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1.
Osama B. Albasheer Mohammed S. Mahfouz Yahia Solan Duaa A. Khan Mohammed A. Muqri Haneen A. Almutairi Ali M. Alelyani Hussain A. Alahmed 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):117-121
Purpose
To determine the prevalence of depression and related risk factors among type 2 diabetes mellitus patients (T2DM) in Jazan area, Saudi Arabia.Method
A cross sectional, self-administered questionnaire study was conducted among T2DM patients in Jazan area, Saudi Arabia. A total of 385 patients were selected at randomly. The Patient Health Questionnaire (PHQ-9) was utilized to measure symptoms and signs of depression.Results
The overall prevalence of depression among T2DM patients was 37.6%. Of them, 24.2% were mildly depressed, 9.6% were moderately severely depressed, and 4.2% were severely depression. Significant predictors of depression include the presence of diabetic foot (P = 0.000), cardio-vascular diseases (P = 0.000), eye complication (P = 0.073), and erectile dysfunction (P = 0.090). The prevalence of depression was not significantly associated with the age (P = 0.375) and gender (P = 0.374). Similarly no association was found with duration of diabetes (P = 0.475) and HbA1c (P = 0.555).Conclusion
The study revealed that diabetes complications are strong predictors of the rate of depression among T2DM patients. Therefore, early depression screening is needed to improve the quality of life of diabetic patients. 相似文献2.
H.S. Bajaj R.E. Brown L. Bhullar N. Sohi S. Kalra R. Aronson 《Diabetes & metabolism》2018,44(6):493-499
Aim
The impact of new classes of glucose lowering medications on markers of non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes (T2D) have been inconsistent in their magnitude and independence. This large retrospective study investigates changes in alanine aminotransferase (ALT) levels among subjects initiated on newer classes of T2D medications in comparison to a reference control group.Methods
We studied people with T2D from a large Canadian diabetes register, who had canagliflozin, dapagliflozin, liraglutide, sitagliptin or no further treatment added to their diabetes treatments. Stepwise multiple regression was used to determine the association of A1c and weight change on ALT. Propensity score weighting was used to balance baseline characteristics between treatment groups.Results
A total of 3667 subjects met study criteria. ALT levels (mean follow-up 4.8 months) were lower after treatment with sodium glucose co-transporter 2 (SGLT2) inhibitors, canagliflozin (?4.3 U/L, P < 0.01) and dapagliflozin (?3.5 U/L, P < 0.01), compared to incretin agents, liraglutide (?2.1 U/L, P < 0.01) and sitagliptin (?1.8 U/L, P < 0.01), each greater than the control group. Only the SGLT2 inhibitor treatment groups maintained a significant ALT reduction vs. control following multivariable adjustment and propensity score weighting. Greater ALT reductions were seen with higher baseline ALT for both the SGLT2 inhibitor treatment groups.Conclusion
SGLT2 inhibitors canagliflozin and dapagliflozin resulted in a weight and A1c-independent reduction of ALT levels compared to incretin agents, with a dose-response observed at higher baseline ALT levels. Further studies investigating the differential effects of these drug classes on NAFLD, and insulin/glucagon levels as potential mechanism explaining these differences, should be performed. 相似文献3.
B. Rasouli E. Ahlqvist L. Alfredsson T. Andersson P.-O. Carlsson L. Groop J.E. Löfvenborg M. Martinell A. Rosengren T. Tuomi A. Wolk S. Carlsson 《Diabetes & metabolism》2018,44(4):354-360
Aim
Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA.Methods
This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction.Results
Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370).Conclusion
Our findings suggest that coffee consumption interacts with HLA to promote LADA. 相似文献4.
