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1.
Rodrigo Staggemeier Diogo André Pilger Fernando Rosado Spilki Vlademir Vicente Cantarelli 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):93-95
A novel SYBR® green-real time polymerase chain reaction
(qPCR) was developed to detect two Bartonella species,
B. henselae and B. clarridgeiae, directly
from blood samples. The test was used in blood samples obtained from cats living
in animal shelters in Southern Brazil. Results were compared with those obtained
by conventional PCR targeting Bartonella spp. Among the 47
samples analyzed, eight were positive using the conventional PCR and 12 were
positive using qPCR. Importantly, the new qPCR detected the presence of both
B. henselae and B. clarridgeiae in two
samples. The results show that the qPCR described here may be a reliable tool
for the screening and differentiation of two important
Bartonella species. 相似文献
2.
Y. Zekraoui A. MegzariT. El Alloussi A. Berraho 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2011,32(4):e46
We report a case of cat-scratch disease neuroretinitis. A 26-year-old man was referred for severe right visual loss. Posterior segment examination showed a papilledema with macular edema. Bartonella henselae immunoglobulin G testing was positive. Four weeks of antibiotic therapy combining oral ciprofloxacin and doxycycline led to progressive resolution of the neuroretinitis and improvement in visual acuity. This report reminds that B. henselae infection can be the cause of neuroretinitis. Its prognosis can be improved by early treatment. 相似文献
3.
Selma Samiko Miyazaki ONUMA Daniel Luis Zanella KANTEK Peter Gransden CRAWSHAW JúNIOR Ronaldo Gon?alves MORATO Joares Adenilson MAY-JúNIOR Zenaide Maria de MORAIS José Soares FERREIRA NETO Daniel Moura de AGUIAR 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(2):177-180
This study aimed to assess the exposure of free-living jaguars (Panthera
onca) to Leptospira spp. and Brucella
abortus in two conservation units in the Pantanal of Mato Grosso, Brazil.
The presence of antibodies in blood samples of eleven jaguars was investigated using
autochthonous antigens isolated in Brazil added to reference antigen collection
applied to diagnosis of leptospirosis by Microscopic Agglutination Test (MAT). The
Rose Bengal test was applied for B. abortus antibodies. Two (18.2%)
jaguars were seroreactive for the Leptospira spp. antigen and the
serovar considered as most infective in both animals was a Brazilian isolate of
serovar Canicola (L01). All jaguars were seronegative for B.
abortus. These data indicate that the inclusion of autochthonous antigens in
serological studies can significantly increase the number of reactive animals, as
well as modify the epidemiological profile of Leptospira spp.
infection. 相似文献
4.
Icaro Boszczowski Gladys Villas Boas do Prado Mirian F. Dalben Roberto C. P. Telles Maristela Pinheiro Freire Thaís Guimar?es Maura S. Oliveira Juliana F. Rosa Robson E. Soares Pedro Enrique Dorlhiac Llacer Frederico Luiz Dulley Silvia F. Costa Anna S. Levin 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):71-76
Aim: The objective was to describe an outbreak of bloodstream infections
by Burkholderia cepacia complex (Bcc) in bone marrow transplant and
hematology outpatients.
Methods: On February 15, 2008 a Bcc outbreak was suspected. 24 cases
were identified. Demographic and clinical data were evaluated. Environment and
healthcare workers'' (HCW) hands were cultured. Species were determined and typed.
Reinforcement of hand hygiene, central venous catheter (CVC) care, infusion therapy,
and maintenance of laminar flow cabinet were undertaken. 16 different HCWs had cared
for the CVCs. Multi-dose heparin and saline were prepared on counter common to both
units.
Findings: 14 patients had B. multivorans (one patient
had also B. cenopacia), six non-multivorans Bcc and
one did not belong to Bcc. Clone A B. multivorans occurred in 12
patients (from Hematology); in 10 their CVC had been used on February 11/12.
Environmental and HCW cultures were negative. All patients were treated with
meropenem, and ceftazidime lock-therapy. Eight patients (30%) were hospitalized. No
deaths occurred. After control measures (multidose vial for single patient; CVC lock
with ceftazidime; cleaning of laminar flow cabinet; hand hygiene improvement; use of
cabinet to store prepared medication), no new cases occurred.
