Study on effect of Baoyuan Qiangshen Tablet No. I in prolongating interval of hemodialysis in patients of renal disease in terminal stagein prolongating interval of hemodialysis in patients of renal disease in terminal stage

Objective: To evaluate the effect of Baoyuan Qiangshen Tablet No. I (BYQS), a Chinese herbal medicine for reinforcing Kidney, activating circulation and eliminating evil Turbid factors, in prolongating interval of hemodialysis in patients of terminal stage of renal disease (TSRD).Methods: Twenty cases of TSRD were treated with BYQS combined with hemodialysis once every 5 days and the effect was observed and compared with control group treated with routine hemodialysis once every 3 days.Results: The increasing levels of serum creatinine, and blood urea nitrogen of BYQS group at dialysis interval were all lower than those of the control group (P < 0.01). After 3 months’ treatment, serum creatinine, blood urea nitrogen of BYQS group were lower than those before treatment, plasma albumin, lipoprotein, urine level of prostaglandin and anemia were all improved to various extent, but the creatinine clearance rate was unchanged. Conclusions: BYQS could prolong the interval and reduce the times of dialysis by way of regulating the lipid metabolic disorder, improving pathological change of kidney and protecting function of residual kidney unit. BYQS combined with hemodialysis is a good way of integrated traditional Chinese and Western medicine in treating TSRD.     

Study on Effect of Baoyuan Qiangshen (保元强肾) Capsule No. Ⅱ on Tubular Interstitial Injury in Chronic Renal Failure Patients

Ｃｈｒｏｎｉｃｒｅｎａｌｆａｉｌｕｒｅ（ＣＲＦ）ｉｓａｐｒｏｇｒｅｓ ｓｉｖｅｄｉｓｅａｓｅ．Ｏｗｉｎｇｔｏｔｈｅｆａｃｔｔｈａｔｉｔｓｐａｔｈｏ ｇｅｎｅｓｉｓｈａｓｎｏｔｂｅｅｎｅｌｕｃｉｄａｔｅｄｃｏｍｐｌｅｔｅｌｙ,ａｎｄｔｈｅｅｆｆｅｃｔｏｆｖａｒｉｏｕｓｔｈｅｒａｐｅｕｔｉｃａｌｍｅｔｈｏｄｓｉｓｎｏｔｓａｔｉｓｆａｃｔｏｒｙ,ｒｅｃｅｎｔｌｙｓｏｍｅａｕｔｈｏｒｓｈｅｌｄｔｈａｔｔｈｅｔｕｂｕｌａｒｉｎｔｅｒｓｔｉｔｉａｌｉｎｊｕｒｙｐｌａｙｓａｎｉｍ ｐｏｒｔａｎｔｒｏｌｅｉｎｔｈ…     

Clinical observation on 30 cases of chronic renal failure treated with Shentekang Capsule and peritoneal dialysisand peritoneal dialysis

Objective: To evaluate the effect of Shentekang Capsule (STKC) combined with peritoneal dialysis (PD) in treating chronic renal failure (CRF).Methods: With single-blind, parallel control and random method, 60 cases of CRF patients were equally divided into 2 groups: (1) STKC group treated with combined therapy of STKC and PD; (2) control group treated with PD alone. The course of treatment were 1~2 months for both groups. Clinical manifestations, blood urea nitrogen, serum creatinine, total protein and hemoglobin were observed before and after the treatment. Results: Blood urea nitrogen decreased in both groups after treatment as compared with that before treatment significantly (P < 0.05), but no obvious difference was found between blood urea nitrogen levels of the two groups (P > 0. 05). However, levels of serum total protein and hemoglobin of the STKC group after treatment were higher than those of the control group (P < 0.01). Clinical manifestation in STKC group also showed more improvement after treatment than that in the control group. Conclusion: STKC could improve nutritional state and quality of CRF patient’s life treated with PD.     

Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats.Methods: Twenty healthy SD rats of both sex were randomly divided into two groups, Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate, and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B, the levels of blood urea nitrogen, serum creatinine, renal phospholipase A₂ (PLA₂) and calcium were all significantly lower than those in Group A,P < 0.01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI.Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation, inhibiting PLA₂ activity and dilating renal vessels.     