H. Kahal A. Aburima B. Spurgeon K.S. Wraith A.S. Rigby T. Sathyapalan E.S. Kilpatrick K.M. Naseem S.L. Atkin 《Diabetes & metabolism》2018,44(5):431-436
Aim
Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes compared to healthy age-matched controls.Methods
Hyperinsulinaemic clamps reduced blood glucose to 2.8 mmol/L (50 mg/dl) for 1 hour. Sampling at baseline; euglycaemia 5 mmol/L (90 mg/dl); hypoglycaemia; and at 24 post clamp were undertaken. Platelet function was measured by whole blood flow cytometry.Results
10 subjects with T2DM and 8 controls were recruited. Platelets from people with T2DM showed reduced sensitivity to prostacyclin (PGI2, 1 nM) following hypoglycaemia. The ability of PGI2 to inhibit platelet activation was significantly impaired at 24 hours compared to baseline in the T2DM group. Here, inhibition of fibrinogen binding was 29.5% (10.3–43.8) compared to 50.8% (36.8–61.1), (P < 0.05), while inhibition of P-selectin expression was 32% (16.1–47.6) vs. 54.4% (42.5–67.5) (P < 0.05). No significant changes in platelet function were noted in controls.Conclusion
Induced hypoglycaemia in T2DM enhances platelet hyperactivity through impaired sensitivity to prostacyclin at 24 hours. 相似文献5.
6.
Aims
rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but the results remain controversial. To investigate the relationship, a meta-analysis involving 21,464 individuals was conducted.Methods
Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was evaluated with Begg’s test. Our research includes three gene models: allelic genetic model (K-allele vs. E-allele), recessive genetic model (KK vs. EK + EE) and dominant genetic model (EE vs. EK + KK).Results
In allelic genetic model, subgroup analysis demonstrated rs5219 K-allele was relevant to T2DM risk in Caucasian (OR: 1.16, 95% CI: 1.09–1.24, P = 0.000) and East Asian (OR: 1.19, 95% CI: 1.13–1.26, P = 0.000), recessive genetic model indicated rs5219 KK genotype was related to T2DM risk in Caucasian, East Asian, South Asian, and North African (OR: 1.27, 95% CI: 1.17–1.38, P = 0.000), dominant genetic model pointed out rs5219 EE genotype was an opposite association with T2DM risk in Caucasian (OR: 0.86, 95% CI: 0.78–0.94, P = 0.001). No obvious evidence of publication bias was found.Conclusions
There was a believable evidence to verify that rs5219 variation was associated with T2DM. 相似文献7.
B.K. Mishra P. Shukla M. Aslam A.A. Siddiqui S.V. Madhu 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):839-842
Background
It is being increasingly reported that some of the youth onset diabetes patients cannot be classified clearly as type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) based on usual criteria and the term double diabetes (DD) coined for these cases.Aim
The objective of the study was to find out the prevalence of DD in youth onset diabetes patients from east Delhi and neighboring NCR region.Methods
A total of 200 patients with youth onset diabetes below 25 years of age were recruited from a tertiary care hospital in East Delhi. Clinical history, family history of diabetes and anthropometry of patients were recorded. Fasting serum C-peptide, Anti-IA2-antibody and Anti-GAD-antibody were measured in all patients. Patients positive for Anti-GAD-antibody (>1.05 U/ml) and C-peptide level >0.3 nmol/l were characterized as DD patients. Patients negative for Anti-GAD-antibody and C-peptide >0.3 nmol/l were kept under the category of T2DM. Patients with low C-peptide level along with one of the following, positive Anti-GAD-antibody, positive Anti-IA2-antibody and diabetic ketoacidosis (DKA) were considered as T1DM. Remaining patients were kept under the unknown category.Results
Mean age of study subjects was 18.2 ± 7.1 years. Seven percent (7%) of the subjects were classified as DD, 51% as T1DM, 13% as T2DM and 29% were kept under the unknown category. Mean age of subjects with 22.2 ± 9.7, 16.9 ± 6.7, 20.6 ± 7.7 and 19.4 ± 7.4 years in DD, T1DM, T2DM and unknown category respectively. Mean BMI of subjects with DD, T1DM, T2DM and unknown category was 19.8 ± 5.7, 16.6 ± 3.7, 19.3 ± 4.1 and 18.0 ± 4.6 kg/m2 respectively.Conclusion
Double diabetes is an important occurrence among youth onset diabetes subjects. Only half of the subjects with youth onset of diabetes had T1DM. 相似文献8.