Conclusions: This polyclonal outbreak may be explained by a common
source containing multiple species of Bcc, maybe the laminar flow cabinet common to
both units. There may have been contamination by B. multivorans
(clone A) of multi-dose vials. 相似文献
5.
Vanessa Cristina Fitipaldi Veloso Guimar?es Pietra Lemos Costa Fernando José da Silva Fábio Lopes de Melo Filipe Dantas-Torres Eduardo Henrique Gomes Rodrigues Sinval Pinto Brand?o Filho 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(4):357-360
Several phlebotomine sand fly species have been regarded as putative or
proven vectors of parasites of the genus Leishmania in Brazil, but
data for the northeastern region remains incipient. In this study, a total of 600
phlebotomine sand flies were grouped in pools of 10 specimens each and tested by a
Leishmania genus-specific PCR and by a PCR targeting
Leishmania (Leishmania)
infantum. Fourteen out of 60 pools were positive by the
genus-specific PCR, being five pools of L. migonei, seven of
L. complexa, one of L. sordellii and one of
L. naftalekatzi, which correspond to a minimal infection rate of
2.3% (14/600). Our results, associated with their known anthropophily and their
abundance, suggest the participation of L. migonei and L.
complexa as vectors of Leishmania in northeastern
Brazil. Remarkably, this is the first time in this country that the detection of
Leishmania DNA in L. sordellii and L.
naftalekatzi has been reported, but future studies are necessary to
better understand the significance of these findings. 相似文献
6.
Ralciane de Paula MENEZES Joseane Cristina FERREIRA Walkiria Machado de Sá Tomaz de Aquino MOREIRA Lucivania Duarte Silva MALVINO Lucio Borges de ARAUJO Denise Von Dolinger de Brito R?DER Mario Paulo Amante PENATTI Regina Celia CANDIDO Reginaldo dos Santos PEDROSO 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(3):185-191
Infections by Candida species are a high-impact problem in public
health due to their wide incidence in hospitalized patients. The goal of this study
was to evaluate frequency, susceptibility to antifungals, and genetic polymorphism of
Candida species isolated from clinical specimens of hospitalized
patients. The Candida isolates included in this study were obtained
from blood cultures, abdominal fluids, and central venous catheters (CVC) of
hospitalized patients at the Clinical Hospital of the Federal University of
Uberlândia during the period of July 2010 - June 2011. Susceptibility tests were
conducted by the broth microdilution method. The RAPD-PCR tests used employed
initiator oligonucleotides OPA09, OPB11, and OPE06. Of the 63
Candida isolates, 18 (28.5%) were C. albicans,
20 (31.7%) were C. parapsilosis complex species, 14 (22.2%)
C. tropicalis, four (6.4%) C. glabrata, four
(6.4%) C. krusei, two (3.3%) C. kefyr, and one
(1.6%) C. lusitaniae. In vitro resistance to
amphotericin B was observed in 12.7% of isolates. In vitroresistance
to azoles was not detected, except for C. krusei. The two primers,
OPA09 and OPB11, were able to distinguish different species. Isolates of C.
albicans and C. parapsilosis complex species presented
six and five clusters, respectively, with the OPA09 marker by RAPD-PCR, showing the
genetic variability of the isolates of those species. It was concluded that members
of the C. parapsilosis complex were the most frequent species found,
and most isolates were susceptible to the antifungals amphotericin B, flucozanole,
and itraconazole. High genetic polymorphisms were observed for isolates of C.
albicans and C. parapsilosis complex species, mainly
with the OPA09 marker. 相似文献
7.
