Analysis of cervico-vaginal (Papanicolaou) smears,in girls 18 years and under

This study was conducted retrospectively at the Queen Elizabeth Hospital and a private laboratory in Barbados to determine the types of epithelial abnormalities in cervico-vaginal Papanicolaou (Pap)-stained smears, and their clinical implications in Barbadian girls, 18 years and under, during the five-year period January 1995 to December 1999. Two hundred and sixty-five Pap smears from 236 patients were examined and the gynaecological history, initial and repeat Pap smear diagnoses, and histology reports of these patients were analyzed. Of the 236 first-visit smears, 94 (39.8%) were abnormal with 36 (15.3%) displaying cytologic features of squamous intra-epithelial lesions (SIL), (33 low grade and 3 high grade). A diagnosis of atypical squamous cells of undetermined significance (ASCUS) was reported in the remaining 58 (24.5%) abnormal smears, of which 35 (60.3%) were suspected to be related to human papillomavirus (HPV) infection. Twenty-two (23.4%) of these 94 patients, who had abnormal smears of either ASCUS or low grade squamous intra-epithelial lesions (LSIL) were re-evaluated within six to twelve months of the initial abnormal Pap smear diagnosis. Eight of these 22 patients (36.4%) had histological diagnosis of LSIL inclusive of cervical intra-epithelial neoplasia grade 1 (CIN 1) and condylomata. High-risk HPV DNA types were detected in two of these eight patients (25%). The study confirms that sexually active teenage girls are at risk of developing SIL and high-risk HPV infection. Screening of sexually active teenaged girls by Pap smears followed by other appropriate investigative procedures is recommended.     

Human papillomavirus screening and cervical cancer prevention

Infection with one of several types of human papillomavirus (HPV) appears to be a necessary first step in the development of invasive cervical cancer. We cannot currently treat HPV infections; thus, the role of HPV testing is to identify women with precancerous lesions that can be removed and, in so doing, prevent progression to invasive carcinoma. Although HPV testing may help to identify women at risk of cervical cancer who might be missed by other screening tests, it is inherently nonspecific at identifying those who would otherwise develop cervical cancer. In order to avoid overtreatment of women with minor lesions with little potential for progression, HPV testing needs to be repeated or combined with Pap smears. Protocols for HPV screening have yet to be properly evaluated. Here we consider several possible applications of HPV testing in the prevention of cervical cancer. The most immediate role is as a secondary test in women with minor cytological abnormalities. Appropriate use of HPV testing as a primary screening tool depends on the setting. In a developed country without an organized screening program, HPV testing might be used in addition to Pap smears in women age 35 and over to increase sensitivity. Within an organized screening program, HPV testing might be used in combination with Pap testing, but with extended screening intervals so as to obtain the maximum advantage to women without unduly increasing costs. Where resources are strictly limited, an attractive option would be to perform visual inspection of the cervix after application of dilute acetic acid using a low threshold for referral, and to test for HPV only on those with abnormal looking lesions.     

液基薄层细胞检查对宫颈病变患者的诊断价值

目的探讨宫颈液基细胞学（TCT）检查及传统巴氏涂片（CS对宫颈病变的诊断价值。方法将2012年3月-2012年9月东莞市大朗医院收治的该类患者进行分组筛查，分为TCT组和GS组，将两组患者的病理学检查符合率进行比较。结果TCT组患者的病理学检查CNⅡ符合率为608％,超过CS组患者的3．61％，差异有统计学意义（P〈0.05）；TCT组患者的CNⅡ＋CINⅢ＋宫颈癌病检符合率达到8.11％，显著高于CS组患者的412％，差异有统计学意义（P〈005）。结论对宫颈病变患者进行TOT检查，对于确诊该疾病具有重要的作用，值得临床推广应用。     

Improving cervical cytology screening in a remote, high risk population

OBJECTIVE: To evaluate the use of the ThinPrep method to reduce rates of unsatisfactory Papanicolaou (Pap) smears in women in remote communities. DESIGN: Prospectively collected samples were split and screened conventionally and by ThinPrep at the Queensland Cytology Service. PATIENTS: Three hundred women having cervical smears taken by a Mobile Women's Health Service nurse or at the antenatal and sexual health clinics of a remote north Queensland community. MAIN OUTCOME MEASURE: Number of Pap smears reported as unsatisfactory for evaluation and requiring a repeat smear request. RESULTS: 17.3% of conventionally prepared smears were technically unsatisfactory, compared with 6.3% prepared with ThinPrep. The overall rate of unsatisfactory smears was only 4.3% when both ThinPrep and conventional smears were assessed for a combined report. CONCLUSION: A significant reduction in the proportion of unsatisfactory Pap smears is possible with the ThinPrep method. Targeted use of ThinPrep in communities with high rates of unsatisfactory smears may prove cost-effective.     