Abdul Hakeem Alrawahi Patricia Lee Zaher A.M. Al-Anqoudi Muna Alrabaani Ahmed Al-Busaidi Faisal Almahrouqi Ahmed M. Albusaidi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):105-110
Aim
To date, no cardiovascular risk assessment tool has been developed specifically for any Arabian population including Omanis. This study aims to develop a suitable cardiovascular risk prediction model in the form of a statistical equation, for Omanis with type 2 diabetes.Materials and methods
A sample of 2039 patients with type 2 diabetes selected from primary care settings in the Aldakhiliyah Province of Oman were involved in a retrospective cohort study. All patients were free of cardiovascular disease at baseline (in 2009–2010) and were followed up until: 1) their first cardiovascular event occurred; 2) the patient died, or 3) the end of the data collection in December 2015.Results
Among the total sample, 192 cardiovascular disease events were recorded within a mean follow-up period of 5.3-year. The 5-year probability of a cardiovascular event was given as 1 ? 0.9991Exp∑XiBi, where Exp ∑XiBi (hazard ratio) = Exp (0.038 age + 0.052 DM duration + 0.102 HbA1c + 0.201 total cholesterol + 0.912 albuminuria [1 if present] + 0.166 hypertension [1 if present] + 0.005 BMI).Conclusion
The first cardiovascular risk prediction tool in the Arab world was developed in this study. It may be used to estimate the 5-year cardiovascular risk among Omanis with type 2 diabetes in order to plan patient management and preventive measures. However, further validation studies are required to determine the accuracy of the model. 相似文献9.
Katja Vince Tamara Poljičanin Marko Brkić Urelija Rodin Ratko Matijević 《Primary Care Diabetes》2018,12(4):325-330
Aims
The aim of this study was to determine the prevalence of diabetes among women 5 years after having gestational diabetes during pregnancy. Also, we sought to determine whether women who develop diabetes after GD during pregnancy differ from women who do not develop diabetes after GD during pregnancy.Methods
This longitudinal study was performed using data from medical birth certificates and CroDiab diabetes registry. Women burdened with gestational diabetes in Croatia in 2011 were followed up until year 2016. Those registered in CroDiab registry were recognised as new patients with diabetes.Results
Among 40,641 deliveries in 2011, gestational diabetes was reported in 1181 (2.9%) women. Among them 853 (72.23%) were followed up in CroDiab diabetes registry and 32 (3.75%) were identified as new patients with diabetes. Median time from childbirth to onset of diabetes was 29.12 months. The diabetes group did not significantly differ to the group without diabetes according to age (p = 0.587), level of education (p = 0.549) or marital status (p = 0.849) except that the diabetes group was significantly more obese than the group without diabetes (p = 0.002).Conclusions
Based on CroDiab diabetes registry data prevalence of diabetes 5 years after pregnancy complicated with gestational diabetes is 3.75% in Croatia. Women with gestational diabetes during pregnancy, and especially those with higher BMIs, are an important risk group for developing diabetes later in life so screening and preventive measures should be oriented toward them in primary care settings. 相似文献10.
