氢质子波谱在阿尔茨海默病中的价值

Objective To study the diagnosis value of proton magnetic resonance spectroscopy(1H-MRS)in Alzheimer disease(AD).Methods Using stimulated echo acquisition mode,29 AD patients and 20 elderlv healthy ones as control group were underwent with Magnetic ResonaJlce Spectrum (MRs)examination in hippocampus,temporal parietal cortex and cingulate gyrus,the metabolites of MRS were analvzed to have N-aeetyl aspartate(NAA),creatine(Cr),choline(Cho),myo-inositol (mI),and comDarle the ratio of each other as well as the difference between the two groups.Rmulta NAA of AD patients in hippocampus,temporal parietal cortex and ringulate gyrus were(0.40±0.06),(0.42±0.06),(0.43±0.08),respectively, and have no significant difference to the healthy group(P＞0.05);mI were(0.25±0.08).(0.23±0.06),(0.21±0.05),respectively,and have significant difference to the healthy group(P＜0.05):NAA/Cr werle(1.30±O.10),(1.40±0.11),(1.42±0.12),respectively,and have no significant differenoe to the healthy group(P＞0.05);mI/Cr were,(0.81±0.07),(0.78±0..08),(0.70±0.06),respectively,and have significant difference to the healthy group(P＜0.05);mI,NAA were(0.61±0.06),(0.55±0.08),(0.49±0.07),respeetively,and have significant difference to the healthy group(P＜0.05).In AD patients,NAA,NAA/Cr decrease and mI,mI/Cr,mI/NAA increase,and the value in hippocampus＞temporal parietal cortex＞cingulate gyrus.Conclusion The changes of MRS in AD patients,mainly reflected a decline in NAA and rise in mI,which has some reference in the diagnosis in AD.     

氢质子波谱在阿尔茨海默病中的价值

Objective To study the diagnosis value of proton magnetic resonance spectroscopy(1H-MRS)in Alzheimer disease(AD).Methods Using stimulated echo acquisition mode,29 AD patients and 20 elderlv healthy ones as control group were underwent with Magnetic ResonaJlce Spectrum (MRs)examination in hippocampus,temporal parietal cortex and cingulate gyrus,the metabolites of MRS were analvzed to have N-aeetyl aspartate(NAA),creatine(Cr),choline(Cho),myo-inositol (mI),and comDarle the ratio of each other as well as the difference between the two groups.Rmulta NAA of AD patients in hippocampus,temporal parietal cortex and ringulate gyrus were(0.40±0.06),(0.42±0.06),(0.43±0.08),respectively, and have no significant difference to the healthy group(P＞0.05);mI were(0.25±0.08).(0.23±0.06),(0.21±0.05),respectively,and have significant difference to the healthy group(P＜0.05):NAA/Cr werle(1.30±O.10),(1.40±0.11),(1.42±0.12),respectively,and have no significant differenoe to the healthy group(P＞0.05);mI/Cr were,(0.81±0.07),(0.78±0..08),(0.70±0.06),respectively,and have significant difference to the healthy group(P＜0.05);mI,NAA were(0.61±0.06),(0.55±0.08),(0.49±0.07),respeetively,and have significant difference to the healthy group(P＜0.05).In AD patients,NAA,NAA/Cr decrease and mI,mI/Cr,mI/NAA increase,and the value in hippocampus＞temporal parietal cortex＞cingulate gyrus.Conclusion The changes of MRS in AD patients,mainly reflected a decline in NAA and rise in mI,which has some reference in the diagnosis in AD.     

氢质子波谱在阿尔茨海默病中的价值

Objective To study the diagnosis value of proton magnetic resonance spectroscopy(1H-MRS)in Alzheimer disease(AD).Methods Using stimulated echo acquisition mode,29 AD patients and 20 elderlv healthy ones as control group were underwent with Magnetic ResonaJlce Spectrum (MRs)examination in hippocampus,temporal parietal cortex and cingulate gyrus,the metabolites of MRS were analvzed to have N-aeetyl aspartate(NAA),creatine(Cr),choline(Cho),myo-inositol (mI),and comDarle the ratio of each other as well as the difference between the two groups.Rmulta NAA of AD patients in hippocampus,temporal parietal cortex and ringulate gyrus were(0.40±0.06),(0.42±0.06),(0.43±0.08),respectively, and have no significant difference to the healthy group(P＞0.05);mI were(0.25±0.08).(0.23±0.06),(0.21±0.05),respectively,and have significant difference to the healthy group(P＜0.05):NAA/Cr werle(1.30±O.10),(1.40±0.11),(1.42±0.12),respectively,and have no significant differenoe to the healthy group(P＞0.05);mI/Cr were,(0.81±0.07),(0.78±0..08),(0.70±0.06),respectively,and have significant difference to the healthy group(P＜0.05);mI,NAA were(0.61±0.06),(0.55±0.08),(0.49±0.07),respeetively,and have significant difference to the healthy group(P＜0.05).In AD patients,NAA,NAA/Cr decrease and mI,mI/Cr,mI/NAA increase,and the value in hippocampus＞temporal parietal cortex＞cingulate gyrus.Conclusion The changes of MRS in AD patients,mainly reflected a decline in NAA and rise in mI,which has some reference in the diagnosis in AD.     