Herintha Coeto Neitzke-Abreu Kárin Rosi Reinhold-Castro Mateus Sabaini Venazzi Regiane Bertin de Lima Scodro Alessandra de Cassia Dias Thaís Gomes Verzignassi Silveira Ueslei Teodoro Maria Valdrinez Campana Lonardoni 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(5):391-395
Sandflies transmit pathogens of leishmaniasis. The natural infection
of sandflies by Leishmania (Viannia) was assessed in
municipalities, in the state of Paraná, in Southern Brazil. Sandflies were
collected with Falcão and Shannon traps. After dissection in search of
flagellates in digestive tubes and identification of the species, female
sandflies were submitted to the Multiplex Polymerase Chain Reaction
(multiplex PCR) for detection of the fragment of the kDNA of
Leishmania (Viannia) and the fragment from the
IVS6 cacophony gene region of the phlebotomine insects. The
analysis was performed in pools containing seven to 12 guts from females of the
same species. A total of 510 female sandflies were analyzed, including nine
Migonemyia migonei, 17 Pintomyia fischeri,
216 Nyssomyia neivai, and 268 Nyssomyia
whitmani. Although none of the females was found naturally infected
by flagellates through dissection, the fragment of DNA from Leishmania
(Viannia) was shown by multiplex PCR in one sample of
Ny. neivai (0.46%) and three samples of
Ny. whitmani (1.12%). It was concluded that
Ny. neivai and Ny. whitmani are
susceptible to Leishmania infection, and that multiplex PCR can
be used in epidemiological studies to detect the natural infection of the
sandfly vector, because of its sensitivity, specificity and feasibility. 相似文献
8.
Adalberto Alves Pereira Filho Clícia Rosane Costa Fran?a Dorlam's da Silva Oliveira Renato Juvino de Arag?o Mendes José de Ribamar Santos Gon?alves Ivone Garros Rosa 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(6):505-510
The action of extracts from the stem, leaves, and fruit of
Jatropha gossypiifolia on Biomphalaria
glabrata was studied by analyzing survival, feeding capacity and
oviposition ability. The extracts were obtained by macerating the plant parts in
92% ethanol, which were then evaporated until a dry residue was obtained
and phytochemically studied. The molluscicidal activity on B.
glabrata was investigated using the procedures recommended by WHO
(1965). The amount of food ingested and oviposition were measured
during each experiment. The extract of leaves from J.
gossypiifolia was shown to be a strong molluscicidal agent, causing
100% mortality of B. glabrata, even in the lowest
concentration tested, of 25 ppm. Regarding the fruit extract, there was
variation in the mortality, depending on the concentration used (100, 75,
50 and 25 ppm). The snails that were in contact with the fruit extract had
significant reduction in feeding and number of embryos in comparison to the
control. The stem extract did not present molluscicidal activity nor had any
influence on the feeding and oviposition abilities of B.
glabrata, in the concentrations tested. In conclusion, the extracts
of leaves and fruits of J. gossypiifolia investigated in this
work show molluscicidal effect and may be sources of useful compounds for the
schistosomiasis control. 相似文献
9.
Vanessa Kummer Perinazzo Oliveira Luciana da Silva Ruiz Nélio Alessandro Jesus Oliveira Débora Moreira Rosane Christine Hahn Analy Salles de Azevedo Melo Angela Satie Nishikaku Claudete Rodrigues Paula 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(4):301-305
Candidemia remains a major cause of morbidity and mortality in the health
care environment. The epidemiology of Candida infection is changing,
mainly in relation to the number of episodes caused by species C.
non-albicans. The overall objective of this study was to evaluate
the frequency of yeasts of the genus Candida, in a four-year period,
isolated from blood of pediatric patients hospitalized in a public hospital of the
city of São Paulo, Brazil. In this period, yeasts from blood of 104 patients were
isolated and, the identified species of Candida by phenotypic and
genotypic methods were: C. albicans (39/104), C.
tropicalis (25/104), C. parapsilosis (23/104),
Pichia anomala (6/104), C. guilliermondii
(5/104), C. krusei (3/104), C. glabrata (2/104) and
C. pararugosa (1/104). During the period of the study, a higher
frequency of isolates of C. non-albicans (63.55%)
(p = 0.0286) was verified. In this study we verified the increase
of the non-albicans species throughout the years (mainly in 2009 and
2010). Thus, considering the peculiarities presented by Candida
species, a correct identification of species is recommended to lead to a faster
diagnosis and an efficient treatment. 相似文献
10.
Vinicius José Maschio Gertrudes Cor??o Marilise Brittes Rott 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(1):81-83
Acanthamoeba is a “Trojan horse” of the microbial world. The aim of
this study was to identify the presence of Pseudomonas as an
amoeba-resistant microorganism in 12 isolates of Acanthamoeba. All
isolates showed the genus Pseudomonas spp. as amoeba-resistant
microorganisms. Thus, one can see that the Acanthamoeba isolates
studied are hosts of Pseudomonas. 相似文献
11.
