SCI数据库关于运动状态下组织工程软骨生物力学变化的相关文章分析★

背景：组织工程软骨研究是近年研究的热点，目前尚无对运动状态下组织工程软骨生物力学变化相关文章的文献计量分析。 目的：通过运动状态下组织工程软骨生物力学变化相关文章文献的计量分析，总结概括目前研究的状况和前沿。 方法：以美国科学情报研究所(ISI)开发的Web of Science网络数据库为数据源基础，对SCI收录的运动状态下组织工程软骨生物力学变化相关文章论文的情况，从论文的发表时间分布、国家地区分布、机构分布、期刊分布和被引频次分布等方面进行统计与分析。 结果与结论：1990/2011共有运动状态下组织工程软骨生物力学变化相关文章文献82篇，文献呈年度递增，以美国发表论文最多，有58篇。得出了运动状态下组织工程软骨生物力学变化相关文章这一领域的研究动态和发展趋势，为中国深入研究组织工程软骨在运动状态下的生物力学变化提供可供借鉴的参考建议。     

某三甲医院脑血管病学科“十一五”期间美国科学引文索引收录文献情况统计与分析

目的 从文献计量学角度评估某三甲医院脑血管病学科的现状,以期为该院科研管理和重点学科建设提供参考依据和信息。方法 对2006～2010年某三甲医院脑血管病学科美国科学引文索引（science citation index,SCI）收录文献进行数量、质量及其影响因素进行统计分析。结果 该院脑血管病学科在“十一五”期间SCI收录文献共计125篇,总影响因子（impact factor,IF）223.913分,文献分别发表于42种期刊,分布在4个专业。结论 某三甲医院脑血管病学科在“十一五”期间SCI收录文献总体质量较高,反映出良好的学科发展势态。     

2010～2020年中医药治疗抑郁症的文献计量分析

目的 对2010～2020年中文期刊发表的中医药治疗抑郁症的临床研究文献进行分析,探索研究规律以指导未来临床研究方向。方法 采用文献计量学方法对2010～2020年中文期刊发表的中医药治疗抑郁症的文献进行计量分析,以年度论文发表量、期刊载文量及被引频次、发文机构发文情况、研究热点及基金资助等为指标进行统计分析。结果 近11年内年平均发文量81篇,从计量分析上看2010～2015年,中医药治疗抑郁症的文章数量呈现逐渐增长态势;2015～2020年逐渐下降,且核心期刊占比较低。结论 今后的研究应通过“分子网络-药理活性-病证效应”多层次整合来阐释中药方剂临床疗效的产生机制,以期为中医药治疗抑郁症提供高质量的循证医学证据。     

自体骨髓干细胞治疗肝硬化基础研究与临床应用现状*

背景：活体肝移植仍面临很多问题：如供体的匮乏、移植后的免疫排异反应及其高额的费用等,因此使其在临床上的开展受到限制。 目的：说明自体骨髓干细胞移植可以分化成熟肝细胞而替代受损的肝脏组织发挥功能,从而改善患者症状,提高患者生活质量。 方法：利用计算机在PubMed、CNKI、万方数据库和维普数据库中检索2000-01/2010-12关于自体骨髓干细胞移植相关文章,在标题和摘要中用“骨髓干细胞;自体骨髓干细胞移植;肝硬化”或“Bone marrow stem cell,autologous bone marrow stem cell,hepatic cirrhosis”为检索词进行检索。选择与骨髓干细胞移植相关的文章内容,同一领域文献选择近期发表或发表在权威杂志文章。初检得到235篇文献,根据纳入标准选择20篇文章进行综述。 结果与结论：通过对自体骨髓干细胞移植从基础研究及临床研究方面的最新进展的了解,说明自体骨髓干细胞移植在对肝硬化的治疗方面前景广阔。     

