共查询到20条相似文献,搜索用时 515 毫秒
1.
Doval DC Bhatia K Pavithran K Sharma JB Vaid AK Hazarika D 《Hepatobiliary & pancreatic diseases international : HBPD INT》2006,5(2):305-307
Gallbladder metastases are very rare and usually arise from malignant melanoma, renal cell carcinoma and cervical carcinoma. Breast carcinoma metastatic to the gallbladder is extremely rare and only 4 cases have been reported in the English literature. We hereby report a 54-year-old lady who was diagnosed as having breast carcinoma and underwent modified radical mastectomy. One month after the operation, she developed acute abdominal pain and underwent cholecystectomy after clinical investigation. Histopathological examination revealed metastasis to the gallbladder. Being considered a patient with metastatic breast carcinoma she was subjected to taxane and anthracycline-based palliative chemotherapy. Later she had CNS involvement and died of the progressive disease soon after few months. 相似文献
2.
Singh S Gupta P Khanna R Khanna AK 《Hepatobiliary & pancreatic diseases international : HBPD INT》2010,9(5):553-554
BACKGROUND:Gallbladder carcinoma is a common malignancy in the Indian subcontinent.It commonly metastasizes through lymphatics,direct invasion,and hematogenous spread.A common extra-abdominal site of metastasis is the lungs.Simultaneous metastasis to breast and ovary is extremely rare.METHOD:This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same time.RESULTS:A 45-year-old woman came to us with complaints of flatulent dyspepsia associated with weight loss and anorexia.Ultrasound of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus,but normal uterus and ovary.Contrast-enhanced computer tomography of the abdomen showed a gallbladder mass infiltrating the liver parenchyma.The patient underwent radical cholecystectomy.Histopathological examination revealed a poorly-differentiated adenocarcinoma with margins free from tumor infiltration.One month after surgery she developed a breast lump.Ultrasound of the abdomen for metastatic workup revealed an ovary mass.Simple mastectomy and salphingo-opherectomy were performed,and histopathological examination revealed a metastatic adenocarcinoma.The patient is now on chemotherapy with gemcitabin.CONCLUSION:This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary,which has not been documented before. 相似文献
3.
Yusuke Taki Teiichi Sugiura Kazuya Matsunaga Hideyuki Kanemoto Takashi Mizuno Yukiyasu Okamura Katsuhiko Uesaka 《Clinical journal of gastroenterology》2013,6(6):480-484
We present a rare case of metachronous splenic metastasis from gallbladder cancer. A 65-year-old female with gallbladder cancer underwent a partial hepatectomy with en-bloc resection of the gallbladder and extrahepatic bile duct. Ten months later, she presented with isolated splenic metastasis and underwent splenectomy with distal pancreatectomy. The histological diagnosis confirmed metastatic adenocarcinoma from gallbladder cancer. She had no signs of recurrence 4 years after the second surgery. To the best of our knowledge, this is the first report of isolated splenic metastasis from gallbladder cancer. 相似文献
4.
Masashi Suganuma Yoshihisa Marugami Yoichi Sakurai Masahiro Ochiai Shigeru Hasegawa Hiroki Imazu Toshiki Matsubara Takahiko Funabiki Makoto Kuroda 《Journal of gastroenterology》1997,32(6):852-856
A 65-year-old woman was admitted to our hospital with the diagnosis of gallbladder tumor. Right extended hepatic lobectomy
plus lymph node dissection of the hepatoduodenal ligament and left hepaticojejunostomy with Roux-en-Y reconstruction was performed
in July, 1993. The gallbladder tumor was histologically proven to be squamous cell carcinoma. Seventeen months later, the
patient experienced dyspnea and pitting edema of the lower legs and was admitted, in December 1994, with a diagnosis of heart
failure. Despite intensive cardiac support, she died 12 days after the second admission. Autopsy revealed multiple cardiac
tumors in the left and right ventricles, left atrium, left coronary artery, and left diaphragm. Histologically, these tumors
were shown to be squamous cell carcinoma, considered to have metastasized from the primary gallbladder carcinoma. As neither
local recurrence of the gallbladder carcinoma. As neither local recurrence of the gallbladder carcinoma nor any lymph node
metastasis was found, the cardiac metastasis of the gallbladder carcinoma may have occurred via the hematogenous route. Although
rare, this route of cardiac metastasis of gallbladder carcinoma may be an important aspect of distant metastasis, which should
be monitored for during follow-up after resection of the primary tumor. 相似文献
5.
