腮腺非肿瘤性疾病唾液总流率和唾液免疫球蛋白与混合唾液细菌总？…

目的：研究腮腺非肿瘤性疾病唾液分泌量和某些成分的改变与混合唾液细菌数量之间的相关性。方法：检测２９例腮腺非肿瘤性疾病患者和１０名正常对照者的唾液总流率、唾液免疫球蛋白及混合唾液细菌总量。结果：静态唾液总流率与混合唾液中需氧菌总娄简有显著的负相关关系,ＳＩｇＡ静态单位时间内分泌总量与混合唾液中需氧 、厌氧菌总数间均有显著的负相关关系。结论：唾液总流率下降和唾液免疫球蛋白降低与混合唾液细菌总数升高有明     

小型猪双侧腮腺萎缩后唾液流率及口腔细菌变化的观察

目的 观察小型猪腮腺萎缩后混合唾液流率的变化以及对口腔主要致病菌的影响.方法 10只小型猪分成两组,每组5只,其中一组双侧腮腺注入甲紫致腺体萎缩,另5只作为健康对照组.分别在萎缩后第12、24个月收集混合唾液并观察唾液流率的变化;同时检测小型猪龈下菌斑和混合唾液中口腔主要致病菌数量并与健康对照组比较.结果 腮腺萎缩后第12个月混合唾液流率自(1.36±0.74)ml/min下降到(1.32±0.65)ml/min,第24个月唾液流率自(0.72±0.34)ml/min上升到(0.86±0.57)ml/min;龈下菌斑中的核梭杆菌、后牙龈下菌斑中厌氧菌总数、产黑菌数量均明显高于健康对照组;第12个月前牙和第24个月后牙的龈下菌斑中变形链球菌有短暂升高,而需氧菌总数、乳酸菌和放线菌数量无明显变化.唾液中除变形链球菌和产黑菌在腮腺萎缩早期有轻度上升外,其余细菌数量均无明显变化.结论 双侧腮腺萎缩后明显降低口腔中唾液总量,导致牙菌斑中的致龋菌和牙周致病菌数量上升.     

腮腺非肿瘤疾病唾液免疫球蛋白及电解质观察

为研究涎腺非肿瘤疾病唾液免疫球蛋白及电解质的变化，作者对２７例舍格伦综合征（Ｓｊｏｇｒｅｎｓｙｎｄｒｏｍｅ，ＳＳ）、２５例慢性阻塞性腮腺炎（ｃｈｒｏｎｉｃｏｂｓｔｒｕｃｔｉｖｅｐａｒｏｔｉｔｉｓ，ＣＯＰ）、３２例腮腺良性肥大患者及３２例对照组的唾液总流率、混合唾液中ＳＩｇＡ、ＩｇＧ、钾、钠、钙、磷、氯的浓度及单位时间分泌总量进行了观察。结果显示：ＳＳ组唾液总流率下降、免疫球蛋白及电解质浓度升高但其总量下降；慢性阻塞性腮腺炎组仅有钾、钠、氯、钙总量的显著降低；腮腺良性肥大组仅有磷浓度及总量显著升高。说明免疫球蛋白及电解质总量的下降是ＳＳ的特征性表现。提示测定唾液成份总量较测定唾液浓度更有意义     

腮腺非肿瘤性疾病混合唾液和腮腺液的细菌学研究

为探讨涎腺非肿瘤性疾病所引起的口腔微生态变化,本研究对29例腮腺非肿瘤性疾病患者和10名健康对照者进行了混合唾液和腮腺液的需氧菌、厌氧菌总数及5种常见的口腔致病菌(产黑色素菌、放线菌、变形链球菌、乳酸菌和核梭菌)数量的对比研究,以加深对涎腺疾病与口腔微生态系统之间相互关系的了解。材料和方法:实验组29例,年龄37～65岁。其中舍格伦综合征(ＳＳ)组11例,腮腺良性肥大组10例,腮腺慢性炎症组8例。对照组10例,年龄32～68岁。要求测试对象口腔卫生状况良好,牙龈出血指数为0～1度。测试前2周内无使用抗生素药物史。收集每个受试者的混…     

