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1.
Takashi Koyama MD Masayuki Matsumori Kazuo Nakamura Takahiro Fujimori 《Surgery today》1991,21(3):352-356
A rare case of esophageal carcinoma metastasizing to early gastric cancer is reported herein. A 66 year old man who had experienced
dysphagia for 8 months was preoperatively diagnosed as simultaneously having esophageal and gastric cancers. Thus, a lower
esophagectomy and total gastrectomy with paraesophageal and paragastric lymph node dissection were performed. The surgical
specimen revealed an ulcerative tumor in the lower esophagus and a slightly depressed lesion with a central elevation similar
to that of early type IIc+IIa1 gastric cancer in the upper part of the stomach. Microscopically, the esophageal tumor was revealed to be well differentiated
squamous cell carcinoma while the gastric tumor was found to be early gastric cancer with a metastatic focus of esophageal
cancer in the center. Though less than one hundred cases of metastasis of cancer to cancer have previously been reported,
metastasis from cancer of one digestive organ to that of another digestive organ is very rare. To our knowledge, this report
represents the first case of an esophageal carcinoma metastasizing to a gastric carcinoma. 相似文献
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3.
Masaya Tamura Yasuhiko Ohta Yoshio Tsunezuka Hideo Sato 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(1):41-44
We present a case of a 65-year-old woman whose thyroid cancer metastasized to the lesion of primary lung cancer. Ten years
after total thyroidectomy for thyroid cancer, chest radiograph by medical checkup demonstrated three nodular lesions in the
bilateral lung fields. Segmental resection of the left S6, partial resection of right S4 and left S10 were performed to remove
those lesions. Histologically, small nodules in the right S4 and S10 were diagnosed as a metastatic tumor of thyroid and well
differentiated adenocarcinoma, respectively. Left S6 lesion 1.5 cm in diameter was also diagnosed as well-differentiated adenocarcinoma
(Noguchi type C), however, small metastatic foci of papillary adenocarcinoma was identified within the lesion which revealed
to be “cancer in cancer metastasis”. Metastasis of cancer to another primary cancer is a rare event. We discuss interesting
phenomenon of cancer in cancer metastasis with a review of the literature. 相似文献
4.
Uzcudun AE Retolaza IR Fernández PB Sánchez Hernández JJ Grande AG García AG Olivar LM De Diego Sastre I Barón MG Bouzas JG 《Head & neck》2002,24(9):830-840
BACKGROUND: Oropharyngeal and hypopharyngeal cancer is increasing all over the world, frequently affecting more and more women and younger individuals and not only the typical 50- to 60-year-old heavy smoker and drinking man. In addition, 5-year overall survival rate remains poor (30% to 40% in most series), despite advances in treatment. Therefore, it is crucial to understand as accurately as possible the risk factors for these malignancies to improve primary prevention. METHODS: We report the results from a case-control study of pharyngeal cancer risk factors conducted in Spain involving 232 consecutive patients who were gender- and age-matched with 232 controls. Data were collected by interviewer-administered personal interview. RESULTS: Our results show that low intake of fruit, fruit juice, uncooked vegetables, dietary fiber-containing foods (legume and cereals), fish, milk, and dairy products is an independent risk factor for pharyngeal cancer and that high consumption of meat and fried foods also increases the risk once data are adjusted for tobacco smoking and alcohol drinking. CONCLUSIONS: Although findings for fruit, juice, and uncooked vegetables are in accordance with those from other authors and can be explained on a biologic basis, the relationship between pharyngeal cancer and dietary excess of saturated fatty acids needs experimental investigation. Findings for milk, dairy products, and fish also warrant more detailed epidemiologic research because of conflicting data reported in the literature and because of the reportedly ambiguous role of retinol in human cancers. No conclusive explanations for the protective effect of dietary fiber-containing foods can be put forward today. Our results are uniquely attributable to oropharyngeal and hypopharyngeal cancers because of the small size of our nasopharyngeal cancer subsample. 相似文献
5.
