扩散加权成像鉴别胰腺癌与肿块型慢性胰腺炎的Meta分析

目的 对磁共振扩散加权成像(DWI)鉴别诊断胰腺癌和肿块型慢性胰腺炎的文献进行汇总复习,评价DWI对胰腺癌与肿块型慢性胰腺炎的鉴别诊断价值.方法 检索主要中、英文数据库,提取相关参数,采用Stata12.0及Meta-Disc 1.4软件进行Meta分析.结果 DWI对该两种疾病鉴别诊断汇总敏感度为0.864(95％ CI:0.799,0.910),汇总特异度为0.816 (95％ CI:0.716,0.886),汇总阳性似然比4.694(95％ CI:3.013,7.312),汇总阴性似然比0.167(95％CI:0.114,0.244),汇总诊断比值比为28.137(95％ CI:15.562,50.872),汇总受试者工作特征曲线(SROC)下面积(AUC)为0.91 (95％ CI:0.88,0.93).结论 DWI用于鉴别诊断胰腺癌与肿块型慢性胰腺炎具有较高的诊断准确性.     

磁共振扩散加权成像在胰腺癌与慢性局灶性胰腺炎中的鉴别诊断价值

目的 探讨磁共振扩散加权成像(DWI)在胰腺癌与胰腺炎中的鉴别诊断价值.方法 对胰腺癌组(n=18)、胰腺炎组(n=12)均行磁共振常规扫描和扩散加权成像(DWI,b值取0,600s/mm2),分析2组病变DWI信号特点,并测定2组表观扩散系数(ADC)值.定量分析比较2组间ADC值有无统计学差异.结果 胰腺癌组、胰腺炎组ADC值分别为(1.82±0.13)×10-3mm2/s、(1.95±0.21)×10-3mm2/s,胰腺癌组ADC值低于胰腺炎组(t=2.10,P＜0.05).结论 DWI有助于胰腺癌与胰腺炎的鉴别诊断,可作为常规MRI的重要补充检查方法.     

扩散加权成像在胰腺癌诊断中的价值初探

目的探讨MR扩散加权成像(DWI)在胰腺癌诊断中的价值。资料与方法健康自愿者20名,经手术病理和随访证实的胰腺癌患者21例、慢性胰腺炎患者12例,分别行常规MRI和DWI检查。应用自旋回波-回波平面成像(SE-EPI)并采用采集空间敏感性编码技术(ASSET),取b=0和600s/mm2获得DWI图像。分别测量感兴趣区(ROI)的表观扩散系数(ADC)值,行配对t检验。结果健康自愿者胰腺DWI呈中等信号,胰头、胰体尾部ADC值分别为(1.535±0.247)×10-3mm2/s、(1.643±0.375)×10-3mm2/s。21例胰腺癌肿瘤区DWI呈均匀或稍不均匀高信号,ADC值为(1.192±0.117)×10-3mm2/s。健康自愿者胰头与胰体尾部ADC值差异无统计学意义(P>0.05),胰头及胰颈部肿瘤患者胰体尾部ADC值与健康自愿者间差异有统计学意义(P<0.001),胰腺肿瘤ADC值与胰头及体尾部之间差异有统计学意义(P<0.001)。慢性胰腺炎DWI呈不均匀等或稍高信号,ADC值为(1.437±0.385)×10-3mm2/s,与胰腺癌间差异有统计学意义(P<0.05)。结论DWI可以清楚显示肿瘤病灶及范围,ADC值的测定在一定程度上有助于胰腺癌的诊断。     

磁共振扩散加权成像在胰腺癌诊断中的价值

目的探讨磁共振扩散加权成像在胰腺癌诊断中的价值。方法选择2012年1月～2013年1月间临床可疑胰腺癌患者75例,对这些患者进行磁共振扩散加权成像检查,将检查结果与病理结果比较,明确两者之间的相关性,同时确定磁共振扩散加权成像在胰腺癌诊断中的敏感性、特异性。结果75例可疑胰腺癌患者经DWI检查,诊断为胰腺癌38例,与病理结果比较,两者存在相关性（r=23．12,P=-0．00〈0．05）,且相关系数为0．56。同时与病理结果比较DWI诊断胰腺癌的敏感性为73．33％,特异性为83．33％,阳性预测值和阴性预测值分别为86．84％和67．57％。结论磁共振扩散加权成像作为无创检查手段能够准确地对胰腺占位做出定性诊断,在临床应用价值较大。     

