CTA与DSA诊断颅内动脉瘤的临床应用分析

目的 探讨以数字减影血管造影(DSA)为标准,评价头颈部CT血管造影检查(CTA)对颅内动脉瘤的诊断价值。方法 选取151例疑似脑动脉瘤患者,行CTA及DSA检查。以DSA检查结果为标准,评价CTA的诊断准确性。结果 经DSA检查确诊颅内动脉瘤的患者114例,CTA诊断检出率、特异度、灵敏度、阳性预测值、阴性预测值分别为95.61%、95.61%、100.00%、100.00%、88.10%。对于直径d <3 mm的动脉瘤,CTA的诊断准确性低于DSA (P=0.036)。CTA诊断时间为(16.21±2.14) min,短于DSA诊断时间(25.68±4.11) min(t=21.436,P <0.001)。结论CTA与DSA相比对颅内动脉瘤具有较高的灵敏度和特异度,但对于直径d <3 mm的动脉瘤,CTA的检出率和灵敏度会降低且CTA明显缩短了检查时间。     

多层螺旋CTA与DSA诊断颅内动脉瘤的对比研究

目的 探讨多层螺旋CT血管造影(multislice spiral CT angiography,MSCTA)对颅内动脉瘤的诊断价值.方法 回顾性分析32例经手术及DSA确诊的颅内动脉瘤16层CT血管成像资料,并与DSA进行对照.结果 32例共38个动脉瘤,其中6例为2个动脉瘤.MSCTA共发现34个动脉瘤, DSA发现36个动脉瘤.38个动脉瘤4个位于前交通动脉,7个位于大脑中动脉,9个位于后交通动脉,14个位于颈内动脉,4个位于椎动脉.结论 MSCTA可以作为外科治疗或介入治疗颅内动脉瘤的筛选方法.     

CTA与DSA诊断颅内动脉瘤的对比研究

目的通过与DSA对比,评价三维CT血管造影在颅内动脉瘤诊断中的价值。方法对30例因蛛网膜下腔出血高度怀疑动脉瘤破裂的病人行CTA检查,同期行DSA检查及可行的血管内栓塞治疗。比较CTA与DSA检出动脉瘤的敏感性、特异性和准确性以及在显示动脉瘤瘤颈和载瘤动脉关系上的优劣。结果CTA检出动脉瘤26个,对动脉瘤的敏感性为95.5%,特异性为87.5%,准确性为93.3%,与DSA比较无显著差异。CTA对动脉瘤细节及瘤颈的显示明显优于DSA。结论CTA能无创有效的诊断颅内动脉瘤,所提供的诊断信息对治疗方案的制订具有极大的帮助,CTA还特别适用于急症病人的动脉瘤筛查。     

CTA对颅内动脉瘤的诊断价值

目的 :探讨16层CTA对颅内动脉瘤的诊断价值。方法:CTA诊断30例颅内动脉瘤,所得原始CT数据传至Philips工作站后运用MPR、CPR、MIP、VR等技术行血管成像;30例颅内动脉瘤均行手术治疗,术后对照CTA检查的准确性。结果:30例患者手术发现动脉瘤36个,CTA发现35个,诊断符合率97.22%(35/36),未能显示的1个位于右大脑中动脉分支末梢,瘤径3 mm;CTA所示动脉瘤的位置、大小、形态、瘤顶指向、瘤颈宽窄、载瘤动脉、瘤体与周围结构关系,与术中所见一致。结论:16层CTA对Willis环周围瘤径3.0 mm以上的动脉瘤显示清晰,是一种准确、快速、价廉、无创的诊断颅内动脉瘤方法 ,可作为脑动脉瘤筛选及动脉瘤破裂致急性出血的首选检查方法。     