Metachronous Triple Cancers of the Sigmoid Colon, Stomach, and Esophagus: Report of a Case 总被引:1,自引:0,他引:1
Iioka Y Tsuchida A Okubo K Ogiso M Ichimiya H Saito K Osaka Y Sato S Aoki T Koyanagi Y 《Surgery today》2000,30(4):368-371
(Received for publication on Feb. 10, 1999; accepted on Nov. 11, 1999) 相似文献
6.
Eriguchi N Aoyagi S Hara M Okuda K Tamae T Fukuda S Hashino K Sato S Fujiki K Furukawa S Jimi A 《Surgery today》2000,30(8):718-721
Pancreatic carcinoma carries a poor prognosis, especially invasive ductal carcinoma of the pancreas. This retrospective study
describes the results of the treatment and prognosis for double cancers in which cancer of the pancreas was associated with
malignancies in other organs in 12 patients who were diagnosed and treated at Kurume University Hospital. The patients included
4 women and 8 men, with an average age of 67 years. Of the 12 tumors, 7 were metachronous pancreatic cancers which occurred
after resections of other organ malignancies. Five patients had synchronous double cancers, one of whom was diagnosed to have
gastric cancer on admission. Two other patients of this group were diagnosed to have lung cancer, while the remaining 2 patients
suffered from colon cancer. By the time pancreatic cancer was diagnosed, gastrectomies had been performed in 7 patients for
either gastric cancer or ulcers. In addition, one patient underwent a hysterectomy for uterine carcinoma and another received
a low anterior resection for rectal carcinoma. Four of 5 patients in the synchronous group had nonresectable tumors and a
palliative bypass operation was performed in 2 of these patients. Six patients who had metachronous double cancers died because
of pancreatic cancer recurrence or metastases. We conclude that the prognosis of double cancers, where cancer of the pancreas
is associated with other organ malignancies, primarily depends on the prognosis of the pancreatic carcinoma, and the present
study suggests the necessity of long-term follow-up examinations for gastrectomy patients in order to make an early diagnosis
of pancreatic cancer.
Received: September 24, 1999 / Accepted: March 24, 2000 相似文献
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8.
Bolton DM 《BJU international》2010,106(11):1578-1593
??Positron emission tomography (PET) is a diagnostic tool using radiotracers to show changes in metabolic activities in tissues. We analysed the role of PET and PET/computed tomography (CT) in the diagnosis, staging, and follow-up of urological tumours. ??A critical, non-structured review of the literature of the role of PET and PET/CT in urological oncology was conducted. ??PET and PET/CT can play a role in the management of urological malignancies. For prostate cancer, the advances in radiotracers seems promising, with novel radiotracers yielding better diagnostic and staging results than 18F-fluorodeoxyglucose (18F-FDG). In kidney cancer, PET and PET/CT allow a proper diagnosis before the pathological examination of the surgical specimen. For testis cancer, PET and PET/CT have been shown to be useful in the management of seminoma tumours. In bladder cancer, these scans allow a better initial diagnosis for invasive cancer, while detecting occult metastases. ??PET and its combined modality PET/CT have shown their potential in the diagnosis of urological malignancies. However, further studies are needed to establish the role of PET in the management of these diseases. Future applications of PET may involve fusion techniques such as magnetic resonance imaging with PET. 相似文献
9.
Dordea M Jones R Nicolas AP Sudeshna S Solomon J Truran P Fetherson A Iwuchukwu O 《Breast (Edinburgh, Scotland)》2011,20(3):212-214
Studies suggest that elderly women receive less aggressive treatment, experience higher disease progression and mortality from breast cancer. We report on an experience of 256 consecutive cases of symptomatic breast cancer in a population of over 75 years of age. 142/256 patients underwent surgical intervention in the form of breast conserving surgery or mastectomy, 114/256 did not. Mean follow up was 6.4 years. Our results show a statistically significant association between surgery and survival (p = 0.05, CI 0.00046-0.19641) and a strong statistically significant association between surgery and disease progression/recurrence (p = 0.001, CI 0.08713-0.03145). Women treated conservatively are significantly less fit hence suffering high cancer unrelated mortality; as a consequence they suffer higher disease related progression and mortality. In our study surgical treatment with adjuvant endocrine and/or radiotherapy was associated with a statistically significant advantage in terms of disease related mortality and local disease control. 相似文献
10.