The 'Pap' or cervical smear and the role of colposcopy in screening for carcinoma of the cervix

Cervical cancer is the commonest female genital tract cancer in Singaporean women with an annual age-standardized rate of 17.4 per 100,000. High risk factors are early sexual intercourse, multiple sexual partners and cigarette smoking. Population screening with annual cervical (Pap) smears after beginning sexual activity until age 35 and at 5 year intervals after that can reduce both incidence and mortality rate from invasive cervical cancer. Benign, premalignant and malignant conditions may be identified in smears. The term cervical intra-epithelial neoplasia (CIN) reflects better the continuum of change in precursor lesions and is preferred over the older dual terminology of dysplasia/carcinoma-in-situ for precursors of cervical cancer. Colposcopy is essential for evaluation of all patients with abnormal cervical smears. Colposcopy is used to identify the site, severity and extent of abnormality as well as to aid directed biopsy, plan treatment and allow use of conservative methods to treat the precursor lesions. Colposcopy however, has no role as a primary screening procedure for cervical cancer but instead cervical smears are used for screening.     

Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results

CONTEXT: A Papanicolaou (Pap) test result of atypical squamous cells of undetermined significance (ASCUS) presents a clinical challenge. Only 5% to 10% of women with ASCUS harbor serious cervical disease, but more than one third of the high-grade squamous intraepithelial lesions (HSILs) in screening populations are identified from ASCUS Pap test results. OBJECTIVE: To determine whether human papillomavirus (HPV) DNA testing of residual material from liquid-based Pap tests and referral of cases found to be HPV-positive directly to colposcopy could provide sensitive detection of underlying HSILs in women with ASCUS Pap results, compared with repeat Pap testing. DESIGN AND SETTING: Natural history of women with ASCUS Pap smear results, all of whom had liquid-based cytology, HPV testing, and subsequent repeat Pap tests and colposcopy with histologic evaluation, conducted at 12 gynecology clinics in a large managed care organization between October 1995 and June 1996. PARTICIPANTS: From a cohort of 46009 women who had routine cervical examinations, 995 women with Pap test results of ASCUS who consented to participate were identified. MAIN OUTCOME MEASURES: Cervical histology, HPV test results, and repeat Pap smear results, and sensitivity of HPV testing to identify patients found to have HSIL+ histology. RESULTS: Of 995 participants with ASCUS Pap test results, 973 had both a definitive histologic diagnosis and HPV result. Sixty-five (6.7%) had histologic HSIL or cancer. For women with histologic HSIL+, the HPV test was positive in 89.2% (95% confidence interval [CI], 78.4%-95.2%), and the specificity was 64.1 % (95% CI, 60.9%-67.2%). The repeat Pap smear result was abnormal in 76.2% (95% CI, 63.5%-85.7%). Triage based on HPV testing only or on repeat Pap testing only would refer similar proportions (approximately 39%) to colposcopy. The sensitivity of HPV DNA testing for HSIL was equivalent to, if not greater than, that of the repeat Pap test. We further estimated that an HPV-based algorithm including the immediate colposcopy of HPV-positive women, and then repeat Pap testing of all others, would provide an overall sensitivity of 96.9% (95% CI, 88.3%-99.5%). CONCLUSIONS: For women with ASCUS Pap tests, HPV DNA testing of residual specimens collected for routine cervical cytology can help identify those who have underlying HSIL. By testing the specimen collected at initial screening, the majority of high-risk cases can be identified and referred for colposcopy based on a single screening.     