腮腺非肿瘤性疾病唾液总流率和唾液免疫球蛋白与混合唾液细菌总量的关系

目的 :研究腮腺非肿瘤性疾病唾液分泌量和某些成分的改变与混合唾液细菌数量之间的相关性。方法 :检测 2 9例腮腺非肿瘤性疾病患者和 1 0名正常对照者的唾液总流率、唾液免疫球蛋白及混合唾液细菌总量。结果 :静态唾液总流率与混合唾液中需氧菌总数间有显著的负相关关系 ,SIgA静态单位时间内分泌总量与混合唾液中需氧菌、厌氧菌总数间均有显著的负相关关系。结论 :唾液总流率下降和唾液免疫球蛋白降低与混合唾液细菌总数升高有明显的相关性。     

腮腺区域切除术对动、静态唾液总流率的影响

目的探讨腮腺区域性切除术对动、静态唾液总流率的影响及在保留残余腺体功能方面的作用。方法对行腮腺区域性切除术的腮腺良性肿瘤患者30人,分别于手术前和术后3个月收集静态混合唾液、酸刺激动态混合唾液及双侧腮腺液,计算各组唾液流率,并进行统计学分析。结果术前患侧腮腺流率明显低于健侧。所有病例手术后患侧腮腺均能收集到唾液,但流率明显降低;而静态及动态唾液总流率与术前相比没有明显降低。结论腮腺良性肿瘤的发生明显影响腮腺唾液分泌功能。腮腺区域性切除术后患侧腮腺仍能够保留部分分泌功能。腮腺区域性切除术虽未能引起对侧腺体代偿,但对患者口腔内唾液分泌总量的影响较小。     

腮腺肿瘤患者唾液及腮腺液中 IgA 和 IgG 含量的初步研究

对正常人31名,腮腺肿瘤患者44名(良性25名,恶性19名)的混合唾液和腮腺液中 IgA,IgG 含量进行了测定,结果表明:腮腺恶性肿瘤患者第一、二段腮腺液中 IgG 浓度比正常组、良性腮腺肿瘤组明显升高。腮腺良、恶性肿瘤腮腺液中 IgA 浓度无显著差别。影响混合唾液中 IgA 和 IgG 的含量因素多,对诊断和鉴别肿瘤性质意义不大。     

腮腺肿瘤患者唾液和血液中CEA、CA125含量的检测及其在肿瘤组织中的表达

目的：检测腮腺肿瘤患者唾液和血液中CA125、CEA的含量及其在腮腺肿瘤组织中的表达。方法选择腮腺良性肿瘤患者83例,腮腺恶性肿瘤患者18例,对照组为30名健康志愿者。采用化学发光法( CLIA)检测唾液及血液样本中CEA和CA125含量。采用免疫组化法检测腮腺肿瘤组织中CEA和CA125的表达。结果腮腺肿瘤患者混合唾液中CEA和CA125水平明显高于对照组。腮腺肿瘤患者与对照组血液中CEA和CA125水平无显著差异。良、恶性肿瘤患者唾液中CEA和CA125含量无显著差异。 CEA及CA125的分布特点为,混合唾液中含量最高,血液中含量最低。相关性分析显示,混合唾液中CEA与CA125呈现明显正相关性( r=0.652-0.913)。在大部分腮腺肿瘤组织中,CEA和CA125均为阳性表达,而且部分病例的肿瘤组织周围正常腺体也可见CEA及CA125的阳性表达。结论唾液中CEA和CA125水平的变化可以反映腮腺肿瘤的存在,但无法区分腮腺肿瘤的良恶性。血液中CEA和CA125不能反映腮腺肿瘤的存在。腮腺肿瘤患者的混合唾液样本中CEA与CA125呈现同步变化的趋势。唾液中CEA与CA125可能主要来源于涎腺腺体及肿瘤组织,而不是来自血液。     

腮腺恶性肿瘤患者患侧腮腺唾液中SIgA检测对腮腺恶性肿瘤诊断的意义

本文报道采用单向琼脂扩散测定法，测定了４０例腮腺恶性肿瘤患者．２７例良性肿瘤患者．３３例正常人唾液中分泌型免疫球蛋白Ａ（ＳＩｇＡ）的含量。由于三组间唾液中ＳＩｇＡ的含量差异有高度显著性（Ｐ＜０．００１），故认为测定患者患侧腮腺唾液中ＳＩｇＡ的含量对腮腺良、恶性肿瘤的鉴别诊断有参考意义。     

96例腮腺混合瘤部份腮腺切除的临床回顾分析

９６例腮腺混合瘤部份腮腺切除的临床回顾分析ＣＬＩＮＩＡＬＡＮＡＬＹＳＩＳＯＦ９６ＣＡＳＥＰＡＲＴＩＡＬＲＥＳＥＣＴＩＯＮＯＦＰＡＲＯＴＩＤＭＩＸＥＤＴＵＭＯＲ宋萌潘劲松吕臻王世惟作者单位：上海市第一人民医院口腔颌面外科（２０００８０）腮腺混合瘤（多形...     