Dr. Hiroshi Satoh MD Akihiro Iyama MD Katsuhiko Hidaka MD Hiromi Nakashiro MD Sadami Harada MD Takeharu Hisatsugu MD 《Digestive diseases and sciences》1991,36(4):520-523
Summary We report a rare case of secondary involvement of the gallbladder by metastatic renal cell carcinoma. A 71-year-old man was diagnosed as having a polypoid mass within the gallbladder when he underwent right nephrectomy for a renal cell carcinoma. A preoperative diagnosis of simultaneous carcinoma of the gallbladder was made, and extended cholecystectomy with regional lymphadenectomy was performed five months after the initial operation.Postoperative histological examination of the polypoid mass within the gallbladder and a pancreatic mass excised during the second surgery revealed these resected tumors to be identical to the clear cell type of renal cell carcinoma. We feel that this case presents synchronous involvement of the gallbladder and pancreas by metastatic renal cell carcinoma of the right kidney. 相似文献
6.
H. El Mernissi N. Benzoubeire M. Salihoune I. Errabih H. E. Krami A. Jahid L. Ouazzani N. Mahassini H. Ouazzani 《Journal Africain d'Hépato-Gastroentérologie》2011,5(2):133-136
Neuroendocrine tumours of the gallbladder are rare. They have been classified as carcinoide tumor and endocrine cell carcinoma. The primary treatment of neuroendocrine carcinoma of gallbladder remains surgery. They are aggressive tumours with poor prognosis. We report the case of a 54-year-old woman with a gallbladder mass with pulmonary and liver metastases. Fine needle biopsy of these revealed neuroendocrine carcinoma. There was no evidence of any other primary site. The patient was treated symptomatically; she died within two months of discharge fromthe hospital. 相似文献
7.
Akatsu T Ueda M Shimazu M Wakabayashi G Aiura K Tanabe M Kawachi S Kameyama K Kitajima M 《Journal of gastroenterology》2005,40(10):993-998
Undifferentiated spindle-cell carcinoma (SpCC) of the gallbladder is extremely rare. There is very little information available
regarding the characteristics and treatment of this disease. We herein report the unique case of a 76-year-old female patient
with a primary SpCC of the gallbladder that presented as a liver tumor. Preoperative radiologic examinations showed a 5-cm
liver tumor around the gallbladder bed, and irregular thickening of the gallbladder wall. The patient underwent en-bloc resection
of the gallbladder and segments 4b and 5 of the liver (including the liver tumor). Microscopic findings revealed that both
lesions consisted mainly of a sarcomatous spindle-shaped component. Small foci of well-differentiated adenocarcinoma cells
were identified in the gallbladder mucosa. There was a gradual transition between the two different components, thereby implying
that these two cell types had a common origin. Immunohistochemical studies showed that the spindle-shaped cells were epithelial
in nature. The patient's postoperative course was uneventful. However, she died of recurrent liver disease 6 months after
the surgery. In conclusion, we surmised that the sarcomatous spindle cells originated from a carcinomatous component in the
gallbladder mucosa through dedifferentiation. Further studies are needed to better understand the characteristics of this
deadly tumor, and to establish an effective therapy for it. 相似文献
8.
Zhen-Hua Hu Zhi-Wei Li Liang Shen Min Zhang Shu-Sen Zheng Hangzhou China Division of Hepatobiliary Pancreatic Surgery Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Key Laboratory of Organ Transplantation Zhejiang Province First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China 《Hepatobiliary & Pancreatic Diseases International》2010,(2)
BACKGROUND:Sarcomatoid carcinoma of the gallbladder is rare and its characteristics are poorly understood.This study aimed to understand the behavior and prognosis of sarcomatoid carcinoma of the gallbladder as well as its clinical manifestations and survival rate of patients after radical or palliative surgery,and to review the reported data worldwide and our 10 patients. METHODS:From 2004 to 2009,ten patients were pathologically diagnosed with sarcomatoid carcinoma of the gallbladder and underwent operati... 相似文献
9.