Gulhan Cosansu Selda Celik Seyda Özcan Nermin Olgun Nurdan Yıldırım Hulya Gulyuz Demir 《Primary Care Diabetes》2018,12(5):409-415
Aims
This study aimed to determine risk factors for type 2 diabetes among adults who were not diagnosed with diabetes.Methods
Adults were included in this study within the public activities performed on World Diabetes Day (n = 1872). Data were collected using the FINDRISC questionnaire and a short questionnaire.Results
Participants’ mean age was 39.35 ± 10.40. The mean FINDRISC score was 7.46 ± 4.62, women's mean score was higher than that for men. The FINDRISC score indicates that 7.4% of the participants were in the highrisk group. Among participants, BMI value of 65.1% was 25 kg/m2 and higher, waist circumference of 58% was over the threshold value; and 50.7% did not engage in sufficient physical activity. Of the participants, 9.5% had a history of high blood glucose, families of 38.9% had a history of diabetes. The mean FINDRISC score was in the slightly high category, 121 participants were found likely to be diagnosed with diabetes within ten years if no action was taken.Conclusions
It is recommended the risk screening studies to be conducted and the FINDRISC tool to be used in Turkey, where diabetes prevalence is increasing rapidly, to determine diabetes risks in the early period and to raise social awareness for diabetes. 相似文献11.
Heidi Hakkarainen Hanna Huopio Henna Cederberg Raimo Voutilainen Seppo Heinonen 《Primary Care Diabetes》2018,12(4):364-370
Aims
Was to determine whether the birth weight of the infant predicts prediabetes (impaired fasting glucose, impaired glucose tolerance, or both) and type 2 diabetes (T2DM) during long-term follow-up of women with or without gestational diabetes mellitus (GDM).Methods
The women with or without GDM during their pregnancies in Kuopio University Hospital in 1989–2009 (n = 876) were contacted and invited for an evaluation. They were stratified into two groups according to the newborn’s birth weight: 10–90th percentile (appropriate-for-gestational-age; AGA) (n = 662) and >90th percentile (large-for-gestational-age; LGA) (n = 116). Glucose tolerance was investigated with an oral glucose tolerance test after a mean follow-up time of 7.3 (SD 5.1) years.Results
The incidence of T2DM was 11.8% and 0% in the women with and without GDM, respectively, after an LGA delivery. The incidence of prediabetes increased with offspring birth weight categories in the women with and without GDM: from 46.3% and 26.2% (AGA) to 52.9% and 29.2% (LGA), respectively.Conclusions
GDM women with LGA infants are at an increased risk for subsequent development of T2DM and therefore represent a target group for intervention to delay or prevent T2DM development. In contrast, an LGA delivery without GDM does not increase T2DM risk. 相似文献12.
Joseph Jonathan Lee Matthew James Thompson Juliet Alexandra Usher-Smith Constantinos Koshiaris Ann Van den Bruel 《Primary Care Diabetes》2018,12(3):254-264
Background
The epidemiology of type 1 diabetes mellitus (T1DM) suggests diagnostic delays may contribute to children developing diabetic ketoacidosis at diagnosis. We sought to quantify opportunities for earlier diagnosis of T1DM in primary care.Methods
A matched case-control study of children (0–16 years) presenting to UK primary care, examining routinely collected primary care consultation types and National Institute for Health and Care Excellence (NICE) warning signs in the 13 weeks before diagnosis.Results
Our primary analysis included 1920 new T1DM cases and 7680 controls. In the week prior to diagnosis more cases than controls had medical record entries (663, 34.5% vs 1014, 13.6%, odds ratio 3.46, 95% CI 3.07–3.89; p < 0.0001) and the incidence rate of face-to-face consultations was higher in cases (mean 0.32 vs 0.11, incidence rate ratio 2.90, 2.61–3.21; p < 0.0001). The preceding week entries were found in 330 cases and 943 controls (17.2% vs 12.3%, OR 1.49, 1.3–1.7, p < 0.0001), but face-to-face consultations were no different (IRR 1.08 (0.9–1.29, p = 0.42)).Interpretation
There may be opportunities to reduce time to diagnosis for up to one third of cases, by up to two weeks. Diagnostic opportunities might be maximised by measures that improve access to primary care, and public awareness of T1DM. 相似文献13.
