影响药物流产效果的因素分析

目的：分析影响药物流产的各种因素,寻找药物流产的最适合条件,提高药物流产成功率。方法：对我院2004年6月—2007年10月要求药物流产终止妊娠的1768例早孕妇女进行分析,从年龄、停经天数、孕囊大小、子宫位置、孕产次、体重、子宫宫颈手术史与流产效果的关系进行分析。结果：总的药物流产失败率为12.6%,药流失败因素为年龄≥35岁,肥胖、停经≥45天,孕囊径线≥20mm,子宫后倾后屈,剖腹产手术史,宫颈物理治疗史。结论：对存在上述因素的早孕妇女慎用药物流产,提高药物流产成功率。     

影响药物流产成功率因素的临床观察及分析

目的探讨分析药物流产失败的原因。方法对389例在我院门诊行药物终止妊娠妇女的年龄、既往分娩方式、孕囊直径、子宫位置、孕产次数、孕龄等资料进行回顾性分析。结果年龄≥35岁、孕囊直径≥2cm、子宫前屈、后倾后屈位、孕产次数增多、停经大于49d者,药物流产失败率明显增高,自然分娩史与剖宫产史者药物流产率无明显差异。结论药物流产的效果受妇女的年龄、孕囊直径、子宫位置、孕产次数、孕龄的影响,自然分娩史与剖宫产史者药物流产的效果无明显差异;临床医生应严格掌握药物流产适应证及禁忌证,对人工流产高危因素者首选药物流产,药物流产失败及时行人工流产或清宫术。     

药物流产安全性的临床分析

目的 分析影响药物流产安全性的相关因素.方法 对275例在我院门诊行药物终止妊娠妇女的年龄、孕囊直径、子宫位置、孕产次数、孕龄、既往分娩方式等资料进行回顾性分析.结果 年龄≥35岁、孕囊直径≥20mm、子宫后倾后屈位、孕产次数多、停经大于49d者,药物流产失败率明显增高,自然分娩史与剖宫产史者药物流产率无明显差异.结论 药物流产的效果受妇女的年龄、孕囊直径、子宫位置、孕产次数、孕龄的影响,自然分娩史与剖宫产史者药物流产的效果无明显差异;在临床中,医生除应严格掌握药物流产适应证和禁忌证外,还要根据以上几种情况进行选择,以提高药物完全流产率.     

影响药物流产失败的相关因素调查

目的对药物流产失败的相关因素进行调查和分析,旨在为提高药物流产的成功率提供进一步的指导依据。方法对我所诊治的1800例行药物流产的患者根据年龄、孕龄、孕囊直径、子宫位置、有无剖宫产史进行分组比较各组的流产失败率。结果本组入选的1800例药物流产患者中,发生药物流产失败者共142例,流产失败率为7．89％。其中年龄≥35岁,孕龄〉42d,孕囊直径≥20mm,子宫处于后倾、前倾及后屈位以及有剖宫产史组患者的流产失败率明显高于相应的对照指标组（P〈0．05）。结论重视孕妇的年龄、孕龄、既往分娩方式、子宫位置、孕囊大小等相关影响药物流产失败的因素,才更有利于降低药物流产的失败率。     

影响药物流产效果的相关因素分析

目的 探讨某些相关因素对药物流产临床效果的影响.方法 回顾近3年笔者所在医院720例经米非司酮配伍米索前列醇终止妊娠的临床资料,分析药物流产者的孕产次、孕囊直径、子宫位置、年龄、剖宫产史、哺乳期妊娠与药物流产效果的关系.结果 年龄≥35 岁,既往有剖宫产史,孕产次≥2次,孕囊直径≥20 mm,子宫后倾后屈,哺乳期妊娠的药物流产效果较差.结论 药物流产不全及失败率与年龄、孕囊直径、子宫位置、孕产次、剖宫产史、哺乳期妊娠有一定关系.药物流产的效果受上述因素的影响,对存在这些因素的患者应慎重选择药物流产.     

