倍他司汀联合胞磷胆碱钠治疗颈椎病性眩晕疗效观察

目的 观察倍他司汀联合胞磷胆碱钠注射液对颈椎病性眩晕的疗效。方法 60例颈椎病性眩晕患者随机分为两组，治疗组用倍他司汀联合胞磷胆碱钠；对照组用曲克芦丁和胞二磷胆碱，两组疗程均为10天。观察两组疗效与副作用。结果 治疗组有效率93．3％，对照组有效率66．7％，经统计学χ^2检验，P〈0．01，两组差异有非常显著性。治疗组不良反应少。结论 倍他司汀联合胞磷胆碱钠注射液治疗颈椎病性眩晕疗效满意，值得临床推广、应用。     

复方丹参和维生素K1治疗婴幼儿支气管肺炎疗效观察

目的探讨联合静滴复方丹参和维生素K1治疗婴幼儿支气管肺炎的临床疗效。方法对100例婴幼儿支气管肺炎随机分为4组，设A组：联合加复方丹参和维生素K1缓慢静滴；B组：单纯加复方丹参缓慢静滴；C组：单纯加维生素K1缓慢静滴；D组：采取常规综合治疗。每组25例，观察4组疗效。结果A组5日与7日总有效率为88％（22／25）与96％（24／25），均高于B、C、D组，比较差异有统计学意义（P均〈0．05）；B组5日与7日总有效率为60％（15／25）与76％（19／25）、C组5日与7日总有效率为64％（16／25）与72％（18／25）均高于D组5日与7日总有效率52％（13／25）与68％（17／25），但比较差异无统计学意义（P均〉0．05）；B、C组5日总有效率与7日总有效率均无明显区别，比较差异无统计学意义（P〉0．05）。结论联合静滴复方丹参和维生素K1治疗婴幼儿支气管肺炎优于单纯加滴复方丹参、单纯加滴维生素K1及常规综合治疗，安全性好，能够提高疗效，缩短疗程，经济实惠。     

胞磷胆碱钠片治疗面神经炎的临床疗效观察

目的评价胞磷胆碱钠片治疗面神经炎的临床疗效。方法随机将入选的100例面神经炎患者分为治疗组52例（采用胞磷胆碱钠片200mg/次,3次/天联合维生素B1片20mg/次,3次/天及甲钴胺B120.5 mg/次,3次/天进行治疗）与对照组48例（单用维生素B1片20mg/次,3次/天及甲钴胺B120.5 mg/次,3次/天）48例,疗程均为4周,并按面瘫简易评分法评分对比观察效果。结果治疗组中治愈12例,好转28例,总有效例数为49例,总有效率为94.2%;对照组中治愈9例,好转15例,总有效例数为24例,总有效率为50.0%,两组疗效有显著性差异（P〈0.05）,说明治疗组疗效优于对照组。结论胞磷胆碱钠片治疗面神经炎疗效确切,可在临床推广应用。     

长春西汀＋胞磷胆碱钠治疗突发性耳聋的疗效观察

目的探讨长春西汀＋胞磷胆碱钠等治疗突发性耳聋的临床疗效。方法随机将64例患者分为治疗组（36耳）与对照组（40耳）各32例分别采用两组药物进行治疗观察。结果治疗组有效率为86.11%;对照组有效率为70.00%,χ2值（Pearson未校正法）=4.0674,P〈0.05;两组效果比较治疗组优于对照组,差别有统计学意义,并且治疗组患者治疗期间未见明显的不良反应。结论长春西汀胞磷胆碱钠联合应用对突发性耳聋有良好的临床疗效,并且有毒副作用少的优点。     

1,6-二磷酸果糖联合复方丹参治疗慢性活动型肝炎疗效观察

为探索１,６－二磷果糖（ＦＤＰ）联合复方丹参治疗慢性活动型乙型肝炎的疗效。将１３５例病人随机分两组。两组均采用基础疗法,治疗组加用ＦＤＰ联合复方丹参进行治疗,静滴,１次／ｄ,１５ｄ为 １疗程,共 ３个疗程。结果显示,治疗组显效 ４３例（５７． ３３％）,有效 ２５例（３３． ３４％）,无效 ７例（９． ３３％）,总有效率 ９０． ６７％。对照组显效 １６例（２６． ６７％）,有效 ２８例（４６．６６％）,无效１６例（２６．６７％）,总有效率７３．３３％。两组疗效比较有明显显著性差异。提示１,６－二磷酸果糖联合复方丹参治疗慢性活动型乙型肝炎疗效好,并且显著改善肝功能。     

