非霍奇金淋巴瘤合并巨球蛋白血症一例

患者 ,女 ,5 8岁 ,因头晕、乏力 ,浅表淋巴结肿大三年余加重一月 ,于 2 0 0 3年 6月 12日入院。患者 2 0 0 0年发现右侧颈部浅表淋巴结肿大 ,且血红蛋白由 10 0g/L降至 66g/L ,在当地医院诊断为双向性贫血 ,给与叶酸和维生素B12 、铁剂治疗后血红蛋白升至 10 8g/L。.一月前头晕乏力渐加重 ,WBC 6.4× 10 9/L ,Hb45g/L ,血球平均体积 (MCV) 10 5 .5fl ,血红蛋白红血球平均比值 (MCH) 40 .9pg ,血红蛋白浓度对红血球平均比值 (MCHC) 3 88g/L ,PLT 186g/L。体查 :重度贫血貌 ,左右颈侧各触及一蚕豆大小淋巴结 ,质中等 ,可活动 ,无压…     

伴单克隆免疫球蛋白血症的淋巴瘤——附3例报告及文献复习

目的:探讨伴单克隆免疫球蛋白血症的淋巴瘤患者的临床特征。方法:对3例伴单克隆免疫球蛋白血症的淋巴瘤患者的临床资料进行回顾性分析。结果:3例患者分别诊断为小淋巴细胞淋巴瘤(B细胞性)(B-SLL)、慢性淋巴细胞白血病(CLL)和脾边缘区淋巴瘤(SMZL),检查血清免疫球蛋白分别为单克隆IgG-kappa型、IgM-kappa型和Kappa型;临床表现均有贫血和肝脾肿大。结论:伴单克隆免疫球蛋白血症的淋巴瘤诊断需根据淋巴结和骨髓的病理学、血清免疫球蛋白、外周血或骨髓细胞免疫分型、融合基因综合判断;应注意与多发性骨髓瘤、原发性巨球蛋白血症的鉴别。     

气管内非霍奇金淋巴瘤一例

患者男 ,72岁。因咳嗽 10余年 ,间断气喘 2个月 ,于2 0 0 1年 7月 2 3日入院。患者有长年吸烟史 ,10余年来经常咳嗽、咳痰 ,冬季明显 ,曾多次住院治疗 ,诊断为慢性支气管炎、阻塞性肺气肿 (慢阻肺 )。近 2个月因住家院内粉刷楼房墙体 ,闻到涂料气味后出现气喘而入院。诊为慢阻肺、支气管哮喘 ?入院体检 :口唇紫绀 ,呼吸极度困难 ,呈重度喘息状 ,神志恍惚 ,双肺布满哮鸣音 ,心率 12 0次 /ｍｉｎ。胸部Ｘ线示双肺纹理粗重。诊断重度支气管哮喘 ?阻塞性肺气肿 ,立即进入呼吸重症监护室 (ＲＩＣＵ)抢救 ,经抗炎、平喘治疗后缓解。自测峰流速 (Ｐ…     

以胸腹水为突出表现的非霍奇金淋巴瘤一例

患者男 ,2 0岁。发热、腹胀、气促 40ｄ入院。诊断为多发性浆膜炎 ,经抗结核及激素治疗 1 0ｄ病情好转出院。出院后 1周因停药病情复发 ,再次以发热、腹痛入院。既往身体健康。体检 :体温 37.3°Ｃ ,巩膜轻度黄染 ,浅表淋巴结未触及肿大 ,右侧肩胛下叩诊浊音 ,听诊呼吸音消失 ,左肩胛下呼吸音减弱 ,心音钝 ,心率 84次 /ｍｉｎ。腹部轻度膨隆 ,腹肌轻度紧张 ,压痛 (+) ,反跳痛 (- ) ,肝脾未触及 ,移动性浊音 (+) ,右侧肾区叩痛 (+)。实验室检查 :红细胞 7.51× 1 0 1 2 /Ｌ ,白细胞 1 3 .0× 1 0 9/Ｌ ,血小板 2 78× 1 0 9/Ｌ。尿蛋白 (+) ,…     