Alessandro Neri Daniele Marrelli Tiziana Megha Francesca Bettarini Damiana Tacchini Lorenzo De Franco Franco Roviello 《BMC surgery》2015,15(1)
Background
The biological and clinical significance of multifocal and multicentric (MF/MC) breast cancers and the choice of appropriate surgical treatment for these tumors are still debated.Methods
1158 women operated on for a stage I-III breast cancer were included in this retrospective study; clinical and pathological data were obtained from the institutional database of the Department of Oncology of the University of Siena, Italy. The impact of MF/MC breast cancers on patterns of recurrence and breast cancer specific survival (BCSS) was investigated in relation to the type of surgical treatment.Results
MF and MC cancers were present in 131 cases (11.3%) and 60 cases (5.2%) respectively and were more frequently treated with mastectomy (55 MF and 60 MC cancers, 81.2%) than with breast conserving surgery (36 MF cancers, 18.9%; p < 0.001). MF and MC breast cancers were associated with a worse prognosis with a BCSS of 154 months compared to 204 months of unicentric cancers (p < 0.001). In multivariate analysis, MF/MC cancers were independent prognostic factors for BCSS together with higher number of metastatic axillary nodes, absence of estrogen receptors and high proliferative activity. MF and MC cancers were related to a significantly shorter BCSS in patients submitted to mastectomy as well as those submitted to breast conserving surgery. Relapse at any site was higher in the subgroup of MF and MC cancers but the incidence of loco-regional and distant recurrences did not differ between patients treated with mastectomy or breast conserving surgery.Conclusions
Our results indicate that MF/MC cancers have a negative impact on prognosis and are related to higher loregional and distant relapse independently from the type of surgery performed. Adjuvant therapies did not modify the poorer outcome, but in patients receiving adjuvant anthacyclines, the differences with unicentric tumors were reduced. Our data support the hypothesis that MF/MC tumors may have a worse biological behavior and that the presence of multiple foci should be considered in planning adjuvant treatments. 相似文献11.
目的 探讨结肠癌肝转移的外科治疗方法及其病理因素对预后的影响。方法 本组79例结肠癌肝转移患者中共有 2 5例接受原发灶根治术以及肝转移灶切除术或射频消融术。其中 14例进行了原发灶根治术及肝脏转移灶切除术 ,11例进行了肝脏转移灶射频消融术。结果 本组结肠癌肝转移患者术后 1年、3年生存率分别为 84 %、4 8%。分化程度高以及单个转移灶的患者预后较好。肝脏肿瘤切除与肝脏肿瘤射频消融术后患者生存时间无明显差异。结论 结肠癌肝转移患者原发肿瘤的分化程度、肝脏转移灶的数量对预测患者的预后有一定的作用。手术切除及射频消融术对治疗结肠癌肝转移能够达到较为接近的治疗效果。 相似文献
12.
《Actas urologicas espa?olas》2014,38(8):491-498
ObjectiveTo present the new findings in oncologic urology with impact on clinical practice which were displayed at 2013 major annual meetings (EAU, ESTRO, AUA, ASCO and ASTRO).MethodsThe abstracts on prostate kidney, bladder and upper tract urothelial cancer with the highest scores by the OncoForum committee, presented in 1013 Congresses are included in this paper.Resultsthe following messages were considered as important by the OncoUrology Forum committee. In renal tumors T1a, comorbidities should be evaluated by its impact on overall and specific cancer survival, especially in men over 65. In metastatic renal tumors, the benefit of Everolimus vs. Sunitinib has not been demonstrated. Patients with non-muscle invasive bladder cancer of high risk, with three or more risk factors, should be considered for radical cystectomy. The ERSPC study’ data demonstrate the benefit of the systematic screening in prostate cancer. In metastatic disease, the results of the Ra-223 and enzalutamide studies show benefit in pain control and overall survival in metastatic disease.ConclusionsLocalized renal and non-muscle invasive bladder of high-risk tumors, should be assessed according to comorbidities or oncologic risk factors, to determinate the adequate treatment options. New data from metastatic prostate cancer clinical trials have shown promising results in the control of the disease 相似文献
13.
