplasty using preserved corneas from keratoconus eyes

PURPOSE: To report and discuss cases of lamellar keratoplasty using corneas obtained during previous penetrating keratoplasty in keratoconus eyes. METHODS: Corneal buttons were obtained from 7 keratoconus patients and stored in a preserving solution for 7-60 days (average, 32.4 days) before use. The recipient eyes comprised recurrent pterygium 3 eyes, primary pterygium 1 eye, pseudopterygium 1 eye, corneal perforation with iris prolapse due to fungal corneal ulcer 1 eye, and limbal dermoid 1 eye. RESULTS: The recipient eyes ran favorable courses in general. Graft rejection developed in 2 eyes and was successfully treated with topical and systemic corticosteroid. CONCLUSIONS: Preserved corneas from keratoconus eyes were found useful in therapeutic lamellar keratoplasty. By this procedure, the current inadequate supply of donor corneas in eye banks in Japan can be augmented.     

翼状胬肉的不同术式对创面上皮修复及复发率的影响

目的:比较羊膜移植、羊膜移植+丝裂霉素C处理和自体带结膜瓣的角膜缘干细胞移植等三种常见辅助治疗,对胬肉切除术术后角膜创面愈合和1a复发率的影响。方法:本研究为随机、单盲的前瞻性研究。选择160例190眼进展期翼状胬肉成年患者,在行胬肉切除手术时,随机辅助三种常见治疗:A组,羊膜移植(60例68眼);B组,羊膜移植+丝裂霉素C应用(50例62眼);C组,自体带结膜瓣的角膜缘干细胞移植(50例60眼)。随访、记录术后角膜创面愈合情况和1a复发率。结果:A,B和C三组患者角膜创面愈合时间分别为2.1±1.5,2.3±1.2和2.8±1.7d,以C组较长(P<0.05);A组术后2wk内有5例(7%)出现鼻侧结膜手术创缘肉芽肿生长,剪除后无再生,而B,C组未见创缘肉芽肿生长;术后1aA组11眼(16%)复发,与B组7眼(11%)和C组4眼(7%)相比较,具有统计学差异(P<0.05)。结论:羊膜移植+丝裂霉素C处理在促进术后角膜创面愈合和降低1a复发率疗效方面更有优势。     

玻璃酸钠滴眼液联合软性角膜接触镜在翼状胬肉切除术后的早期应用

目的:探讨3g/L玻璃酸钠滴眼液联合软性角膜接触镜对翼状胬肉术后早期角膜上皮愈合及局部舒适度的影响.方法:选取90例90眼原发性单眼翼状胬肉患者,行翼状胬肉切除联合自体角膜缘干细胞移植术,术毕随机将患者分为3组,A组(研究组)术毕立即戴软性角膜接触镜,次日给予3g/L玻璃酸钠滴眼液及左氧氟沙星滴眼液点眼(4次/d),妥布霉素地塞米松眼膏涂眼(1次/晚),术后7d取下角膜接触镜;B组(常规用药组)常规予左氧氟沙星滴眼液点眼(4次/d),妥布霉素地塞米松眼膏涂眼(1次/晚);C组在B组的基础上加用3g/L玻璃酸钠滴眼液(4次/d).观察并比较各组术后角膜上皮愈合时间及不同时间点的眼部疼痛评分情况.结果:A组术后6h,1、3d疼痛评分均低于其余两组,差异有统计学意义(P<0.05);术后5、7d,三组疼痛评分无明显差异(P>0.05).术后第1d,三组均无完全愈合者;术后2d,A组的角膜上皮愈合率显著高于B组(P=0.015),而A组和C组及B组和C组比较,差异均无统计学意义(P>0.05);术后3d,A组的角膜上皮完全愈合率均高于其余两组,差异有统计学意义(P<0.05).结论:翼状胬肉术后早期应用3g/L玻璃酸钠滴眼液联合佩戴软性角膜接触镜可以加快角膜上皮缺损修复,减轻局部疼痛,显著改善患眼局部舒适度.     