米非司酮配伍米索前列醇流产成功相关因素分析

目的：探讨米非司酮配伍米索前列醇流产（药物流产）成功相关因素。方法：选取孕80天以内药物流产病例,计算流产成功率与Х^2检验。结果：不同年龄组药物流产成功率相比无显著性差异（P〉0．05）,停经≤49天药物流产成功率明显高于对照组（P〈0．05）,初孕与复孕组间药物流产成功率无显著性差异（P〉0．05）,但与多次妊娠史组相比差异有极显著性（P〈0．01）,孕囊直径〈23mm组药物流产成功率明显高于对照组（P〈0．01）。结论：药物流产成功率与年龄无关,与妊娠天数及孕囊直径大小有关,初孕与复孕药物流产成功率之间差异不显著,但与多次妊娠药物流产成功率相比差异显著。     

药物流产的临床防治与原因分析

目的 分析药物流产失败的原因.方法 对2248例在门诊药物流产妇女的年龄、孕囊直径、子宫位置、分娩史、经期、孕龄进行分析.结果 年龄>35岁、有剖宫产史、孕囊直径>2cm、子宫后倾后屈位、经期>5d,停经40～49d者,药物流产失败率明显增高.结论 药物流产的效果受妇女的年龄,分娩史、孕囊直径、子宫位置、经期时间、孕龄的影响.     

影响药物流产效果的相关因素分析

目的探讨影响药物流产效果的相关因素,以指导患者选择终止早孕的方法,预防药物流产后的并发症。方法回顾性分析395例药物流产者的年龄、孕囊直径、子宫位置、孕产次、剖宫产史与药物流产效果的关系。结果年龄≥35岁,既往有剖宫产史,孕产次≥3次,孕囊直径≥20mm,子宫极度后倾,药物流产效果不好。结论药物流产的效果受上述因素的影响,对存在这些因素的患者应尽量避免选择药物流产。     

探究影响药物流产效果的相关因素

目的：探讨分析影响药物流产效果的相关因素。方法：选取2010年10月～2013年10月间我院收治的要求终止妊娠的孕妇200例作为研究对象,对其实施药物流产,观察总结导致流产成功或失败的原因,并将总结的结果及所有孕妇的临床资料进行回顾性的分析。结果：在这200例孕妇中,完全流产者有182例（占孕妇总数的91.0%）,不完全流产者有11例（占孕妇总数的5.5%）,流产失败者有7例（占孕妇总数的3.5%）。停经天数≥50d孕妇的药流失败率明显高于停经天数＜50d的孕妇,差异显著（P＜0.01）,具有统计学意义。胎囊最大径线＞25mm孕妇的药流失败率明显高于胎囊最大径线≤25mm的孕妇,差异显著（P＜0.01）,具有统计学意义。合并后位子宫孕妇的药流失败率明显高于前位或水平位子宫的孕妇,差异显著（P＜0.01）,具有统计学意义。合并慢性盆腔炎孕妇的药流失败率明显高于无炎症病变的孕妇,差异显著（P＜0.01）,具有统计学意义。结论：胎囊的最大径线＞25mm、停经的天数≥50d、合并后位子宫及慢性盆腔炎是导致药流失败的重要因素。     

影响药物流产效果的因素分析

目的:探讨影响药物流产效果的因素.方法:回顾性分析600例在门诊行药物终止妊娠健康妇女的年龄、既往分娩方式、孕产次、孕龄、孕囊直径、子宫位置、经期时间、妊娠反应、合并胃肠疾病、文化程度等资料.结果:年龄＞35岁、有剖宫产史、停经40～49d者、孕囊直径＞2cm、子宫后倾及后倾后屈位、经期＞5d,有明显妊娠反应、合并胃肠疾病、文化程度低者、药物流产失败率明显增高.结论:药物流产的效果受孕妇的年龄、分娩史、孕龄、孕囊直径、子宫位置、经期时间、有无明显妊娠反应、合并胃肠疾病的影响.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.