食管Pv_1-P_E和R-P_E对室上性心动过速的诊断价值

目的：探讨经射频消融治疗１４２例患者Ｐｖ１－ＰＥ、Ｒ－ＰＥ 和ΔＡ、Ｖ－Ａ间的关系。　方法：所有患者均经食管电生理和心内电生理检查。　结果：顺传型房室折返心动过速（ＡＶＲＴ）Ｐｖ１ －ＰＥ＞ ７５ ｍ ｓ,且Ｒ－ＰＥ＞ ７５ ｍ ｓ,右间隔旁路Ｐｖ１ －ＰＥ＝ ０,Ｒ－ＰＥ＞ ７５ ｍ ｓ,房内折返（ＡＲＴ）Ｐｖ１－ＰＥ＞ ７５ ｍ ｓ,Ｒ－ＰＥ＞ １５０ ｍ ｓ,且Ｒ－ＰＥ＞ ＰＥ－Ｒ,慢－快型房室结折返性心动过速（ＡＶＮＲＴ）Ｐｖ１－ＰＥ＞ ７５ ｍ ｓ,Ｒ－ＰＥ＜ ７０ｍ ｓ。　结论：食管Ｐｖ１－ＰＥ 和Ｒ－ＰＥ 对不同类型的室上性心动过速及旁路所在的不同部位具有重要的临床诊断价值。     

隐匿性慢旁路折返性心动过速的诊断

为了明确2例反复发作的室上性心动过速的诊断，我们给予心内电生理检查及心内标测和消融治疗，其结果：①心房和心室电刺激易诱发和终止心动过速；②心动过速时体表心电图QRS波窄型、逆行的P波、RP＞PR；③心动过速与右心室起搏均呈同样的偏心性心房激动顺序；④心动过速时于希氏束不应期刺激心室可提早夺获心房；⑤经劳路室房传导呈递减性，未发现旁路有前传特性；⑥射频消融阻断心动过速的逆传支，2例分别于600ms及500ms心室起搏时显示室房分离。根据以上结果诊断为隐匿性慢旁路折返性心动过速。隐匿性慢旁路折返性心动过速的诊断@王…     

射频消融治疗阵发性室上性心动过速262例分析

经导管射频消融治疗阵发性室上性心动过速（ＰＳＶＴ）２６２例,探讨ＲＦＣＡ治疗ＰＳＶＴ的安全性及疗效。方法：房室结双径路改良采用下位法;左侧旁道采用冠状窦电极粗标,大头电极在心室国标。右侧旁道采用左前斜４５度。大头电极在心房侧三尖瓣环处细标;房扑时标测心房激动顺序,用隐匿必拖法确定折返环部位,在心房内行线性消融方法治疗。结果：２６２例中慢－快型房室结折生心动过速（ＡＶＮＲＴ）７８例。,房室折返性心动     

食道调搏无跳跃现象的房室结折返性心动过速二例报道

食道调搏 (ＴＥＡＰ)诊断阵发性室上性心动过速(ＰＳＶＴ)是房室结折返性心动过速 (ＡＶＮＲＴ)还是房室折返性心动过速 (ＡＶＲＴ) ,主要根据有无房室结传导的跳跃现象 ,即Ｓ Ｒ间期≥ 6 0ｍｓ为ＡＶＮＲＴ ,Ｓ Ｒ间期 <6 0ｍｓ为ＡＶＲＴ[1] 。本文报道 2例经心内电生理检查及射频消融术治疗确诊为慢—快型ＡＶＮＲＴ ,而ＴＥＡＰ时无房室结传导的跳跃现象。1　病例介绍例 1,女患 ,35ａ ,阵发心悸 5ａ ,突发突止 ,持续时间 10ｍｉｎ～ 1ｈ左右。入院后经体格检查、心脏Ｂ超及Ｘ线胸片检查 ,心脏结构和功能正常。ＴＥＡＰ检查Ｓ1Ｓ2 刺激 ,…     

左、右心室起搏判断左侧房室旁路逆传功能的对比研究(摘要)

目的：探讨左、右心室起搏时左侧房室旁路逆传功能有何异同点。方法：近几年来我院经射频消融证实为左侧房室旁路并房室折返性心动过速的患者258例，所有患者放电消融前、后在右室心尖部和左心室行S1S1和／或S1S2刺激，观察逆传心房激动顺序、有无文氏逆传现象和室房分离或递减传导。结果：共有前间隔旁路5例和中间隔旁路3例，放电消融前左、右心室S1S1刺激逆传心房激动均呈向心性，S1S1（180次／分钟室房逆传仍呈1：1，S1S2刺激不呈递减传导，室上性心动过速时在希斯束不应期行心室RS2刺激，S2能够预激心房；有效消融后S1S1（150次／分钟呈室房分离，S1S2刺激呈递减传导。其余均为左后、左侧游离壁和左前旁路，放电消融前左、右心室S1S1刺激时逆传心房激动顺序呈偏心性，此时不再行心室S1S2刺激和RS2刺激；消融后右心室S1S1刺激逆传心房激动顺序呈向心性，S1S1（150次／分钟呈室房分离，而在左心室标测、消融处行S1S1刺激有10例患者逆传心房激动顺序仍呈偏心性，改行左室心尖部S1S1刺激逆传心房激动顺序仍呈偏心性，提示旁路逆传功能仍然存在，继续标测消融后在左心室标测处和左室心尖部行S1S1刺激逆传心房激动顺序由偏心性变为向心性，提示消融成功。结论：左心室刺激有助于提高左侧旁路患者射频消融的成功率。     