轻度认知功能障碍患者认知功能与氢质子磁共振波谱的相关性

目的 探讨轻度认知功能障碍(MCI)患者认知功能与氢质子磁共振波谱(1H-MRS)的相关性.方法 选取2020年1月至12月在沈阳市精神卫生中心住院及门诊就诊的20例MCI患者作为MCI组,选取同期在医院住院和门诊就诊的15例阿尔茨海默病(AD)患者作为AD组,选取同期认知功能正常的20例老年志愿者作为对照组.对三组研...     

氢质子磁共振波谱在脑肿瘤中的应用现状分析

磁共振波谱（magnetic resonance spectroscopy,MRS）是一种利用核磁共振现象和化学位移作用对一系列特定原子核及其化合物进行分析的方法,是目前对人体惟一无创性、用以研究器官、组织代谢、生化改变及化合物分析的方法.它能够反映肿瘤独特的代谢过程和方式.当今,MRS已广泛应用于磁共振（MR）常规检查中,并且取得了很大进展.     

磁共振氢质子波谱成像对新生儿缺氧缺血性脑病的诊断价值

新生儿缺氧缺血性脑病(HIE)是指围生期时由于母亲因素、胎盘、脐带异常、分娩用药、产程延长、新生儿本身呼吸、循环、CNS疾病等所有引起窒息的原因导致的脑缺氧缺血性损伤,而临床出现一系列中枢神经异常的表现.因为缺血缺氧致使患儿留有不同程度的神经系统后遗症,如智力发育障碍、癫痫、脑瘫等.MRI以无创、无辐射及任意方位成像的手段不仅从解剖角度反映新生儿脑部变化,而且磁共振氢质子波谱成像(HMRS)从脑内代谢产物变化规律的角度反映病程的演变,此技术能在HIE早期从分子水平和代谢水平的方面反映其变化,进行HIE病变性质与程度评价.     

氢质子磁共振波谱在胶质瘤中的应用进展

随着磁共振(MR)成像技术的发展,不仅能显示脑肿瘤精细的解剖结构,而且也能显示肿瘤的代谢特征。磁共振波谱(MRS)是一种无损伤性研究人体正常或病理组织代谢、生化改变及化合物定量分析的方法,其特异性强。因肿瘤代谢变化早于结构变化,MRS提供代谢方面的变化比磁共振成像(MRI)所     

颅脑不同区域磁共振波谱分析在精神分裂症中的价值

目的探讨质子磁共振波谱（1H—MRS）在精神分裂症中的诊断价值。方法采用点分辨解析采样方式对26例精神分裂症患者和25例健康志愿者的左右侧额叶、海马和丘脑行MRS检查,分析的代谢产物有N～乙酰天门冬氨酸（NAA）、肌酸（cr）、胆碱（Cho）及相互间比值在两组间的差别。结果精神分裂症患者在左额叶、右额叶、左海马、右海马、左丘脑和右丘脑的NAA／Cr分别为1．41±0．33、1．40±0．36、1．43±0．27、1．42±0．26、1．46±0．30、1．45±0．28,低于健康组对应位置,但差异无统计学意义（P〉0．05）;Cho／cr分另4为1．36±0．38、1．37±0．29、1．30±0．31、1．31±0．28、1．20±0．20、1．22±0．19,高于健康组对应位置,但差异无统计学意义（P〉0．05）;NAA／（Cho＋Cr）分别为0．60±0．14、0．61±0．16、0．62±0．20、0．63±0．23、0．66±0．18、0．66±0．21,明显低于健康组对应位置,且二组差异有统计学意义（P〈0．05）。精神分裂症患者NAA／Cr、NAA／（Cho＋Cr）的下降幅度和Cho／Cr的上升幅度,额叶〉海马〉丘脑。结论精神分裂症患者MRS改变,主要体现在NAA的下降和Cho的上升,对精神分裂症的诊断有一定的参考作用。     