碳酸氢钠合并复方丹参治疗眩晕症83例疗效观察

目的观察碳酸氢钠联合复方丹参治疗眩晕的临床疗效。方法选166例眩晕症患者按就诊顺序随机分为二组，治疗组：用5％葡萄糖液250ml联合复方丹参注射液16ml加入5％葡萄糖液250ml静滴1天1次，3天为一疗程。对照组：用复方丹参注射液16ml加入5％葡萄糖液250ml静滴，1天1次，3天为一疗程。结果治疗组：显效61例（73．5％），有效22例（26．5％），总有效83例（100％）。对照组：显效25例（30．1％），有效36例（43．3％），总有效率61例（73．5％），无效22例（26．5％）。结论碳酸氢钠联合复方丹参治疗眩晕症疗效显著，与单用复方丹参比较P〈0．01，差异有非常显著意义。     

黄芪注射液联合环磷腺苷葡胺注射液治疗急性心肌炎90例疗效观察

目的观察黄芪注射液合用环磷腺苷葡胺注射液治疗急性病毒性心肌炎（AVM）的临床疗效。方法176例AVM患者按数字随机表法分为两组：治疗组90例、对照组86例。两组均采用常规治疗,卧床休息,镇静、吸氧、抗病毒、口服维生素C、滴注极化液静脉等,治疗组在对照组基础上静脉加用黄芪注射液50ml／d和环磷腺苷葡胺120mg／d。两组疗程均为4周。观察比较两组的临床治疗效果。结果总有效率治疗组为91％,对照组为65％,治疗组疗效明显优于对照组（P〈0．01）;不良反应发生率：两组均为6％,差异无统计学意义（P〉0．05）。结论黄芪注射液联合环磷腺苷葡胺注射液对AVM有较好疗效,不良反应亦轻微。     

低分子肝素治疗脑梗死的临床疗效观察

目的：探讨低分子肝素治疗脑梗死的临床疗效。方法：选取脑梗死患者138例，随机分为治疗组68例，对照组70例。对照组予丹参10ml及胞磷胆碱1．0g分别加入0．9%NS 250ml静脉点滴，1次／d为基础治疗，治疗组在对照组的基础治疗上加用低分子肝素4100IU脐旁皮下注射，2次／d，治疗10d。结果：低分子肝素治疗组总有效率86．76％，对照组总有效率71．43％，治疗组疗效明显优于对照组（P＜0．05）。结论：低分子肝素治疗急性脑梗死安全有效。     

内美通用于卵巢子宫内膜异位症腹腔镜手术治疗的临床观察

目的研究腹腔镜手术与内美通联合治疗卵巢子宫内膜异位囊肿的疗效。方法2005年11月至2006年12月我院将98例腹腔镜下卵巢子宫内膜异位囊肿术后的患者随机分两组：单纯腹腔镜手术组43例；联合治疗组55例，术后口服内美通2．5mg每周两次连续3个月。所有患者随访3—12个月。结果随访率94．9％（93／98）。联合治疗组有效率61．5％，单纯手术组有效率46．3％，联合治疗的疗效明显高于单纯手术组（P〈0.05）。服用内美通的患者有4例转氨酶轻度升高。结论腹腔镜术后联合内美通治疗优于单纯手术治疗，可以作为卵巢子宫内膜异位囊肿临床治疗选择方案。     

中西医结合治疗单纯疱疹病毒性角膜炎

目的：观察黄芪注射液联合聚肌胞注射液对单纯疱疹病毒性角膜炎的疗效。方法：将46例患者（48只眼）随机分为治疗组和对照组，治疗组用聚肌胞注射液和黄芪注射液结膜下注射，对照组用无环鸟苷滴眼液点眼治疗。结果：治疗组治愈19例，好转5例，无效1例；对照组治愈13例，好转4例，无效6例。治疗组治愈率76．oo％，高于对照组56．52％，两组差异显著（P〈0．05）；治疗组总有效率96．00％明显高于对照组73．91％，有显著差异（P〈0．01）。结论：黄芪注射液与聚肌胞注射液舍用治疗单纯疱疹病毒性角膜炎疗效更佳。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.