CTA对颅内微小动脉瘤的诊断价值并与DSA对照研究

目的：探讨16层螺旋CT血管成像和数字减影造影在颅内微小动脉瘤（VSD）诊断及治疗中的应用价值。方法：对843例原发性蛛网膜下腔出血的动脉瘤疑似患者行CTA和DSA检查。CTA后处理采用多平面重建（MPR）,最大密度投影（MIP）,容积再现（VR）。DSA常规摄正、侧位、双侧斜位片。结果：经手术及介入栓塞治疗证实39枚微小动脉瘤,CTA诊断36枚,DSA诊断35枚。减影后CTA与DSA比较,对瘤体直径≤3mm的VSA的判断,无明显统计学差异,敏感性为92.3%,特异性为85.7%,准确性为91.3%。结论：CTA诊断微小动脉瘤是一种可靠方法,在临床诊断上与DSA基本等同,在对临床治疗提供帮助上,CTA明显优于DSA。     

64层螺旋CTA在颅内动脉瘤夹闭术后评价中的应用价值

目的 评价64层螺旋CT血管造影(CTA) 在颅内动脉瘤术后复查中的临床应用价值. 资料与方法 对21例颅内动脉瘤患者接受手术治疗后行64层螺旋CTA检查,图像后处理方法包括多平面重组(MPR)、容积再现(VR)及最大密度投影重组(MIP). 结果 使用钛制动脉瘤夹者,64层螺旋CTA可以清楚显示动脉瘤体消失、载瘤动脉与动脉瘤夹之间的关系及动脉瘤夹的数量和位置. 结论 64层螺旋CTA可以作为采用钛制动脉瘤夹治疗患者的术后随访工具.     

64层螺旋CT脑血管成像对颅内动脉瘤的临床诊断价值

目的:探讨64层螺旋CT脑血管成像(CTA)对颅内动脉瘤的临床诊断价值。方法:对55例临床怀疑颅内动脉瘤的蛛网膜下腔出血患者行64层螺旋CT脑血管成像检查,观察其原始图像及采用VR、MIP、MPR技术重建三维脑血管成像,部分病例同DSA或手术所见对照。结果:55名自发性蛛网膜下腔出血患者中,共检出动脉瘤患者47例,动脉硬化、狭窄3例,正常5例。CTA表现与手术结果、DSA基本一致。结论:64层螺旋CT脑血管成像能清晰的显示颅内动脉瘤的部位、大小、形态、瘤颈、与载瘤动脉及邻近血管及骨结构的关系,对颅内动脉瘤诊断敏感性及特异性较高,对绝大部分动脉瘤能迅速、准确地诊断,对临床治疗方案的制定有重要指导作用,并可作为术后复诊和随诊的重要手段。     

双源CTA在颅内动脉瘤中的应用价值

目的:探讨双源CT血管造影(DSCTA)在颅内动脉瘤中的临床应用价值.方法:22例颅内动脉瘤患者行双源CTA检查,分别对双能量去骨法与常规法获得的重建图像按0～5级进行质量评分并记录后处理时间,进行配对样本t检验.以DSA为标准,,评估DSCTA的敏感性、特异性.结果:共检出动脉瘤30个.双能量法平均后处理时间明显少于常规法(6.85±1.38min vs 13.20±2.02min,P<0.01).图像质量评分分别为4.35±0.50和3.23±0,36,有统计学显著性差异(P<0.05).与DSA对照,双能量法和常规法检出率分别为100%和85.7%.按动脉瘤个数计算,DSCTA的敏感性为93.4%,特异性为100%.结论:双源CT的双能量CTA与DSA有高度一致性,可替代DSA而成为颅内动脉瘤筛选及术后随访的首选检查方法.     

64层螺旋CTA在颅内动脉瘤术前及术后的应用价值

目的：探讨64层螺旋CT血管造影（CTA）对颅内动脉瘤术前诊断及术后评价的应用价值。方法：回顾性分析临床怀疑为颅内动脉瘤患者25例,行64层螺旋CTA检查,其中21例诊断为动脉瘤,并经手术证实,术后亦行CTA复查,通过比较两次CTA结果评价动脉瘤夹闭情况。结果：在25例患者中共发现21例25个动脉瘤,CTA可清楚显示的动脉瘤位置、大小形态及与周围结构的关系,与手术所见一致（符合率100％）;术后CTA能够清楚显示动脉瘤体消失,载瘤动脉与动脉瘤夹之间关系及动脉瘤夹的数量和位置。结论：64层CTA在诊断颅内动脉瘤及动脉瘤术后随访中具有重要临床价值。     