氢质子磁共振波谱联合磁共振成像诊断脑胶质瘤的临床意义

目的：分析氢质子磁共振波谱（IH-MRS）联合磁共振成像（MRI）在脑胶质瘤中的效果。方法：选取该院2020年5月—2021年5月诊治的82例脑胶质瘤患者,按病理分型将患者分为低级别组（48例）与高级别组（34例）。所有患者均施行IH-MRS联合MRI检查,分析MRI扫描结果,并比较不同级别脑胶质瘤代谢物指标[胆碱（Cho）、肌酸（Cr）、N-乙酰天门冬氨酸（NAA）]。结果：MRI扫描显示,低级别脑胶质瘤与高级别的瘤周水肿区水肿情况及强化程度比较,差异无统计学意义（P>0.05）。高级别脑胶质瘤的脑肿瘤实质区与瘤周水肿区的Cho/Cr、Cho/NAA均高于低级别脑胶质瘤,差异有统计学意义（P<0.05）。结论：IH-MRS联合MRI在脑胶质瘤的鉴别诊断中具有较高的价值,可通过定量检测结果评估肿瘤的恶性程度。     

海马磁共振波谱分析在颞叶癫痫症中的价值

目的探讨海马氢质子磁共振波谱分析（1H—MRS）在颞叶癫痫症中的应用价值。方法采用PhihpsAchieva1．5T双梯度磁共振扫描仪,对38例颞叶癫痫患者和20例健康志愿者行颅脑MRI和海马’H—MRs检查,观察NAA、Cr、Cho浓度和NAA／（Cho＋Cr）、NAA／Cr和NAA／Cho值。分别对癫痫患者病灶侧与正常侧,病灶侧与正常对照组海马的NAA／（Cho＋Cr）、NAA~r和NAA／Cho值进行t检验,分析两者之间差异有无显著性。结果癫痫患者组癫痫侧、正常侧和对照组海马的NAA／（Cho＋Cr）值分别为（O．424-0．06）、（0．67±0．09）、（O．72±0．07）,癫痫组癫痫侧与正常侧、对照组比较差异有显著性（尸〈0．05）,而正常侧与对照组比较差异无显著性（尸〉0．05）。以NAA／fCho＋c0来检出癫痫,灵敏度曲线呈现低一高一低的变化,在0．60时,灵敏度最高。结论-H—MRS不仅能早期诊断海马硬化,而且可进一步提高术前癫痫灶定位的准确性。     

不同运动障碍亚型原发性帕金森病质子磁共振波谱研究

目的研究不同运动障碍亚型原发性帕金森病（Idiopathic Parkinson＇s Disease,IPD）壳核和黑质质子磁共振波谱（IH—MRS）变化,探讨1H—MRS在IPD诊断及分型诊断的价值。方法对42例PD患者进行运动障碍评分并进行临床分型,依据主要运动症状分为震颤为主型PD（24例）、姿势异常步态障碍（PIGD）PD（18例）两组,健康对照组20例,对各组双侧壳核、黑质进行1H—MRS检测,计算其双侧N-乙酰基天门冬氨酸（NAA）／肌酸（Cr）和胆碱复合物（Cho）／Cr平均值。结果PD组双侧壳核、黑质NAA／Cr平均值较健康对照组明显下降（P〈0．01）,而Cho／Cr均值略高于健康对照组,但差异无显著性;震颤为主型PD组双侧壳核NAA／Cr均值高于强直少动型PD（P〈0．01）,而黑质的NAA／Cr两型间无统计学差异;震颤为主型PD组壳核、黑质区Cho／Cr比值略低于强直少动型PD,但差异无显著性。结论原发性帕金森病壳核、黑质NAA／Cr降低,尤以强直少动型PD壳核NAA／Cr下降明显;1H—MRS有望成为PD诊断及不同运动障碍亚型分型诊断的辅助方法。     