J. Mortensen A.J. Clark T. Lange G.S. Andersen M. Goldberg C.H. Ramlau-Hansen J. Head M. Kivimäki I.E.H. Madsen C. Leineweber R. Lund R. Rugulies M. Zins H. Westerlund N.H. Rod 《Diabetes & metabolism》2018,44(1):38-44
Aim
To examine whether informal caregiving is associated with increased risk of type 2 diabetes (T2D), and whether job strain and social support at work modify the association.Methods
Individual participant's data were pooled from three cohort studies—the French GAZEL study, the Swedish Longitudinal Occupational Survey of Health (SLOSH) and the British Whitehall II study—a total of 21,243 study subjects. Informal caregiving was defined as unpaid care for a closely related person. Job strain was assessed using the demand-control model, and questions on co-worker and supervisor support were combined in a measure of social support at work. Incident T2D was ascertained using registry-based, clinically assessed and self-reported data.Results
A total of 1058 participants developed T2D during the up to 10 years of follow-up. Neither informal caregiving (OR: 1.09, 95% CI: 0.92–1.30) nor high job strain (OR: 1.04, 95% CI: 0.86–1.26) were associated with T2D risk, whereas low social support at work was a risk factor for T2D (OR: 1.18, 95% CI: 1.02–1.37). Also, informal caregivers who were also exposed to low social support at work were at higher risk of T2D (OR: 1.40, 95% CI: 1.08–1.82) compared with those who were not informal caregivers and had high social support at work (multiplicative test for interaction, P = 0.04; additive test for interaction, synergy index = 10).Conclusion
Informal caregiving was not independently associated with T2D risk. However, low social support at work was a risk factor, and informal caregivers with low social support at work had even higher risks of T2D. 相似文献14.
Hayford Mawuli Avedzi Nonsikelelo Mathe Kate Storey Jeffrey Allen Johnson Steven Thomas Johnson 《Primary Care Diabetes》2018,12(1):71-79
Aim
We examined self-reported dietary behaviours and actual food intakes among adult men and women with type 2 diabetes participating in Alberta’s Caring for Diabetes (ABCD) Study.Methods
Participants completed 3-day food records and questions about glycemic index (GI) concept knowledge and dietary behaviours. Daily average GI and glycemic load (GL) were calculated for all carbohydrates consumed. Dietary intake was analyzed using ESHA FoodPro (version 10.13.1). Sex differences in nutrient intakes were explored across categories of GI knowledge and dietary practices.Results
Participants (N = 170) mean (SD) age 65.8 (9.6) years were 46.5% women, 90.6% Caucasian with a mean BMI of 31.3 (7.0) kg/m2 and diabetes duration of 13.4 (8.6) years. Overall, 60% of men versus 40% of women consumed carbohydrates in quantities below Acceptable Macronutrient Distribution Ranges (AMDR). About 80% of men versus 90% of women consumed proteins above AMDR whereas 60% versus 65% of women consumed fats above AMDR. Fibre intake among men was lower than recommended (p < 0.01). Men who reported having knowledge of the GI-concept also reported lower GI intake versus men who did not (p = 0.03).Conclusion
Sex differences exist in low-GI diabetes self-care dietary behaviours among adults with type 2 diabetes participating in this study. Gender-sensitive approaches for enhancing diabetes self-care low-GI dietary behaviour should be explored. 相似文献15.
N.H. Kim J. Choi N.H. Kim K.M. Choi S.H. Baik J. Lee S.G. Kim 《Diabetes & metabolism》2018,44(4):361-367
Aims
This study examined whether dipeptidyl peptidase (DPP)-4 inhibitor use is beneficial or harmful to diabetic retinopathy (DR) compared with other glucose-lowering agents in patients with type 2 diabetes (T2D).Methods
From a population-based cohort provided by the National Health Insurance Service in Korea, 67,743 adults with T2D were identified as having been treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was performed for two groups comparing ever-use (cases) and never-use (controls) of DPP-4 inhibitors (n = 14,522 in each group). Cox regression analyses were used to assess risk of the following DR events: vitreous haemorrhage; vitrectomy or photocoagulation; intravitreal agent use; and blindness.Results
During a median follow-up of 28.4 (14.0–45.2) months, there were 305 (in controls) and 342 (in cases) composite DR events. DPP-4 inhibitor ever-use was not associated with overall risk of composite DR events [adjusted hazard ratio (HR): 1.08, 95% CI: 0.93–1.26] compared with never-use, nor was the risk of each DR outcome increased with DPP-4 inhibitor therapy either. However, DPP-4 inhibitor administration for < 12 months was associated with a greater risk of composite DR events (adjusted HR: 1.31, 95% CI: 1.09–1.57) compared with other glucose-lowering agents over the same treatment period.Conclusion
In comparison to other oral glucose-lowering agents, DPP-4 inhibitor treatment did not increase overall risk of DR. However, DPP-4 inhibitors may be associated with an increased risk of retinopathy events early in the treatment phase. 相似文献16.
