共查询到20条相似文献,搜索用时 15 毫秒
1.
P. A. Prodius I. Yu. Malyshev F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,120(3):938-940
Substantial seasonal differences are found in the development of the cardioprotective effect of adaptation to physical exercise:
in winter such adaptation results in an increase of the resistance of the isolated heart to the contracture and arrhythmogenic
effects of ischemia and reperfusion, while in summer the anticontracture effect is absent and the antiarrythmic effect is
significantly lowered.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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9, pp. 299–301, September, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
2.
L. A. Mikhailichenko M. I. Reutov 《Bulletin of experimental biology and medicine》1996,121(3):322-324
Morphometric parameters of microvessels in paired rabbit ears and blood sampled from the internal vein were studied after
ischemia reproduced under conditions of prior hemodilution and hemoconcentration. In hemodilution the postischemic alterations
were found to be more pronounced in microvessels of the left ear, while for the right the same was true for rheological characteristics
of the outflowing blood. Under conditions of hemoconcentration after ischemia the changes in rheological indexes were more
marked on the left and in vasomotor indexes on the right.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 352–354, March, 1996
Presented by V. V. Kupriyanov, Member of the Russian Academy of Medical Sciences 相似文献
3.
K. Yu. Sarkisova I. A. Kolomeitseva P. Oehme 《Bulletin of experimental biology and medicine》1995,120(2):774-778
Substance P administered 30 min after the onset of cerebral ischemia improved the neurological status and prevented postischemic
hyperactivity in rats with a passive type of behavior; had no effect on the neurological status of rats with an intermediate
type of behavior but reduced their postischemic hyperactivity; aggravated the neurological status of rats with an active type
of behavior without exerting a significant effect on their behavioral responses; and averted a rise in the level of depression
in rats of all three groups. The results of this study indicate that there is a relationship between the type of behavior,
manifestations of cerebral ischemia, and the effects of substance P.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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8, pp. 132–136, August, 1995
Presented by P. V. Simonov, Member of the Russian Academy of Medical Sciences 相似文献
4.
L. N. Maslov A. V. Krylatov Yu. B. Lishmanov 《Bulletin of experimental biology and medicine》1996,121(1):20-21
Rats adapted to stress showed a decreased severity and incidence of cardiac arrhythmias induced by epinephrine, and these
effects of adaptation were abolished by naloxone. It is suggested that stress adaptation mitigates arrhythmia by activating
the endogenous opioid system and stimulating the μ-opiate receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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1, pp. 24–25, January, 1996
Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences 相似文献
5.
T. G. Sazontova L. M. Belkina Fu Syan Zun F. Z. Meerson 《Bulletin of experimental biology and medicine》1994,117(2):128-134
Ischemia and reperfusion of various duration are shown to result in a nonlinear increase in the level of free Ca in myocardial
homogenates. A striking dissociation has been observed in the effect of ischemia and reperfusion on the rate of Ca transport
in the sarcoplasmic reticulum, on the one hand, and the permeability of its membranes on the other.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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2, pp. 130–135, February, 1994 相似文献
6.
Cytophotometric determination of RNA in various brain structures of hypoxia-adapted and unadapted epilepsy-prone rats at different
times after an epileptic seizure shows much smaller decreases in RNA levels and their much more rapid return to normal in
the adapted than in the unadapted rats. The adaptation to hypoxia produces a marked anticonvulsive effect, and this effect
is enhanced and prolonged considerably by pharmacotherapy.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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2, pp. 120–123, February, 1994 相似文献
7.
L. D. Luk'yanova G. N. Chernobaeva V. E. Romanova 《Bulletin of experimental biology and medicine》1995,120(6):1189-1192
After long-term adaptation to intermittent hypoxia, rats with an initially low resistance to acute oxygen deficiency were
2 to 4 times more resistant to it, while highly resistant rats did not show a significant change in resistance. The adaptation
was accompanied by weakening of the electron-transporting function of the respiratory chain and increasing efficiency of oxidative
phosphorylation in the brain mitochondria oxidizing NAD-dependent substrates, indicating that energy was produced in a more
economical way. The succinate oxidase pathway of oxidation was found to be utilized to only a limited extent as a compensatory
mechanism in animals exposed to intermittent hypoxia over a prolonged period. The effects of adaptation were more marked in
the brain mitochondria of rats initially highly sensitive to oxygen deficiency.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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12, pp. 572–575, December, 1995 相似文献
8.