非霍奇金淋巴瘤并肾癌1例

患者 ,男 ,65岁。因咽部不适 2周于 1 996年 3月入我院五官科。检查发现双咽侧索肿胀、肥厚 ,无发热、盗汗、消瘦。咽侧索病理检查报告为非霍奇金淋巴瘤 (弥漫性 ,B细胞来源 )。肝、肾功能正常 ,骨髓涂片检查有淋巴瘤细胞浸润。1 996年 4月行胸腹部 CT检查示胸部未见明显病变 ,左肾实质有 3cm× 3cm类圆形低密度影 ,边缘清 ,密度不均匀 ,后腹膜及主动脉旁淋巴结未见肿大。临床诊断为非霍奇金淋巴瘤 期 A。给予 ACOP方案化疗 4个疗程 ,咽侧索肿胀、肥厚消失 ,骨髓浸润消退。患者化疗期间无血尿。多次作肾脏 CT复查 ,与前变化不大 ,1 998…     

双侧卵巢非霍奇金淋巴瘤并子宫颈癌一例

1病例介绍患者女，32岁。因发现腹部包块两个月入院。查体：全身皮肤粘膜无苍白、黄染及出血点，浅表淋巴结未触及，腹软，略隆，下腹部可扪及13cm×12cm大小包块，肝脾助下未触及。妇检；宫颈轻度糜烂，它体中位与附件相连，似常大。附件双侧盯们及直径约10cm的包块。腹部B超显示，双侧附件区实性占位病变，考虑双侧卵巢肿瘤，阴道彩超显示右侧包块大11．4cm×7．7cm，外形不规则，有分叶感，血流丰富，呈树枝状。子宫后方包块9．8cm×7．1cm，外形不规则，内呈均匀一致的中低回声，有分叶感，彩超示血流丰富，树技状，考虑双侧卵巢恶性肿…     

累及胰腺的非霍奇金淋巴瘤一例

患者，女性，46岁。上腹痛伴发热、恶心8天入院，腹痛呈持续性胀痛，阵发性加剧，且向腰背部放射，伴发热(体温37．3℃—38℃)，以午后为甚，盗汗，且恶心呕吐，呕吐物为胃内容物，呈非喷射状，无关节疼痛、腹泻、咳嗽和胸痛。门诊血常规检查正常，尿常规检查结果：尿蛋白( )、隐血( )，血淀粉酶、尿淀粉酶在正常范围，以腹痛待查收住院。1个月前因发热     

软组织原发性非霍奇金淋巴瘤1例并文献分析

非霍奇金淋巴瘤是一组高度异质性的淋巴系统恶性肿瘤,主要发生在淋巴组织及富于淋巴组织的器官,发生于结外淋巴组织器官者为结外淋巴瘤,原发结外部位有胃肠道、皮肤、中枢神经系统、头颈部、肝脏等,而原发于软组织的非霍奇金淋巴瘤十分少见[1-4],Travis报道其发病率仅占淋巴瘤的0.11%[4],组织学类型以非霍奇金淋巴瘤为主[5].本文分析我院收治的1例软组织原发性非霍奇金淋巴瘤,探讨该病的临床病理特征、诊断及治疗等情况.     

