穿琥宁注射液雾化吸入治疗小儿上呼吸道感染疗效观察

目的 比较穿琥宁与病毒唑对小儿急性上呼吸道感染（A唧）的疗效。方法 将110例AURI的患儿随机分为治疗组（穿琥宁组60例）和对照组（病毒唑组50例）。两组均在给予对症治疗同时，治疗组用穿琥宁4～8mg／（kg．d），分2次与a-4000u，地塞米松2mg溶于0．9％生理盐水20ml中雾化吸入，对照组用病毒唑10—15mg／（kg．d）替换穿琥宁雾化吸入，3—5天为1个疗程。结果 治疗组总有效率为96．67％，对照组为84％，两组比较，差异有显著性，（P〈0．05）。结论 穿琥宁注射液治疗小儿急性上呼吸道感染，可显著缩短病程及缓解症状，防止并发症的发生，且疗效确切，优于病毒唑注射液。     

喜炎平注射液治疗小儿急性上呼吸道感染100例

目的比较喜炎平与病毒唑对小儿急性上呼吸道感染（AURI）的疗效。方法将200例急性上呼吸道感染患儿随机分为治疗组（喜炎平组100例）和对照组（病毒唑组100例）。治疗组给予喜炎平注射液0.1~0.2 mL/（kg.d）,加用10%葡萄糖注射液稀释后静脉滴注,每天1次,3 d~5 d为1疗程。对照组给予病毒唑注射液10 mg/（kg.d）,每天1次,3 d~5 d为1疗程。结果 2组患儿治疗总有效率比较及临床症状改善情况比较,差异有显著性,治疗组优于对照组。结论喜炎平注射液治疗小儿急性上呼吸道感染可显著缩短病程及缓解症状,防止并发症的发生,且疗效确切,优于病毒唑注射液。     

速尿与病毒唑雾化吸入治疗小儿喘息性疾病疗效观察

目的：观察速尿、病毒唑（利巴韦林）混合液超声雾化吸入治疗小儿喘息性疾病的疗效。方法：将58例住院患儿随机分为对照组和治疗组各29例,在综合治疗的基础上,治疗组加用速尿1mg／kg～2mg／kg,病毒唑5mg／kg～10mg／kg,每日2次,超声雾化吸入。结果：治疗组显效8例（27．6％）,有效19例（65．5％）,总有效率93．1％。对照组显效1例（3．4％）,有效18例（62．1％）,总有效率65．5％。两组总有效率相比,差异有统计学意义。结论：速尿、病毒唑超声雾化吸入可提高小儿喘息性疾病的治疗效果,缩短病程,且安全、无副作用。     

热必清颗粒治疗小儿上呼吸道感染发热84例

目的观察中药热必清颗粒对小儿急性病毒性上呼吸道感染发热的临床疗效。方法采治疗组84例用中药热必清颗粒口服。对照组80例采用口服病毒唑和尼美舒利，均3d为1疗程。结果治疗组总有效率94．05％，对照组总有效率52．5％，治疗组疗效优于对照组，疗效有显著性差异（P〈0．05），两组完全退热时间也有显著性差异（P〈0．05）。结论中药热必清颗粒对小儿上呼吸道感染引起的发烧、扁桃体肿大等症状改善疗效显著。     

银黄颗粒辅助治疗小儿急性上呼吸道感染的临床疗效观察

目的观察银黄颗粒辅助治疗小儿急性上呼吸道感染的临床疗效。方法将98例急性上呼吸道感染患儿随机分为观察组和对照组,对照组在常规治疗基础上加用利巴韦林10mg／kg,1次／d;观察组在对照蛆基础上加用银黄颗粒4g,2次／d;治疗结束后进行疗效评定。结果观察组临床总有效率为93．87％,显著优于对照组的75．51％（P〈0．05）。结论银黄颗粒辅助治疗小儿急性上呼吸道感染的临床疗效显著,值得推广。     

西药配合推拿治疗小儿支气管肺炎70例

目的观察西药配合推拿治疗小儿支气管肺炎的疗效。方放将70例支气管肺炎患儿随机分为治疗组35例，对照组35例。对照组给予抗感染、对症、支持等常规西医治疗，治疗组在对照组基础上用小儿推拿法，1次／d，连用7d。结果治疗组总显效率94．3％；对照组总显效率88．6％，经统计学处理，差异有显著性意义（P〈0．05）。结论西药配合推拿治疗小儿支气管肺炎疗效明显，值得推广。     

泰胃美治疗流行性腮腺炎50例疗效观察

目的：研究泰胃美对流行性腮腺炎的疗效。方法：治疗组50例，泰胄美剂量20mg／kg·d，静滴，用4～8d。对照组50例，用相同剂量病毒唑静滴，用4～8d。结果：治疗组治疗后退热时间为1．5±0.98d，对照组为4．36±1．57d。治疗组治疗后腿肿消退时间为2．06±1．39d，对照组3.72±2．01d，治疗组72h治疗后显效48例（显效率为96．0％）．对照组显效38例（显效率为76.0％）。用卡方检验，X2＝4，P＜0．05。结论：作者意见．治疗流行性腮腺炎．泰胃美疗效明显优于病毒唑。     

中西医结合治疗小儿急性肠系膜淋巴结炎疗效观察

目的观察中西医结合治疗小儿急性肠系膜淋巴结炎的疗效。方法将60例急性肠系膜淋巴结炎患儿随机分为两组,对照组30例予头孢哌酮舒巴坦钠100mg／（kg·d）,分两次静滴。治疗组30例在对照组基础上加肠炎宁糖浆〈3岁2．5mL/次,3-5岁5mL／次,6-9岁8mL／次,每日3次口服。结果总有效率治疗组93．33％,对照组63．33％,两组比较差异有显著性（χ2=7．95,P〈0．01）。结论中西医结合治疗小儿急性肠系膜淋巴结炎疗效明显,值得临床推广。     

清开灵治疗小儿上呼吸道感染退热疗效观察

目的探讨清开灵治疗小儿上呼吸道感染的退热疗效。方法将80例患儿随机分为2组,对照组给予病毒唑静滴治疗;治疗组在病毒唑基础上加用清开灵靜滴治疗,对2组患儿疗效进行比较。结果 2组患儿总有效率比较有显著性差异（P〈0.01）,治疗组明显优于对照组。结论清开灵治疗小儿上呼吸道感染退热疗效确切,效果好。     

小儿反复上呼吸道感染诱发相关因素分析

目的探讨分析导致小儿反复上呼吸道感染（RURTI）的诱发因素。方法将反复上呼吸道感染患儿128例设为观察组，同期就诊的单纯呼吸道感染患儿128例设为对照组，采集两组患儿静脉血，测定血清中EB病毒、肺炎支原体以及骨源性碱性磷酸酶（BALP）的含量。结果观察组中33例（25．8％）、对照组中13例（10．2％）患儿血清EB病毒检测结果阳性；观察组中42例（32．8％）、对照组中16例（12．5％）患儿血清肺炎支原体检测结果阳性；观察组中39例（30．5％）、对照组中8例（6．3％）患儿血清BALP检测结果阳性，观察组各项指标均高于对照组（P〈0．01）。结论EB病毒、肺炎支原体感染以及维生素D缺乏是诱发小儿反复上呼吸道感染的重要因素，在治疗上应予以充分重视。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.