扩散加权成像结合3D-FAST TOF SPGR对胰腺癌的诊断及鉴别诊断

目的 探讨扩散加权成像(DWI)结合3D -FAST TOF SPGR序列对胰腺癌的诊断价值,提高诊断及鉴别诊断水平.方法 对病理证实的25例胰腺癌及6例慢性胰腺炎的MR表现进行回顾分析,重点观察DWI及3D -FAST TOF SPGR表现及胰周血管受侵情况,并与手术及病理结果进行对照分析.结果 DWI结合3D -FAST TOF SPGR 示胰腺癌24例,慢性胰腺炎7例,以病理结果为金标准.DWI结合3D -FAST TOF SPGR诊断胰腺癌的敏感性、特异性、准确性、阳性预测值及阴性预测值分别是92.00%,83.33%,90.32%,95.83%,71.43%.结论 DWI结合3D -FAST TOF SPGR对胰腺癌的诊断及术前可切除性的评价具有较高价值.     

磁共振扩散加权成像在胰腺癌的初步应用

目的探讨表观扩散系数在诊断胰腺癌的价值。方法病变组25例,均经手术病理证实;对照组20例。DWI选用5个不同的扩散敏感系数b=50,100,300,500,700s/mm2,并分别测量出瘤区、非瘤区及正常胰腺的ADC值,并进行χ2检验。结果b值为50s/mm2时3组ADC值无显著性差异,当b值为100、300s/mm2时,非瘤区ADC值与正常组织的ADC值无显著性差异,而这两者与瘤区的ADC值比较均有显著性差异,当b值为500s/mm2和700s/mm2时,瘤区与非瘤区ADC值无显著性差异,而这两者与对照组的ADC值比较均有显著性差异。结论对于胰腺癌,其DWI图像有助于检出病变。     

磁共振扩散加权成像对慢性胰腺炎及胰腺癌的诊断价值分析

目的 探讨3.0 T磁共振扩散加权成像(DWI)及表观扩散系数(apparent diffusion coefficient,ADC)对于慢性胰腺炎及胰腺癌的诊断价值.资料与方法对15名健康自愿者、16例慢性胰腺炎和15例胰腺癌患者进行DWI扫描,采用单次激发自旋回波-回波平面成像(SE-EPI)序列,b值为0、600和O、1000 s/mm2.测量胰腺ADC值,比较不同b值下,自愿者组、慢性胰腺炎组、胰腺癌组的ADC值差异.结果自愿者组、慢性胰腺炎组、胰腺癌组在b值为0、600 s/mm2时,三组的ADC值(10-3 mm2/s)95%可信区间分别是3.176～1.670(2.423±0.384)、2.153～1.287(1.720±0.221)、1.613～1.005(1.309±0.155);b值为0、1000 s/mm2时,三组的ADC值(10-3mm2/s)95%可信区间分别是2.456～1.390(1.923±0.272)、1.979～1.085(1.532±0.228)、1.585～0.773(1.179±0.207).三组的ADC值差异在b值为0、600及0、1000 s/mm2时,均有统计学意义(P＜0.05).结论测量DWI中胰腺的ADC值对于胰腺癌与慢性胰腺炎的鉴别诊断有一定意义.     

磁共振VIBE序列鉴别胰腺癌与肿块型慢性胰腺炎的价值探讨

目的:探讨磁共振三维容积式内插值法屏气检查(VIBE)序列在胰腺癌和肿块型慢性胰腺炎鉴别诊断中的价值。方法:41例经手术病理或临床随访证实的胰腺疾病患者(胰腺癌26例,慢性胰腺炎15例),行常规MRI检查及3DVIBE三期动态增强扫描。对所获得的图像资料主要观测以下内容:①肿块形态学特点;②肿块多期强化特征,计算病灶的信噪比(SNR)和对比噪声比(CNR);③胰管、胆管的改变;④胰周血管显示情况;⑤胰周器官受累情况及有无远处转移病灶等。结果:①胰腺癌中出现小泡征2例(7.7%),炎性肿块中出现此征象5例(33.3%);胰腺癌中肿块处胰管狭窄、中断22例(84.6%),而炎性肿块中出现胰管穿通征8例(53.3%);近端胰管相对均匀扩张者胰腺癌组18例(69.2%),炎性肿块组仅1例(6.7%);近端胰管不规则扩张或呈串珠状改变者胰腺癌组3例(11.5%),炎性肿块组12例(80%);两组间上述征象的差异均有显著性意义(P<0.05);②肿块包绕邻近血管范围>180°者胰腺癌组10例(38.5%),胰腺炎组3例(20%),两组间差异无显著性意义(P>0.05);③肿块强化特点方面,胰腺癌与胰腺炎性肿块的SNR值和CNR值的差异无显著性意义(P>0.05)。结论:MRI VIBE序列能较好显示胰腺肿块的一些细微形态学特征,有助于胰腺癌与肿块型慢性胰腺炎的鉴别诊断;两种病变在血供特点和强化特征方面差异无显著性意义。     

