共查询到20条相似文献,搜索用时 328 毫秒
1.
Joerg Schwock Grace Bradley James C Ho Bayardo Perez-Ordonez David W Hedley Jonathan C Irish William R Geddie 《BMC clinical pathology》2010,10(1):1
Background
SNAI1 can initiate epithelial-mesenchymal transition (EMT), leading to loss of epithelial characteristics and, in cancer, to invasion and metastasis. We hypothesized that SNAI1 reactivation occurs in oral squamous cell carcinoma (OSCC) where it might also be associated with focal adhesion kinase (FAK) expression and p63 loss. 相似文献2.
Chaido Dafni Nikolaos Drakoulis Olfert Landt Dimitris Panidis Martin Reczko Dennis V Cokkinos 《BMC medical genetics》2010,11(1):133
Background
Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), plays a key role in the regulation of vascular tone. Endothelium-derived NO exerts vasoprotective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation. The E298D polymorphic variant of eNOS has been associated with myocardial infarction (MI), but data relating to this variant are divergent in Greece. Accordingly, we examined a possible association between the E298D polymorphism of the eNOS gene and MI in a subgroup of the Greek population. 相似文献3.
Young-A Song Young-Lan Park Sun-Hye Yoon Kyu-Yeol Kim Sung-Bum Cho Wan-Sik Lee Ik-Joo Chung Young-Eun Joo 《Inflammation research》2011,60(5):493-500
Objective
The aim of this study was to determine the impact of the black tea polyphenol, theaflavin, on the expression of adhesion molecules and activation of lipopolysaccharide (LPS)-induced innate signaling in rat intestinal epithelial (RIE) cells. 相似文献4.
Antoniella Souza Gomes Henrique Paula Lemos Jand Venes Rolim Medeiros Fernando Queiroz Cunha Marcellus Henrique Loiola Ponte Souza 《Inflammation research》2009,58(10):717-723
Objective and design
To investigate the role of non-protein sulfhydryl groups (NP-SH) and leukocyte adhesion in the protective effect of lipopolysaccharide (LPS) from Escherichia coli against indomethacin-induced gastropathy. 相似文献5.
Objective
We investigated C-peptide effects on inflammatory cytokine release and adhesion of monocytes exposed to high glucose and lipopolysaccharide (LPS) in vitro. 相似文献6.
Azizah Ugusman Zaiton Zakaria Chua Kien Hui Nor Anita Megat Mohd Nordin 《BMC complementary and alternative medicine》2011,11(1):31
Background
Aqueous extract of Piper sarmentosum (AEPS) is known to possess antioxidant and anti-atherosclerotic activities but the mechanism responsible for it remains unclear. In early part of atherosclerosis, nuclear factor-kappa B (NF-κB) induces the expression of cellular adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin. NADPH oxidase 4 (Nox4) is the predominant source of superoxide in the endothelial cells whereas superoxide dismutase 1 (SOD1), catalase (CAT) and glutathione peroxidase (GPx) are the antioxidant enzymes responsible for inactivating reactive oxygen species. The present study aimed to investigate the effects of AEPS on the gene expression of NF-κB, VCAM-1, ICAM-1, E-selectin, Nox4, SOD1, CAT and GPx in cultured human umbilical vein endothelial cells (HUVECs). 相似文献7.
Lediana?Iagalo?Miguel Camila?B.?Almeida Fabiola?Traina Andreia?A.?Canalli Venina?M.?Dominical Sara?T.?O.?Saad Fernando?F.?Costa Nicola?Conran
Objective
Leukocyte adhesion to vessel walls may initiate vaso-occlusion in sickle cell anemia (SCA); however, the extent to which inflammation participates in this mechanism is not understood. This in vitro study investigated whether inflammatory molecules, commonly augmented in SCA, can affect neutrophil adhesive properties and whether cyclic guanosine monophosphate (cGMP)-elevating agents can inhibit such adhesion. 相似文献8.
Yael Gazit Adi Mory Amos Etzioni Moshe Frydman Oded Scheuerman Ruth Gershoni-Baruch Ben-Zion Garty 《Journal of clinical immunology》2010,30(2):308-313
Introduction
Leukocyte adhesion deficiency (LAD) is a group of rare inherited disorders characterized by immune deficiency and peripheral neutrophilia. There are only seven reported cases of LAD type II worldwide, and no long-term follow-up data. 相似文献9.
Ming Xie Yanying Dong Linjing He Huixun Ren Yuqiang Ji Shemin Lv 《Inflammation research》2011,60(7):613-617
Objective and design
The very late antigen-4 (VLA-4) bound to vascular cell adhesion molecule-1 could provide co-stimulatory signals for the activation of T lymphocytes, and these adhesion molecules play key roles in leukocyte adherence and propagation of inflammatory responses. We examined the levels of VLA-4 in the peripheral blood mononuclear cells (PBMC) of patients with hemorrhagic fever with renal syndrome (HFRS). 相似文献10.