Akatsu T Kameyama K Kawachi S Tanabe M Aiura K Wakabayashi G Ueda M Shimazu M Kitajima M 《Journal of gastroenterology》2006,41(1):83-87
Extraskeletal tumors containing multinucleated, osteoclast-like giant cells (OGCs) are uncommon. These neoplasms are most
frequently reported in the breast and pancreas. Recently, some authors have suggested that carcinomas containing OGCs may
represent a distinct clinicopathological entity with a more favorable prognosis. Occurrence in the gallbladder is extremely
rare, with only one previous case. We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs.
A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder
with direct liver invasion. Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs.
Immunohistochemical analysis demonstrated that the giant cells were of histiocytic origin. The patient survived for 6 years
without evidence of recurrence. This case adds to a small body of literature on gallbladder carcinoma with OGCs. Further studies
are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences
between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma)
with those cells. 相似文献
10.
Kobayashi A Miyagawa S Miwa S Nomura K Nakata T Mihara M Kusama K Soeda J 《Hepato-gastroenterology》2007,54(74):350-353
We report three patients who underwent radical resections for advanced squamous cell carcinoma of the gallbladder, two of whom are still alive without recurrence 10 and 9 years after surgery. The other patient, who had lymph node involvement, suffered recurrence of the disease and died 9 months after surgery. Our experience indicates that radical surgery can sometimes provide a chance for long-term survival in patients with this neoplasm. Lymph node metastasis, albeit a rare event, might be a poor prognostic factor in patients with this type of gallbladder carcinoma. 相似文献
11.
Early Carcinoma of the Gallbladder, Noninvasive Carcinoma Originating in the Rokitansky-Aschoff Sinus: A Case Report 总被引:4,自引:0,他引:4
Yoshifumi Kawarada M.D. F.A.C.S. Masaaki Sanda M.D. Ryuji Mizumoto M.D. F.A.C.S. F.A.C.G. Ryuichi Yatani M.D. 《The American journal of gastroenterology》1986,81(1):61-66
A patient was reported who underwent cholecystectomy under the diagnosis of chronic cholecystitis with calculi and adenomyomatosis, but it proved to be an early carcinoma of the gallbladder originating in and limited to the Rokitansky-Aschoff sinus (cyst-like structure). Early carcinoma of the gallbladder in this category is rare and this case report may be the first one in the literature. 相似文献
12.
Yuta Kawaguchi Sayaka Kuba Michi Morita Xiangyue Meng Hiroko Hayashi Kazuma Kobayashi Tomohiko Adachi Masaaki Hidaka Shinichiro Itoh Kengo Kanetaka Susumu Eguchi 《Internal medicine (Tokyo, Japan)》2022,61(15):2387
A 66-year-old woman underwent partial mastectomy and a sentinel lymph node biopsy for left breast cancer; the pathological diagnosis was invasive ductal carcinoma (pT1aN0, pStage I, triple-negative subtype). Postoperative radiotherapy was performed. Two years later, she developed redness and induration at both breasts. The diagnosis was bilateral inflammatory breast cancer. After four cycles of dose-dense epirubicin and cyclophosphamide followed by 12 weekly paclitaxel cycles, bilateral total mastectomy and axillary lymph node dissection were performed. At the one-year follow-up after undergoing operation and radiotherapy, she remained alive without recurrence. Dose-dense treatment regimens may help patients achieve complete resection without short-term recurrence. 相似文献
13.
Gallbladder cancer has an extremely poor prognosis because it is often diagnosed at an advanced stage. We describe a 63-year-old woman who was treated 4 years previously for gallbladder cancer, with laparoscopic cholecystectomy and secondary hepatectomy after presenting with acute cholecystitis and gallbladder rupture. At her second presentation, she had a left lower gingival tumor and deep neck infection. Incision and drainage and tumor biopsies were performed, and pathology at both sites revealed adenocarcinoma. Positron emission tomography revealed other tumors in the left breast and left lower lung field, which were both proven to be adenocarcinoma by biopsy. The patient's presentation with a metastatic oral tumor was rare. Although the incidence is very low, physicians should consider the possibility of metastatic cancer in a patient with a history of cancer, who presents with new oral tumor or deep neck infection. 相似文献
14.