Clinical studies on Liangxue Piyan Granule No. 2 2 in treatment of psoriasisin treatment of psoriasis

Objective: To evaluate the therapeutic mechanism of Liangxue Piyan Granule No. 2 (LPG, 2 ) on psoriasis.Methods: Ninety six patients with psoriasis were treated with LPG, another 32 patients treated with Fufang Qingdai Capsule (FQC, ) were taken as control; clinical comparison was done with experimental studies.Results: The total effective rate of LPG group was 84.7 %, that of the control 71.9%, there was no significant difference (P<0.05). However, the recurrence rate of LPG group (3.6%) was significantly lower than that of the control (21.7%),P<0.01. Conclusions: LPG could modulate the immune function of the body, by inhibiting directly the proliferation of epidermal cells and the production of interleukin-6.     

Comparative study of Tiaoxue Yisui recipe with SSL regimen in treating infantile chronic aplastic anemia) with SSL regimen in treating infantile chronic aplastic anemia

Objective: To find the effective method in treating infantile chronic aplastic anemia (ICAA) by using traditional Chinese medicine (TCM).Methods: Seventy-eight cases of ICAA were observed, 48 in the treated group were treated with Tiaoxue Yisui recipe, and 30 cases in the control group with SSL regimen.Results: The remission rate and total effective rate in the treated group were 52.08% and 81.25% respectively, which were higher than those in the control group (P < 0.05). After one year’s treatment the ratio of hemopoietic and non-hemopoietic cells in the treated group was higher than that in the control group (P < 0.05).Conclusion: Tiaoxue Yisui recipe could improve the living quality of ICAA patients. The therapeutical mechanism of the recipe might be related to its promoting the proliferation of hemopoietic stem cells and regulating the immune function.     

Study on treatment of uloerative colitis with Liver-Qi stagnation by nourishing the Liver

Objective: To study the links between stagnation of the Liver-Qi and the pathogenesis of ulcerative colitis (UC) were studied clinically and experimentally.Methods: Using the principle of nourishing the Liver in the treated group and invigorating the Spleen in the control group.Results: The effective rate was 96% in the treated group and 82% in the control group, and the difference was significant (P<0.05); the formation rate of E rosettes and the transformation rate of lymphocytes were significantly raised in the two groups compared with the pre-treatment period, and the rate of adjusting dysfunction of vegetative nerve system in the treated group was evidently higher than that in the control group (P < 0.01). The level of intestinal styrenated phenol (SP) and vasoactive intestinal polypeptide (VIP) of UC model were determined in rats, and results showed that the level of SP and VIP significantly increased in the UC model group. They were markedly lowered in the treated group compared with model group (P < 0. 01) and there was significant difference from the control group (P<0.01).Conclusion: Wei Chang Ning , a drug to nourish the Liver, had the action of regulating neurological-endocrinological (gastrointestinal hormone)-immunological system.     

Studies on Nutritional Effects of Traditional Chinese Tonics with Nutrients Fortification on Pregnantrats

Ｓｔｕｄｉｅｓ　ｏｎ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｅｆｆｅｃｔｓ　ｏｆ　Ｔｒａｄｉｔｉｏｎａｌ　Ｃｈｉｎｅｓｅ　Ｔｏｎｉｃｓ　ｗｉｔｈ　Ｎｕｔｒｉｅｎｔｓ　Ｆｏｒｔｉｆｉｃａｔｉｏｎ　ｏｎ　Ｐｒｅｇｎａｎｔ　Ｗｏｍｅｎ　ａｎｄ　Ｐｒｅｇｎａｎｔ　Ｒａｔｓ...     

Clinical Study of Weishu capsule () in treating precancerous lesions of chronic atrophic gastritis) in treating precancerous lesions of chronic atrophic gastritis

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC), in treating precancerous lesions of chronic atrophic gastritis (CAG).Methods: Seventy-five cases of precancerous lesions of CAG were distributed to two groups randomly, the WSC group (45 patients) treated with WSC taken orally and the Weining granule (WNG) group (30 patients) treated with Weining granule orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy, intestinal metaplasia (IM) and its subgroups, dysplasia, carcinoembryonic antigen and proliferating cell nuclear antigen expression were observed before and after treatment.Results: The total effective rate was 91% and the effective rate of atrophy, IM, dysplasia in the WSC group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the WNG group, the difference between the two groups was statistically significant (P < 0.01,P < 0.05). Immunohistochemical test showed that WSC could inhibit the subgroups of IM, circinoembryonic antigen and proliferating cell nuclear antigen expression significantly (P < 0.01).Conclusions: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of IM cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.     