三种方法在鲁西南地区宫颈癌筛查中的可用性分析

目的 了解鲁西南地区的宫颈癌流行状况,比较3种流行筛查方法的优劣,为宫颈癌的防治提供依据.方法 鲁西南地区选取890名适龄妇女进行宫颈癌筛查,以阴道镜检查的病理组织学结果为金标准,比较巴氏涂片、液基细胞学、肉眼观察辅以醋酸白染色3种方法的可用性.结果 三种方法对宫颈上皮内高度病变的敏感度、特异度、阳性预测值、阴性预测值分别为:巴氏涂片:27.8％,87.5％,29.9％,98.1％；液基细胞学:79.6％,91.2％,38.4％,99.3％；肉眼观察辅以醋酸白染色:67.2％,78.5％,9.2％,99.6％.结论 液基细胞学的诊断价值最高,可作为首选的宫颈癌筛查方法；肉眼观察辅以醋酸白染色简单易行,适用于贫困地区的宫颈癌筛查工作.     

The pivotal role of the pathology laboratory in the context of a Singapore cervical cancer screening programme

Singapore is poised to implement a national cervical screening programme and pathology laboratories have a pivotal role to play. This review describes the laboratory examination of Pap smears and the importance of providing a first class service. This will require sufficient experienced cyto-technologists and pathologists. There also needs to be a mechanism in place to monitor all stages of the Pap smear, from the time it is taken until it is reported. The Bethesda System for reporting Pap smears, new smear collection devices, liquid-based specimens, use of computer screening and other measures to enhance laboratory standards, are also discussed.     

Cervical cancer screening in developing countries: why is it ineffective? The case of Mexico.

BACKGROUND: Mexico established a national cervical cancer-screening program in 1974. Despite the implementation of the program, there was a steady mortality trend of 16 per 100,000 women over 15 years. METHODS: A diagnostic procedure of the pitfalls was applied to the following steps of the screening procedure: Pap sampling quality; cytological diagnosis validity; compliance of women; and determinants of non-participation. RESULTS: The low effectiveness of screening on cervical cancer is principally due to factors associated with quality and coverage. Pap quality is deficient; 64% of a random sample of specimens lacked endocervical cells. Reading centers presented false negative indices of between 10 and 54%. Women seek screening in a late stage of disease (55% with cervical cancer seek care because they have symptoms). In addition, coverage is low; in women between 15 and 49 years of age in Mexico City, 64.2% have a history of Pap, compared with 30% in rural areas. Knowledge of what the Pap is used for strongly determines the use of screening. In rural areas, only 40% of women are informed about the purpose of the Pap test. CONCLUSIONS: A proposal to reorganize Mexico's screening program includes the following five main strategies: (a) increased coverage; (b) improved quality control of how cervical smears are taken; (c) better interpretation of Pap tests; (d) guaranteed treatment for those whose tests show abnormalities, and (e) improved follow-up.     

薄层液基细胞学检查与宫颈涂片检查在宫颈病变诊断中的对比分析

目的对比分析薄层液基细胞学检查与宫颈涂片检查在宫颈病变诊断中的应用情况。方法回顾性分析我院2010年10月-2011年9月妇产科行薄层液基细胞学检查与宫颈涂片检查患者的临床资料,随机选取薄层细胞学检查480例和宫颈涂片检查480例．以病理结果为对照判定以上两种检查宫颈病变诊断中应用效果。结果薄层液基细胞学检查取材满意率为99．8％,宫颈涂片检查的涂片满意率为96．O％,前者明显高于后者,差异有统计学意义（P〈0．05）;薄层液基细胞学检查宫颈细胞学与病理学结果符合率为98.3％,宫颈涂片检查的符合率为92．9％,前者明显高于后者,差异有统计学意义（P〈O．05）。结论薄层液基细胞学检查与宫颈涂片检查在宫颈病变诊断中均具有重要的临床价值,薄层液基细胞学检查对对病变的检查率更高,有利于及早发现宫颈早期病变。     

Papanicolaou smear interpretation with progestin-only hormonal birth control methods