生物材料研究经典论文、核心著者与期刊：SCI收录生物材料类期刊的引文分析

摘要 背景：第九次世界生物材料大会将于2012年在中国召开,中国生物材料科学研究已开始同国际接轨,其相关研究也成为热点,其发表的论文数量、作者人群和期刊品种非常之多,研究者很难从众多的文献中寻找资料。 目的：为使国内研究者了解国际相关研究轨迹和前沿,文章从引文分析的角度,选取SCI生物材料领域的10种期刊发文的引文进行分析,以获取该领域研究者所需的经典论文、核心著者和核心期刊,以期对相关研究者有帮助。 方法：应用计算机检索SCI(科学引文数据库)收录生物材料期刊,并根据其影响因子选取期刊,下载到所刊登文章引文 406 753条,并对数据利用Excl和Access进行统计分析。 结果与结论：经过统计分析获取Tissue engineering等10篇经典论文、Hench, Larry L.等10位核心作者和Biomaterials等20种核心期刊,生物材料相关科技者着重研究所列经典文章,掌握相关核心作者的研究动态,着重阅读上述核心期刊可以对相关研究有帮助。 关键词：引文分析;生物材料;经典论文;核心著者;核心期刊 doi:10.3969/j.issn.1673-8225.2011.12.027     

干细胞移植治疗肝病的研究现状☆

学术背景：常规的内科保肝治疗效果不佳，原位肝移植仍然是治疗终末期肝病最有效的措施，但肝源缺乏、费用昂贵、移植排斥反应及长期应用免疫抑制剂引起并发症等成为限制其广泛应用的主要原因。干细胞移植有利于受损肝组织修复，能够代偿部分肝功能，已成为治疗肝病的一种新方法。 目的：介绍干细胞移植治疗肝病的研究现状。 检索策略：由该论文的研究人员应用计算机检索 Pubmed 2002-01/2007-12的相关文献，检索词“transplantation of stem cell，liver disease，hepatic disease”，并限定文献语种为“English”。同时计算机检索中国知识资源总库CNKI 2002-01/2007-12的相关文献，检索词“干细胞移植，肝病”，并限定文献语种为中文。共检索到125篇文献，对资料进行初审，纳入标准：①文章内容与干细胞移植应用于肝病的治疗相关。②同一领域选择近期发表或在权威杂志上发表的文章。排除标准：重复研究或Meta分析类文章。 文献评价：文献的来源主要是通过对干细胞移植治疗肝病方面内容进行汇总分析，其中36篇相关度较高，对完全符合标准的30篇作为参考文献进行综述。进一步查找全文，2篇为综述，其余均为临床或基础实验研究。 资料综合：①干细胞移植动物实验：采用不同方法建立肝损伤动物模型，对成模动物以不同途径进行不同种类的干细胞移植实验，移植后行肝脏组织学检查及检测转氨酶和白蛋白等肝功能指标，结果显示干细胞移植能够改善肝功能，修复肝脏组织结构，减轻肝脏损伤。②干细胞移植用于临床治疗：多项通过干细胞移植治疗终末期肝病和难治性肝病患者的研究表明，干细胞移植后患者症状缓解，肝功能和凝血功能明显好转，治疗时间缩短，改善预后，且无严重并发症出现。③干细胞移植相关并发症及其应用评价：行干细胞移植治疗肝病患者的临床研究，未经合理的多中心、大样本、随机对照实验设计，其治疗效果不确切，至今仍存在不同观点，且移植后可出现病毒感染及肝静脉梗阻等并发症，以及干细胞的致瘤性，均限制了其应用。 结论：尽管目前多项干细胞移植用于治疗肝病患者的临床研究均已取得一些疗效，但有报道认为其对肝损伤无明显改善，且产生相关并发症，同时仍存在一定问题。因此需要合理设计，并进行随机对照来确证以往研究结果的可靠性，使其成为治疗肝病的一个安全有效措施，从而排除质疑，推进其临床应用。     

干细胞及神经相关因子对运动性周围神经损伤再生的影响

背景：当前干细胞技术在心脑血管病、中枢神经损伤和外周神经损伤等都具有十分重要的作用。但是在对运动引起周围神经损伤方面的研究还处于基础阶段。 目的：论文旨在研究当前干细胞技术运用于运动性周围神经损伤的研究现状,为运动性周围神经损伤的康复奠定科学基础。 方法：通过计算机检索PubMed数据库1991-01/2010-01的相关文献,文献所述内容与干细胞和运动性周围神经损伤的研究密切相关。共选取26篇文献, 结果与结论：运动训练中经常出现所谓的周围神经损伤性疾病,而依靠干细胞移植和诱导分化技术可以促进周围神经损伤的再生,且对促进运动训练中周围神经损伤的防治具有十分重要的作用。但由于目前尚处于基础研究阶段,还有待进一步的深入研究。     