Effect of Zhuchun Pill on immunity and endocrine function of senile Kidney-Yang Deficiency) on immunity and endocrine function of senile Kidney-Yang Deficiency

Objective: To evaluate the effect of Zhuchun pill (ZCP) on senile Kidney-Yang Deficiency (KYD).Methods: By single blind method, 45 elderly males with KYD were divided randomly into the ZCP group (treated by ZCP) and the control group (treated by placebo, starch capsule) and treated for 3 months.Results: ZCP could greatly improve the main symptoms of KYD,P < 0. 01 in comparison with the control group. After treatment, in the ZCP group, the³H-TdR lymphocyte transformation rate, levels of serum C₃, IgA, IgD, IgG and IgM, superoxide dismutase, plasma adrenocortical hormone, testosterone and cyclic adenosine monophosphate all increased,P < 0.01, and plasma lipid peroxide decreased,P < 0.01. While in the control group, no remarkable change was found in these parameters.Conclusion: ZCP could improve the KYD through regulating the immunity, endocrine function and scavenging the free radicals in organism.     

Clinical and experimental study on treatment of infantile autumn diarrhea by retention enema with Qilian Liquid ()

Objective: To find out the effective treatment for infantile autumn diarrhea (IAD).Methods: Retention enema with Qilian Liquid(QLL) was applied to 106 patients of IAD with positive antigen of rotavirus in stool, and the result in the treated group was compared with that in the control group(82 patients) in aspects of clinical effect, negative conversion rate of rotavirus in stool and change of serum immunoglobulin. Animal experimental study was also conducted.Results: The disappearance time of principal symptoms, negative conversion rate of rotavirus in stool and serum levels of IgA and IgG in the treated group were significantly better than those in the control group (P<0.01,P< 0.05). Experimental study showed that QLL not only has the antiviral effects to stop diarrhea, but also has effects in enhancing immune function and protecting intestinal mucous membrane.Conclusion:Retention enema with QLL is an effective therapy for the treatment of IAD.     

Clinical observation on effect of Yishen Jiedu Recipe in retarding the course of chronic renal failurein retarding the course of chronic renal failure

Objective

To observe the effect of Yishen Jiedu Recipe (YSJDR) in retarding the course of chronic renal failure (CRF)

Methods

Forty-five patients were divided into two groups, the 22 patients in Group A were treated with low-protein diet and blood pressure controlling therapy only, while the 23 patients in Group B were treated with additional YSJDR. The time (month) for doubling serum creatinine (SCr) level was taken to evaluate the speed of CRF progression

Results

In Group A, the time for SCr increased from 288.4±96.7 μmol/L to 586.3±251.3 μmol/L was 16.7±5.1 months, while in Group B the time for SCr increased from 291.2±101.2 μmol/L to 589.6±257.5 μmol/L was 28.2±8.7 months. Comparison between the two groups showed significant difference (P<0.05 )

Conclusion

On the basis of low-protein diet and blood pressure controlling therapy, the additional treatment of YSJDR could markedly retard the progression speed of CRF     

Experimental study on effect of renal failure granule in treating uremia

Objective: To observe the efficacy of Renal Failure Granule (RFG) in treating uremia and explore its mechanism. Methods: Platt's method was used to establish the chronic renal failure model. Forty-eight rats were divided into normal group, model group, Jiangzhuo recipe (降浊方) group, Fuzheng recipe (扶正方) group, RFG group and aldehyde-oxygen encapsulated starch group, 8 rats in each group, to observe the effects of RFG on serum creatinine (SCr), blood urea nitrogen (BUN), plasma calcium (Ca), plasma phosphorus (P), parathyroid hormone (PTH), middle molecular substance (MMS), methylguanidine (MG), guanidinosuccinic acid (GSA) and other parameters. Results: Comparison of SCr and BUN changes after medication for 30 and 60 days, the RFG group, the Fuzheng recipe group and the Jiangzhuo recipe group, with the aldehyde-oxygen encapsulated starch group or model group, demonstrated that the difference was significant (P<0.05, P<0.01), For PTH, Ca, P, MMS, MG and GSA, RFG was clearly different with the model group (P<0.05, P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters. Conclusions: RFG can retard the development of uremia, and its mechanism may be related to the decrease of uremic toxin.     

