Cutaneous leishmaniasis: Clinical report of two cases and review of the recent literature

With 1–1.5 million cases reported every year cutaneous leishmaniasis represents an increasing health problem. The course of cutaneous leishmaniasis varies from a single self‐healing ulcer to a persistent ulcer or progressive mucosal disease with nasopharyngeal destruction. An enormous array of topical and systemic treatment modalities has been endorsed. The response to treatment depends on the species of parasite as well as the host's immunological and genetic status. Species‐specific treatment guidelines based on evidence from controlled studies are highly desirable. We present two cases of cutaneous leishmaniasis, one in a child and one during pregnancy, reviewing various diagnostic and therapeutic measures with special attention to problems in young and pregnant patients.     

无水疱性类天疱疮二例并文献复习

报道2例无水疱性类天疱疮并复习以往相关文献。例1，男，72岁，因全身皮肤红斑、丘疹伴瘙痒20天就诊，查体未见水疱。实验室检查血嗜酸性粒细胞升高，直接免疫荧光示基底膜带线状C3沉积，间接免疫荧光示抗基底膜带抗体阳性，抗BP230抗体、抗BP180抗体阳性。例2，女，79岁。因全身皮肤散在分布丘疹伴严重瘙痒20天就诊，查体见躯干四肢皮肤抓痕明显，未见水疱。血清中抗BP180抗体阳性。2例均诊断：无水疱性类天疱疮。予以小剂量糖皮质激素治疗后，控制病情，目前在随访中。     

带状疱疹后假性腹壁疝二例并文献复习

带状疱疹后假性腹壁疝是带状疱疹发生的一种罕见的与腹壁疝相似的神经系统并发症,所引起的腹壁隆起性肿物实际上是病毒引起节段性腹肌瘫痪或无力的结果,大多数可完全恢复,预后良好。本文报道2例带状疱疹后假性腹壁疝并对10年国内外文献报道病例进行分析。共分析27例患者,平均年龄68.2岁,63.0%为男性,常受累的神经是T11（31.4%）。25例腹壁假疝发生在皮肤症状之后,平均时间为23天。行肌电图检查3例,异常2例; 影像学检查15例,其中异常5例。27例中,14例(51.9%)腹壁假疝完全自然康复,平均时间为3.4个月(范围1~8个月);3例(11.1%)部分恢复,平均随访时间2.3个月。7例患者恢复时间不详,1例失访。     

毛囊黏蛋白病二例并文献复习

报道2例毛囊黏蛋白病并进行文献复习.患者1,男,44岁,颈项部局限性浸润性红斑伴疼痛2个月,组织病理示:真皮毛囊水肿,毛囊内外淋巴组织细胞浸润,个别嗜酸粒细胞.阿新蓝染色:毛囊黏蛋白阳性.患者2,男,32岁,左面部浸润性暗红斑45天,组织病理示:表皮大致正常,毛囊上皮水肿,淡蓝色黏液样物质沉积,毛囊内及毛囊周围较多嗜酸...     

Cutaneous metastatic cholangiocarcinoma: a report of three cases and review of the literature

Cutaneous metastasis from cholangiocarcinoma is an extremely rare event. Herein, we present three cases with review of the literature. Case 1 is that of a young female with scalp metastasis. Cases 2 and 3 involve cutaneous metastasis to the sites of prior biliary drains, one occurring in a young female with a history of multiple biliary surgeries and one in a male with a history of sclerosing cholangitis. Review of the literature shows that the presentation of cutaneous metastases from cholangiocarcinoma can vary in terms of anatomic location and clinical features. The pathological and immunohistochemical profile of metastatic cholangiocarcinoma can be non-specific, and accurate diagnosis relies in part on clinical correlation. In summary, metastatic disease should always be included in the differential diagnosis of cutaneous lesions in patients with known malignancy.     

播散性带状疱疹二例报道并文献复习

带状疱疹（HZ）皮损通常限于单个皮区,而涉及两个或更多个皮区的非邻近HZ比较少见,我们报道2例播散性HZ患者并回顾相关文献。病例1,男,77岁。右臀部簇集性丘疹、水疱伴疼痛6天,全身皮疹2天,治疗上给予抗病毒、营养神经和对症治疗,病情得到控制,未见新发皮疹,仍有神经疼痛。病例2,女,32岁。左侧胸背部簇集性丘疹、水疱伴疼痛4天,全身皮疹伴痒1天,因患者处于哺乳期,未使用抗病毒药物,局部涂抹炉甘石洗剂,2周后自愈。     

肉芽肿性蕈样肉芽肿二例并文献复习

报道2例以局部浸润性斑块为主要表现的肉芽肿性蕈样肉芽肿并复习相关文献.2例患者均表现为红斑、斑块,皮损组织病理检查见真皮内淋巴样细胞及巨细胞浸润,患者1免疫组化示CD2、CD3、CD5、CD7阳性,患者2 CD2、CD3、CD4阳性及CD68组织细胞阳性.诊断:肉芽肿性蕈样肉芽肿.患者1口服阿维A及肿块局部浅层X线照射...     

海分枝杆菌感染二例并文献复习

报道2例海分枝杆菌感染并复习相关文献.患者1,男,25岁.右侧拇指红肿破溃伴疼痛1个月.患者2,女,54岁.左侧大拇指及手背手腕红斑结节伴疼痛2个月.2例患者均有鱼扎伤病史,常规抗感染治疗无效,最终诊断为游泳池肉芽肿,给予抗分枝杆菌感染治疗3个月后痊愈.     