干细胞移植治疗缺血性脑卒中

学术背景：缺血性脑卒中发病后的神经损伤一旦形成,则没有有效的促进神经功能恢复的治疗方法。大量的实验研究证实，干细胞移植不仅具有功能保护作用，也为细胞替代和功能恢复提供了可能。 目的：综述干细胞移植治疗缺血性脑卒中的实验研究及应用特点。 检索策略：应用计算机检索Pubmed1997-01/2007-10期间相关文章，检索词为“stem cells transplant，stroke，ischemia”，并限定文章语言种类为English。同时计算机检索万方数据库2001-01/2006-12期间相关文章，检索词为“干细胞、移植、缺血性脑卒中”，并限定文章语言种类为中文。对资料进行初审，并查看每篇文献后的引文。纳入标准：文章所述内容应与移植后巨细胞病毒感染的诊断和防治等研究进展中的应用相关。排除标准：重复研究或Meta分析类文章。共收集到60篇相关文献，26篇文献符合纳入标准，排除的34篇为内容陈旧或重复文献。 文献评价：符合纳入标准的26篇文献中，1篇涉及缺血性脑卒中进行细胞移植治疗的特殊性，10篇涉及用于治疗缺血性脑卒中的干细胞介绍，4篇涉及干细胞移植治疗缺血性脑卒中的机制，7篇涉及干细胞植入的时机，4篇涉及干细胞移植的部位。 资料综合：①脑卒中发病后影响的是多个不同的种（系）的神经细胞。目前应用于治疗缺血性脑卒中的干细胞来源于骨髓、脐血、成熟动物脂肪组织或脑组织。②干细胞移植治疗缺血性脑卒中的作用机制主要可以归纳为两方面的机制：重建损伤组织结构包括血管、神经环路、恢复损伤部位组织结构的完整性；分泌各种营养因子减少内源性细胞凋亡、促进内源性血管再生和神经再生。③目前关于干细胞移植治疗缺血性脑卒中的最佳时机还未明确。④不同部位的脑组织环境有利于不同类型的干细胞生存和增殖，不同类型的干细胞所植入的部位也不同。 结论：尽管干细胞移植治疗缺血性脑卒中实验证实，干细胞移植能促进缺血性脑卒中损伤部位神经功能的恢复，但尚缺乏长期观察的研究数据。干细胞移植治疗缺血性脑卒中的机制还有待于进一步明确。     

2010-2020年中国和美国缺血性卒中研究态势分析

目的 对2010-2020年中国和美国发表的缺血性卒中研究进行文献计量分析，展示中国和美国在该 疾病领域主要研究力量、优秀学者，对比中国和美国缺血性卒中研究热点，为后续该领域的研究提供 思路和借鉴。 方法 基于Web of Science核心合集数据库，以“ischemic stroke”为主题检索词，检索2010-2020年 中国、美国发表的英文文献，采用文献计量法对发文类型、机构、期刊进行分析。选择研究论著，采 用CiteSpace软件对中国和美国在该领域的研究特征进行聚类分析。采用被引频次、突现值、中介中心 性及Sigma 4项文献评价指标对发表文章的参考文献进行被引分析，对主要研究力量、研究热点等 进行讨论。 结果 2010-2020年中国学者在缺血性卒中领域发文量逐年增长，共发表SCI文章13 109篇，美国学 者发文量波动增长，共发表21 706篇；中国学者文章刊载量前10位的出版物中位数期刊位于Q2分区， 影响因子为2.815，美国学者文章刊载量前10位的出版物中位数期刊位于Q1分区，影响因子为5.282； 中国主要研究机构为首都医科大学，美国为哈佛大学和美国加州大学系统；聚类分析显示，中美两国学 者共同最关注的研究主题有心房颤动、神经炎症和血栓切除术，另外，中国学者还关注急性缺血性卒 中、肺腺癌转移相关转录因子1、轻度卒中、神经保护、同型半胱氨酸、死亡率和抑郁情绪等，美国学者 还关注溶栓、颈动脉内膜切除手术、灌注、远程医疗及卒中分类等，以上研究主题均可成为后续关注 的研究热点。 结论 目前美国学者研究成果的影响力较大，我国学者需深化与国际主要研究机构的合作。中、美 两国学者关注的研究领域主要集中在血栓切除术、神经炎症、心房颤动三个研究主题。     