G. Reach M. Pellan A. Crine C. Touboul A. Ciocca Y. Djoudi 《Diabetes & metabolism》2018,44(6):500-507
Background
The aim of this study was to determine whether adherent and non-adherent patients with type 2 diabetes can be differentiated according to psychosocial characteristics.Methods
A total of 1214 patients were included in the analysis. Data were derived from a cross-sectional observational study of adults with diabetes of the Access Santé (Access Health) panel of Kantar Health France. Patients completed a questionnaire on adherence to medication, psychological determinants (trust in physicians, constancy of habits, patience, temporal horizon, health locus of control, obedience, psychological reactivity, prevention vs promotion, optimism vs pessimism) and social deprivation.Results
Of these 1214 subjects, 46.2% were considered strictly adherent to antidiabetic medication, as reflected by negative answers to all six questions suggesting a non-adherent behaviours, whereas 48.9% provided 1–2 positive answers and 4.9% provided 3–6 positive answers, and were considered non-adherent. In addition to the effect of younger age (P = 0.03), multivariate logistic regression analysis demonstrated the following psychosocial determinants of non-adherence: chance locus of control (P = 0.02); lack of trust in physicians (P = 0.010); and pessimism (P = 0.021). Multiple factor analysis identified adherence and social deprivation as dimensions separating three distinct patient populations: (i) non-adherent; (ii) adherent and socially deprived; and (iii) adherent and non-socially deprived. It also revealed that patience, obedience, cautious behaviour, optimism, trust in physicians and constancy of habits were associated with adherence.Conclusion
Of the multiple determinants of adherence, trust in physicians and constancy of habits represent modifiable factors, and constitute targets to prevent non-adherence because they can be reinforced through patient education and improved physician – patient relationship. Also, psychosocial determinants of adherence differ widely between socially deprived and non-deprived patients. 相似文献17.
E. Papakonstantinou M.D. Kontogianni P. Mitrou E. Magriplis D. Vassiliadi T. Nomikos V. Lambadiari E. Georgousopoulou G. Dimitriadis 《Diabetes & metabolism》2018,44(3):226-234
Background/objectives
The study aimed to compare the effects of two eucaloric meal patterns (3 vs 6 meals/day) on glycaemic control and satiety in subjects with impaired glucose tolerance and plasma glucose (PG) levels 140–199 mg/dL at 120 min (IGT-A) or PG levels 140–199 mg/dL at 120 min and >200 mg/dL at 30/60/90 min post-oral glucose load on 75-g OGTT (IGT-B), or overt treatment-naïve type 2 diabetes (T2D).Subjects/methods
In this randomized crossover study, subjects with IGT-A (n = 15, BMI: 32.4 ± 5.2 kg/m2), IGT-B (n = 20, BMI: 32.5 ± 5 kg/m2) or T2D (n = 12, BMI: 32.2 ± 5.2 kg/m2) followed a weight-maintenance diet (45% carbohydrates, 20% proteins, 35% fats) in 3 or 6 meals/day (each intervention lasting 12 weeks). Anthropometrics, diet compliance and subjective appetite were assessed every 2 weeks. OGTT and measurements of HbA1c and plasma lipids were performed at the beginning and end of each intervention period.Results
Body weight and physical activity levels remained stable throughout the study. In T2D, HbA1c and PG at 120 min post-OGTT decreased with 6 vs 3 meals (P < 0.001 vs P = 0.02, respectively). The 6-meal intervention also improved post-OGTT hyperinsulinaemia in IGT-A subjects and hyperglycaemia in IGT-B subjects. In all three groups, subjective hunger and desire to eat were reduced with 6 vs 3 meals/day (P < 0.05). There were no differences in HOMA-IR or plasma lipids between interventions.Conclusion
Although weight loss remains the key strategy in hyperglycaemia management, dietary measures such as more frequent and smaller meals may be helpful for those not sufficiently motivated to adhere to calorie-restricted diets. Our study shows that 6 vs 3 meals a day can increase glycaemic control in obese patients with early-stage T2D, and may perhaps improve and/or stabilize postprandial glucose regulation in prediabetes subjects. 相似文献18.