Raquel O. Sim?es José L. Luque Marta Júlia Faro Ester Motta Arnaldo Maldonado JR. 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(5):455-457
The nematode Calodium hepaticum (syn.
Capillaria hepatica) is a zoonotic helminth found
mainly infecting rats. It was studied the prevalence of C.
hepaticum infection in Rattus norvegicus in an
urban area of Rio de Janeiro (Brazil), with low urban planning and
sanitation. The presence of C. hepaticum was identified through
visible yellowish-white lesions in liver tissue and histological analyses. The
total prevalence of infection was 45%, with no significant differences
between sex and age. The presence of infected rodents near the peridomestic area
poses substantial risk to human health. 相似文献
12.
Jorge Isaac Gracia-Paez Juliana Rosa Ferraz Ivan Avelino Fran?a E Silva Flávia Rossi Anna Sara Levin Silvia Figueiredo Costa 《Revista do Instituto de Medicina Tropical de S?o Paulo》2013,55(6):417-420
SUMMARY
Stenotrophomonas maltophilia contains a novel chromosomally-encoded qnr gene named Smqnr that contributes to low intrinsic resistance to quinolone. We described Smqnr in 13 clinical isolates of S. maltophilia from two Brazilian hospitals, over a 2-year period. The strains were identified by API 20 NE (bioMérieux, France). Susceptibility by microdilution method to trimetroprim/sulfamethoxazole, ciprofloxacin, levofloxacin, minocycline, ceftazidime, chloramphenicol and ticarcillin/clavulanate was performed according to CLSI. PCR detection of Smqnr gene was carried out. The sequence of Smqnr was compared with those deposited in GenBank. Pulsed-field gel electrophoresis (PFGE) of all strains was performed. Thirteen Smqnr positives isolates were sequenced and three novel variants of Smqnr were identified. All 13 Smqnr isolates had distinguishable patterns by PFGE. This is the first report of Smqnr in S. maltophilia isolated in Brazil. 相似文献13.
I. KhoudriG. Frémont B. FlageulJ. Brière L. DubertretM. Viguier 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2011,32(3):e34
Cat scratch disease is usually revealed by a proximal lymphadenopathy related to the inoculation site. We report a 22-year-old female who presented with erythema nodosum and bilateral inguinal lymphadenopathy. Serologic test and lymph node PCR detection for Bartonella henselae were negative. Nevertheless, the patient received doxycycline and clinical manifestations rapidly resolved. A follow-up detection of IgM and IgG against Bartonella henselae performed 1 month later was positive. This case report illustrates an original presentation of cat scratch disease and reminds us the lack of sensitivity of laboratory investigations. 相似文献
14.
Sita C. Bennema Ronaldo Guilherme Carvalho Scholte Marcelo Beltr?o Molento Camilla Medeiros Omar dos Santos Carvalho 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):35-41
Fasciolosis is a disease of importance for both veterinary and public
health. For the first time, georeferenced prevalence data of Fasciola
hepatica in bovines were collected and mapped for the Brazilian territory
and data availability was discussed. Bovine fasciolosis in Brazil is monitored on a
Federal, State and Municipal level, and to improve monitoring it is essential to
combine the data collected on these three levels into one dataset. Data were
collected for 1032 municipalities where livers were condemned by the Federal
Inspection Service (MAPA/SIF) because of the presence of F.
hepatica. The information was distributed over 11 states: Espírito Santo,
Goiás, Minas Gerais, Mato Grosso do Sul, Mato Grosso, Pará, Paraná, Rio de Janeiro,
Rio Grande do Sul, Santa Catarina and São Paulo. The highest prevalence of
fasciolosis was observed in the southern states, with disease clusters along the
coast of Paraná and Santa Catarina and in Rio Grande do Sul. Also, temporal variation
of the prevalence was observed. The observed prevalence and the kriged prevalence
maps presented in this paper can assist both animal and human health workers in
estimating the risk of infection in their state or municipality. 相似文献
15.