美国干细胞领域的相关政策及研发和投入分析

背景：美国在干细胞领域的研究居世界顶级水平，但其相关的监管及政策一直在变化。 目的：研究美国政府及企业对干细胞研究政策和投入的变化，及其可能对世界格局产生的重大影响。 方法：由第一作者检索2000-01/2010-10 SCI数据库，万方数据库，维普数据库，美国国家卫生研究院(National Institutes of Health，NIH)的官方网站，及GBI Research公司的研究报告。英文检索词为“stem cell，USA，policy，invest”，中文检索词为“干细胞，美国”。共收集到128篇有关美国干细胞政策和投入的相关的文献，排除发表时间较早、重复及类似研究，共有30篇符合标准的文献。 结果与结论：美国对于干细胞研究政策及投入的争议，主要集中在联邦经费是否可以用于人类胚胎干细胞研究，但对非联邦资助的人类胚胎干细胞研究没有太多限制。奥巴马总统上任后对联邦政府资助胚胎干细胞研究的限制较以前有了部分松绑，但目前政策的后继影响还不明显。美国虽然在联邦政府层面对干细胞的研究投入有限，但地方政府以及私人资金对其大力支持，加上产业界对于干细胞治疗的巨大投入，美国的干细胞研究和产业前景乐观，胚胎干细胞可能成为以后的优先发展领域。     

Stem cell transplantation for treating Parkinson's disease Literature analysis based on the Web of Science

OBJECTIVE:To identify global research trends of stem cell transplantation for treating Parkinson’s disease using a bibliometric analysis of the Web of Science.DATA RETRIEVAL:We performed a bibliometric analysis of data retrievals for stem cell transplantation for treating Parkinson’s disease from 2002 to 2011 using the Web of Science.SELECTION CRITERIA:Inclusion criteria:(a) peer-reviewed articles on stem cell transplantation for treating Parkinson’s disease which were published and indexed in the Web of Science;(b) type of articles:original research articles,reviews,meeting abstracts,proceedings papers,book chapters,editorial material and news items;(c) year of publication:2002-2011.Exclusion criteria:(a) articles that required manual searching or telephone access;(b) we excluded documents that were not published in the public domain;(c) we excluded a number of corrected papers from the total number of articles.MAIN OUTCOME MEASURES:(1) Type of literature;(2) annual publication output;(3) distribution according to journals;(4) distribution according to subject areas;(5) distribution according to country;(6) distribution according to institution;(7) comparison of countries that published the most papers on stem cell transplantation from different cell sources for treating Parkinson’s disease;(8) comparison of institutions that published the most papers on stem cell transplantation from different cell sources for treating Parkinson’s disease in the Web of Science from 2002 to 2011;(9) comparison of studies on stem cell transplantation from different cell sources for treating Parkinson’s disease RESULTS:In total,1 062 studies on stem cell transplantation for treating Parkinson’s disease appeared in the Web of Science from 2002 to 2011,almost one third of which were from American authors and institutes.The number of studies on stem cell transplantation for treating Parkinson’s disease had gradually increased over the past 10 years.Papers on stem cell transplantation for treating Parkinson’s disease appeared in journals such as Stem Cells and Experimental Neurology.Although the United States published more articles addressing neural stem cell and embryonic stem cell transplantation for treating Parkinson’s disease,China ranked first for articles published on bone marrow mesenchymal stem cell transplantation for treating Parkinson’s disease.CONCLUSION:From our analysis of the literature and research trends,we found that stem cell transplantation for treating Parkinson’s disease may offer further benefits in regenerative medicine.     