A. M. Dupin I. V. Barskov I. V. Viktorov A. N. Erin 《Bulletin of experimental biology and medicine》1994,118(6):1280-1281
Pathomorphological changes in a focus of ischemia, the level of lipid peroxidation (as indicated by the content of products
reacting with thiobarbituric acid), and the postischemic levels of adenyl nucleotides and tissue lipids were studied in rats
with focal compression ischemia of the cerebral cortex. An increased level of the TBA-reactive products paralleled by a reduction
of the concentrations of adenyl nucleotides and tissue lipids was found to be in clear-cut correlation with the processes
of neuronal injury and death and with subsequent repair phenomena in the focus of cortical ischemia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 589–590, December, 1994
Presented by O. S. Adrianov, Member of the Russian Academy of Medical Sciences 相似文献
9.
A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,120(6):1193-1195
After a prolonged (for 30 days) adaptation of rats to intermittent hypoxia, their brains contained lowered levels of mitochondrial
cytochromes, despite an increase in the number of mitochondria in the brain tissue mass, along with similar levels of high-energy
compounds and more protein as compaired to the brains of unadapted controls. A mitochondrial population with novel properties
presumably emerged in the brain. These effects were all more strongly marked in rats with an initially low resistance to hypoxia.
In the liver of hypoxiaadapted animals, unlike in their brain, cytochrome levels in the mitochondrial and microsomal redox
chains were lowered and the biogenesis of mitochondria was much less intensive.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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12, pp. 576–579, December, 1995 相似文献
10.
V. V. Belousova A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,119(1):23-27
It is demonstrated that the lactate-Po2 dependence is the same in hepatocytes of rats with high and low resistance to hypoxia and does not correlate with phasic
changes in the ATP concentration in the 890–50 μM O2 region. Strong activation of lactate formation against the background of ATP decrease indicates that glycolysis is not the
major mechanism determining the steady-state ATP level in the cell and affecting the ATP-Po2 relationship in a wide range of oxygen concentrations. The intensity of glycolysis in hepatocytes of rats with high resistance
to hypoxia is markedly increased after periodic adaptation to hypoxia but remains practically unchanged in the hepatocytes
of low-resistance rats. This indicates that fundamentally different compensatory mechanisms are involved in this process in
the liver of high- and low-resistance rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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1, pp. 28–32, January, 1995 相似文献
11.
T. G. Sazontova Yu. V. Arkhipenko F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,120(1):687-690
The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective
factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is
shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times
in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At
the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a
high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 42–45, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
12.
T. P. Storozhevykh V. G. Pinelis V. B. Koshelev O. E. Fadyukova 《Bulletin of experimental biology and medicine》1996,121(2):120-123
Examination of the reactivity exhibited by the basilar artery of the brain in Krushinsky-Molodkina rats before and after an
induced epileptiform seizure accompanied by subarachnoid hemorrhages showed increased contractility of this artery in response
to endothelin-1 and its reduced sensitivity to ATP 24 h after the seizure. Such changes in the reactivity of brain vessels
may contribute to the development of vasospasm and secondary ischemia of the brain after an epileptic seizure.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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2, pp. 131–134, February, 1996
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献
13.
I. Yu. Malyshev P. A. Prodius F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,119(1):20-22
Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th
min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion
of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser,
and the total period of tachycardia and fibrillation were 3-fold shorter than in the control.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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1, pp. 25–27, January, 1995
Presented by S. S. Debov, Member of the Russian Academy of Medical Sciences 相似文献
14.
V. Kh. Vaizov T. M. Plotnikova T. V. Yakimova O. E. Vaizova A. S. Saratikov 《Bulletin of experimental biology and medicine》1994,118(3):975-977
It is demonstrated that ammonium succinate is capable of increasing the survival of rats with acute brain ischemia. In transient
brain ischemia therapeutic injection of ammonium succinate prevents the development of postischemic hypoperfusion and hypooxygenation
of the brain. The antiischemic effect of ammonium succinate is due to a decrease of the oxygen affinity of hemoglobin and
to limitation of the accumulation of malonic dialdehyde, a secondary product of lipid peroxidation, in the brain. No vasotropic
activity of ammonium succinate is revealed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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9, pp. 276–278, September, 1994
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
15.
