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Carey JJ Coughlan RJ O'Sullivan M 《Arthritis care & research》2012,64(7):1099; author reply 1099-1099; author reply 1100
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Ritu Valiyil Livia Casciola‐Rosen Grace Hong Andrew Mammen Lisa Christopher‐Stine 《Arthritis care & research》2010,62(9):1328-1334
Objective
The myopathy associated with anti–signal recognition particle (anti‐SRP) is a severe necrotizing immune‐mediated disease characterized by rapidly progressive proximal muscle weakness, markedly elevated serum creatine kinase (CK) levels, and poor responsiveness to traditional immunosuppressive therapies. Reports on the efficacy of B cell depletion therapy for anti‐SRP–associated myopathy are mixed. We describe 8 patients with anti‐SRP–associated myopathy and their response to treatment with the anti‐CD20 monoclonal antibody rituximab.Methods
We identified 8 patients with myopathy who tested positive for anti‐SRP antibodies by immunoprecipitation and were treated with rituximab as part of clinical care. We reviewed their medical records to assess clinical, serologic, and histologic characteristics and response to therapy. In 5 patients, serum was collected before and after rituximab therapy. Autoantibodies were detected by immunoprecipitation and quantitated by densitometry, and the percent decreases in anti‐SRP autoantibody levels were calculated.Results
Six of 8 patients who had been refractory to standard immunosuppressive therapy demonstrated improved manual muscle strength and/or decline in CK levels as early as 2 months after rituximab treatment. Three patients sustained the response for 12–18 months after initial dosing. All of the patients were continued on adjunctive corticosteroids, but doses were substantially reduced after rituximab. Quantitative levels of serum anti‐SRP antibodies also decreased after rituximab treatment.Conclusion
B cell depletion therapy with rituximab is effective for patients with myopathy associated with anti‐SRP. The substantial decrease in anti‐SRP antibody levels after rituximab treatment also suggests that B cells and anti‐SRP antibodies may play a role in the pathogenesis of this myopathy. 相似文献3.
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Cryer BL 《Arthritis and rheumatism》2003,48(7):2074-5; author reply 2075-7
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R S Cloud 《Arthritis and rheumatism》1992,35(12):1538-1539
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Alarcón GS Kremer J Weinblatt M 《Arthritis and rheumatism》2004,50(8):2710; author reply 2710-2710; author reply 2711
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Bader-Meunier B 《Arthritis and rheumatism》2008,58(8):2583; author reply 2583-2583; author reply 2584
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Seaman WE 《Arthritis and rheumatism》2005,53(5):800; author reply 800-800; author reply 801
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Gemignani F Brindani F Marbini A 《Arthritis and rheumatism》2007,56(8):2810; author reply 2810-2810; author reply 2811
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Belloli L Massarotti M Marasini B 《Arthritis and rheumatism》2008,59(3):455; author reply 455-455; author reply 456
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Bruyn GA Iagnocco A Naredo E Wakefield RJ Schmidt WA 《Arthritis and rheumatism》2004,50(9):3054; author reply 3055-3054; author reply 3056