Objective To define the relationship between the use of progestogen-only contraception and the occurrence of abnormal cervical cytology and cervical intraepithelial lesion.Methods The present study was designed as a case-control study including 200progestogen-only contraceptive(POC) users recruited as cases(group A) and 50 women who were non-hormonal contraceptive users as a control group(group B). Positive Papanicolau(Pap) smear was reported in cervical cell abnormalities from atypical squamous cell of undetermined significance(ASCUS) to invasive cancer. Pap smear was evaluated according to the Bethesda system classification 2001. Cases with positive Pap smears were subjected to visual inspection of the cervix with 5.0% acetic acid(VIA test) and punch biopsy.Results Statistical analysis of Pap smear results in this study showed epithelial cell abnormalities in 44 cases(22.0%) in group A and 9 cases(18.0%) in group B showing no statistically significant difference(P0.05). ASCUS abnormality was reported in31 cases(15.5%) of group A and 6 cases of group B(12.0%). Low-grade squamous intraepithelial lesion(LSIL) was found in 11 cases(5.5%) and 3 cases(6.0%) of group A and group B, respectively. High-grade squamous intraepithelial lesion(HSIL) was found in 2 cases(1.0%) of group A and none of group B. The incidence of abnormal Pap smears in group A did not greatly vary between different methods of POCs. Among Depo medroxyprogesterone acetate(DMPA) users, ASCUS was found in 17 cases(16.8%), LSIL was found in 11 cases(10.8%) and HSIL was found in 2 cases(1.9%).While in progesterone-only pills(POPs) users and Implanon#174;users, ASCUS was found in 10 cases(12.8%) and 4 cases(20.0%) respectively with no higher epithelial abnormalities found. Levonorgestrel intrauterine device(LNG-IUD) was used by 1 casein group A and was not associated with Pap smear abnormality. Cases with ASCUS abnormality were followed up by repeated Pap smear after 3 months. Twenty cases(64.5%) and 3 cases(50.0%) of groups A and B, respectively showed complete regression to normal. Eleven cases(35.5%) and 3 cases(50.0%) of groups A and B respectively showed persistent features of ASCUS. Punch biopsy was done in cases with higher grade epithelial lesions(LSIL HSIL) showing 4 cases(30.8%) with mild dysplasia or CIN I, 2 cases(15.4%) with moderate dysplasia in group A, 2 cases(66.7%)with mild dysplasia and 1 case(33.3%) with moderate dysplasia in group B. Seven cases(53.8%) of group A showed cytological abnormality without concurrent dysplasia seen in histopathological examination. None of the included cases in this study were active smokers, while in group A passive smoking was found in 44 cases with abnormal Pap smear(100.0%) including 31 ASCUS cases(100.0%), 11 LSIL cases(100.0%) and2 HSIL cases(100.0%). In group B passive smoking was found in 9 cases with Pap smear abnormality including 6 ASCUS cases(100.0%), 3 LSIL cases(100.0%). There was a statistically significant difference between cases with normal and abnormal Pap smears regarding smoking status.Conclusion POCs use is not associated with increased risk of abnormal cytologic findings and preinvasive disease of the cervix. Smoking including passive smoking has a positive association with abnormal Pap smears. The use of the Bethesda system for cytological interpretation is a simple and accurate method for management of abnormal cytology.     

传统巴氏涂片与液基细胞学筛查宫颈病变的对比研究

目的 分析比较传统巴氏涂片(conventional smears,CS)及新柏氏液基细胞学(thinPrep cytology test,TCT)在宫颈病变筛查中的应用价值及临床意义.方法 回顾性分析了2247例宫颈细胞学检查结果,其中行CS1 204例,行TCT1 043例,分别对两种方法的标本满意率及宫颈病变的阳性检出率及病检符合率进行了比较.结果 TCT组标本满意率明显高于CS组(TCT组99.81%,CS组76.83%,P<0.01);宫颈病变的检出率TCT组亦明显高于CS组(TCT组23.78%,CS组8.64%,P<0.05),但二组的病检符合率无统计学差异(TCT组86.84%,CS组83.33%,P>0.05).结论 液基细胞学技术明显提高了标本满意率及宫颈病变的阳性检出率,液基细胞学技术是宫颈病变筛查的有效手段.     

Screening for cervical cancer: a new scope for general practitioners? Results of the first year of colposcopy in general practice

A survey was carried out over one year of all the women who attended a colposcopy clinic in a general practice. During the year 1254 women underwent cytological screening in the practice and 197 of these underwent colposcopy. Of 79 women with abnormal smears that suggested cervical intraepithelial neoplasia, 62 (79%) were confirmed by biopsy to have cervical premalignancy. In addition, the remaining 118 women with normal or inflammatory smears underwent colposcopy either because of their history or because they requested the investigation. A general underestimate of cervical intraepithelial neoplasia when cytology alone was used was discovered. Seven out of 28 women with inflammatory smears were found to have important cervical premalignancy. Mildly dyskaryotic smears led to a falsely reassuring estimate of the degree of severity of cervical lesions. Seven out of 13 patients who underwent colposcopy because they were thought to be at high risk of neoplasia because of a history of genital warts, unexplained recurrent cystitis, heroin abuse, or immunosuppression had cervical intraepithelial neoplasia proved at biopsy. This report shows that both in screening for and in the follow up of known cervical disease a normal smear cannot guarantee normal pathology. Diagnostic colposcopy is a valuable complementary investigation that could be carried out in a general practice.     