Aim
In this study, the impact of serum bilirubin on new-onset type 2 diabetes mellitus (T2DM) in Korean adults was investigated.Methods
Data were obtained from the Korean Genome and Epidemiology Study (KoGES), a population-based prospective cohort study. The study enrolled 8650 adults (4015 men and 4635 women), aged 40 to 69 years, who underwent a mean follow-up of 8.4 years. The study population was divided into quartiles (Q) of serum bilirubin levels, with cut-off points at 0.46, 0.61 and 0.82 mg/dL for men, and 0.35, 0.47 and 0.61 mg/dL for women. T2DM was defined based on the following data: fasting blood glucose ≥ 7.0 mmol/L, HbA1c level ≥ 6.5% or 2-h plasma glucose ≥ 11.1 mmol/L during a 75-g oral glucose tolerance test.Results
Over the mean 8.4-year follow-up, 786 participants (9.1%) developed T2DM. Compared with Q1, the odds ratios (ORs) and 95% confidence intervals (CIs) for T2DM incidence were 0.52 (0.36–0.74) in men and 0.56 (0.38–0.83) in women aged ≥50 years, respectively, in the highest Q group after adjusting for possible confounding factors. These significant results persisted in those with impaired glucose tolerance and impaired fasting glucose.Conclusion
The results of this study reveal a protective role for serum total bilirubin on new-onset T2DM in Korean men and women. In addition, serum total bilirubin had favourable effects on new-onset T2DM in those with impaired glucose tolerance and impaired fasting glucose. 相似文献19.
Hamideh Lari Rahim Tahmasebi Azita Noroozi 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):45-50
Background
By high prevalence of inactivity, particularly in diabetic patients, the need to effective interventions to promote physical activity is essential. The aim of this study was to determine the effects of education based on health promotion model (HPM) through multimedia on the physical activity in diabetic patients.Method
In this quasi-experimental study, 76 patients with type II diabetes were evaluated (40 patents in intervention group and 36 patients in control group). The intervention group members and a friend or a family member, that could be supportive in physical activity, received teaching CD based on health promotion model. Both group members at the beginning of the study, two weeks and three months after the training, completed questionnaires. After data collection, statistical analysis was conducted using independent T-test, chi-square test, and repeated measurement of ANOVA.Results
Finding showed that self-efficacy (P < 0.001), health status (p = 0.032), benefits (P < 0.001) and friends support in physical activity (P < 0.001) were perceived to be higher, and barrier of physical activity (P < 0.001) was perceived to be lower in multimedia group compared to control group 3 months after training. There was a significant difference in average of metabolic equivalent of task (MET) between two groups after the intervention (P < 0.001).Conclusion
Planning of education based on the HPM and implementation through multimedia can change belief about physical activity and increase participation in physical activity. 相似文献20.
S. Imai S. Kajiyama Y. Hashimoto A. Nitta T. Miyawaki S. Matsumoto N. Ozasa M. Tanaka S. Kajiyama M. Fukui 《Diabetes & metabolism》2018,44(6):482-487