Sequential quantitative scintigraphy of parotid glands with chronic inflammatory diseases.

A practical, time-saving procedure for sequential quantitative scintigraphy is introduced and 4 parameters chosen from 12 parameters by discriminant analysis are used to evaluate the function of the parotid gland. The examination was performed in 120 cases, including 16 cases with recurrent parotitis in childhood, 33 with chronic obstructive parotitis (COP), 37 with Sj?gren's syndrome (SS), 4 with sialadenosis, and 30 normal controls. The scintigraphic findings were analyzed and compared with the histologic findings. The diagnostic value of this method was investigated and scaling for differential diagnosis of COP and SS was established. Scintigraphy is considered to be a useful method for evaluation of parotid function and as a diagnostic aid for SS and COP, especially in patients in whom sialography cannot be performed.     

Recurrent swelling of parotid glands and Sjögren's syndrome

This study included 125 patients with chronic parotitis, and it presents, in particular, a long-term clinical, laboratory, and sialographic study of 22 patients who were diagnosed as having adult recurrent sialadenitis of the parotid glands (ARSPG). Twelve of the 22 patients with ARSPG were shown to have Sjogren's syndrome (SS). These patients had recurrent parotid gland swelling for 1.5–14 years (mean, 5.2 years) before xerostomia and keratoconjunctivitis sicca occurred. Ten of the 22 patients with ARSPG did not develop SS, but did experience recurrent parotitis which extended from childhood into adulthood. The ARSPG underwent remission in seven of these patients. It is suggested that patients with ARSPG, but without a history of parotid gland swellings in childhood, should be diagnosed provisionally as having subclinical SS (SCSS).     

Classification and management of chronic sialadenitis of the parotid gland

Summary  Saliva has numerous oral functions and multiple functions in relation to digestion in the upper gastrointestinal tract. Chronic salivary hypofunction can lead to severe adverse health outcomes. Chronic sialadenitis is one of the major conditions that can cause salivary hypofunction. A correct diagnosis and management of chronic sialadenitis is essential for the recovery of salivary hypofunction. Chronic sialadenitis of the parotid gland is often seen in the clinic, sometimes also referred to as recurrent pyogenic parotitis, recurrent parotitis, non-obstructive parotitis, sialadenitis or obstructive parotitis, among other terms. The literature describes several different classifications and denominations for chronic sialadenitis of the parotid gland. These various classifications and denominations complicate the definition and diagnostic criteria, and if chronic sialadenitis of the parotid gland can develop into Sjogren's syndrome remains unclear. Treatment of this condition is also a challenging problem. Here, we review the presented classification and denomination of chronic sialadenitis of the parotid gland, proposing a classification based on the disease entities identified in a long-term follow-up investigation, and discuss the treatment principles for the condition.     

Enzyme activities in parotid saliva of patients with the restrictive type of anorexia nervosa

ObjectiveIn patients with anorexia nervosa (AN) specific signs may occur in the oral cavity, but there are conflicting reports about their significance, especially concerning changes in salivary composition.The aim of this clinical study was to evaluate the resting parotid flow rate (PFR) and the activity of the following enzymes in parotid saliva: amylase, aspartate amino transferase (AST), lysozyme, peroxidase, serine and acidic proteases in the acute phase of the restrictive type of AN and to compare the findings with those in healthy controls.DesignForty-one subjects participated (20 patients with AN, 21 matched healthy controls), parotid saliva was collected using a modified Lashley cap at rest. Enzyme activities were measured with fluorimetric and photometric assays.ResultsThe unstimulated PFR was significantly lower than in the controls, lysozyme and AST activity was significantly lower, and amylase showed a high inter-individual variability. A positive correlation for amylase and lysozyme and negative ones for lysozyme and BMI, lysozyme and IBW%, serine protease and salivary flow were observed.ConclusionsThe reduced PFR and enzyme activities levels suggest that AN does not only affect the quantity of the saliva but also its quality and, its biological functions. The results obtained should help to provide a better understanding of the effect of AN disease on the pathogenesis of at least some oral diseases. Further research is needed on any possible role of reduced lysozyme and transaminase activity in maintaining oral protection against external toxic agents and bacteria.     