子宫颈细胞学不典型腺细胞的临床意义

目的 探讨宫颈细胞学结果中不典型腺上皮细胞(AGC)的组织病理学特点及临床意义.方法 选择87例宫颈细胞学AGC患者,分析其阴道镜检查,宫颈活检、分段诊刮、子宫颈电热圈环切术(LEEP)的病理及随访结果.结果 (1)87例中病理异常35例(40.23%):腺上皮病变10(11.49%)例,包括子宫内膜轻度非典型增生2例、宫颈腺上皮内瘤变3例、宫颈腺癌3例、子宫内膜腺癌2例;宫颈鳞状上皮内病变(CIN)25例(28.74%).(2)61例细胞学AGC不明意义(AGC NOS)有18例病理异常(29.51%);16例AGC提示倾向内瘤变(AGC SIL)中有9例组织学异常;10例为原位腺癌(A1S)/腺癌中,6例病理异常.病理异常在细胞学AGC NOS与AGC SIL或AIS比较差异有统计学意义,P<0.05.(3)除2例子宫内膜腺癌及3例宫颈腺癌行开腹手术外,余82例行随访,随访率100%.随访时间6～46个月.随访中3例再次出现细胞学异常,经病理证实1例CIN1、1例CIN2、1例CIN3.(4)10例病理腺上皮病变中,除1例CGIN1患者的年龄<35岁,余年龄均≥35岁.结论 AGC中40.23%的患者有组织学异常.因存在CIN及癌,应行阴道镜检查及组织学确诊.疾病的存在与年龄有关,年龄≥35岁的患者存在腺癌和子宫内膜癌的概率增加,因此应重视年龄35岁以上妇女宫颈细胞学AGC的结果.     

Correlation of PAP smear findings with clinical findings and cervical biopsy

Objectives: Carcinoma of the cervix is the most common cause of the death in Nepal. Cervical carcinoma does not develop suddenly from normal epithelium but is presented by a spectrum of intraepithelial neoplastic changes that are precancerous lesion and were termed as cervical intraepithelial neoplasia (CIN). Cervical cytological screening is designed to detect over 90% of cytological abnormalities. It has also been established that most cervical cancers can be diagnosed at the preinvasive stage with adequate and repetitive cytological screening. Keeping in view of the importance of carcinoma and the precancerous lesion (CIN) of cervix, study of different methods for the early detection of abnormalities in cervix, correlation with the clinical findings and comparison between the techniques was carried out. Material and methods: Patients with suspicious cervix attending Gynaecology OPD of TUTH and Western regional hospital (Pokhara) who have undergone for pap smear cytology test along with biopsy were selected. Detail history with clinical examination was performed and the findings were correlated. Results and conclusion: Unhealthy cervix with discharge was found to be common even in chronic cervicitis however bleeding and tenderness were associated with more advanced lesions. Pap smear test was found to be equally sensitive to histopathological examination for the early detection of different cervical lesions. However, it is advised to perform biopsy if any abnormalities are detected in pap smear for correlation and confirmation. Key words: Pap smear, CIN.     

妇产科门诊异常宫颈涂片的管理及分析研究

目的 探讨如何制定并完善妇产科门诊宫颈涂片的管理制度来加强宫颈癌的预防工作.方法 选取妇产科门诊行宫颈细胞学涂片检查,其结果 为没有明确意义的不典型鳞状细胞及以上患者共计1950例,对其根据异常宫颈涂片处理指南进行管理,并对所得数据进行统计分析.结果 所有异常宫颈涂片患者中有1108例行阴道镜检查,其中包括79.3%的...     

