大剂量碘油治疗原发性巨块型肝癌的疗效分析

【目的】回顾性分析巨块型肝癌经肝动脉灌注化疗并大剂量碘油加化疗药栓塞治疗的临床疗效。【方法】150例原发性巨块型肝癌患者,经皮股动脉穿刺插管至肝动脉,化疗栓塞治疗肝癌;碘油用量为20～60 ml。再注入明胶海绵颗粒栓塞治疗。发现肝外肿瘤供血动脉,超选择插管化疗栓塞后,注入适量明胶海绵栓塞治疗。【结果】治疗的总有效率(RR)为77.3%,治疗后1、2、3年生存率分别为78%、59.3%、45.3%。介入术后未出现严重并发症。【结论】原发性巨块型肝癌大剂量碘油栓塞联合肝外肿瘤供血动脉介入治疗,对于提高疗效具有重要意义。     

肝动脉灌注药物加栓塞治疗60岁以上原发性肝癌49例分析

目的　观察肝动脉药物灌注加栓塞治疗６０ 岁以上老年患者原发性肝癌的疗效。方法　经肝总动脉或肝固有动脉灌注阿霉素５０ｍｇ 、丝裂霉素１０ｍｇ 、５ － Ｆｕ１０００ｍｇ ,再用明胶海绵微粒加碘油混合剂进行肿瘤血管栓塞治疗４９ 例６０ 岁以上原发性肝癌。结果　甲胎蛋白 Ａ Ｆ Ｐ 转阴１８ ％ ,明显下降的近４０ ％ ;生存期三个月为９８ ％ ,六个月为５４ ．５ ％ ,一年为２６ ．２ ％ ,两年以上为２ ．５ ％ 。结论　肝动脉灌注药物加栓塞治疗６０ 岁以上老年原发性肝癌效果良好,患者生存期明显长于全身化疗。     

肝动脉化疗栓塞治疗原发性肝癌疗效及影响因素分析

目的 探讨肝动脉灌注化疗加栓塞治疗原发性肝癌的临床疗效及影响疗效的因素。方法 对１９９４年９月至１９９８年９月间１０５例不能手术切除的原发性中晚期肝癌患者行选择性肝动脉插管灌注化疗加栓塞治疗。结果 肝动脉灌注化疗加栓塞治疗原发性中晚期肝癌的１,２,３,４ａ累积生存率分别为５５．２％,２２．９％,２．９％。其中１例存活５５个月以上。结论 肝动脉灌注化疗加栓塞是治疗不能手术切除的原发性肝癌的有效方法;     

肝动脉化疗栓塞配合无水酒清、白细胞介素Ⅱ治疗中晚期肝 …

目的：探讨肝动脉化疗栓塞（ＴＡＣＥ）配合无水酒精瘤内注射（ＰＥＩ）与ＴＡＣＥ合并灌注ＩＬ－２Ｉ治疗中晚期原发性肝癌的临床疗效。方法：采用Ｓｅｌｄｉｎｇｅｒ插管至肝肿瘤供血动脉行灌注化疗（卡铂０．３～０．５ｇ,Ｅ－ＡＤＭ６０～８０ｍｇ,５－Ｆｕ７５０～１０００ｍｇ）加碘没栓塞术。在治疗组介入治疗后２周,经Ｂ超引导下行经皮肝穿刺瘤内注入无水酒精。对照组经ＴＡＣＥ同时灌注ＩＬ－２。结果：治疗组有效率（Ｐ     

碘油抗癌药物乳剂栓塞治疗肝癌58例疗效分析

为探讨抗癌药物碘油乳剂栓塞治疗肝癌肿的疗效,对５８例经Ｂ超、ＣＴ、ＡＦＰ检查确诊的肝癌患者用碘油抗癌药物化疗栓塞剂经肝动脉栓塞治疗。结果８８％患者肿块有不同程度的缩小、坏死,１年生存率达６７％。表明碘油抗癌药物乳化剂栓塞是治疗肝癌是一种简便有效的方法,并能减少全身副作用。     