Kuniyasu Soda Shigeki Yamada Takeo Yamanaka Akiyoshi Kashii Michio Miyata 《Surgery today》1995,25(5):444-446
We present herein the case of a 73-year-old Japanese man in whom a minute malignant islet cell tumor, 7 mm in maximal diameter, was discovered. The patient was admitted to our hospital to undergo a gastrectomy for gastric cancer, at which time preoperative ultrasonography (US) revealed a minute hypoechoic mass located in the head of the pancreas. Endoscopic retrograde pancreatography, angiography, computed tomography, and magnetic resonance imaging failed to reveal the features or location of the tumor; nowever, these details were obtained by endoscopic and intraoperative US. Although intraoperative fine-needle aspiration cytology of the tumor enabled a diagnosis of islet cell tumor to be made, it failed to provide enough material to evaluate the grade of malignancy, which was confirmed by histologic examination of the enucleated tumor, allowing the appropriate surgical procedure to be decided. 相似文献
14.
Clinical characteristics of patients with multiple potentially human papillomavirus–related malignancies
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Heath D. Skinner MD PhD Erich M. Sturgis MD Ann H. Klopp MD PhD Kie‐Kian Ang MD PhD David I. Rosenthal MD Adam S. Garden MD William H. Morrison MD G. Brandon Gunn MD Beth M. Beadle MD PhD 《Head & neck》2014,36(6):819-825
15.
Raja KalayarasanAmit Javed M.S. M.Ch. Puja SakhujaAnil K. Agarwal M.S. M.Ch. 《American journal of surgery》2013
Background
Literature on squamous variants of gallbladder cancer (GBC) is limited.Methods
This was a retrospective analysis of GBC patients operated on between August 2009 and March 2012. Patients with adenosquamous carcinoma or squamous cell carcinoma were compared with adenocarcinoma for clinicopathologic features and surgical outcomes.Results
Of the primary GBC patients resected with curative intent, 14 had adenosquamous carcinoma (10) or squamous cell carcinoma (4) (group A), whereas 122 had adenocarcinoma (group B). Abdominal pain was the most common symptom in both groups; however, presentation with vomiting and an abdominal lump was more common in group A (P = .04 and <.01, respectively). Group A had a significantly larger tumor size (7.9 vs 4.8 cm, P = .01) and a higher incidence of adjacent organ involvement requiring extended resections (85.7% vs 26.2%, P < .01). Despite the higher T stage, node-negative disease was significantly higher in group A (42.9% vs 17.2%, P = .03). There was no significant difference in the median survival after curative resection between the 2 groups (28 vs 31 months, P = .24).Conclusions
The squamous variant of GBC presented at an advanced T stage; however, nodal involvement and distant metastasis were less common. Despite the higher T stage, curative resection could be achieved in the majority with a comparable survival. 相似文献16.
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目的 探讨结肠癌术后复发的原因,以期达到早期诊断提高术后复发的治疗效果。方法 回顾性分析1999~2003年36例结肠癌术后复发病人的临床资料。结果 吻合口复发18例,腹腔、盆腔种植复发13例,局部复发6例,腹壁切口复发6例。非手术治疗2例,手术治疗34例。根治性切除14例,姑息性切除11例。根治性切除和非根治性切除病人的中位生存时间分别为26个月和9个月。结论 结肠癌术后复发的预防重在术中无瘤操作,定期随访是早期诊断的关键。应积极手术治疗,以延长生存期,提高生活质量。 相似文献
17.
