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用免疫印迹法检查40例具有某些莱姆病相关症状的病人血清,发现4例血清中同时存在高滴度抗-31KDa和抗-4KDa莱姆病抗原的特异性抗体,占总检查例数的10%。该4例病人分别被误诊为心肌炎和风湿性关节炎各1例,系统性红斑狼疮2例,无一例诊断为莱姆病。此结果证明湖南存在莱姆病 相似文献
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用免疫印迹法检查40例湖南病人血清莱姆病抗体 总被引:2,自引:0,他引:2
用免疫印迹法检查40例具有某些莱姆病相关症状的病人血清,发现4例血清中同时存在高滴度抗-31KDa和抗-4KDa莱姆病抗原的特异性抗体,占总检查例数的10%。该4例病人分别被误诊为心肌炎和风湿性关节炎各1例,系统性红斑狼疮2例,无一例诊断为莱姆病。此结果证明湖南存在莱姆病。 相似文献
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莱姆病系全身性感染症,造成人体多系统、多脏器的损害,依据损害程度及症状,临床上可分为早、中、晚三个病期若干个型,本文仅报告晚期莱姆病关节炎型1例。 相似文献
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两项安慰剂对照试验显示抗博氏疏螺旋体疫苗能有效地预防莱姆病。此试验包括来自美国莱姆病流行地区的21000名受试者。由蜱传播的莱姆病是美国最常见的媒介传播疾病,每年向亚特兰大疾病控制与预防中心报告的新病例约有10000例。此试验用的疫苗由重组博氏疏螺旋体外表面脂蛋白A(OspA)组成。在两项试验中,给受试者注射两次疫苗、两次时间相隔一个月,在第 相似文献
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本文介绍了太平洋区7种虫媒病,包括登革热、疟疾、莱姆病、鼠疫、型伤寒、日本乙型脑炎与丝虫。夏威夷最后一例登革热是在1945年。近4年来该病在南太平洋岛屿流行,所以与夏威夷有关。从1984到1990年夏威夷报告有44例输入疟疾病例。因夏威夷没有发现按蚊媒介,所以疟疾并不重要。1989年报告1例因带犬到夏威夷而发生的莱姆病与1例输入的人病例。最后1例鼠疫发生在1947年,但在鼠间持续到1957年。现唯一的虫媒病在夏威夷流行的是鼠型伤寒,从1984到1989年共报告19例病人。在夏威夷从未遇到乙型脑炎,但广泛传播到较大区域的可能性很大。认为丝虫是夏威夷的一种虫媒病,因为有此媒介,历史上在南太平洋群岛也有此病。在WHO虫媒病地理分布(1989)一书中可以发现这7种病的分布现状。 相似文献
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中国莱姆病研究的新进展 总被引:2,自引:1,他引:1
莱姆病(Lyme disease)是一种新发现的蜱传螺旋体感染性人兽共患病。主要经蜱叮咬人、兽而传染。其病原体莱姆病螺旋体(Borrelia burgdorferi)可引起人体多系统、器官的损害,严重者终生致残甚至死亡。该病分布甚广,现已有30多个国家报告发现有 相似文献
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Numerous concerns regarding the potential for misdiagnosis of Lyme disease using commercial assays have been voiced by the US Food and Drug Administration (FDA). We attempted to clarify the clinical value of serologic testing for Lyme disease using the results of commonly marketed assays for detecting antibody to Borrelia burgdorferi, the organism that causes Lyme disease. We reviewed published studies on B burgdorferi test performance published through 1998, package insert labeling from FDA-cleared test kits for B burgdorferi, and Lyme Disease Survey Set LY-A from the College of American Pathologists. We assessed the sensitivity and specificity of commercial serologic tests (enzyme-linked immunosorbent assay [ELISA], immunofluorescence antibody [IFA], and immunodot) for diagnosis of Lyme disease. To reduce this risk of misdiagnosis, it is important that clinicians understand the performance characteristics and limitations of these tests. These tests, in common use in clinical or commercial laboratories, should be used only to support a clinical diagnosis of Lyme disease, not as the primary basis for making diagnostic or treatment decisions. Serologic testing is not