Stem cell transplantation for treating spinal cord injury A literature comparison between studies of stem cells obtained from various sources

OBJECTIVE:To identify global research trends of stem cell transplantation for treating spinal cord injury using a bibliometric analysis of the Web of Science.DATA RETRIEVAL:We performed a bibliometric analysis of data retrievals for stem cell transplantation for treating spinal cord injury from 2002 to 2011 using the Web of Science.SELECTION CRITERIA:Inclusion criteria:(a) peer-reviewed articles on stem cell transplantation for treating spinal cord injury that were published and indexed in the Web of Science;(b) type of articles:original research articles,reviews,meeting abstracts,proceedings papers,book chapters,editorial material,and news items;and(c) year of publication:2002-2011.Exclusion criteria:(a) articles that required manual searching or telephone access;(b) documents that were not published in the public domain;and(c) a number of corrected papers from the total number of articles.MAIN OUTCOME MEASURES:(1) Annual publication output;(2) distribution according to country;(3) distribution according to institution;(4) distribution according to journals;(5) distribution according to funding agencies;and(6) top cited articles over the last 10 years.RESULTS:Bone marrow mesenchymal stem cells and embryonic stem cells have been widely used for treating spinal cord injury.In total,191 studies of bone marrow mesenchymal stem cell transplantation and 236 studies of embryonic stem cell transplantation for treating spinal cord injury appeared in the Web of Science from 2002 to 2011,and almost half of which were derived from American or Japanese authors and institutes.The number of studies of stem cell transplantation for treating spinal cord injury has gradually increased over the past 10 years.Most papers on stem cell transplantation for treating spinal cord injury appeared in journals with a particular focus on stem cell research,such as Stem Cells and Cell Transplantation.Although umbilical cord blood stem cells and adipose-derived stem cells have been studied for treating spinal cord injury,the number of published papers was much smaller,with only 21 and 17 records,respectively,in the Web of Science.CONCLUSION:Based on our analysis of the literature and research trends,we found that stem cells transplantation obtained from various sources have been studied for treating spinal cord injury;however,it is difficult for researchers to reach a consensus on this theme.     

Stem cell transplantation for treating Duchenne muscular dystrophy A Web of Science-based literature analysis

OBJECTIVE: To identify global research trends in stem cell transplantation for treating Duchenne muscular dystrophy using a bibliometric analysis of Web of Science. DATA RETRIEVAL: We performed a bibliometric analysis of studies on stem cell transplantation for treating Duchenne muscular dystrophy from 2002 to 2011 retrieved from Web of Science. SELECTION CRITERIA: Inclusion criteria: (a) peer-reviewed published articles on stem cell transplantation for treating Duchenne muscular dystrophy indexed in Web of Science; (b) original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items; and (c) publication between 2002 and 2011. Exclusion criteria: (a) articles that required manual searching or telephone access; (b) documents that were not published in the public domain; and (c) corrected papers. MAIN OUTCOME MEASURES: (1) Annual publication output; (2) distribution according to subject areas; (3) distribution according to journals; (4) distribution according to country; (5) distribution according to institution; (6) distribution according to institution in China; (7) distribution according to institution that cooperated with Chinese institutions; (8) top-cited articles from 2002 to 2006; (9) top-cited articles from 2007 to 2011. RESULTS: A total of 318 publications on stem cell transplantation for treating Duchenne muscular dystrophy were retrieved from Web of Science from 2002 to 2011, of which almost half derived from American authors and institutes. The number of publications has gradually increased over the past 10 years. Most papers appeared in journals with a focus on gene and molecular research, such as Molecular Therapy, Neuromuscular Disorders, and PLoS One. The 10 most-cited papers from 2002 to 2006 were mostly about different kinds of stem cell transplantation for muscle regeneration, while the 10 most-cited papers from 2007 to 2011 were mostly about new techniques of stem cell transplantation for treating Duchenne muscular dystrophy. CONCLUSION: The publications on stem cell transplantation for treating Duchenne muscular dystrophy were relatively few. It also needs more research to confirm that stem cell therapy is a reliable treatment for Duchenne muscular dystrophy.     