临床孤立综合征磁共振波谱的临床应用

目的探讨氢质子磁共振波谱(1H-MRS)技术在临床孤立综合征(CIS)中的临床应用价值。方法对6例CIS患者和5名健康自愿者进行3.0TMRI和1H-MRS检查,测量CIS病灶组、病灶邻近或对侧表现正常脑白质组(NAWM组)及自愿者正常脑白质组(对照组)主要代谢产物NAA、Cr、Cho、mI、Lac峰值,及NAA/Cr、NAA/Cho、Cho/Cr、mI/Cr的比值。结果 CIS病灶组、NAWM组NAA、Cr、Cho、mI峰下降,Lac峰升高,Lip峰变化不明显。病灶组、NAWM组NAA/Cr(分别为1.50±0.17、1.67±0.15)明显低于对照组(1.82±0.08,P<0.01);病灶组NAA/Cho(1.40±0.28)亦显著低于NAWM组(1.79±0.16)及对照组(2.10±0.25,P<0.001);病灶组的Cho/Cr(1.09±0.14)显著高于NAWM组(0.93±0.02)及对照组(0.83±0.11,P<0.001);病灶组和NAWM组的mI/Cr则与对照组无差异。结论 1H-MRS可反映CIS病灶的代谢异常、NAWM的早期生化代谢改变,对CIS患者神经功能损伤、疗效评价及预后判断有重要价值。     

氢质子磁共振波谱在脑星形细胞瘤强化区中的应用

目的探讨氢质子磁共振波谱(1H-MRS)在脑星形细胞瘤强化区中代谢物特点及其与病理分级的相关性。方法选择26例脑星形细胞瘤患者,经病理证实的低级别星形细胞瘤(LGA)12例、间变性星形细胞瘤(AA)7例和胶质母细胞瘤(GBM)7例,并分成LGA组、AA组和GBM组3组。所有患者术前均行磁共振(MR)常规扫描和增强扫描,随后行二维多体素1H-MRS检查,检测肿瘤强化区及对侧正常参照区N一乙酰天冬氨酸(NAA)、胆碱(Cho)、肌酐(Cr)、乳酸(Lac)和肌醇(mI)代谢物浓度,比较3组间肿瘤强化区和各组内肿瘤强化区与对侧正常参照区NAA/Cr、Cho/Cr及NAA/Cho比值平均值变化情况。结果脑星形细胞瘤强化区波谱表现NAA下降,Cho升高,22例出现Lac峰,24例出现mI峰。脑星形细胞瘤3组各组内肿瘤强化区与对侧正常参照区NAA/Cr、Cho/Cr及NAA/Cho比值差异均有统计学意义(P<0.05)。强化区Cho/Cr比值在LGA组与AA组、GBM组之间差异均有统计学意义(P<0.05),Lac和mI在各组间差异均无统计学意义(P>0.05)。结论1H-MRS可提高对脑星形细胞瘤诊断及分级的准确性,并提供了一个定量分析的方法。     

阿尔茨海默病侧脑室角度变化的高场磁共振研究

目的 探讨阿尔茨海默病（AD）患者侧脑室角度的变化情况.方法 对2010年12月至2012年3月20例AD患者（AD组）及20例健康志愿者（对照组）行全脑磁共振成像扫描,对比分析其侧脑室角度的变化规律.结果 AD组双侧侧脑室前后角均较对照组增大,差异有统计学意义（P＜0.05）;双侧颞角宽度明显较对照组增大,差异有统计学意义（P＜0.001）.结论 侧脑室角度的变化可为AD的临床诊断提供可信的影像学依据,借助此思路可有助于AD的诊断.     

A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania

BACKGROUND: Several neurochemical abnormalities have been reported in bipolar disorder (BD), but the exact mechanisms that underlie its pathophysiology remain to be elucidated. Proton magnetic resonance spectroscopy (1HMRS) allows in vivo measurements of certain neurometabolites in the human brain. 1HMRS was used to investigate the dorsolateral prefrontal cortex (DLPFC) in bipolar subjects during a manic or mixed phase. N-acetyl-L-aspartate (NAA), choline-containing molecules (Cho), creatine plus phosphocreatine (Cr) and myoinositol (Ino) were measured. METHOD: Ten bipolar patients (nine manic, one mixed), diagnosed by a semi-structured clinical interview (SCID), and ten age- and gender-matched healthy volunteers were studied. Absolute neurometabolites levels were measured from two 8 cm3 voxels placed in left and right DLPFC using a short TE 1HMRS method at 1.5 T. T1- and T2-weighted anatomical magnetic resonance imaging was performed to exclude any neuroanatomical abnormality. RESULTS: No significant differences were found for NAA, Cho, Cr, Ino, NAA/Cr, Cho/Cr or Ino/Cr between patients and controls. Manic/mixed patients had significantly higher left-to-right myoinositol ratios in DLPFC (p = 0.044). CONCLUSIONS: Increased left-to-right myoinositol ratios in the DLPFC in bipolar patients during acute mania may represent a dysfunction in the phosphoinositide-signaling pathway. Longitudinal studies with larger samples of unmedicated patients assessing pre- and post-treatment times will be required for further clarification of the time course of these abnormalities and the relationship with treatment effects.