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妊娠相关血浆蛋白A(PAPP—A)是一种大分子蛋白质,属于a3巨球蛋白。Overgaard等发现,人体血管平滑肌细胞、细胞外基质、单核细胞和血管内皮细胞中均有PAPP-A表达,而且发现PAPP-A作为一种金属蛋白酶参与炎性反应,其外周血水平可反映动脉粥样硬化斑块炎症反应状态及其稳定性,有可能成为预测、诊断急性冠状动脉综合征(ACS),以及预后评价等相关生物学标志物。 相似文献
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血浆降钙素基因相关肽含量的变化与妊娠 总被引:5,自引:0,他引:5
随机选择52例妊高征患者,20名健康未孕妇女,30例正常妊娠妇女用放射免疫测定测定血浆降钙素基因相关肽水平。结果表明:妊娠组与未孕组之间CGRP含量差异显著。 相似文献
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目的:探讨可溶性血管黏附分子1(soluble vascular cell adhesion molecule-l,sVCAM-1)、妊娠血浆相关蛋白-A (pregnancy associated plasmaprotein A ,PAPP-A)和白细胞介素6(interleukin-6,IL-6)在妊娠高血压综合征(妊高征)发病中的作用。方法选取92例妊娠期高血压疾病孕妇(其中妊娠期高血压50例,子痫前期30例,子痫12例)和80例健康孕妇为对照组,检测其sVCAM-1、PAPP-A和IL-6水平。结果子痫前期、子痫患者血清sVCAM-1、PAPP-A和IL-6水平显著高于对照组(P<0.01),子痫前期、子痫患者sVCAM-1和PAPP-A有显著正相关性(r=0.85, P<0.05), IL-6和sVCAM-1呈正相关(r=0.64, P<0.05)。结论 sVCAM-1、PAPP-A和IL-6与妊娠期高血压疾病发作进展存在明显关联性,可推广性应用于实际临床工作,提高子痫早期诊疗率,降低孕产妇及围生儿病死率。 相似文献
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目的 探讨妊娠早中期孕产妇血清 β-人绒毛膜促性腺激素(β-hCG)、妊娠相关血浆蛋白-A(PAPP-A)、甲胎蛋白(AFP)及游离雌三醇(uE3)检测对子痫前期的预测价值.方法 选取自2018年7月至2019年7月于北部战区总医院产科进行检查及分娩的单胎孕产妇1000例为研究对象,将确诊为子痫前期的孕产妇纳入子痫前期... 相似文献
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目的采用血管内超声(IVUS)和血管内超声虚拟组织学(IVUS-VH)检查方法分析冠状动脉分叉处斑块的影像学特点。方法收集2006年6月-2011年10月行选择性冠脉造影检查患者147例,用IVUS和IVUS-VH分析患者冠状动脉分叉近端、远端以及分叉处的对侧和内侧斑块负荷及其组成成分。结果冠状动脉分叉处血管对侧壁的斑块负荷百分数为47%±14%,大于内侧壁的35%±11%,组间差异有统计学意义(P<0.01)。分叉血管对侧壁的钙化成分为34%±31%,亦大于内侧的22%±21%,组间差异有统计学意义(P<0.01)。结论冠状动脉分叉对侧低剪切力血管处动脉粥样硬化斑块负荷重,且动脉粥样硬化斑块中钙化成分比例较高。 相似文献
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近年研究发现 ,妊娠高血压综合征 (简称妊高征 )患者体内血液凝血与纤溶系统平衡失调 ,血管内皮细胞受损[1] 。为此 ,我们对 3 0例妊高征患者血浆D 二聚体 (DD)纤维结合蛋白 (Fn)含量进行了检测 ,旨在探讨凝血纤溶在妊高征发病过程中的作用。1 资料与方法1.1 对象1.1.1 观察组 :1998- 0 6~ 2 0 0 0 - 0 7在我院妇产科住院的妊高征患者共 3 0例 ,按乐杰主编的全国统编教材《妇产科学》(第 4版 )妊高征诊断标准分类[2 ] ,轻、中、重度各 10例 ,平均年龄 ( 2 5 .7± 5 .6)岁 ,平均孕龄 ( 3 5 .3± 3 .1)周。1.1.2 对照组 :随机选择同… 相似文献
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目的 应用血管内超声虚拟组织学(ⅣUS-VH)方法评价稳定型心绞痛(SAP)及不稳定型心绞痛(UAP)患者冠状动脉病变的特点。资料与方法 将199例心绞痛患者按临床表现、心电图及心肌酶学分成SAP组101例和UAP组98例。所有患者行冠状动脉造影检查确定“罪犯”血管,采用灰阶血管内超声方法测量并比较两组“罪犯”血管的外弹力膜面积、管腔横截面积、斑块面积、斑块负荷、重构指数、斑块偏心指数。采用ⅣUS-VH方法测量并比较两组“罪犯”血管的斑块组成中钙化组织、纤维组织、脂质组织、坏死组织的面积及百分比。结果 两组在最小管腔面积处测量的参数外弹力膜面积、管腔横截面积、斑块面积、斑块偏心指数、重构指数比较,差异均无统计学意义(t=1.392、-0.345、1.921、0.378、0.857,P>0.05)。在最小管腔面积处测量的斑块组成方面,UAP组坏死核心面积明显高于SAP组(t=2.361,P<0.05)。两组纤维面积、脂质面积、钙化面积之间比较差异无统计学意义(t=1.045、1.884、0.787,P>0.05)。在斑块成分分布方面,UAP组纤维斑块面积百分比明显低于SAP组(t=-2.418,P<0.05),坏死核心面积明显高于SAP组(t=2.602,P<0.05),两组脂质面积及钙化面积之间比较差异无统计学意义(t=-0.551、0.085,P>0.05)。结论 UAP组斑块构成中,坏死核心面积更大,坏死百分比更高。“罪犯”病变更加不稳定,更容易并发急性心血管事件。 相似文献