Application of magnetic resonance imaging for monitoring stem cell transplantation for the treatment of cerebral ischemia

OBJECTIVE:To identify global research trends in the application of MRI for monitoring stem cell transplantation using a bibliometric analysis of Web of Science.DATA RETRIEVAL:We performed a bibliometric analysis of studies relating to the application of MRI for detecting stem cell transplantation for the treatment of cerebral ischemia using papers in Web of Science published from 2002 to 2011.SELECTION CRITERIA:The inclusion criteria were:(a) peer-reviewed articles on the application of MRI for detecting transplanted stem cells published and indexed in Web of Science;(b) year of publication between 2002 and 2011.Exclusion criteria were:(a) articles that required manual searching or telephone access;(b) some corrected papers.MAIN OUTCOME MEASURES:(1) Annual publication output;(2) distribution according to journals;(3) distribution according to institution;(4) distribution according to country;(5) top cited authors over the last 10 years.RESULTS:A total of 1 498 studies related to the application of MRI for monitoring stem cell transplantation appeared in Web of Science from 2002 to 2011,almost half of which were derived from American authors and institutes.The number of studies on the application of MRI for detecting stem cell transplantation has gradually increased over the past 10 years.Most papers on this topic appeared in Magnetic Resonance in Medicine.CONCLUSION:This analysis suggests that few experimental studies have been investigated the use of MRI for tracking SPIO-labeled human umbilical cord blood-derived mesenchymal stem cells during the treatment of cerebral ischemia.     

The top cited articles on glioma stem cells in Web of Science

BACKGROUND: Glioma is the most common intracranial tumor and has a poor patient prognosis. The presence of brain tumor stem cells was gradually being understood and recognized, which might be beneficial for the treatment of glioma. OBJECTIVE: To use bibliometric indexes to track study focuses on glioma stem cell, and to investigate the relationships among geographic origin, impact factors, and highly cited articles indexed in Web of Science. METHODS: A list of citation classics for glioma stem cells was generated by searching the database of Web of Science-Expanded using the terms "glioma stem cell" or "glioma, stem cell’" or "brain tumor stem cell". The top 63 cited research articles which were cited more than 100 times were retrieved by reading the abstract or full text if needed. Each eligible article was reviewed for basic information on subject categories, country of origin, journals, authors, and source of journals. Inclusive criteria: (1) articles in the field of glioma stem cells which was cited more than 100 times; (2) fundamental research on humans or animals, clinical trials and case reports; (3) research article; (4) year of publication: 1899-2012; and (5) citation database: Science Citation Index-Expanded. Exclusive criteria: (1) articles needing to be manually searched or accessed only by telephone; (2) unpublished articles; and (3) reviews, conference proceedings, as well as corrected papers. RESULTS: Of 2 040 articles published, the 63 top-cited articles were published between 1992 and 2010. The number of citations ranged from 100 to 1 754, with a mean of 280 citations per article. These citation classics came from nineteen countries, of which 46 articles came from the United States. Duke University and University of California, San Francisco led the list of classics with seven papers each. The 63 top-cited articles were published in 28 journals, predominantly Cancer Research and Cancer Cell, followed by Cell Stem Cell and Nature. CONCLUSION: Our bibliometric analysis provides a historical perspective on the progress of glioma stem cell research. Articles originating from outstanding institutions of the United States and published in high-impact journals are most likely to be cited.     

自体骨髓间充质干细胞移植治疗早期股骨头缺血性坏死44例

股骨头缺血性坏死患者股骨头内间充质干细胞数量减少,成骨分化能力降低是不能实现有效自身修复的细胞病理原因,坏死区周围的硬化带阻碍了骨修复的实现。对于早期股骨头缺血性坏死,自体骨髓间充质干细胞移植结合髓芯减压改善坏死区的血运及促进骨修复的治疗结果分析尚缺乏系统报告。 目的：根据随访结果分析自体骨髓间充质干细胞移植结合髓芯减压治疗早期股骨头缺血性坏死的效果。 方法：2005-05/2008-09共治疗早期股骨头缺血性坏死患者44例,所有接受细胞移植股骨头坏死均为ARCO1或2期,共76髋。采用浓缩自体骨髓细胞悬液回注坏死股骨头内并结合髓芯减压,剩余骨髓血洗涤回输。其中ARCO1期患者仅行干细胞悬液注射,ARCO2期患者移植后行髓芯减压,以Harris评分评价髋关节功能状态。 结果与结论：至2009-03,共随访(22.3±4.2)个月。至随访终期,66髋较细胞移植前疼痛缓解或无明显进展,功能改善,占86.9%;10髋疼痛加重,ARCO分期进展至3或4期,其中3髋行人工关节置换。提示自体骨髓间充质干细胞移植结合髓芯减压是治疗早期股骨头缺血性坏死的有效方法,在早期股骨头缺血性坏死的各种治疗方法中,与其他减压及手术方法相比更符合针对病因的治疗,进一步扩大应用有可能获得更佳的临床效果。     