MRI多种成像技术在胰腺肿块鉴别诊断中的价值

【摘要】目的：研究MRI多种成像技术在胰腺癌和胰腺炎性肿块鉴别诊断中的价值。方法：搜集经手术病理证实的胰腺癌和胰腺炎性肿块病例共47例,采用的MRI技术分别为FLASHT1WI、TSET2WI、T1WI+FS、T2WI+FS、Gd DT PA动态增强扫描和MRCP,分析其MRI表现。结果：T1WI、T2WI、T1WI+FS、T2WI+FS、Gd DTPA动态增强扫描以及MRCP对26例胰腺癌的检出率分别为53.9%、50.0%、73.1%、76.9%、88.5%、84.6%,对21例胰腺炎性肿块的检出率分别为52.4%、57.1%、71.4%、71.4%、81.0%、85.7%。结论：T1WI+FS、T2WI+FS、Gd DTPA动态增强扫描和MRCP成像技术对胰腺癌和胰腺炎性肿块的定位、定性准确率较高,是鉴别诊断胰腺癌和胰腺炎性肿块的理想方法。     

MRI多种成像技术在胰腺肿块鉴别诊断中的价值

目的研究MRI多种成像技术在胰腺癌和胰腺炎性肿块鉴别诊断中的价值。方法搜集经手术病理证实的胰腺癌和胰腺炎性肿块病例共47例,采用的MRI技术分别为FLASHT1WI、TSET2WI、T1WI FS、T2WI FS、Gd DT PA动态增强扫描和MRCP,分析其MRI表现。结果T1WI、T2WI、T1WI FS、T2WI FS、Gd DTPA动态增强扫描以及MRCP对26例胰腺癌的检出率分别为53.9%、50.0%、73.1%、76.9%、88.5%、84.6%,对21例胰腺炎性肿块的检出率分别为52.4%、57.1%、71.4%、71.4%、81.0%、85.7%。结论T1WI FS、T2WI FS、Gd DTPA动态增强扫描和MRCP成像技术对胰腺癌和胰腺炎性肿块的定位、定性准确率较高,是鉴别诊断胰腺癌和胰腺炎性肿块的理想方法。     

CT及MRI多模态参数对鉴别胰头部肿块型慢性胰腺炎与胰头癌的价值

目的 分析胰头部肿块型慢性胰腺炎(MFCP)与胰头癌的CT以及MRI定性及定量表现,总结二者有效的影像鉴别特点.方法 选取我院16例胰头部MFCP及16例胰头癌临床及影像资料进行回顾性分析.结果 胰头部MFCP与胰头癌影像表现:1)肿块形态密度:分叶状(2例,11例),假性囊肿(11例,0例),肿块内钙化(6例,0例)...     

Evaluation of MR diffusion-weighted imaging in differentiating endometriosis infiltrating the bowel from colorectal carcinoma

Objective

Endometriosis infiltrating the bowel may be difficult to differentiate from colorectal carcinoma in cases that present with non-specific clinical and imaging features. The aim of this study is to assess the value of MR diffusion-weighted imaging (DWI) in differentiating endometriosis infiltrating the bowel from colorectal carcinoma.

Methods

In 66 patients, MR DWI was added to the standard imaging protocol in patients visiting our outdoor MR clinic for the analysis of suspected or known deep infiltrating endometriosis (DIE). In patients diagnosed with DIE infiltrating the bowel on MR imaging, high b-value diffusion-weighted images were qualitatively assessed by two readers in consensus and compared to high b-value diffusion weighted images in 15 patients evaluated for colorectal carcinoma. In addition, ADC values of lesions were calculated, using b-values of 50, 400 and 800 s/mm².