Effect of Sanhuang Jiangtang recipe on insulin peripheral resistance in Type II diabetes mellitus) recipe on insulin peripheral resistance in Type II diabetes mellitus

Objective: To observe the effect of Sanhuang Jiangtang recipe ( , SHJT) on insulin peripheral resistance in Type II diabetes mellitus (DM).Methods: Ninety-five patients with type II DM were randomly divided into two groups. Fifty-three cases of SHJT group were given decoction and tablets of SHJT orally for 4–6 months. The efficacy was compared with that of 42 cases treated with Glipizide as the control. Before and after treatment standard steamed bread meal test was performed to measure the insulin peripheral sensitivity, insulin release to glucose and insulin sensitivity index.Results: (1) The total effective rates of improving insulin peripheral resistance and reducing blood sugar in SHJT group were 79. 2% and 80.1 %, which was equivalent to levels in the control group, but SHJT recipe was more effective in relieving symptoms of Qi deficiency and signs of blood stasis. (2) In SHJT group, the insulin peripheral sensitivity and insulin sensitivity index were significantly increased (P < 0.05 and 0.01), meanwhile the fasting blood sugar and blood sugar area were reduced (P < 0.05), but the change of insulin release to glucose was blunted. (3)The lowering of blood sugar in SHJT group was significantly negative correlated with the changing of degree of insulin peripheral sensitivity and index of insulin sensitivity (P < 0.01 and 0.05), but not with that of insulin area.Conclusion: It suggested that the treatment of SHJT recipe might decrease insulin peripheral resistance (partial reversal) by means of reducing hyperinsulinemia and improving insulin sensitivity.     

Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C

HepatitisCvirus(HCV)hasbeenshowntobeanetiologicagentresponsibleforchronicliverdisease,witheventualprogressiontocirrhosisin20%ofpatients.Althoughinterferon(IFN)hasbeenusedasaneffectivetherapyforchronicHCVinfectionsofar,itseffectismuchlowerthanexpected.Furthermoreitisexpensive(').ItisnecessarytofindothermedicinewhichwillbeeffectiveoneliminatingHCV--RNAwithfairprice.Inrecentyears,evidencehasbeenaccumulatingontheantiviraleffectofmatrineextract.Matrinealkaloidhadeffectonanti-coxsackievirus(a…     

Experimental Study on Effect of Cordyceps Sinensis on Renal Protection,Urinary Enzymes and Nephrotox icity of Cyclosporine A in Rats

Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｓｔｕｄｙ　ｏｎ　Ｅｆｆｅｃｔ　ｏｆ　Ｃｏｒｄｙｃｅｐｓ　Ｓｉｎｅｎｓｉｓ　ｏｎ　Ｒｅｎａｌ　Ｐｒｏｔｅｃｔｉｏｎ,Ｕｒｉｎａｒｙ　Ｅｎｚｙｍｅｓ　ａｎｄ　Ｎｅｐｈｒｏｔｏｘｉｃｉｔｙ　Ｏｆ　Ｃｙｃｌｏｓｐｏｒｉｎｅ　Ａ　ｉ...     

Clinical observation on effect of ruangan granule in treating chronic hepatitic liver fibrosis

Objective

To observe the clinical effect of Ruangan granule (RGG) in treating liver fibrosis.Methods: One hundred and twenty patients of chronic viral hepatitis B were randomly divided into two groups, 60 patients in the treated group and 60 patients in the control group. They were treated with RGG or composite Biejia Ruangan tablet ( ) respectively for three months. The changes of liver function, liver fibrosis indices, including fibronectin (FN), laminin (LN) and hyaluronic acid (HA), as well as liver morphology by B-ultrasonic examination were observed after treatment A three-month follow-up study was also conducted.