Olfactory ensheathing cell transplantation for spinal cord injury An 18-year bibliometric analysis based on the Web of Science

OBJECTIVE:Olfactory ensheathing cell (OEC) transplantation is a promising new approach for the treatment of spinal cord injury (SCI),and an increasing number of scientific publications are devoted to this treatment strategy.This bibliometric analysis was conducted to assess global research trends in OEC transplantation for SCI.DATA SOURCE:All of the data in this study originate from the Web of Science maintained by the Institute for Scientific Information,USA,and includes SCI-EXPANDED,SSCI,A&HCI,CPCI-S,CPCI-SSH,BKCI-S,BKCI-SSH,CCR-EXPANDED and IC.The Institute for Scientific Information’s Web of Science was searched using the keywords "olfactory ensheathing cells" or "OECs" or "olfactory ensheathing glia" or "OEG" or "olfactory ensheathing glial cells" or "OEGs" and "spinal cord injury" or "SCI" or "spinal injury" or "spinal transection" for literature published from January 1898 to May 2012.DATA SELECTION:Original articles,reviews,proceedings papers and meeting abstracts,book chapters and editorial materials on OEC transplantation for SCI were included.Simultaneously,unpublished literature and literature for which manual information retrieval was required were excluded.MAIN OUTCOME MEASURES:All selected literatures addressing OEC transplantation for SCI were evaluated in the following aspects:publication year,document type,language,author,institution,times cited,Web of Science category,core source title,countries/territories and funding agency.RESULTS:In the Web of Science published by the Institute for Scientific Information,the earliest literature record was in April,1995.Four hundred and fourteen publications addressing OEC transplantation for SCI were added to the data library in the past 18 years,with an annually increasing trend.Of 415 records,405 publications were in English.Two hundred and fifty-nine articles ranked first in the distribution of document type,followed by 141 reviews.Thirty articles and 20 reviews,cited more than 55 times by the date the publication data were downloaded by us,can be regarded as the most classical references.The journal Experimental Neurology published the most literature (32 records),followed by Glia.The United States had the most literature,followed by China.In addition,Yale University was the most productive institution in the world,while The Second Military Medical University contributed the most in China.The journal Experimental Neurology published the most OEC transplantation literature in the United States,while Neural Regeneration Research published the most in China.CONCLUSION:This analysis provides insight into the current state and trends in OEC transplantation for SCI research.Furthermore,we anticipate that this analysis will help encourage international cooperation and teamwork on OEC transplantation for SCI to facilitate the development of more effective treatments for SCI.     

Catastrophic demyelinating encephalomyelitis after intrathecal and intravenous stem cell transplantation in a patient with multiple sclerosis

Stem cell transplantation is an investigational therapy for multiple sclerosis. The authors describe a case of catastrophic demyelinating encephalomyelitis following stem cell transplantation in a 17-year-old girl. Nine months after an initial diagnosis of multiple sclerosis, she underwent stem cell transplantation in Costa Rica. Subsequently, she deteriorated and was transported back to the United States with headache and vomiting progressing to quadriparesis, locked-in syndrome, and superimposed encephalopathy. Magnetic resonance imaging and brain biopsy were consistent with fulminant demyelinating encephalomyelitis with enhancing parenchyma and leptomeninges. Cerebrospinal fluid analysis revealed lymphocytic pleocytosis and high protein. The protracted illness required tracheostomy and gastrostomy. After methyleprednisone, intravenous immunoglobulin, and cyclophosphamide, she improved during 2.5 months to an ambulatory, functionally independent state. Subsequently, typical less severe multiple sclerosis relapses occurred. This case demonstrates that stem cell transplantation may provoke life-threatening encephalomyelitis in patients with multiple sclerosis. This highlights the need to restrict transplantation to trials with appropriate safety controls.