共查询到6条相似文献,搜索用时 15 毫秒
1.
Anu Haveri Nina Ekström Anna Solastie Camilla Virta Pamela Österlund Elina Isosaari Hanna Nohynek Arto A Palmu Merit Melin 《European journal of immunology》2021,51(12):3202-3213
Most subjects develop antibodies to SARS-CoV-2 following infection. In order to estimate the duration of immunity induced by SARS-CoV-2 it is important to understand for how long antibodies persist after infection in humans. Here, we assessed the persistence of serum antibodies following WT SARS-CoV-2 infection at 8 and 13 months after diagnosis in 367 individuals. The SARS-CoV-2 spike IgG (S-IgG) and nucleoprotein IgG (N-IgG) concentrations and the proportion of subjects with neutralizing antibodies (NAb) were assessed. Moreover, the NAb titers among a smaller subset of participants (n = 78) against a WT virus (B) and variants of concern (VOCs): Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) were determined. We found that NAb against the WT virus persisted in 89% and S-IgG in 97% of subjects for at least 13 months after infection. Only 36% had N-IgG by 13 months. The mean S-IgG concentrations declined from 8 to 13 months by less than one third; N-IgG concentrations declined by two-thirds. Subjects with severe infection had markedly higher IgG and NAb levels and are expected to remain seropositive for longer. Significantly lower NAb titers against the variants compared to the WT virus, especially after a mild disease, suggests reduced protection against VOCs. 相似文献
2.
3.
4.
5.
Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors Helena Winstone Suzanne Pickering Rui Pedro Galao Liane Dupont Maria Jose Lista Jose M. Jimenez-Guardeño Adam G. Laing Yin Wu Magdalene Joseph Luke Muir Marit J. van Gils Weng M. Ng Katie J. Doores 《Immunity》2021,54(6):1276-1289.e6