Maria Teresa Nascimento Silva José Valfrido Santana Gérson Bragagnoli Alexandre Magno da Nóbrega Marinho Elizabeth Malague?o 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(5):451-454
There is a clear need to perform epidemiological studies to find the
true prevalence of Entamoeba histolytica around the world. The
evaluation of this prevalence has been hindered by the existence of two
different species which are morphologically identical, but genetically
different, namely E. histolytica, which causes amebiasis, and
E. dispar, which is non-pathogenic. In Brazil, the
E. dispar has been detected in communities in the
Southeastern (SE) and Northeastern (NE) regions with poor
sanitation. However, individuals infected with E. histolytica
have been identified in other regions. There is an absence of reports on the
prevalence of these parasites in the state of Paraíba, which also has areas
with poor sanitary conditions where a high prevalence of the E.
histolytica/E. dispar complex has been detected in children
from urban slums. The present study evaluated the prevalence of E.
histolytica and E. dispar in 1,195 asymptomatic
children between two and 10 years of age, living in a sprawling urban slum in
Campina Grande, in the state of Paraíba, in Northeastern Brazil. These
children were examined and their feces samples were analyzed microscopically. A
total of 553 children tested positive for the E. histolytica/E.
dispar complex, and 456 of the positive samples were tested with
the E. histolytica II® ELISA kit. All 456 samples were
negative for the presence of the adhesin E. histolytica
specific antigen. The evidence suggests that in this community E.
histolytica is absent and E. dispar is the
dominant species. 相似文献
16.
Karin Kirchgatter Rosa Maria Tubaki Rosely dos Santos Malafronte Isabel Cristina Alves Giselle Fernandes Maciel de Castro Lima Lilian de Oliveira Guimar?es Robson de Almeida Zampaulo Gerhard Wunderlich 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(5):403-409
Anopheles (Kerteszia) cruzii has been
implicated as the primary vector of human and simian malarias out of the
Brazilian Amazon and specifically in the Atlantic Forest regions. The presence
of asymptomatic human cases, parasite-positive wild monkeys and the similarity
between the parasites infecting them support the discussion whether these
infections can be considered as a zoonosis. Although many aspects of the biology
of An. cruzii have already been addressed, studies conducted
during outbreaks of malaria transmission, aiming at the analysis of blood
feeding and infectivity, are missing in the Atlantic Forest. This study was
conducted in the location of Palestina, Juquitiba, where annually the majority
of autochthonous human cases are notified in the Atlantic Forest of the state of
São Paulo. Peridomiciliary sites were selected for collection of mosquitoes
in a perimeter of up to 100 m around the residences of human malaria cases. The
mosquitoes were analyzed with the purpose of molecular identification of
blood-meal sources and to examine the prevalence of Plasmodium.
A total of 13,441 females of An. (Ker.) cruzii were
collected. The minimum infection rate was calculated at 0.03% and
0.01%, respectively, for P. vivax and P.
malariae and only human blood was detected in the blood-fed
mosquitoes analyzed. This data reinforce the hypothesis that asymptomatic human
carriers are the main source of anopheline infection in the peridomiciliary
area, making the probability of zoonotic transmission less likely to happen. 相似文献
17.
Cecília Bittencourt Severo Luciana Silva Guazzelli Marinez Bizarro Barra Bruno Hochhegger Luiz Carlos Severo 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):89-91
Nondiphtherial corynebacteria are ubiquitous in nature and commonly
colonize the skin and mucous membranes of humans, however they rarely account for
clinical infection. We present the first reported case of multiple pulmonary nodules
caused by Corynebacterium striatum. The infection occurred in a
72-year-old immunocompetent female, and the diagnosis was obtained by Gram''s stain
and culture of lung biopsy. C. striatum should be recognized as a
potential pathogen in both immunocompromised and normal hosts in the appropriate
circumstances. 相似文献
18.
Camila Oliveira Vasconcelos Zirlane C. Branco Coêlho Cristina de Souza Chaves Clarissa Romero Teixeira Margarida M. Lima Pompeu Maria Jania Teixeira 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):21-27
Recruitment of a specific cell population after
Leishmania infection can influence the outcome of the disease.