Accessory tragus: report of two cases and review of the literature

Accessory tragus is a fairly common congenital malformation of the external ear. In the vast majority of cases it is an isolated developmental defect not associated with other abnormalities. However, the remote possibility exists that it could be associated with other abnormalities of the first and second branchial arch. Accessory tragus is a consistent feature of the oculoauriculovertebral syndrome (Goldenhar syndrome). When correctly identified, surgical excision of accessory tragus is quite simple and rarely results in any complications.     

Verrucous hemangioma: report of two cases and review of the literature

Verrucous hemangiomas are usually congenital lesions which typically present as warty, bluish, vascular papules, plaques, or nodules, mainly on the lower limbs of children. They show no tendency to spontaneous resolution, and tend to spread and recur after inadequate treatments. We report two instances of verrucous hemangioma, one in an adult and one in a child, discuss the clinical, histopathologic, and therapeutic aspects of this entity, and review the literature.     

CREST综合征2例

目的:探讨CREST综合征的临床特点及诊治方法.方法:报告2例CREST综合征患者,2例均为女性,年龄分别为45岁和58岁,将其临床表现、实验室检查及组织病理改变的资料,结合相关文献作回顾性分析.结果:2例患者中,1例表现为双上肢皮肤变硬20余年,伴鼻根部两侧、左肩部、左臀部皮下结节及吞咽困难1年;另1例表现为面部、双手、下肢皮肤变硬,伴吞咽困难20年,部分手指萎缩、坏死伴右手背、左小趾背皮下结节5年.结合各项实验室检查结果和病史确诊为CREST综合征.结论:CREST综合征临床较为少见,对于硬皮病患者,除做组织病理、自身抗体检查外,建议仔细进行体格检查、食管钡餐造影、胸部X线片及肺功能检查,以明确诊断,同时坚持长期治疗.     

Cutaneous oncocytoma - a report of three cases and review of the literature

The oncocyte is a cell characterized by capacious, eosinophilic, finely granular cytoplasm, and lesions composed primarily of oncocytes are termed oncocytomas. Whereas oncocytic metaplasia has been reported in various cutaneous neoplasms, oncocytomas typically occur in the kidneys, thyroid and salivary glands and are uncommon in the dermatopathology literature. We present three cases of cutaneous oncocytoma so that dermatopathologists are cognizant of this uncommon entity. Although some believe that oncocytomas are locally aggressive lesions, our cases indicate that their clinical course is perhaps as banal as their histology.     

Cutaneous larva migrans with folliculitis: report of seven cases and review of the literature

Seven patients (four men, three women, mean age 31 years), all returning from the tropics, presented with pruritic folliculitis and creeping eruption. The folliculitis consisted of 20-100 follicular papules and pustules confined to a particular area of the body, mainly the buttocks. The creeping eruption consisted of two to 10 serpiginous or linear burrows 1-5 cm long located either in the same area or in a different area from the folliculitis. Five patients were cured with one to three courses of ivermectin (one course in two cases, two courses in two cases and three courses in one case) and two patients were cured with a 3-day regimen of albendazole. Folliculitis should be added to the dermatological manifestations of cutaneous larva migrans. Treatment is more difficult than in classical forms of cutaneous larva migrans.     

Cutaneous solitary fibrous tumor: a report of 2 cases and review of the literature

Solitary fibrous tumor is an uncommon mesenchymal neoplasm that can arise in both pleural and extrapleural locations. Composed of spindled cells intimately admixed with collagen bundles arranged in a "patternless pattern," this heterogeneous tumor can mimic a variety of benign and malignant mesenchymal neoplasms. We present the histological and immunohistochemical findings of two primary cutaneous solitary fibrous tumors, discuss the differential diagnosis, and review the literature. Although solitary fibrous tumors in cutaneous and subcutaneous regions are extremely rare, it should be considered in the differential diagnosis of primary spindle cell neoplasms of the skin.     

Olmsted syndrome: report of two new cases and literature review

Olmsted syndrome is a rare keratinization disorder; 18 cases have been published so far. It associates a mutilating cogenital palmoplantar keratoderma with periorificial erythematokeratotic lesions. We report herein two new unrelated male children with Olmsted syndrome (OS), one of whom was studied by light and electron microscopy. Our histological, immunohistochemical, and ultrastructural findings suggest that this disease is related to epidermal hyperproliferation. We present herein a review of the twenty cases published so far and discuss the major clinicopathological and genetic features of this disease.     

Cutaneous annular sarcoidosis developing on a background of exogenous ochronosis: a report of two cases and review of the literature

Exogenous (cosmetic) ochronosis is caused by the long term use of skin‐lightening creams containing hydroquinone. Three cases of systemic sarcoidosis with cutaneous sarcoidal granulomas, which developed on ochronotic skin were last described by Jacyk in 1995. Dogliotti and Leibowitz previously reported cases of granulomatous ochronosis with sarcoid‐like histological changes but with no associated systemic sarcoidosis. We report two additional cases of cutaneous sarcoidal granulomas, which developed on a background of cosmetic ochronosis in patients recently diagnosed with systemic sarcoidosis.     

注射美容致皮肤脓肿分枝杆菌感染三例并文献复习

目前有多篇外科手术、美容手术、美容注射、文身后发生皮肤脓肿分枝杆菌感染的报道,更有在整容手术或抽脂的诊所中发生爆发事件的报道,其中一些病例的发生与未经批准的药物注射和不规范的操作相关,本文报道3例美容注射后罹患皮肤脓肿分枝杆菌感染的病例并复习相关文献.     

Verrucous hemangioma: a report of two cases and review of the literature

Verrucous hemangioma represents a rare congenital vascular proliferation that may be mistaken for angiokeratoma. Histopathological examination of a deep biopsy is necessary to confirm the diagnosis of verrucous hemangioma based on its involvement of the deep dermis and subcutaneous tissue. We present two cases of verrucous hemangioma and discuss the clinicopathologic and immunohistochemical findings.