原发性肝癌介入化疗栓塞的治疗探讨

目的：探讨原发性肝癌介入化疗栓塞的治疗效果。方法：1996年1月—2001年10月，对76例中晚期原发性肝癌患者行超选择性插管化疗栓塞228例次，肝动脉化疗 碘化油栓塞26例；肝动脉化疗 碘化油 明胶海绵栓塞35例；肝动脉单纯灌注化疗15例。结果：化疗 碘化油 明胶海绵治疗效果最佳；化疗 碘化油治疗次之；单纯灌注化疗效果最差。本组患者6个月、1年、2年生存率分别为84．2％、59．2％、21．1％。结论：肝动脉化疗栓塞可作为不能切除的中晚期原发性肝癌患者常规治疗方法，经过治疗，在临床症状改善，肿瘤明显缩小者，可行积极采取二期手术切除。     

肝动脉化疗栓塞治疗原发性肝癌26例临床观察

目的 观察肝动脉化疗栓塞术对原发性肝癌的治疗效果。方法 采用seldinger法选择性或超选择性插管，注入抗肿瘤药物及超液态碘油、明胶海绵颗粒至肝肿瘤血管内进行化疗栓塞。结果 经治疗85％病人临床症状改善．疼痛减轻或消失，90．5％患者AFP转阴或降低，80．8％病人肿瘤缩小。结论 肝动脉化疗栓塞治疗原发性肝癌明显延长了患者生命，提高生存质量，疗效满意。     

肝动脉化疗栓塞术治疗原发性肝癌的临床研究

目的:分析肝动脉化疗栓塞术治疗原发性肝癌的临床疗效。方法:对2012年8月-2014年8月在我院住院的32例原发性肝癌患者进行回访,且这32例患者均采用肝动脉化疗栓塞术治疗,分析该治疗的疗效。结果:对原发性肝癌患者采取肝动脉化疗栓塞术后,患者1年、2年的生存率依次为78.8%、53.1%。影响疗效的因素有:肿瘤的大小、血供、数量与范围、分期、包膜、治疗方法、碘油沉积。结论:肝动脉化疗栓塞术治疗是无法手术的原发性肝癌的首选方法,肝功能分级、肿瘤数量及范围、门静脉栓塞是影响肝动脉化疗栓塞术治疗效果的重要因素,应该根据患者的具体情况,选择适合的手术方法进行治疗。     

肝外动脉参与供血的原发性肝癌TACE治疗

目的探讨原发性肝癌的肝外动脉供血规律,提高其在介入治疗肝癌中的意义。方法回顾性分析2015年1月至2016年1月我院320例原发性肝癌的肝动脉化疗栓塞术中的DSA资料。寻找肝癌肝外动脉的来源,并采用微导管超选择性行灌注化疗及栓塞治疗。结果共发现30例患者存在37条肝外动脉参入肿瘤供血。其中右膈下动脉11条,肠系膜上动脉分支8条,胃十二指肠动脉6条,胃左动脉4条,右肾上腺动脉3条,右侧内乳动脉2条,右结肠上动脉、胃网膜动脉、肋间动脉各1条。其中4例患者存在2条肝外肿瘤供血动脉。1例患者有3条肝外供血动脉,共30条供血动脉插管成功行灌注化疗及栓塞,26例插管成功栓塞良好的患者均取得较好疗效。结论肝外动脉供血的存在直接影响肝癌栓塞治疗的疗效,对原发性肝癌肝外供血动脉进行化疗栓塞能有效提高介入治疗的效果。     

供血动脉造影灌注化疗与栓塞治疗(附103例分析)

我院自１９９７年７月至１９９９年７月,共收治原发性中晚期肝癌１０３例,采用介入放射学治疗（经供血动脉造影灌注化疗与栓塞治疗）,获得较好疗效。本文对肝动脉解剖变异及肝癌多支供血的化疗灌注（ＴＡＩ）、肝动脉栓塞（ＴＡＥ）、化疗栓塞（ＴＡＣＥ）等进行探讨。临床资料　　１．一般资料　本组１０３例中,男７５例,女２８例;年龄２５～７７岁,平均４６．３岁;均为原发性中晚期肝癌患者,其中肿块型５６例,结节型２８例,弥漫型１９例。经临床检查、ＡＦＰ测定、影像方法等综合作出诊断。２．治疗方法　采用Ｓｅｌｄｉｎｇｅ…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.