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目的:观察不同类型颈动脉粥样硬化斑块患者血浆内皮素(ET)、一氧化氮(NO)含量的变化及与斑块稳定性的相关性。方法:55例伴有颈动脉粥样斑块的患者根据超声斑块形态分为易损斑块(vulnerable plaque,VP)组30例和稳定斑块(stable plaque,SP)组25例,另选30例无斑块组(NCP)为对照组,分别测定血浆ET、NO的含量。结果:与无斑块组比较,有斑块组ET明显增高,NO明显降低,有显著差异(P〈0.05);与稳定斑块组比较,易损斑块组ET明显增高,NO明显降低,有显著差异(P〈0.05)。结论:血清ET、NO在颈动脉粥样硬化患者中有明显变化,ET,NO与患者斑块稳定性相关。 相似文献
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目的探讨颈动脉粥样斑块患者血清氧化低密度脂蛋白(ox-LDL)与C反应蛋白的相关性。方法观察80例高血压患者,根据是否有斑块形成将其分为斑块组46例,无斑块组34例。检测这些患者的血清三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、氧化低密度脂蛋白和C反应蛋白水平。结果斑块组ox-LDL显著高于无斑块组(P<0.01)且斑块组患者ox-LDL与CRP呈正相关(r=0.357,P=0.001)。结论 ox-LDL是形成动脉粥样斑块和斑块活动的较有意义的临床血清学指标。 相似文献
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目的探讨肺泡表面活性物质蛋白A(SP-A)基因多态性与儿童支原体肺炎发病风险的相关性。方法应用基因测序技术检测SP-A基因在100例支原体肺炎患儿及100例非支原体肺炎患儿中基因分布的频率;观察两组间基因型频率和等位基因频率的差异。结果病例组患儿100例的+186位点AA、AG、GG3种基因型的分布频率分别为73%、26%、1%,而对照组为61%、30%、9%,两组比较差异有统计学意义(P〈0.05);+655位点CC、CT、TT基因型的分布频率分别为76%、23%、1%,对照组为52%、36%、12%,两组比较差异也有统计学意义(P〈0.05);+667位点AA、AG、GG3种基因型的分布频率分别为28%、47%、25%,而对照组这3个基因基因型的分布频率分别为35%、51%、14%,两组比较差异无统计学意义(P〉0.05)。结论 SP-A基因+186位点及+655位点基因多态性可能与儿童支原体肺炎易感性有关,但该位点的突变如何影响SP-A的表达和活性,还有待进一步的研究。 相似文献
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Time course of contrast enhancement patterns after Gd-BOPTA in correlation to myocardial infarction and viability: a feasibility study. 总被引:1,自引:0,他引:1
J J Sandstede M Beer C Lipke T Pabst W Kenn K Harre S Neubauer D Hahn 《Journal of magnetic resonance imaging : JMRI》2001,14(6):789-794
Our objective was to analyze contrast enhancement patterns (CEP) and their time course after myocardial infarction (MI) following injection of Gd-BOPTA in correlation with recovery of regional function. Seven patients with subacute MI (18 +/- nine days) were examined before, as well as three and six (n = six) months after, revascularization of the infarct-related artery. Regional wall motion abnormalities were assessed by cine-MRI, and repetitive images of one representative slice were acquired up to 45 minutes after 0.05 mmol/kg Gd-BOPTA using a T1-w TSE-sequence. Two patients showed mid-wall/subendocardial, one patient subendocardial enhancement of MI associated with mechanical improvement after revascularization. Three patients without improvement revealed a mid-wall hypoenhanced zone within the first five minutes after injection, which was