Results

A total of 15 patients were diagnosed with DIE infiltrating the bowel on MR imaging. Endometriosis infiltrating the bowel showed low signal intensity on high b-value diffusion-weighted images in all patients, whereas colorectal carcinoma showed high signal intensity on high b-value diffusion-weighted images in all patients. Mean ADC value in endometriosis infiltrating the bowel (0.80 ± 0.06 × 10⁻³ mm²/s) was significantly lower compared to mean ADC value in colorectal carcinoma (0.86 ± 0.06 × 10⁻³ mm²/s), but with considerable overlap between ADC values.

Conclusion

Only qualitative assessment of MR DWI may be valuable to facilitate differentiation between endometriosis infiltrating the bowel and colorectal carcinoma.     

The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas

The usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging for the diagnosis of uterine sarcomas was investigated, as well as whether DW images and quantitative measurement of apparent diffusion coefficient (ADC) values can facilitate differentiating uterine sarcomas from benign leiomyomas. MR images including DW images were obtained in 43 surgically treated patients with 58 myometrial tumors, including seven uterine sarcomas (five leiomyosarcomas and two endometrial stromal sarcomas) and 51 benign leiomyomas (43 ordinary leiomyomas, two cellular leiomyomas and six degenerated leiomyomas). Qualitative analysis of non-enhanced and postcontrast MR images and DW images and quantitative measurement of ADC values were performed for each myometrial tumor. Both uterine sarcomas and cellular leiomyomas exhibited high signal intensity on DW images, whereas ordinary leiomyomas and most degenerated leiomyomas showed low signal intensity. The mean ADC value (10⁻³ mm²/s) of sarcomas was 1.17 ± 0.15, which was lower than those of the normal myometrium (1.62 ± 0.11) and degenerated leiomyomas (1.70 ± 0.11) without any overlap; however, they were overlapped with those of ordinary leiomyomas and cellular leiomyomas. In addition to morphological features on nonenhanced and postcontrast MR sequences, DW imaging and ADC measurement may have a potential ability to differentiate uterine sarcomas from benign leiomyomas.     

The role of diffusion-weighted MR imaging for differentiating benign from malignant bile duct strictures

Objectives

To assess the added value of diffusion-weighted imaging (DWI) to conventional magnetic resonance imaging (MRI) for differentiating benign from malignant bile duct strictures.

Methods

Twenty-seven patients with a benign stricture and 42 patients with a malignant stricture who had undergone gadoxetic acid-enhanced MRI with DWI were enrolled. Qualitative (signal intensity, dynamic enhancement pattern) and quantitative (wall thickness and length) analyses were performed. Two observers independently reviewed a set of conventional MRI and a combined set of conventional MRI and DWI, and receiver operating characteristic (ROC) curve analysis was assessed.

Results

Benign strictures showed isointensity (18.5–70.4 %) and a similar enhancement pattern (22.2 %) to that of normal bile duct more frequently than malignant strictures (0–40.5 % and 0 %) on conventional MRI (P?<?0.05). Malignant strictures (90.5–92.9 %) showed hypervascularity on arterial and portal venous phase images more frequently than benign strictures (37.0–70.4 %) (P?<?0.01) On DWI, all malignant strictures showed hyperintensity compared with benign cases (70.4 %) (P?<?0.001). Malignant strictures were significantly thicker and longer than benign strictures (P?<?0.001). The diagnostic performance of both observers improved significantly after additional review of DWI.

Conclusions

Adding DWI to conventional MRI is more helpful for differentiating benign from malignant bile duct strictures than conventional MRI alone.

Key points

? Accurate diagnosis and exclusion of benign strictures of bile duct are important. ? Diffusion-weighted MRI helps to distinguish benign from malignant bile duct strictures. ? DWI plus conventional MRI provides superior diagnostic accuracy to conventional MRI alone.     