Cellular migration in response to Leishmania or vector saliva has
been reported in air pouch model, however, cellular migration induced by
Leishmania associated with host''s blood and vector saliva in this
model has not been described. Herein we investigated cellular migration into air
pouch of hamster after stimulation with combination of L. chagasi
and host''s blood and Lutzomyia longipalpis saliva. Migration induced
by saliva was 3-fold more than those induced by L. chagasi alone.
Additionally, L. chagasi associated with blood and saliva induced
significantly even more leukocytes into air pouch than Leishmania
alone. L. chagasi recruited a diverse cell population; however, most
of these cells seem to have not migrated to the inflammatory exudate, remaining in
the pouch lining tissue. These results indicate that L. chagasi can
reduce leukocyte accumulation to the initial site of infection, and when associated
with vector saliva in the presence of blood components, increase the influx of more
neutrophils than macrophages, suggesting that the parasite has developed a strategy
to minimize the initial inflammatory response, allowing an unlimited progression
within the host. This work reinforces the importance of studies on the salivary
components of sand fly vectors of leishmaniasis in the transmission process and the
establishment of the infection. 相似文献
19.
Milagro Fernández-Delgado María Alexandra García-Amado Monica Contreras Renzo Nino Incani Humberto Chirinos Héctor Rojas Paula Suárez 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(1):21-26
The causative agent of cholera, Vibrio cholerae, can
enter into a viable but non-culturable (VBNC) state in response to unfavorable
conditions. The aim of this study was to evaluate the in situ
survival of V. cholerae in an aquatic environment of the Southern
Caribbean Sea, and its induction and resuscitation from the VBNC state. V.
cholerae non-O1, non-O139 was inoculated into diffusion chambers placed
at the Cuare Wildlife Refuge, Venezuela, and monitored for plate, total and viable
cells counts. At 119 days of exposure to the environment, the colony count was <
10 CFU/mL and a portion of the bacterial population entered the VBNC state.
Additionally, the viability decreased two orders of magnitude and morphological
changes occurred from rod to coccoid cells. Among the aquatic environmental
variables, the salinity had negative correlation with the colony counts in the dry
season. Resuscitation studies showed significant recovery of cell cultivability with
spent media addition (p < 0.05). These results suggest that
V. cholerae can persist in the VBNC state in this Caribbean
environment and revert to a cultivable form under favorable conditions. The VBNC
state might represent a critical step in cholera transmission in susceptible
areas. 相似文献
20.
Juliana Moscardini Chavasco Bárbara Helena Muniz Prado E Feliphe Claudio Daniel Cerdeira Fabrício Damasceno Leandro Luiz Felipe Leomil Coelho Jéferson Junior da Silva Jorge Kleber Chavasco Amanda Latercia Tranches Dias 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):13-20
The antimicrobial activity of plant hidroethanolic extracts on bacteria
Gram positive, Gram negative, yeasts, Mycobacterium tuberculosis H37
and Mycobacterium bovis was evaluated by using the technique of Agar
diffusion and microdilution in broth. Among the extracts evaluated by Agar diffusion,
the extract of Bidens pilosa leaf presented the most expressive
average of haloes of growth inhibition to the microorganisms, followed by the extract
of B. pilosa flower, of Eugenia pyriformis'' leaf
and seed, of Plinia cauliflora leaf which statistically presented
the same average of haloes inhibitory formation on bacteria Gram positive, Gram
negative and yeasts. The extracts of Heliconia rostrata did not
present activity. Mycobacterium tuberculosis H37 and
Mycobacterium bovis (BCG) appeared resistant to all the extracts.
The susceptibility profile of Candida albicans and
Saccharomyces cerevisiae fungi were compared to one another and
to the Gram positive Bacillus subtilis, Enterococcus
faecalis and the Gram negative Salmonella typhimurium
bacteria (p > 0.05). The evaluation of cytotoxicity was carried
out on C6-36 larvae cells of the Aedes albopictus mosquito. The
extracts of stem and flower of Heliconia rostrata, leaf and stem of
Plinia cauliflora, seed of Anonna crassiflora
and stem, flower and root of B. pilosa did not present toxicity in
the analyzed concentrations. The highest rates of selectivity appeared in the
extracts of stem of A. crassiflora and flower of B.
pilosa to Staphylococcus aureus, presenting potential
for future studies about a new drug development. 相似文献