宝鸡地区宫颈癌筛查方案的可行性研究

目的探讨宝鸡地区宫颈癌筛查方案的可行性。方法收集分析2010年1月-2013年11月在宝鸡市妇幼保健院进行宫颈癌筛查的患者资料,筛查方法包括巴氏细胞学、液基细胞学、高危型HPV检测,多功能醋酸白肉眼检测法,并经阴道镜检查,病理确诊宫颈癌及癌前病变。结果共筛查89714例,其中组织性筛查59745例,机会性筛查29969例,筛查方法依次为巴氏细胞学69285例,液基细胞学16114例,HPV检测625例,多功能醋酸白肉眼检测3604例。最常用的筛查方案是细胞学检查占95.19％。组织性筛查检出宫宫颈癌前病变（CINⅠ＋CINⅡ＋CINⅢ）916例（1.53％）,宫颈癌96例（0.16％）,机会性筛查检出颈癌前病变（CINⅠ＋CINⅡ＋CINⅢ）892例（2.98％）,宫颈癌159例（0.53％）。结论巴氏细胞学仍为经济欠发达地区主要的宫颈癌筛查方法,机会性筛查宫颈病变检出率高,但仍不能忽视组织性筛查。     

新柏氏薄层液基宫颈细胞涂片1600例临床分析

目的：分析妇女宫颈疾病患病情况和年龄分布,探讨TBS细胞学诊断宫颈上皮内病变的处理方法。方法：2007年7月2009年6月对1 600例妇科门诊患者行液基膜式薄层细胞学技术（Thin Prep cyto-logical test,TCT）检查,采用TBS诊断分类,结果按不同年龄分4个组进行观察和对照,对107例上皮异常者进行阴道镜检查和LEEP活检做病理诊断对照,随访318个月。结果：宫颈上皮内病变患病率≤20岁组最高（33.33%）,明显高于其他3个年龄组（9.76%,7.23%,7.41%）,差异有统计学意义（P〈0.01）;细胞学随访转阴性者：性质未定的不典型鳞状细胞（ASCUS）占84.47%（136/161）,低度鳞状上皮内病变（LSIL）占85.00%（17/20）;高度鳞状上皮内病变（HSIL）占57.14%（4/7）。结论：宫颈疾病患病年龄趋向年轻化;TCT技术对性质未定的不典型腺细胞（ASCUS）检出率仍低;不典型上皮细胞根据个体情况观察36个月或阴道镜下活检,LSIL应进行阴道镜检查,必要时镜下指导病理组织活检以诊断和治疗,HSIL必须治疗并以手术为主。     

液基细胞学在宫颈疾病诊断中应用

目的探讨液基细胞学（TCT）检查在诊断宫颈疾病中临床价值。方法收集我院2011年8月“2012年8月门诊和住院妇产科患者1150例,进行宫颈TCT检测,1200例进行宫颈阴道细胞学巴氏涂片染色,两种方法检查结果阳性行宫颈电子阴道镜检查及多点活检。结果TCT制片和传统巴氏涂片法对低度鳞状上皮内病变（LSIL）以上病变的检出率分别为4．28％、1．78％,P〈0．01。TCT检出LSIL、高度鳞状上皮内病变（HSIL）、鳞状细胞癌（SCC）与阴道镜活检阳性符合率分别为83．33％、88．23％、100％高于巴氏涂片法的60％、66．66％、100％,P〈0．05。结论对LSIL和HSIL的患者,宫颈TCT检查可作为宫颈疾病普查的首选方法之一。     

HPV分型检测对不能明确意义的非典型鳞状细胞的分流作用

目的：评估人乳头瘤病毒（HPV）分型检测对不能明确意义的非典型鳞状细胞（ASC-US）分流监测的临床价值。方法：对60例子宫颈超柏氏薄层液基细胞学（LCT）检查结果为ASC—US的患者进行HPV核酸扩增分型检测,所有患者均同时进行阴道镜检查及组织病理学检查。结果：在60例ASC—US患者中,高危型HPV阳性者37例。子宫颈高度病变在高危型HPV阳性组和阴性组的发生率分别为35．14％和8．70％,差异有统计学意义俨〈0．05）。以组织病理学检查结果作为诊断的金标准,计算出HPV DNA分型检测高危型HPV阳性对诊断子宫颈高度病变的灵敏度为86．67％,阴性预测值为91．30％。结论：HPV DNA分型检测对子宫颈细胞学结果为ASC-US的患者可有效地进行分流监测,提高筛查效力。