配子输卵管移植术的临床初步应用

目的 探讨输卵管配子移植术（GIFT）的临床应用价值。方法 采用促性腺激素促超排卵，电视腹腔镜下输卵管插管移植配子。结果 9例患者治疗后妊娠2例，妊娠率为22．2％。结论 GIFT是一种获得较高妊娠率的辅助生育技术，省略了体外培养时间，更接近生理状态，在临床上具有较大的应用价值。     

经腹腔镜配子输卵管内移植治疗女性不孕症

对１６例不孕症妇女，以氯蒂酚（ＣＣ）、人绝经促性腺激素（ｈＭＧ）、人绒毛膜促性腺激素刺激超排卵，以阴道Ｂ超及尿ＬＨ酶标法测定来监则卵泡发育和成熟，在空镜下进行采卵和配子输卵管内移植（ＧＩＦＴ）共１６个周期。结果共有７例临床妊娠（６例单胎，１例３胞胎）其中５例足月妊娠，分娩５个健康和，１例单胎妊娠早期流产，１例３胞胎晚期注产。每个移植周期临床妊娠率为４３．８％（７／１６）。足月产率为３１．３％（５／     

经阴道配子输卵管移植术应用研究

目的：探讨经阴道配子输卵管移植（ＴＶ－ＧＩＦＴ）治疗输卵管阻塞性不孕症的效果。方法：对７例（８个周期）不孕症患者,分别采用超排卵方案。在超声下取卵,经阴道一宫颈内输卵管内插管,注入配子（卵细胞和精子）,同时用黄体酮或ｈＣＧ增强黄体功能。结果：平均植入卵子数３个,临床妊娠２例,临床妊娠率２８．５７％,周期妊娠率２５％。结论：经阴道配子输卵管移植是一种操作简单而有效的助孕技术,与经腹腔镜配子输卵管移植     

经阴道输卵管插管行配子输卵管移植的临床研究

目的了解经阴道配子输卵管移植治疗非输卵管性不孕症（子宫内膜异位症、男性少弱精症、不明原因不孕等）的效果。方法对引例（对个周期）不孕症患者分别采用（１）绝经期促性腺激素（ｈＭＧ）ｈＣＧ（７个周期）：（２）卵泡刺激素（ＦＳＨ）／ｈＭＧ／ｈＣＧ（２）个周期）;（３）短方案促性腺激素释放激素激动剂（ＧｎＲＨ－ａ）／ｈＭＧ／ｈＣＧ（２个周期）;（４）长方案ＧｎＲＨ－ａ／ＦＳＨ／ｈＭＧｈＣＧ（１２个周期）进行超促排卵。阴道超声下取卵,经阴道向输卵管内插管注人卵母细胞和精子,用ｈＣＧ或黄体酮维持黄体功能。结果平均每周期植人卵子数为（３．３±２．１）个（１～８个）;５例妊娠,周期妊娠率为引７％．其中宫内妊娠４例,输卵管妊娠１例。２例胚胎停止发育,２例继续妊娠已达３０～３４周。结论经阴道配子输卵管移植是一种操作较简单而有效的助孕技术,与经腹腔镜配子输卵管移植相比,价格低廉,无需麻醉,可用于治疗输卵管正常的多种不孕症。     

腹腔镜下配子输卵管内移植婴儿诞生

１９９４年３－１２月，在诱发超排卵条件下配子输卵下，经腹腔镜共进行１６例１６周期配子输卵管内移植，临床妊娠７例，临床妊娠率为４３．８％，其中单胎６例，三胞胎１例；第１例ＧＩＦＴ婴儿于１９９５年１月１４日经剖宫产分娩，为一女婴，体重２７００ｇ，身长５１ｃｍ，体检无异常。     

经腹腔镜配子输卵管内移植治疗女性不孕症

对16例不孕症妇女，以氯蒂酚（CC）、人绝经促性腺激素（hMG）、人绒毛膜促性腺激素（hCG）刺激超排卵，以阴道B超及尿LH酶标法测定来监测卵泡发育和成熟，在腹腔镜下进行采卵和配子输卵管内移植（GIFT）共16个周期。结果共有7例临床妊娠（6例单胎，1例3胞胎）其中5例足月妊娠，分娩5个健康儿，1例单胎妊娠早期流产，1例3胞胎晚期流产。每个移植周期临床妊娠率为43．8％（7／16），足月产率为31．3％（5／16），无异位妊娠发生。提示：经腹腔镜配子输卵管内移植治疗女性不孕症，技术较简便、经济、成功率高，是一种具有实用价值的治疗女性不孕症的新方法。     