Results

In the treated group, the markedly effective rate was 50.0% and effective rate was 41.7%, while in the control group, the corresponding rates were 26.7% and 55.0% respectively. Comparison of the markedly effective rate between the two groups showed significant difference (P<0.01). The serum levels of FN, LN, HA as well as splenomegaly and portal vein widening in the treated group after treatment were significantly improved (P<0.05), as compared with those in the control group after treatment; significant difference was shown in comparison of serum FN, LN and HA.

Conclusion

RGG could improve effectively serum liver fibrosis indices and liver function in patients of chronic hepatitic fibrosis. It is helpful in alleviating and inhibiting the genesis and development of liver fibrosis so as to block the progression of liver cirrhosis.     

Effect of Yunqi decoction on esophageal mucosal morphology and esophageal motility in reflux esophagitis patients) on esophageal mucosal morphology and esophageal motility in reflux esophagitis patients

Objective: To observe the effects of Yunqi decoction ( , YQD) on both esophageal mucosal morphology and esophageal motility in patients with reflux esophagitis (RE).Methods: According to syndrome differentiation of traditional Chinese medicine (TCM), 42 RE patients were divided into three groups: disharmony of Liver and Stomach (group D), Deficiency-Cold of Spleen and Stomach (Group DC), Heat Syndrome caused by stagnation of Liver Qi (Group H). No. I, II, III of YQD were taken respectively for 4 weeks. Before and after treatment scores of typical symptoms were collected, gastroscopy was performed and esophageal motility were measured.Results: (1) The symptom remission rate was 81.1%, there were significant differences between the group DC with group D and group H(P < 0.01). (2) The esophageal mucosal healing rate was 61.9%, the effective rate was 90.5%, and the ineffective rate was 9.5%. There were not significant differences of effective rate among the three groups (P>0.05). (3) The changes of esophageal motility: Lower esophageal sphincter pressure (LESP) and average peristaltic pressure (APP) of group D were obviously higher than before treatment (P < 0.05), LESP, gastro-esophageal barrier pressure (GEBP) and peristaltic conduct speed (PCS) of group DC were remarkably higher (P < 0.05). GEBP of group H was improved (P < 0.05). Conclusions: YQD has a good therapeutic effect. It’s not only resolving reflux esophageal symptoms, healing esophageal mucosa, but also improving esophageal motile function.     

Clinical and experimental study on treatment of chronic hepatitis B with Yanggan Aoping Mixture

Objective: To assess the efficacy of Yanggan Aoping Mixture ( , YGAPM) in treating hepatitis B.Methods: Patients suffered from chronic hepatitis B were treated with YGAPM. Observe their short- and long-term efficacy and the change of serum hepatitis B virus marker. In experiment, the effects of YGAPM in treating rat’s liver injury as well as HBV-infected tree shrew and duck HBV-infected ducks were observed.Results: In 79 cases of chronic persistent hepatitis, the markedly effective rate was 60.76%, and further raised to 70.00% in follow-up study in 40 cases. In 73 cases of chronic active hepatitis, the markedly effective rate was 60.27%, and further raised to 62.50% in 32 follow-up cases. In the treatment group, 85 of the 119 cases (71.43%) with HBeAg-positive were converted to negative. Whereas in the control group, only 40 of 89 HBeAg-positive cases (44. 94%) were converted to negative,P < 0. 01. Results of experimental study showed that negative conversion rate of tree shrew infected with HBV marker was raised, while the duck HBV DNA in infected duck blood was inhibited. Those compared with the control group separately, the difference was markedly significant.Conclusion: YGAPM is an effective drug in treating chronic hepatitis B, and it could effectively convert the marker to negative.     

Clinical and experimental study on treatment of mid-late stage rheumatoid arthritis with Shuguan Granules ())

Objective: To explore the therapeutic mechanism of Shuguan Granule ( , SGG) in treating mid-late stage rheumatoid arthritis (RA).Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid-late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted.Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant-induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin-1, plasma prostaglandin E₂ and thromboxane B₂, as compared with the model group, the difference was significant (P < 0.05,P < 0.01).Conclusion: The two SGG have a comprehensive function of anti-inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.