美罗华治疗难治性非霍奇金淋巴瘤3例

非霍奇金淋巴瘤(NHL)是最常见的淋巴系统恶性肿瘤，其中绝大多数来源于B细胞，90％的病例表达CD20抗原。常规化疗、放疗难以延长NHL患者生存期，且复发率高，治愈率低。近年来针对B细胞CD20抗原研制的特异性单抗美罗华，用于治疗B细胞淋巴瘤，能导致B细胞溶解，并能抑制其增殖，诱导凋亡和提高肿瘤化疗的敏感性。据国内外临床证明，对B细胞淋巴瘤有肯定疗效。现将我科应用美罗华治疗的3例难治性NHL报告如下。     

原发性脾脏非霍奇金淋巴瘤1例

<正>脾脏血运丰富,原发性肿瘤发生率极低,而原发性脾脏恶性淋巴瘤临床更为罕见,Ahmann等〔1〕报告的5 100例脾脏恶性淋巴瘤中,仅49例为原发性脾脏恶性淋巴瘤,占0.96%。由于脾脏原发性恶性肿瘤缺乏特异性临床表现,故难以早期诊断,并在一定程度上增加了临床诊治的难度。1临床资料患者男性,73岁,主因发热3 d入院。持续性高热,体温最高达39.6℃,伴全身乏力,无畏寒、寒战,无其他不适,自行静点氨曲南、利巴韦林(病毒唑)等药物3 d,仍有发热,门诊查胸     

A case of Non-Hodgkin's lymphoma in a patient with Crohn's disease]

Although adenocarcinoma is a well known complication of chronic inflammatory bowel disease, primary gastrointestinal lymphoma occurring in Crohn's disease is rare. A 40-year-old man with 10 year-history of Crohn's disease had multiple longitudinal ulcerative lesions on descending colon in follow-up colonoscopic examination. Microscopic examination of proximal descending colon revealed peripheral T cell lymphoma and other site of the descending colon was consistent with Crohn's disease. The patient reached complete remission of malignant lymphoma after three cycles of combined chemotherapy. He has been well for 10 months with sulfasalazine maintenance therapy but was admitted to the hospital due to spontaneous bowel perforation of ascending colon. Right hemicolectomy was done, but the patient died of post-surgical recurrent mesenteric abscess and sepsis. To the best of our knowledge, this is the first case of Non-Hodgkin's lymphoma complicating Crohn's disease in Korea which was confirmed by immunohistochemical studies.     

Non-Hodgkin's lymphoma in the thyroid: case report

The authors describe the case of a 33 year-old white female, without any clinical or laboratorial evidence of thyroiditis or clinical hypothyroidism, who presented with a rapidly enlarging anterior neck mass. Diagnosis of a follicular non-Hodgkin's lymphoma was made through histopathological and immunohistochemical analysis.     

Non-Hodgkin's lymphoma with Toxoplasma encephalitis]

A 62-year-old man was admitted to our hospital due to fever and systemic lymph-node swelling on June 9, 1998. He was given a diagnosis of non-Hodgkin's lymphoma (diffuse mixed T cell lymphoma) with involvement of mediastinum and para-aortic lymph nodes, pleura, peritoneum, and bone marrow. After diagnosis, combined chemotherapy (CHOP regimen) was started. On day 11, the patient's consciusness level suddenly deteriorated. A brain computed tomographic scan showed no abnormal findings. A cytospin smear of cerebrospinal fluid disclosed tachyzoides (Toxoplasmic bodies), thus yielding a diagnosis of Toxoplasma encephalitis. Oral sulfadoxine pyrimethamine rapidly alleviated the patient's consciousness disturbance. One month later, a cytospin smear and RT-PCR analysis of cerebrospinal fluid detected no tachyzoides. Complete remission of lymphoma was achieved after 2 courses of CHOP therapy. Toxoplasma encephalitis should be considered a potential cause of consciousness disturbance in immunocompromised hosts, such as patients with malignant lymphoma. Cytospin smears of cerebrospinal fluid are a useful tool for the early diagnosis of Toxoplasma encephalitis.     

Non-Hodgkin's lymphoma presenting with amegakaryocytic thrombocytopenic purpura

 A 91-year-old patient was diagnosed with amegakaryocytic thrombocytopenic purpura (AATP) as a presenting symptom for CD5-positive B cell non-Hodgkin's lymphoma. Lymphoma is another condition that should be considered in the differential diagnosis of AATP. Received: 29 January 1996 / Accepted: 29 April 1996