The purpose of this study was to evaluate the overexpression of cyclin G in colorectal neoplasia, which may be a more frequent
event than cyclin D1 during the cell cycle and thus may have a more enhanced therapeutic potential in treating colorectal
cancer. Ninety formalin-fixed, paraffin-embedded human colon and rectal specimens were obtained from the Pathology Department
of Norris Cancer Center/ University of Southern California. The tissues had been obtained after surgical resection between
1995 and 2001, and had been processed by routine clinical histopathologic methods. Ninety-one percent of colorectal tumors
had cyclin G overexpression. These cyclin-positive patients were evenly distributed between men and women, and between tumor
locations, that is, 36% rectal tumors and 34% rightsided tumors. Thirty-two percent were well differentiated, and 66% were
moderately differentiated. Thirty patients (38%) had stage I disease, 16 (20%) had stage II disease, 25 (32%) had stage III,
and seven (9%) had stage IV disease. Eight patients (10%) in this group had recurrent disease during follow-up. There was
no correlation between cyclin G overexpression and clinical and pathologic characteristics. Cyclin D1 overexpression was found
to be present in only 42% of colorectal adenocarcinomas. There was no correlation between cyclin D1 overexpression and clinical
and pathologic characteristics. The present study demonstrates that cyclin G overexpression is a frequent event in colorectal
cancer. This frequent event in colorectal carcinogenesis may facilitate new therapeutic approaches acting as a target for
gene therapy, possibly directed at downregulating cyclin G in colorectal cancer.
Presented at the Forty-Fourth Annual Meeting of The Society for Surgery of the Alimentary Tract, Orlando, Florida, May 18-21,
2003 (poster presentation). 相似文献
18.
《The surgeon》2023,21(3):e97-e103
IntroductionDespite advances in oncology therapies and surgical techniques, survival from oesophagogastric cancer remains low. Poorer cancer outcomes and survival for rural dwellers is documented worldwide and has been an area of focus in Scotland since 2007 when changes to suspected cancer national referral guidelines and governmental mandates on delivering remote and rural healthcare occurred. Whether these changes in clinical practice has impacted upon upper gastrointestinal cancer remains unclear.MethodsA prospective, single-centre observation study was performed. Data from the regional oesophagogastric cancer MDT between 2013 and 2019 were included. The Scottish Index of Multiple Deprivation 2020 tool provided a rurality code (1 or 2) based on patient postcode at time of referral. Survival outcomes for urban and rural patients were compared across demographic factors, disease factors and stage at presentation.ResultsA total of 1038 patients were included in this study. There was no significant difference between rural and urban groups in terms of sex of patient, age at diagnosis, cancer location, or tumour stage. Furthermore, no difference was identified between those commenced on a radical therapy with other treatment plans. Despite this, rurality predicted for an improved outcome on survival analysis (p = 0.012) and this was independent of other factors on multivariable analysis (HR = 0.78, 95%CI 0.66–0.98; p = 0.032).DiscussionThe difference in survival demonstrated here between urban and rural groups is not easily explained but may represent improvements to rural access to healthcare delivered as a result of Scottish Government reports. 相似文献
19.
Laparoscopic surgery has gained wide acceptance for its use in benign gastrointestinal cancer in the past 20 years, while its use in malignant gastrointestinal cancer has been highly controversial until the recent 3-5 years. Several prospective randomized clinical trials have suggested that the long-term outcome of laparoscopic surgery for colon cancer is the same as or better than that of open surgery. As for rectal cancer, whether the principles of total mesorectal excision can be well followed in laparoscopic surgery remains. Most recently, the trial of large number of patients doesn't show any differences upon local recurrence and 3-year survival rate between rectal cancer patients in laparoscopic group and open group. Laparoscopic surgery has been widely accepted as a standard treatment regimen for early gastric cancer in many specialized centers. Meanwhile, the feasibility and effectiveness of laparoscopic D2 lymphadenectomy for gastric cancer has been proved by several scholars. The use of laparoscopic surgery for advanced gastric cancer especially for T3 gastric cancer still remains controversial. The early concern that laparoscopic surgery for malignant cancer might increase tumor dissemination is not confirmed. The system of technical training and occupational qualification, proper selection of patients and adherence to all the principles of cancer clearance will ensure a good result of laparoscopic surgery for malignant gastrointestinal cancer. 相似文献
20.
The risk connotation of terminology in influencing decision-making should not be underestimated. For example, “superficial” T1HG bladder cancer has the same poor cancer-specific survival as that conferred by the “highest risk” prostate cancer (Gleason 10, T3b). Co-management of concomitant prostate cancer and non-muscle invasive bladder cancer requires a careful competing risk analysis by both the physician and patient. Herein, we detail how patients and physicians should be careful not to underestimate the risk attributed to “non-muscle invasive” bladder cancer. 相似文献