Congenital parotid gland fistula

A rare case of congenital parotid gland fistula is reported. A 4-year-old boy presented with a fistula opening at the facial surface of the skin posterior to the left commissure of the lips. This fistula originated from an accessory parotid gland with a duct entirely distinct from the original Stensen's duct. Because of the salivary outflow from the fistula opening, the opening was translocated to the oral cavity using Delore's method.     

腮腺导管龙胆紫灌注实验研究

目的晚期慢性阻塞性腮腺炎是临床较难治疗的一种疾病。为了解龙胆紫灌注对于腮腺及全身其它组织的影响。方法对６只狗的１２侧腮腺各灌注５ｍｌ龙胆紫，于灌注后３０、６０、１２０分钟、２１天、９个月分别观察腮腺、心、肝、肾等组织的改变，分析灌注对于机体的局部和整体影响。结果腮腺灌注后３天内局部有明显的水肿，一般一周以后基本消退。２１天左右腺体开始明显变化，９个月左右腺体明显萎缩，结缔组织逐渐代替腺体。结论龙胆紫灌注腮腺后逐渐导致腮腺组织被纤维结缔组织所代替，这一过程对于心、肝、肾等组织无明显损害。     

自体动脉移植修复腮腺导管的远期疗效观察

目的 评价自体动脉移植在修复腮腺导管缺损中的临床效果。方法 回顾分析2003年8月—2012年12月应用自体动脉重建腮腺导管的6例患者资料。通过临床观察、腮腺造影检查评价治疗效果。随访时间为1个月~9 a。结果 术后随访1个月~2 a,6例患者腮腺无肿胀,腮腺导管通畅,腮腺分泌功能正常;术后2~9 a,患者双侧腮腺基本对称,挤压腮腺,2例腮腺导管有少量唾液分泌。腮腺造影显示重建区导管狭窄;3例腮腺导管无唾液分泌; 1例患者失访。结论 采用自体动脉重建腮腺导管,近期效果良好。但从远期疗效来看,自体动脉不适合重建腮腺导管。     

腮腺造影用于腮腺疾病的诊断112例分析

目的探讨腮腺造影对腮腺疾病的诊断价值。方法回顾性分析112例139个腺体的腮腺造影影像学特征及诊断结果。结果舍格伦综合征38例、儿童复发性腮腺炎27例、慢性阻塞性腮腺炎29例,其影像学表现符合其各自的特征性表现而得到确诊,良性肥大8例中的2例结合B超检查确诊,腮腺肿瘤10例中有2例结合B超检查定性。结论腮腺造影对腮腺非肿瘤性疾病有诊断价值,腮腺肿瘤应结合病史、化验并配合高频超声等其他手段提高诊断准确率。     

Effect of increasing the bulk content of the diet on the rat parotid gland and saliva

The present study, along with others, shows that when the requirement of a diet for mastication is increased, enlargement of the parotid gland occurs. This study demonstrated for the first time that the magnitude of the gland enlargement is directly related to the amount of nonnutritive bulk incorporated into the diet, and that the concentration of protein is significantly increased in the parotid saliva of rats fed such a diet. The findings show that, although the concentration of protein is increased in the parotid saliva, the composition of proteins is unchanged, leading to the conclusion that all secretory proteins are increased in parallel. A comparison of the gland enlargement observed in response to the bulk diet with that observed in response to chronic isoproterenol treatment reveals many similarities. However, the fact that the protein composition of the parotid saliva is not altered when rats are fed the bulk diet is in marked contrast to the striking changes observed following chronic isoproterenol treatment. The reason for the dissimilar response is not known. However, an investigation into the differences that exist in the gland response to these two means of inducing gland enlargement may lead to a better understanding of the factors that regulate the size of the rat parotid gland and the complement of proteins in its secretion.