The contribution of blood flow by the anterior ciliary arteries to the anterior segment in the primate eye

The rate and mode of corneal wound healing in severely diabetic rats were studied by light microscopy and scanning electron microscopy. Diabetes mellitus was induced in 52 rats by alloxan injection, and 52 nondiabetic rats were used as controls. After 3 weeks, a nonpenetrating razor-blade wound was made in the central cornea of both eyes in 48 diabetic and 48 normal rats. The incision passed through the epithelium and into the stroma. The effects of diabetes on the unwounded cornea were observed by comparison with corneas from eight unwounded rats (four diabetic and four normal). Whole corneas from wounded diabetic and normal rats were studied at 0, 1, 3, 6, 12 and 24 hr and at 2–7 days after wounding. The rate and mode of healing were not found to differ between diabetics and normals. The surfaces of corneal wounds in both groups appeared to be completely healed and indistinguishable from the surrounding unwounded epithelium after 24 hr. The epithelial cells involved in the initial healing process were derived primarily from the layer of wing cells which progressed across the wound close to the connective-tissue base. Only in the final stages of healing, after the wound had been filled by the deeper epithelial cells, did superficial epithelial cells migrate. There appeared to be more exfoliating superficial epithelial cells over the entire cornea in diabetic rats than in normals. Because the healing of central corneal incisions occurs initially and primarily by sliding of the deeper epithelial cells, and because the diabetic condition appears to be associated with increased exfoliation of surface cells, the healing of central incisions may be less affected by diabetes than the healing of defects of the whole corneal surface, where the superficial epithelial cells have been reported to be the main migratory cells in the initial healing process and where healing in diabetics is delayed.     

Corneal refractive changes after acrysof lens versus PMMA lens implantation

PURPOSE: Do foldable acrylic lenses yield not only reduced posterior capsular opacification but also significant refractive advantages? PATIENTS AND METHODS: 147 cataract patients including 47 with spherical corneas and 100 with preoperative astigmatism of 0.8 +/- 0. 7 dpt were treated in one of two ways: 70 patients received 5.5-mm Acrysof lens implants through 3.2-mm outer and 4-mm inner temporal clear corneal openings (stretch incision); 77 patients received 5-mm PMMA lenses through temporal clear corneal incisions of 4.1-mm outer and 6.5-mm inner diameter incisions. Corneal topography was examined in all patients before the operations as well as 3 days and 6 months after the operations. RESULTS: 6 months after the operations, we observed a surgically induced astigmatism of 0.4 +/- 0.2 dpt for the 3.2-mm incisions compared to 0.8 +/- 0.7 dpt for the 4.1-mm incisions; evaluation according to Holladay of the preoperative spherical corneas yielded a with-the-wound change of 0.0 +/- 0.3 dpt after 3.2-mm incisions versus 0.6 +/- 0.7 dpt after 4.1-mm incisions. The difference in astigmatism for the two types of incisions was statistically significant (p = 0.001). CONCLUSION: Acrysof lens implantation is especially useful for patients with spherical corneas because of avoidance of postoperative astigmatism. The 4. 1-mm corneal incision using PMMA lens implants can be used on the steep meridian to reduce preoperative astigmatism.     

