共查询到19条相似文献,搜索用时 234 毫秒
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新型水性胃溶薄膜包衣预混辅料的制备及防潮防裂性能研究 总被引:1,自引:0,他引:1
目的研究新型水性胃溶薄膜包衣预混辅料。方法制备一种新型水性胃溶薄膜包衣预混辅料,对其处方结构和制备工艺特点进行分析。将用该预混辅料配制的包衣液分别对复方丹参片、花红片、普乐安片和钙尔奇D片进行包衣,在温度(40±2)℃、相对湿度(75±5)%的条件下进行裸片加速试验7d,考察其防潮防裂性能;通过对该预混辅料中镁元素含量及100目筛余率的测定,考察其均匀度和粒度。结果该预混辅料粒度小于100目,混合均匀度不低于99.5%,并具有较强的防潮、防裂性能。结论制备得到了一种粒度细、均匀度高、防潮防裂性能强的水性胃溶薄膜包衣预混辅料。 相似文献
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普乐安片薄膜包衣工艺研究 总被引:3,自引:0,他引:3
王开疆 《中国医药工业杂志》2002,33(10):489-490
采用自配薄膜包衣液及两种市售薄膜包衣材料对普乐安片进行薄膜包衣,比较了包衣材料的防潮性能,并对包衣液的用量进行了筛选。 相似文献
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用特殊防潮性包衣材料--OpadryAMB对阿司匹林片进行包衣,考察素片和薄膜包衣片中阿司匹林的含量、溶出度、稳定性等.结果表明阿司匹林包复Opadry薄膜衣后增加了稳定性,OpadryAMB防潮效果明显. 相似文献
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摘 要 目的: 对西罗莫司(SRL)滴丸进行薄膜包衣,以期达到防潮的目的。方法: 选用欧巴代为SRL滴丸的包衣材料,对其使用溶剂、欧巴代浓度、增重及包衣工艺参数进行筛选,确定包衣处方及工艺;测定包衣SRL滴丸的临界相对湿度,并与未包衣SRL滴丸进行比较。结果:选用95%的乙醇作为溶剂系统,其中欧巴代的浓度为6.5%,增重为4%,进风温度为(35±2)℃,进液速度为12 ml·min-1,喷雾压力为3.0 MPa。包衣SRL滴丸的临界相对湿度为63.1%,明显高于未包衣SRL滴丸(36.1%)。结论: 欧巴代薄膜包衣可明显提高SRL滴丸的防潮性能,有利于其稳定性。 相似文献
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金胆片全水型薄膜包衣的生产工艺研究 总被引:1,自引:0,他引:1
目的:对金胆片包衣生产工艺进行研究,降低包衣片的顶裂、剥落现象,同时优化包衣的生产工艺条件.方法:通过崩解、耐温湿试验比较醇溶型薄膜包衣及全水型薄膜包衣对金胆片理化性质的影响,通过正交试验摸索出全水型薄膜包衣的最佳工艺条件.结果:全水型薄膜包衣可显著减少金胆片项裂、剥落现象,提高贮存期稳定性,在优选的金胆片工艺条件下各项质量指标均合格.结论:金胆片可采用全水型薄膜包衣. 相似文献
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Oguz Bayraktar
zge Malay Yarkn
zgarip Ayegül Batgün 《European journal of pharmaceutics and biopharmaceutics》2005,60(3):373-381
The aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min−1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products. 相似文献
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A physical-chemical analysis of the extent of sorption of water by tablets containing superdisintegrants was carried out following the aqueous film coating of formulated tablets. Characterization of the uncoated and coated tablet properties was conducted using thermo-gravimetric analysis, differential scanning calorimetry, mercury intrusion porosimetry, and measurement of the tablet tensile strength. Tablet residual moisture content, pore system characteristics, tensile strength, and glass transition temperature of the amorphous polymer components of the tablet matrix were significantly affected after the coating operation. These findings were attributed to the penetration of water from the aqueous film coating solution into the tablet matrix. 相似文献
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Objectives The impact of a carmellose sodium (sodium carboxymethycellulose)‐based coat (Opaglos 2) on the stability of an oxygen‐sensitive compound A and in‐vitro dissolution and bioperformance of compound B has been investigated. Methods Tablets containing compounds A and B were coated with various weight gains of Opaglos 2 and a comparative elegance coating (poly(vinyl alcohol)‐based Opadry II). Film‐coated tablets were assessed for oxidative degradation under accelerated stability conditions (30°C/65% RH and 40°C/75% RH). Key findings An apparent rank order of restriction of oxygen (O2) permeability afforded by the coatings was observed, with only higher Opaglos 2 coating weight gains (6 and 8% w/w) providing adequate oxidative degradation stability for up to 52 weeks. Improved stability at the higher coating weight gains was attributed to incomplete polymeric film formation at lower coating weight gains. The 6% and 8% w/w Opaglos 2 formulations showed dissolution retardation compared with elegance‐coated formulations in USP dissolution apparatus II, predicting significant impact on formulation bioperformance. However, pharmacokinetic studies in Beagle dogs showed similar bioperformance for all formulations. Conclusions The Opaglos 2 coating system evaluated in these studies afforded adequate protection from oxidative degradation with no negative impact on bioperformance as compared to elegance coating. However, further studies are needed using several compounds to assess the broader applicability of these coatings. 相似文献
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The purpose of this study was to develop and evaluate the thin-layer sugarless coated tablets containing Vitamin C, Vitamin E, Vitamin B2, calcium pantothenate, and L-cysteine. As a result of the formulation study, three coating layers, 2% under coating (UC), 38% build-up coating (BC), and 5% syrup coating (SC) were necessary for sufficient impact toughness, elegant appearance, and improvement of appearance stability after storage at 25 degrees C/75% RH for 6 months under open conditions. We demonstrated that the thin-layer sugarless coated tablets are superior to the sugar-coated tablets in terms of small tablet size and stability of calcium pantothenate. It was due to the coating method, the continuous spray mist method, which can minimize the thicknesses of coating layers and the moisture content in the tablets. We also demonstrated that the thin-layer sugarless coated tablets are superior to the film-coated tablets in terms of masking ability of the unpleasant odor and the appearance, stability of the appearance, and low hygroscopicity. It was due to the dense, opaque, and stable coating layers mainly consist of erythritol. We revealed that thin-layer sugarless coated tablets have both advantages of film-coated tablets and sugar-coated tablets. 相似文献
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目的 研究温度对3种中药浸膏片包衣工艺的影响.方法 将素片置恒湿变温环境中,不同时间称定片重,记录、计算吸湿增重,分析吸湿数据;将素片置干燥环境中,其余条件相同情况下,记录、计算减重百分率、绘制减重速率曲线图.结果 冠心平片和健肾片的吸湿速率随温度升高而降低,而保肾片的吸湿速率随温度升高而升高;保肾片和冠心平片在60℃的减重百分率大于50℃的减重百分率,而健肾片的减重百分率在50℃和60℃之间变化不明显.结论 吸湿性参数、干燥速率参数可为包衣工艺参数的制订提供科学数据. 相似文献