MSCT血管成像对颅内动脉瘤的临床应用与手术对比分析

目的 研究MSCTA诊断颅内动脉瘤的方法及临床应用价值.方法 回顾性分析34例颅内动脉瘤患者资料,运用最大密度投影法(MIP)、多平面重建(MPR)、容积显示法(VR)技术进行三维重建,并与手术结果对比.结果 34例患者中,其中2例MSCTA未发现动脉瘤,32例患者MSCTA发现颅内动脉瘤为36个,与手术结果一致.结论 MSCTA检查一旦发现动脉瘤,不需要其它影像检查,临床医生便可以制定治疗方案.MSCTA没有发现动脉瘤而临床又高度怀疑的,DSA检查是非常有价值的.     

Whole-brain CT digital subtraction angiography of cerebral dural arteriovenous fistula using 320-detector row CT

Introduction

The purpose of this study was to evaluate the usefulness of CT digital subtraction angiography (CTDSA) by using 320-detector row CT in the diagnosis and classification of cerebral dural arteriovenous fistula (dAVF) and comparing it with DSA as the standard reference.

Methods

A total of 29 CTDSA/DSA from 25 patients with dAVF were retrospectively evaluated by two neuroradiologists. The presence, Cognard classification, and feeding arteries of dAVFs on CTDSA were assessed according to DSA.

Results

DSA depicted 33 dAVFs in 28 cases. By consensus reading, CTDSA correctly detected 32 dAVFs in 27 cases and properly graded 31 lesions. The intermodality agreement for the presence and classification of dAVFs was excellent (kappa?=?0.955 and 0.921, respectively). CTDSA detected 77 of 109 feeding arteries (70.6 %) in 25 cases. The intermodality agreement for the feeding arteries was good (kappa?=?0.713).

Conclusion

Although CTDSA is limited in temporal and spatial resolution in comparison with DSA, it is an effective non-invasive tool for the detection and classification of dAVF.     

Comparison of the accuracy of subtraction CT angiography performed on 320-detector row volume CT with conventional CT angiography for diagnosis of intracranial aneurysms

Objective

The accuracy of diagnosis of intracranial aneurysms by subtraction computed tomography angiography (CTA) was compared with conventional non-subtracted CTA and with digital subtraction angiography (DSA).

Methods

56 patients with spontaneous subarachnoid hemorrhage (SAH) and suspected intracranial aneurysms were evaluated from September 2009 to January 2010. All underwent 320-detector row volume CT-CTA examinations. Non-contrast CT of each patient's head with the same scan range was performed before the routine CTA scan as the mask image for subtraction. The subtraction CTA volume data was obtained by subtracting the mask image volume data from the conventional non-subtracted CTA volume data. Subtraction and conventional CTA volume data were transmitted to a VOXAR workstation and two physicians with experience in diagnostic imaging of the nervous system independently carried out image post-processing and judged the results. Neurosurgeons performed endovascular treatment or surgical clipping based on information available through the CTA alone.

Results

In 42 patients, 51 aneurysms were detected by DSA. On a per-aneurysm basis, the diagnostic sensitivity of subtraction CTA was 98.9% for physician 1 and 100% for physician 2. The sensitivity of conventional CTA was 93.7% for physician 1 and 92.6% for physician 2. There was excellent inter-observer agreement (κ = 0.84, 95% confidence interval 0.82–0.85). The overall sensitivity, specificity, positive predictive and negative predictive values of subtraction CTA were all 100%. The overall sensitivity, specificity, positive predictive and negative predictive values of non-subtracted CTA were 94%, 100%, 100% and 76%, respectively. Therapeutic decisions could be made for all 42 patients based on subtraction CTA images, whereas conventional non-subtracted CTA provided sufficient information to make therapeutic decisions for only 35 patients.

Conclusion

Conventional CTA has lower sensitivity for the detection of very small aneurysms and aneurysms adjacent to the skull when compared to subtraction CTA. Subtraction CTA performed on a 320-detector row volume CT is an accurate diagnostic tool that provides data equivalent to that obtained with three-dimensional-DSA for the detection of intracranial aneurysms.     