原发性翼状胬肉两种治疗方法的疗效观察

目的:探讨原发性翼状胬肉两种治疗方法的疗效观察。方法:A组25例采用翼状胬肉切除联合丝裂霉素术治疗,B组10例采用自体球结膜+角膜缘干细胞移植术治疗。根据角膜创面恢复、结膜伤口愈合、胬肉有无复发进行观察。结果:A组患者术后角膜上皮第3～7d恢复,结膜充血10～15d消退,3例复发;B组患者术后角膜上皮第2d恢复,结膜充血7～10d消退,1例复发。结论:翼状胬肉切除术联合丝裂霉素和自体球结膜+角膜缘干细胞移植术都能降低胬肉复发率,二者相比较,自体球结膜+角膜缘干细胞移植术优于翼状胬肉切除联合丝裂霉素。     

Dynamic morphology of clear corneal cataract incisions

OBJECTIVE: Clear corneal cataract incisions without sutures allow for rapid visual rehabilitation after phacoemulsification but might be associated with an increased risk of postoperative infection. The goal of this study was to examine in vitro dynamic changes in unhealed clear corneal cataract incisions that might adversely affect the risk of intraocular infection. DESIGN: Laboratory investigation. METHODS: Self-sealing clear corneal incisions were created in cadaveric human and rabbit eyes, and intraocular pressure was controlled with an infusion cannula. Incisions were imaged in real time using optical coherence tomography as intraocular pressure was varied. Using an artificial anterior chamber, India ink was applied to the surface of cadaveric human corneas with clear corneal incisions to detect possible flow of surface fluid along the incision. Intraocular pressure was varied by raising and lowering the infusion bottle so as to simulate the variation in intraocular pressure that would occur with successive blinks. RESULTS: Optical coherence tomography demonstrated variation of corneal wound morphology in response to changes in intraocular pressure. Higher intraocular pressures were associated with close apposition of the wound edges, with no tendency for wound leakage. At low intraocular pressures, however, wound edges tended to gape, starting at the internal aspect of the wound. One incision opened along the entire length, allowing fluid flow across the cornea. Histologic examination revealed India ink particles in all incisions for up to three fourths of the length of the wound. CONCLUSIONS: Transient reduction of intraocular pressure might result in poor wound apposition in clear corneal incisions, with the potential for fluid flow across the cornea and into the anterior chamber, with the attendant risk of endophthalmitis.     

翼状胬肉术后不同处理方法对创面上皮修复的影响

目的：比较包扎术眼及局部滴用重组人表皮生长因子对翼状胬肉术后角膜上皮修复的影响。 方法：单侧原发性翼状胬肉38例38眼,胬肉侵入角膜在2~5mm范围内。均行翼状胬肉单纯切除术,术后将病例随机分为两组,A组19例术后每日结膜囊内涂氧氟沙星眼膏,绷带包眼至角膜上皮完全愈合;B组19例术后当日给予结膜囊内涂氧氟沙星眼膏包眼,自术后第2d起每日给予氧氟沙星眼水4次+重组人表皮生长因子眼水4次滴眼。对两组病例的角膜情况进行观察,统计角膜上皮完全愈合的时间,进行比较分析。 结果：角膜上皮平均愈合时间A组为4.1±1.4d,B组为65±2.9d,两组间比较有显著统计学差异（P<0.01）。 结论：翼状胬肉术后包眼较局部滴用表皮生长因子眼水更能加快角膜上皮愈合。     

Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy

PURPOSE: To establish a rat model of neurotrophic keratopathy and to examine the effects of the combination of substance P (SP) and insulin-like growth factor (IGF)-1 on corneal epithelial barrier function and wound healing in this model. METHODS: Corneal denervation was achieved by thermocoagulation of the ophthalmic branch of the trigeminal nerve. A modified Schirmer test was performed without topical anesthesia. Corneal epithelial barrier function was assessed by measurement of fluorescein permeability with an anterior fluorophotometer. Epithelial wound healing was evaluated by measurement of the area of the defect at various times after removal of the entire epithelium. Eye drops containing both 1 mM SP and IGF-1 (1 micro g/mL) were administered six times daily. RESULTS: The Schirmer test result in eyes subjected to trigeminal denervation was lower than that in control eyes. The fluorescein permeability of the corneal epithelium of denervated eyes was increased relative to that of control eyes. Furthermore, trigeminal denervation induced a delay in corneal epithelial wound healing. Application of eye drops containing SP and IGF-1 to denervated corneas restored the fluorescein permeability of the corneal epithelium to control levels and abolished the delay in epithelial wound healing. CONCLUSIONS: A rat model of neurotrophic keratopathy, characterized by reduced tear secretion, loss of corneal sensation, impaired epithelial barrier function, and delayed epithelial wound healing, was established by trigeminal denervation. Treatment with both SP and IGF-1 improved corneal epithelial barrier function and stimulated corneal epithelial wound healing in this model.     