腹腔镜下配子输卵管内移植婴儿诞生

１９９４年３～１２月，在诱发超排卵条件下，经腹腔镜共进行１６例１６周期配子输卵管内移植（ＧＩＦＴ），临床妊娠７例，临床妊娠率为４３．８％（７／１６）。其中单胎６例，三胞胎１例；第１例ＧＩＦＴ婴儿于１９９５年１月１４日经剖宫产分娩，为一女婴，体重２７００ｇ，身长５１ｃｍ，体检无异常。该婴儿为我国大陆首例腹腔镜下配子输卵管内移植婴儿。     

Tubal catheterization for transvaginal gamete intrafallopian transfer: an alterative technique for non-tubal infertility

Gameteintrafallopiantransfer(GIFT),whichisoneoftheassistedreproductivetechniques,canbeusedininfertilepatientswithnormaltubes.Comparedwithinvitrofertilization--embryotransfer(IVF--ET),GIFTisclosertothephysiologicalstatusandhashigherclinicalpregnancyrate(30%--48%),aswellasmuchlesscomplicatedproceduresascomparedwiththoseinvolvedininyiircfertilizationandculture.Previously,GIFTwasperformedlaparoscopicallyunderanesthesia.Recently,amodifiedtechniquecalledtransvaginalGIFT(TV--GIFT)wasintrod…     

体外受精─胚胎移植治疗不孕症(附20周期分析)

目的探讨体外受精－胚胎移植（InvitrofertilizationandembryoTransferIVF－ET）治疗不孕症的效果。方法对18例不孕症妇女实施20周期IVF－ET治疗。采用BuserelinFSH／HMG／HCG或FSH／HMG／HCG方案控制起排卵,B型超声为主监测卵泡发育;阴道超声引导下穿刺取卵;上游法处理精液,Earle’s平衡盐液进行体外受精及增养。Tom导管进行宫腔内胚胎移植。结果均每周期取卵6．7个,卵细胞回收率74％,受精率88％,卵裂率74％,获4例临床妊娠．1例生化妊娠,妊娠率25％。结论IVF－ET是治疗输卵性不孕最有效的方法。     

腹腔镜诊治不孕症患者盆腔病变156例疗效分析

目的探讨应用腹腔镜手术诊治不孕症的临床价值。方法2001年1月至2008年12月中山市人民医院对156例女性不孕症患者行腹腔镜诊断和治疗,观察术后妊娠率。结果156例中发现盆腔病变145例,占92．9％。慢性盆腔炎是不孕症的第1位病因,继发不孕较原发不孕发生率高（P〈0．01）;其次为子宫内膜异位症、多囊卵巢综合征,原发不孕发生率高于继发不孕（P〈0．01）。腹腔镜手术术后妊娠率为47．1％,2例发生异位妊娠。结论腹腔镜手术对女性不孕症盆腔病变的诊治具有重要的价值。     

经阴道超声对子宫峡部妊娠的诊断分析

目的探讨经阴道超声检查对子宫峡部妊娠的诊断价值。方法回顾性分析41例子宫峡部妊娠超声声像图特征及术后结果。结果 41例峡部妊娠中,超声检查正确诊断33例,准确率为80.49%（33/41）,误诊8例（宫颈部妊娠4例、难免流产2例、滋养叶细胞疾病1例、子宫切口血肿1例）。典型超声声像图表现为胎囊型、非均质包块型两种类型。结论经阴道超声检查对子宫峡部妊娠的诊断是一种可靠的诊断方法,具有重要的临床价值。     