unchanged at follow-up. One patient with partial functional improvement showed transmural enhancement and a mid-wall hypoenhanced zone in adjacent areas. With this feasibility study, we concluded that mid-wall and/or subendocardial enhancement after Gd-BOPTA was associated with viable myocardium, whereas detection of microvascular obstruction correlating with scar formation is suggested by mid-wall hypoenhancement within the first five minutes after injection. 相似文献
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Hideya Yamamoto Yasuki Kihara Shinichiro Fujimoto Hiroyuki Daida Kazuhiro Kobuke Yoshitaka Iwanaga Shunichi Miyazaki Tomohiro Kawasaki Takashi Fujii Sachio Kuribayashi 《Journal of Cardiovascular Computed Tomography》2021,15(2):148-153
BackgroundWhether coronary plaque characteristics assessed in coronary computed tomography angiography (CCTA) in association with the coronary artery calcium score (CACS) have predictive value for coronary events is unclear. We aimed to examine the predictive value of the CACS and plaque characteristics for the occurrence of coronary events.MethodsAmong 2802 patients who were analyzed in the PREDICT registry, 2083 with suspected coronary artery disease (CAD) were studied using post hoc analysis. High-risk plaques were defined as having ≥2 adverse characteristics, such as low computed tomographic attenuation, positive remodeling, spotty calcification, and napkin-ring sign. An adjudicative composite of coronary events (cardiac death, nonfatal acute coronary syndrome, and coronary revascularization ≥3 months after indexed CCTA) were analyzed.ResultsSeventy-three (3.5%) patients had coronary events and 313 (15.0%) had high-risk plaques. Multivariate Cox proportional hazard analysis showed that high-risk plaques remained an independent predictor of coronary events (adjusted hazard ratio [HR] 1.95, 95% confidence interval [CI] 1.13–3.34, P ?= ?0.0154), as well as the log-transformed CACS (adjusted HR 1.24, 95% CI 1.11–1.39, P ?= ?0.0002) and the presence of obstructive stenosis (adjusted HR 5.63, 95% CI 3.22–10.12, P 0.0001). In subgroup analyses, high-risk plaques were independently predictive only in the low CACS class (<100).ConclusionThis study shows that assessment of adverse features by coronary plaque imaging independently predicts coronary events in patients with suspected CAD and a low CACS. Our findings suggest that the clinical value of high-risk plaques to CACS and stenosis assessment appears marginal. 相似文献