useful early in the course of Lyme disease because of the low sensitivity of tests in early disease. Serologic testing may be more useful in later disease, at which time sensitivity and specificity of the test are improved. Positive or equivocal results on an ELISA, IFA, or immunodot assay requires supplemental testing with a Western blot assay. A negative result on the Western blot or ELISA indicates that there is no serologic evidence of infection by B burgdorferi at the time the sample was drawn. 相似文献
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目的 研究中国莱姆病螺旋体 PD91 重组外膜蛋白 C(r Osp C)检测莱姆病特异性抗体Ig M的效果 ,为莱姆病的早期特异性诊断提供依据。方法 r Osp C经纯化、定量后 ,用于酶联免疫吸附试验 (EL ISA) ,检测早期莱姆病患者和莱姆病疫区工人血清 Ig M,并与其他检测方法比较检测效果。结果 用 r Osp C EL ISA和全菌蛋白 Western blotting方法检测了 12例早期莱姆病患者血清 Ig M,其阳性率分别为 75 %和 6 6 .7% (P>0 .0 5 ) ;r Osp C EL ISA、全菌蛋白 EL ISA检测 98份健康人血清 Ig M,特异度分别为 10 0 %和 96 .94 % (P>0 .0 5 ) ;用 r Osp C EL ISA、全菌蛋白 EL ISA和 IFA检测 2 10例莱姆病疫区工人血清 ,其阳性率分别为 5 .2 4 %、8.5 7%和 7.6 2 % ,3种检测方法间无统计学差异 (P>0 .0 5 )。结论 r Osp C具有较好的灵敏度和特异性 ,其用于我国早期莱姆病患者的临床检测和莱姆病流行病学调查上有一定的应用价值。 相似文献
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回顾性分析北京协和医院1994年4月至2008年1月诊断为莱姆病的21例住院患者的临床表现、实验室检查、治疗及转归。其中临床表现为发热16例(76%),皮肤损害14例(67%),神经系统症状17例(81%),关节表现10例(48%),心脏受累2例(10%)。使用的治疗药物包括青霉素、头孢曲松、多西环素。21例患者均临床好转出院,有12例(57%)随访1个月~12年,其中2例(17%)Ⅲ期莱姆病患者出现过复发,8例有慢性遗留症状。这说明莱姆病临床表现复杂,对临床疑似病例及时进行病原检测,有利于早诊断。 相似文献
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Lyme disease is a tick-borne multisystem disease. It was first described in Lyme, Connecticut, USA in 1975. Cases have been reported in Canada, Switzerland, Austria, Australia and Great Britain. It is an inflammatory disease that has varied clinical manifestations ranging from skin rash (erythema migrans), arthritis, fibromyalgia, and regional lymphadenopathy, cardiac conduction defects to neurological manifestations of meningoencephalitis, Bell's palsy, peripheral neuropathy, and painful radiculoneuropathy. There has been no case record of Lyme disease in Kenya and indeed literature on Lyme disease in Africa is very scanty. We present two cases of Lyme disease with predominant neurological manifestations; outline their clinical presentation and management. 相似文献
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24例患者均在蜱咬后出现皮肤慢性游走性红斑,其中16例伴淋巴结大、头痛、发热及项强。用ELISA法测定24例患者血清抗BB抗体水平,20例IgM—抗BB抗体阳性;11例IgG—抗BB抗体阳性;两种抗体总阳性率达91.67%。7例皮肤红斑标本病理检查呈急性非特异性渗出性炎症。提示血清抗BB抗体测定是诊断LD的一种敏感和特异的方法。 相似文献
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Lyme disease during pregnancy 总被引:5,自引:0,他引:5
Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease. 相似文献
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