子宫内膜息肉合并不孕患者TCRP术后妊娠结局及影响因素分析

目的分析宫腔镜子宫内膜息肉合并不孕患者行TCRP术后的妊娠结局及影响因素。方法选择2014年1~12月在我院接受治疗的子宫内膜息肉合并不孕者75例,均在院内接受宫腔镜子宫内膜息肉电切(TCRP)术,术后随访12~24个月,分析妊娠结局及影响因素。结果术后12个月内自然妊娠者15例,其中正常分娩者10例(66.67%),流产1例(6.67%),早产4例(26.67%);术后24个月内自然妊娠者33例,其中正常分娩者26例(78.79%),流产2例(6.06%),早产5例(15.15%);术后24个月自然妊娠率及正常分娩率均高于术后12个月(P均0.01);患者年龄、子宫息肉直径、个数、部位、糖尿病、不孕类型以及BMI值与术后妊娠情况存在一定的关系。结论采取宫腔镜子宫内膜息肉电切术(TCRP)可获得良好的临床效果,而且年龄、子宫息肉直径、个数、部位、糖尿病、不孕类型以及BMI值与术后妊娠率之间存在一定的关联。     

Pregnancy outcomes of the first thawing cycle in "freeze-all" strategy of infertility patients with fever during oocyte recruitment: a matched-pair study

Background::It is currently unknown whether patients with a fever after controlled ovulation during egg retrieval could increase the risk of pelvic infection or...     

经三维子宫输卵管超声造影在不孕症的应用价值

目的：探讨经阴道三维子宫输卵管超声造影(3D-HyCOSy)在不孕症中的作用。方法将不孕症患者66例按照数字表法随机分为3D-HyCOSy组与X线子宫输卵管造影（HSG）组,每组各33例,并与腹腔镜检查结果进行自身对比分析。结果3D-HyCOSy组33例66条,输卵管通畅53条占80.30%(53/66),通而不畅9条占13.64%（9/66）,阻塞4条占6.06%（8/66）。HSG组33例66条输卵管通畅37条占56.06%(37/66),通而不畅14条占21.21%（14/66）,阻塞15条占22.73%（15/66）。经腹腔镜检查提示3D-HyCOSy组符合率为(80.41±2.4)%,而HSG组为(59.13±5.76)%(P＜0.05)。结论3D-HyCOSy诊断不孕症是一种简便、有效、无创、安全、准确、可重复、无辐射又不影响怀孕等优点,对子宫宫腔病变和输卵管的通畅性的诊断及鉴别明显优于传统的HSG。     

Pregnancy outcomes of the first thawing cycle in “freeze-all” strategy of infertility patients with fever during oocyte recruitment: a matched-pair study

Background:It is currently unknown whether patients with a fever after controlled ovulation during egg retrieval could increase the risk of pelvic infection or not, and fever itself may affect endometrial receptivity or embryo quality with poor pregnancy outcomes. The aim of this study was to analyze the outcomes of patients with fever during oocyte retrieval after the first frozen-thawed embryo transfer (FET) cycle.Methods:This was a 1:3 retrospective paired study matched for age. In this study, 58 infertility patients (Group 1) had a fever during the control ovulation, and the time of the oocyte retrieval was within 72 hours, they underwent ovum pick up and whole embryo freezing (“freeze-all” strategy). The control subjects (Group 2) are 174 patients matched for age who underwent whole embryo freezing for other reasons. The baseline characteristics, clinical data of ovarian stimulation, and outcomes, such as the clinical pregnancy rate, ongoing clinical pregnancy rate were compared between the two groups in the subsequent FET cycle.Results:All patients had no pelvic inflammatory disease after oocyte retrieval. Anti-Mullerian hormone (AMH) levels (4.2 vs. 2.2, P <0.001) were higher in group 2, and the number of oocytes retrieved, and fertilization rate were lower in group 1 (P < 0.001), but the endometrial thickness, the number of embryo transfers, and the type of luteal support supplementation were similar between the two groups. Regarding pregnancy outcomes in the subsequent FET cycle, the implantation rate, clinical pregnancy rate, early spontaneous rate, ectopic pregnancy rate, and ongoing pregnancy rate were all not significantly different. Further regression analyses showed that the clinical pregnancy rate and ongoing pregnancy rate were also not significantly different.Conclusions:Transvaginal ultrasound-guided follicular puncture for oocyte retrieval is a safe and minimally invasive method for patients with fever. Moreover, the fever had almost no effect on embryo quality.     

Pregnancy and delivery after liver transplantation: the first successful case in China

Severe liver diseases usually cause menstrual dysfunction and infertility in women of reproductive age. Liver transplantation is one of the treatment choices for patients with liver diseases. Among patients receiving liver transplantation, 11% are women of reproductive age. Successful liver transplantation,