Effect of temporal and nasal unsutured limbal tunnel incisions on induced astigmatism after phacoemulsification

PURPOSE: To compare the surgically induced corneal astigmatism after unsutured temporal and nasal unsutured limbal tunnel incisions. SETTING: Departments of Ophthalmology, Marienhospital, Aachen, and Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. METHODS: In a prospective clinical study, 42 eyes of 21 patients with a mean age of 75.1 years had phacoemulsification and implantation of a foldable hydrophobic acrylic intraocular lens using a 3.6 to 3.8 mm unsutured limbal tunnel incision. The right eye always received a temporal incision and the left eye, a nasal incision. Computerized videokeratography was performed preoperatively and 2 weeks and 6 months postoperatively. Surgically induced astigmatism was calculated by vector analysis using the Holladay-Cravy-Koch formula. The 2 groups were compared using a paired Wilcoxon test. RESULTS: The mean surgically induced corneal astigmatism in the temporal incision group was 0.62 diopters (D) +/- 0.48 (SD) 2 weeks postoperatively and 0.47 +/- 0.32 D at 6 months and in the nasal incision group, 1.55 +/- 0.84 D and 1.05 +/- 0.57 D, respectively. The difference between the groups was statistically significant (P <.05). CONCLUSIONS: There was a highly statistically significant difference in surgically induced corneal astigmatism after temporal and nasal unsutured limbal tunnel incisions. The degree of induced astigmatism and the difference between the temporal and the nasal incisions decreased over time. A nasal tunnel incision is not appropriate for astigmatism-neutral surgery.     

The effect of topical parasympathomimetics on corneal epithelial healing in rabbits

Corneal wound healing is an important process that involves interaction between the different corneal cell layers, growth factors, and environmental conditions. More powerful therapies for the treatment of delayed epithelial wound healing are still being proposed. The objective of this study is to investigate the effects of the direct-acting parasympathomimetic agents on the healing process of corneal epithelium in rabbits. The corneal epithelial defects, 10 mm in diameter, were created in 32 eyes of 16 island rabbits by combination of chemical debridement using n-heptanol and mechanical scraping. Animals were randomly divided into four groups. Groups 1, 2 and 3 were treatment groups; each group consisted of four rabbits (8 eyes). The animals in these groups were treated with topical 1% acetylcholine (ACh), 2% pilocarpine, and 0.75% carbachol drops respectively. In group 4, four rabbits (8 eyes) were used as control group and left for spontaneous healing. The length and area of the defect were measured at days 3,6,9,12,15,18 and 22 after wounding. Areas of the photographically documented fluorescein-stained defects were measured by planimetry. All eyes in the treatment groups reepithelialized completely. The duration for reepithelialization in Groups 1 and 2 was 12 days, and 18 days for Group 3. In the control group reepithelialization occurred within 22 days. The healing rates of corneal epithelium were statistically significantly faster in all treatment groups as compared with the control group at all times (p=0.0001 to 0.0279). Although the rates of wound healing varied, all of the parasympathomimetics used in the present study were found to facilitate wound healing. Our results indicate that direct-acting cholinergic agents, especially ACh and pilocarpine, may have an important therapeutic role in the treatment of severe corneal epithelial injury.     