E. B. Manukhina A. V. Lapshin S. Yu. Mashina F. Z. Meerson V. D. Mikoyan L. N. Kubrina A. F. Vanin 《Bulletin of experimental biology and medicine》1995,120(5):1117-1120
Adaptation to intermittent hypoxic hypoxia did not affect the endothelium-dependent relaxation of the aorta in rats, but significantly
increased the relaxation of their tail artery. Following the adaptation, the NO level fell in the liver, intestine, and kidneys
and remained unchanged in the spleen. Adaptation to hypoxia presumably limits NO synthesis and/or release in the vascular
endothelium or enhances the capacity of this oxide to bind in a physiologically active depot.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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11, pp. 495–498, November, 1995
Presented by Yu. A. Vladimirov, Member of the Russian Academy of Medical Sciences 相似文献
16.
L. D. Luk'yanova A. M. Dudchenko V. V. Belousova 《Bulletin of experimental biology and medicine》1994,118(6):1268-1272
It is shown that isolated hepatocytes are capable of perceiving slight changes in the envioronmental oxygen concentration.
A complicated phase dependence exists between adenosine triphosphate and partial oxygen pressure, which differs in cells from
animals with high and low resistance to hypoxia, the former showing a more stable and resistant energy-synthesizing function
than the latter. After long-term adaptation to periodic hypoxia, the resistance of the energy-synthesizing function rises
in hepatocytes from high-resistant animals, and falls in low-resistant animals suggesting a fundamentally different organization
of the emergency compensatory mechanisms of the energy-synthesizing function in hepatocytes of animals of these two types.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 576–581, December, 1994 相似文献
17.
N. I. Artyukhina K. Yu. Sarkisova 《Bulletin of experimental biology and medicine》1994,118(5):1226-1231
Structural changes in the brain were studied at later (one and three months) stages of cerebral hypoxia caused by occlusion
of the common carotid arteries, which were indicative of the development of recovery and destructive processes. Brain ultrastructure
was found to be better preserved in rats with an active type of behavior one month after the onset of ischemia than in rats
of the other groups; motor activity was restored to the baseline level, thus demonstrating a higher rate of recovery processes.
Significant ultrastructural damage to the brain at the same stage of ischemia was observed in rats with a passive type of
behavior (especially in rats of the middle group), while motor activity was increased.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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11, pp. 529–534, November, 1994
Presented by P. V. Simonov, Member of the Russian Academy of Sciences 相似文献
18.
N. P. Lebkova A. Ya. Chizhov L. N. Zeitlenok 《Bulletin of experimental biology and medicine》1995,119(6):574-579
A comparative ultrastructural study of organelles involved in supplying cardiac myocytes with energy (nucleus, mitochondria,
microbodies, and lysosomes) in pregnant rats that had been exposed to intermittent normobaric hypoxia and in rats not so exposed
showed no significant differences between these two groups of animals. In both groups, glycogen granules were present in the
nucleus, mitochondria, lysosomes, and microbodies (peroxisomes) of cardiac myocytes, and many of their mitochondria had a
dense matrix and appeared hyperplastic.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 597–602, June, 1995
Presented by A. V. Smol'yannikov, Member of the Russian Academy of Medical Sciences 相似文献
19.
V. V. Malyshev L. S. Vasil'eva S. B. Belogorov T. V. Nefedova 《Bulletin of experimental biology and medicine》1995,119(6):567-570
Preadaptation of rats to altitude hypoxia results in reduced activation of lipid peroxidation during subsequent stress, inflammation,
or both, as compared to hypoxiaunadapted animals, with the result that secondary changes in organs and tissues of adapted
rats are much less pronounced and conditions are created for alleviating the acute inflammation and the stress reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 590–593, June, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
20.
Newborn rats euthanized 24 h after birth were examined. The rats were born to females exposed to chronic hypobaric hypoxia
on days 14–19 of gestation. The index of nuclei labeled with3H-thymidine in the tracheal epithelium of newborn rats exposed to prenatal hypoxia was 3 times lower than in the control.
The LPO level was higher in posthypoxic animals than in intact rats. Prenatal hypoxia led to the suppression of antioxidant
defense in the lungs of newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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5, pp. 531–533, May, 1994 相似文献