Aortoiliac and lower extremity arteries assessed with 16-detector row CT angiography: prospective comparison with digital subtraction angiography

PURPOSE: To prospectively compare the accuracy of 16-detector row computed tomographic (CT) angiography with conventional digital subtraction angiography (DSA) as the reference standard in the assessment of aortoiliac and lower extremity arteries in patients with peripheral arterial disease. MATERIALS AND METHODS: This study was approved by the institutional review board, and informed consent was obtained. A total of 39 consecutive patients (27 men [mean age, 66 years] and 12 women [mean age, 64 years]) with peripheral arterial disease underwent both conventional DSA and 16-detector row CT angiography. For data analysis, the arterial vascular system was divided into 35 segments. A total of 1365 arterial segments were analyzed for arterial stenosis by two independent blinded readers using a four-point grading system (grade 1, <10% luminal narrowing; grade 2, 10%-49% luminal narrowing; grade 3, 50%-99% luminal narrowing; grade 4, occlusion). Interobserver agreements were calculated by using kappa statistics. A third independent blinded reader assessed possible reasons for disagreements between 16-detector row CT angiographic findings and conventional DSA findings. Effective radiation dose was calculated for both imaging modalities. RESULTS: Sixteen-detector row CT angiographic and conventional DSA findings were diagnostic in all vascular segments. Compared with conventional DSA, the sensitivity and specificity of 16-detector row CT angiography with regard to detection of hemodynamically significant stenosis in all 35 arterial segments were 96% and 97%, respectively, for both readers. Readers 1 and 2 overestimated arterial stenosis in 42 (3%) and 34 (2%) arterial segments, respectively, and underestimated arterial stenosis in 13 (1%) and 10 (1%) arterial segments, respectively. Interobserver agreement was excellent (kappa = 0.84-1.00). Presence of anteroposteriorly located luminal narrowing and extensive vascular wall calcification were considered main reasons for disagreements between imaging modalities. Effective radiation dose was lower for 16-detector row CT angiography (1.6-3.9 mSv) than for conventional DSA (6.4-16.0 mSv). CONCLUSION: Sixteen-detector row CT angiography is an accurate and reliable noninvasive alternative to conventional DSA in the assessment of aortoiliac and lower extremity arteries in patients with peripheral arterial disease.     

320排容积CT冠状动脉血管成像在心律失常患者的应用

目的 评价320排CT容积扫描在心律失常(房颤和室性早搏)患者冠状动脉CT血管成像(CTCA)的可行性及其图像质量.方法 31例持续房颤和8例室性早搏患者.经320排CTCA检查.由2名有经验的放射科医师对CT图像质量(4级评分)进行评价,分析图像质量与患者的辐射剂量.2名评价者之间的一致性采用Kappa检验.结果 31例持续房颤和8例室性早搏患者中可评估的冠状动脉血管510段,其中496段(97.2％)达到诊断要求.患者的平均辐射剂量为(12.7±4.8)mSv.2名评价者对冠状动脉评分的一致性较好(Kappa=0.72).结论 房颤和室性早搏患者的CTCA检查具有可行性,心律失常患者可以不作为检查的禁忌证,但仍须进一步降低辐射剂量.     

320排容积CT冠状动脉血管成像前瞻性心电门控最佳重建时相的初步研究

目的 探讨320排容积CT(320-DVCT)冠状动脉血管成像前瞻性心电门控最佳重建时相,初步评价其对图像质量、曝光剂量及诊断准确性的影响.方法 对77例行DVCT心功能扫描的患者[平均扫描心率(70±13)次/min( bpm),范围46～ 102 bpm]做回顾性心电门控扫描,分析最佳重建时相与心率的关系.利用不同心率最佳重建时相作为前瞻性心电门控扫描曝光时相,对53例需接受冠状动脉导管造影的患者[平均扫描心率(75±11) bpm,范围57～114 bpm]同时行冠状动脉CT成像,评价曝光时相对图像质量、曝光剂量及诊断准确性的影响.图像质量评分随机区组多样本比较采用Friedman检验,双变量统计行直线回归分析及Spearman相关分析.结果 随着心率的增加,收缩期比例逐渐增高(r=0.78,P＜0.01).收缩期与舒张期最佳重建图像质量随着心率的增加明显下降(r分别为0.38、0.82,P均＜0.01).根据回归方程分析,最佳重建时相按心率分组如下:心率＜ 70 bpm,65％～80％;70～80 bpm,70％ ～85％;81 ～90 bpm,70％～90％;＞90 bpm,35％ ～ 50％.利用上述最佳重建时相行前瞻性心电门控扫描结果表明,前瞻性心电门控扫描较回顾性心电门控扫描明显降低辐射剂量[分别为(6.1±3.8)和(12.4±7.0) mSv,t=6.5,P＜0.01],对诊断准确性并无明显影响.但是随着心率的增加,前瞻性心电门控扫描辐射剂量仍会明显增加(r=0.64,P＜0.01).结论DVCT可在更宽心率范围内应用前瞻性心电门控扫描技术对冠状动脉进行准确诊断;但在高心率条件下需要多个心动周期扫描,辐射剂量明显增加,建议尽可能降低患者心率以降低辐射剂量.     