Ultrastructural changes of the rabbit corneal epithelium and endothelium after Timoptic treatment

The purpose of this study was to determine whether timolol maleate (Timoptic) is cytotoxic to the cornea. The drug was applied as topical drops for 1 month to control rabbit eyes and rabbit eyes from which the epithelium had been removed or to de-epithelialized full-thickness autografts. Clinically all corneas and grafts remained clear. Scanning and transmission electronmicroscopy however revealed is drug induced epithelial damage, defective epithelial wound healing, and endothelial changes. The endothelial changes were most prominent in the group of rabbits that underwent de-epithelialization before corneal grafting.     

结膜下角膜缘潜行小切口手法白内障手术

目的探讨结膜下角膜缘潜行小切口手法白内障摘出人工晶状体植入术的效果和并发症。方法于9～12点位问角膜缘的角膜与结膜结合处后方0．5mm,以45。角斜向切开结膜角膜组织,达1／2角膜厚度,切口宽5．5～6．01mm／1。向前在透明角膜内制作隧道,长约2．0／11／11。穿刺进入前房。常规连续环形撕囊或截囊,然后借助注水圈匙手法娩核,囊袋内植人人工晶状体。观察1210例1293眼。术前术后测视力及角膜曲率,并做裂隙灯显微镜检查及A／B超检查。随访4～6周。结果视力：手术前：光感～0．15,手术后：0．05～1．0。角膜曲率：手术前：Kl=（43．99±1．83）D,K2=（43．83±2．06）D,手术后2周：K,=（45．08±2．30）D,K,=（4J4．07±2．86）D（“检验：P〉0．5）。意外撞伤致切口裂开并虹膜脱出6例6眼,占0．46％。角膜水肿及前房渗出均较轻微,无前房积血、人工晶状体移位或感染等并发症。手术时间一般为5～8min。结论结膜下角膜缘潜行小切口手法白内障摘出人工晶状体植入术操作简单,易于掌握,且手术时间短伤口愈合快,并发症少。     

Limbal relaxing incisions to correct astigmatism in clear corneal cataract surgery.

PURPOSE: To prevent surgically induced astigmatism following clear corneal cataract surgery. METHODS: Limbal relaxing incisions of 6- or 8-mm length and 0.55-microm depth were performed in 52 patients (52 eyes) with a spherical cornea (20 eyes) or mean with-the-rule astigmatism (32 eyes) of 0.80 +/- 0.30 D after temporal corneal cataract incision. A control group (47 eyes; 19 spherical and 28 with-the-rule astigmatism) underwent the same surgical procedure without limbal relaxing incisions. RESULTS: Six months after surgery, mean with-the-wound change using the Holladay analysis was -0.08 +/- 0.50 D in spherical eyes with limbal relaxing incisions and +0.50 +/- 0.70 D in control eyes. Patients with preoperative with-the-rule astigmatism showed a mean with-the-wound change of -0.09 +/- 0.50 D after limbal relaxing incisions; in corresponding control eyes, mean change was +0.39 +/- 0.70 D. CONCLUSION: Limbal relaxing incisions are a reliable and safe procedure to reduce postoperative astigmatism.     

软性角膜接触镜对复发性翼状胬肉术后患者舒适度的影响

目的：评价软性角膜接触镜对复发性翼状胬肉术后患者舒适度的作用。

方法：复发性翼状胬肉切除术后患者98例100眼,采用上部自体带角膜缘干细胞的结膜植片,转位并覆盖手术区巩膜表面,50眼术后角膜加用角膜绷带镜5d(试验组A组),另外50眼常规包盖(对照组B组),观察术后角膜创面愈合时间以及各种症状和体征的情况。

结果：胬肉术后1d,A组角膜刺激症状和体征与B组相比,差异有统计学意义(P<0.05); 术后1d,两组患者角膜上皮愈合情况,差异有统计学意义(P<0.05),A组角膜上皮愈合更快。

结论：角膜接触镜可明显改善患者翼状胬肉术后早期的角膜刺激症状,促进角膜创面愈合,减轻患者术后的不适感。