磁共振弥散加权成像观察胰腺癌冷冻术后近期疗效的应用价值

目的 探讨采用磁共振弥散加权成像(MRI-DWI)评估胰腺癌冷冻术后肿瘤坏死及肿瘤残存的应用价值.方法 对接受冷冻治疗的26例胰腺癌患者行T1WI、T2WI常规MRI平扫、DWI序列及动态增强扫描.观察胰腺癌冷冻前后MRI信号改变.测量并比较正常胰腺、术前肿瘤组织及术后残存、坏死组织的表现弥散系数(ADC)值.评价肿瘤组织ADC值与肿瘤大小的相关性,不同肿瘤直径、肿瘤位置及分期表现ADC值的差异.结果 26例患者中16例肿瘤完全坏死,冷冻坏死的胰腺肿瘤组织在T1WI图像上呈低信号,T2WI呈高信号,DWI呈低信号,动态增强无强化.活性肿瘤组织残留9例(其中7例肿瘤直径＞5.0 cm),残留率为34.6％.ADC值由低到高依次为:术前胰腺肿瘤组织(1.022±0.126)×10-3 mm2/s、术后残存肿瘤组织(1.130±0.155)×10-3 mm2/s、正常胰腺组织(1.924±0.124)×10-3 mm2/s及术后坏死组织(2.312±0.214)×10-3 mm2/s.术前胰腺肿瘤组织ADC值与术后残存肿瘤组织相比,差异无统计学意义(P=0.452),与正常胰腺组织、术后坏死组织相比,差异有显著统计学意义(P＜0.001).胰腺肿瘤ADC值与肿瘤大小呈负相关(R=-0.43,P=0.027 2),与肿瘤位置、肿瘤分期无关(P=0.738 8,P=0.089 5).结论 DWI能有效鉴别胰腺癌冷冻治疗后的病灶坏死及残存,为进一步临床诊治提供依据.     

3.0T磁共振弥散加权成像在胰腺癌中的应用价值

目的:分析评价在3.0T磁共振非脂肪抑制憋气DWl序列在胰腺癌中的应用价值.方法-30例正常志愿者与30例经手术病理证实的胰腺癌患者,在3.0T磁共振上,术前行基于SE-EPI的非脂肪抑制憋气DWI序列,b值为0和600s/mm2,统计学比较分析正常胰腺、胰腺癌及远端炎症区的ADC值.结果:不同组织的ADC值从低到高依次为胰腺癌、正常胰腺、远端炎症,单因素方差分析显示不同组织的ADC值有明显统计学差异,F值为18.716,P值为0.0004,两两比较分析显示胰腺癌分别与正常胰腺及远端炎症的ADC值统计学有明显差异,P值分别为0.00483及0.00191.结论:在3.0T磁共振上,非脂肪抑制憋气DWI序列有助于病灶筛查,其ADC值能够较好的反映胰腺癌、正常胰腺及远端炎症的组织病理状态.     

The added value of diffusion-weighted MR imaging to MR cholangiopancreatography in differentiating malignant from benign extrahepatic biliary strictures

Purpose

To investigate the added value of diffusion-weighted imaging (DWI) to magnetic resonance cholangiopancreatography (MRCP) in differentiating benign from malignant extrahepatic biliary strictures.

Methods

Magnetic resonance examination including, T2-weighted imaging, MRCP and DWI using different b-values (0,500,800 s/mm²) were performed in 38 patients with suspicious extrahepatic biliary strictures. Apparent diffusion coefficient (ADC) value was calculated. The signal intensity of the lesions on DWI using b = 500 and 800 s/mm² was examined. Analysis of the DWI and MRCP images for the cause of the extrahepatic biliary stricutre was performed. Patients were further confirmed by histopathological diagnosis and follow up. Sensitivity, specificity, accuracy, positive predictive and negative predictive values were calculated for both the MRCP images and DWI.

Results

Of the 38 cases, 23 cases had malignant extrahepatic biliary strictures and 15 had benign strictures. DWI detected 21 out of the 23 malignant biliary strictures and 14 out of 15 benign biliary strictures. Malignant strictures more frequently appeared hyperintense than benign strictures on DWI using b-values of 500 and 800 s/mm². There was a significant difference in sensitivity (91.3% vs. 73%), specificity (93.3% vs. 64.7%), accuracy (92.1% vs. 73.6%), positive predictive value (95.4% vs. 81%), and negative predictive value (87.5% vs. 64.7%) between DWI and MRCP in differentiating biliary strictures.

Conclusion

Combined evaluation using DWI added to MRCP improves the differentiation of malignant from benign extrahepatic biliary strictures.