Andreas C Eriksson Lena Jonasson Tomas L Lindahl Bo Hedb?ck Per A Whiss 《Journal of translational medicine》2009,7(1):42-14
Background
Despite the use of anti-platelet agents such as acetylsalicylic acid (ASA) and clopidogrel in coronary heart disease, some patients continue to suffer from atherothrombosis. This has stimulated development of platelet function assays to monitor treatment effects. However, it is still not recommended to change treatment based on results from platelet function assays. This study aimed to evaluate the capacity of a static platelet adhesion assay to detect platelet inhibiting effects of ASA and clopidogrel. The adhesion assay measures several aspects of platelet adhesion simultaneously, which increases the probability of finding conditions sensitive for anti-platelet treatment. 相似文献11.
Elias Zintzaras Chrysoula Doxani Theocharis Koufakis Alkibiadis Kastanis Paraskevi Rodopoulou Theofilos Karachalios 《BMC medicine》2011,9(1):9
Background
Focal adhesion (FA) family genes have been studied as candidate genes for osteoporosis, but the results of genetic association studies (GASs) are controversial. To clarify these data, a systematic assessment of GASs for FA genes in osteoporosis was conducted. 相似文献12.
Background
The effect of silicones on the immune function is not fully characterized. In clinical and experimental studies, immune alterations associated with silicone gel seem to be related to macrophage activation. In this work we examined in vivo, phenotypic and functional changes on peritoneal macrophages early (24 h or 48 h) and late (45 days) after the intraperitoneal (i.p.) injection of dimethylpolysiloxane (DMPS) (silicone). We studied the expression of adhesion and co-stimulatory molecules and both the spontaneous and the stimulated production of reactive oxygen intermediates and nitric oxide (NO). 相似文献13.
Background
Neutrophil infiltration is one of the critical cellular components of an inflammatory response during peritonitis. The adhesion molecules, P-selectin and intercellular adhesion molecule (ICAM)-1, mediate neutrophil-endothelial cell interactions and the subsequent neutrophil transendothelial migration during the inflammatory response. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy, suggesting that the length of injury might be a critical factor in neutrophil infiltration. Therefore, the objective of this study was to determine the role of P-selectin and ICAM-1 in neutrophil infiltration into the peritoneal cavity during early and late phases of peritonitis. 相似文献14.
Objective
Reducing the expression of endothelial cell adhesion molecules (ECAMs) is known to decrease inflammation-induced vascular complications. In this paper we looked at whether statins can reduce inflammation-induced ECAM expression after lipopolysaccharide (LPS) treatment in endothelial cells. 相似文献15.
Qunying Han Wen Kang Lei Zhang Sai Lou Qianzi Zhao Zhengwen Liu 《Inflammation research》2010,59(2):135-139
Background
In view of the role of fibronectin in adhesion, signal transduction pathways and the infectious disease process, changes in serum fibronectin levels may influence disease evolution and severity in patients with hemorrhagic fever with renal syndrome (HFRS). 相似文献16.
17.
Background
Helicobacter pylori (H. pylori) infection is associated with chronic gastritis, peptic ulceration and gastric carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activation of mitogen-activated protein kinases (MAPK), cell proliferation and apoptosis in several cells. Previously, we found that H. pylori induces the expression of PAR-2, which mediates the expression of adhesion molecules integrins in gastric epithelial cells. In the present study, the role of PAR-2 on H. pylori-induced cell death was investigated by determining cell viability, DNA fragmentation, and the activation of MAPK in gastric epithelial AGS cells. 相似文献18.
19.
Adriana C Dos Santos Ester Roffê Rosa ME Arantes Luiz Juliano Jorge L Pesquero João B Pesquero Michael Bader Mauro M Teixeira Juliana Carvalho-Tavares 《Journal of neuroinflammation》2008,5(1):49
Background
Kinins are important mediators of inflammation and act through stimulation of two receptor subtypes, B1 and B2. Leukocyte infiltration contributes to the pathogenesis of autoimmune inflammation in the central nervous system (CNS), occurring not only in multiple sclerosis (MS) but also in experimental autoimmune encephalomyelitis (EAE). We have previously shown that the chemokines CCL2 and CCL5 play an important role in the adhesion of leukocytes to the brain microcirculation in EAE. The aim of the present study was to evaluate the relevance of B2 receptors to leukocyte-endothelium interactions in the cerebral microcirculation, and its participation in CNS inflammation in the experimental model of myelin-oligodendrocyte-glycoprotein (MOG)35–55-induced EAE in mice. 相似文献20.
Yong Il Kim 《Yonsei medical journal》2013,54(6):1491-1497