Intracranial intravenous digital subtraction angiography

Summary Intravenous digital subtraction angiography (iDSA) promises to significantly alter the use of conventional cerebral angiography in the workup of neurological patients. Understanding its diagnostic potential and its limitations are important in incorporating this new examination into the diagnostic thought process of neuroradiologic tests. Different image processing techniques such as integration of mask and contrast images promise to improve image quality for neuroradiologic application. At present, iDSA is suitable for the diagnosis and follow-up of vascular lesions (atherosclerosis, aneurysms, arteriovenous malformations, venous sinus occlusion), and tumor (meningioma). Although limited, the spatial resolution of iDSA studies is capable of demonstrating diffuse vascular disease such as arteritis and vasospasm after subarachnoid hemorrhage. In some patients in conjunction with the CT scan, iDSA may prove sufficient as the primary and only diagnostic angiographic test necessary, supplanting conventional angiography.Supported by NJH Contract 1 RO1HL 25905-O1A1     

Intracranial stenoocclusive disease: double-detector helical CT angiography versus digital subtraction angiography.

BACKGROUND AND PURPOSE: To our knowledge, no large-scale studies comparing the accuracy of CT angiography (CTA) to intraarterial digital subtraction angiography (DSA) of intracranial stenosis have been reported. We attempted to determine the diagnostic value of intracranial CT angiography (CTA) of normal vasculature and variants as well as of stenoocclusive disease. METHODS: One-hundred and twelve patients underwent CTA and intraarterial angiography, and 2205 vascular segments were examined to ascertain presence, visibility, and degree of arterial stenoses (n = 105) as well as anatomic variants. Source, maximum intensity projection (MIP), and MIP-generated multiplanar reformatted (MPR) images were evaluated. RESULTS: All 55 anatomic variants were identified correctly. Visibility of small-vessel segments was increased from 75% to 83% by using source images. MPR was helpful in differentiating distal vertebral hypoplasia from stenosis and in overcoming artifacts. All 43 occlusive segments were graded correctly (sensitivity = 100%, predictive value = 93.4%) as follows: severely stenotic ([n = 23], sensitivity = 78%, predictive value = 81.8%); moderately stenotic ([n = 36], sensitivity = 61%, predictive value = 84.6%); and mildly stenotic ([n = 3], sensitivity = 66%, predictive value = 28%). Normal segments (n = 2100) had a sensitivity of 99.5%, and CTA evinced a specificity of 99% for detecting stenoocclusive disease. Approximately one-third of wrong assessments were related to the petrous segment of the carotid artery. CONCLUSION: CTA with double-detector technology and advanced postprocessing algorithms, including MPR, is about as reliable as MRA in depicting the vasculature of the anterior and posterior circulation and in grading intracranial stenoocclusive lesions, with the exception of the petrous segment of the carotid artery. CTA might be superior to MRA in the evaluation of poststenotic low-flow segments.     

数字减影CT血管成像与三维数字减影血管造影(DSA)技术检测颅内动脉瘤的比较研究

目的评价数字减影CT血管成像技术对颅内动脉瘤诊断的准确度,将三维旋转数字减影血管造影(DSA)技术作为参考标准,进行单中心大队列样本的研究。材料与方法本研究免除机构审查委员会批准,因为它本质上是回顾性的