房室结改良术终点、快径传导功能与 复发率三者关系的回顾性研究

探讨射频消融（ｒａｄｉｏｆｒｅｑｅｎｃｙ　　ｃａｔｈｅｔｅｒ　ａｂｌａｔｉｏｎ,　ＲＦＣＡ）房室结慢径终点、快径前向传导功能与心动 过速复发率的关系。方法：对７６例经系统电生理检查、ＲＦＣＡ证实为房室结折返性心动过速（ａｔｒｉｏｖｅｎｔｒｉｃｕｌａｒ ｔａｃｈｙ－ ｃａｒｄｉａ,ＡＶＮＲＴ）的患者根据消融终点分为三组：①Ａ组,为４４例慢径消融后慢径完全消失病人;②Ｂ组,为１７例慢 径消融后慢径尚残存,但无心房回波病人;③Ｃ组,为１５例慢径消融后慢径残存且有心房回波病人。对以上三组 病人进行回顾性研究,探讨慢径消融终点、房室结快径传导功能及复发率三者关系。结果：①Ａ组和Ｂ组,慢径 消融后其快径前传功能不应期和有效不应期明显缩短,随访期间无心动过速发作;②Ｃ组,慢径消融后其快径前 传功能不应期和有效不应期缩短不明显,随访期间有５例复发心动过速。结论：房室结双径路是彼此关联的两 条径路,功能慢径的存在可能在一定程度上抑制快径的传导功能;ＡＶＮＲＴ慢径消融最好达到慢径消失,若慢径残 存,亦应消融到无心房回波和快径传导功能明显改善。     

202例快速心律失常射频消融的回顾分析

目的：总结经导管射频消融（ＲＦＣＡ）治疗２０２例快速心律失常的经验。　方法：对２０２ 例快速心律失常进行ＲＦＣＡ 治疗,其中房室旁路折返性心动过速（ＡＶＲＴ）１３６例,房室结折返性心动过速（ＡＶＮＲＴ）５６ 例,房性心动过速２ 例,心房扑动２ 例,心房纤颤１例,特发性室性心动过速５ 例。本文重点总结ＡＶＲＴ和ＡＶＮＲＴ 的ＲＦＣＡ 经验。　结果：２０２ 例中阵发性室上性心动过速１９２ 例（ＡＶＮＲＴ５６ 例,ＡＶＲＴ１３６ 例）,首次消融成功率９５．８％ （１８４／１９２ 例）,８例复发,其中６ 例经再次ＲＦＣＡ 治疗成功,最终治愈率为９４．８％ 。结论：ＲＦＣＡ治疗ＰＳＶＴ成功率高,严重并发症少,可作为这类快速心律失常治疗的首选方法。     

室上性心动过速的食管心房标测与心内膜标测定位价值的对照分析

旨在评价食管心房标测在室上性心动过速中的定位价值对３０例室上性心动过速（ＰＳＶＴ）患者射频消融术前行食管心房标测测量ＲＥ—Ｐ′Ｅ及Ｐ′Ｖ１—Ｐ′Ｅ时距，与腔内电生理及消融靶点对照结果发现左右两侧房室旁道（ＡＰ）并房室折返性心动过速（ＡＶＲＴ）与房室结折返性心动过速（ＡＶＮＲＴ）的ＲＥ—Ｐ′Ｅ及Ｐ′Ｖ１—Ｐ′Ｅ时距各具特征，相互无重叠，该特征对区别三者有肯定价值诊断符合率为９３％     

射频消融术治疗心动过速10例分析

目的：对１０例心动过速病人射频消融术（ＲＦＣＡ）进行分析。方法：全部病人行心内电生理检查,准确找到靶点后行ＲＦＣＡ。结果：诊断室速（ＶＴ）２例,房室结折返心动过速（ＡＶＮＲＴ）２例,右侧旁路（ＲＡＰ）１例,左侧旁路（ＬＡＰ）５例。７例消融成功无复发,１例ＬＡＰ术后３月复发,２例ＶＴ不成功,但长期随访比术前状况改善,随访７月所有病人均无并发症发生,效果良好,结论：准确靶点定位和导管操作技巧是ＲＦＣＡ     

体表心电图逆行P波对鉴别房室及房室结折返性心动过速的临床意义

慢 快型房室结折返性心动过速 (Ｓ Ｆ型ＡＶＮＲＴ)及隐匿性旁路传导的房室折返性心动过速(ＡＶＲＴ)是阵发性室上性心动过速 (ＰＳＶＴ)中常见的类型 ,但通过体表心电图鉴别有一定难度。本文对经心内电生理检查及射频电消融术确诊的 4 5例Ｓ Ｆ型ＡＶＮＲＴ及ＡＶＲＴ患者心动过速发作时体表心电图逆行Ｐ(Ｐ′)波的位置、形态进行对比分析 ,以寻求体表心电图在ＰＳＶＴ分型诊断中的价值。1　临床资料收集 1999年 4月至 2 0 0 2年 1月在我院住院的ＰＳＶＴ患者 4 5例 ,男性 2 6例 ,女性 19例 ,年龄 13～6 0ａ。有反复发作心动过速史 ,无器…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.