Nuzzo G Clemente G Cadeddu F Ardito F Ricci R Vecchio FM 《Hepato-gastroenterology》2005,52(64):1034-1038
BACKGROUND/AIMS: Papillary carcinoma of the gallbladder is less invasive, less frequently metastasizes and results in a longer survival than other gallbladder tumors. It is frequently associated with Anomalous Pancreatico-biliary junction (APBJ), a malformation that occurs most frequently in Japan. Consequently, most cases of papillary cancer have been reported in the Japanese literature, while the incidence of this neoplasm, and its association with APBJ, is still unknown in Western Countries. METHODOLOGY: Seventy cases of gallbladder cancer, observed between January 1992 and December 2000, were retrospectively evaluated. All the histological sections and available cholangiograms were reviewed. RESULTS: Three cases of papillary carcinoma were found (4.2%); APBJ was detected in one of these. All patients underwent resection and are long-term survivors; one patient developed, three years later, a papillary cancer of the common bile duct and was treated by Whipple's procedure. CONCLUSIONS: This study provides evidence that papillary carcinoma is more rare in Western countries than in Japan and it is characterized by a longterm survival after surgical resection. Further studies and reports are necessaries to define if this different incidence can justify differences between Western and Japanese results after surgery for gallbladder cancer. 相似文献
15.
Naoaki Sakata Masanori Suzuki Kazuhiko Shibuya Kazunori Takeda Seiki Matsuno 《Journal of hepato-biliary-pancreatic sciences》2002,9(4):511-514
On March 1, 1999, a 71‐year‐old woman was diagnosed as having cholecystolithiasis, for which she underwent laparoscopic cholecystectomy at a local hospital. Intraoperative cholangiography was not performed. No malignant lesion was detected in the gallbladder. In March 2000, a subcutaneous tumor was pointed out at the port site in her abdomen, and resected. Histological examination revealed metastatic adenocarcinoma. On detailed examination, endoscopic retrograde cholangiopancreatography (ERCP) revealed a tumor, about 2 cm in diameter, in the lower bile duct. On June 1, she underwent pylorus‐preserving pancreatoduodenectomy at our institute, and several disseminated lesions were detected at the port site and in the abdominal cavity. There have been few reports of bile duct carcinoma that developed peritoneal dissemination caused by leakage of bile during cholecystectomy. Leakage of bile should be prevented during laparoscopic cholecystectomy, even in patients not diagnosed as having cancer preoperatively. 相似文献
16.
G Ercolani M Nagino T Sano J Kamiya S Kondo M Kanai H Nishio Y Nimura 《Hepato-gastroenterology》1999,46(27):1650-1654
A 70 year-old female, who presented with jaundice and abdominal pain, was found to have an advanced gallbladder cancer involving the liver parenchyma, duodenum, and transverse colon. This was complicated by a bilio-biliary fistula between the gallbladder and both the right and left hepatic ducts. After obtaining an accurate pre-operative diagnosis, the patient underwent hepatopancreatoduodenectomy (HPD) with lymph node dissection around the hepatic pedicle, celiac trunk, aorta, and inferior vena cava. Histologic examination revealed adenosquamous carcinoma. This rare variant accounts for 3.5% of gallbladder cancers, and is associated with a worse prognosis than adenocarcinoma. The patient is in good condition without any signs of recurrence 42 months after the HPD. In this case report, we discuss the histological type and internal biliary fistula with regard to the literature, and the usefulness of an aggressive surgical procedure such as HPD with extended lymph node dissection which can improve survival and quality of life in selected patients. 相似文献
17.
目的 总结胆囊腺肌症与胆囊癌患者多层螺旋CT(MSCT)表现特征。方法 2015年9月~2020年9月我院诊治的胆囊腺肌症患者113例和胆囊癌患者78例,均接受MSCT和超声检查,外科手术治疗后行组织病理学检查。结果 MSCT检查结果与术后组织病理学检查结果的一致性(Kappa=0.749)显著高于超声检查(Kappa=0.577);MSCT诊断胆囊腺肌症的准确度为88.0%,显著高于超声检查的79.6%(P<0.05);MSCT对局限型胆囊腺肌症的检出率为97.1%,显著高于超声检查的82.9%(P<0.05);在CT检查上,胆囊腺肌症表现为胆囊壁光滑、RAS窦和肝胆交界清楚显示率分别为36.3%、36.3%和69.0%,显著高于胆囊癌组的9.0%、6.4%和38.5%(P<0.05)。结论 MSCT检查诊断胆囊腺肌症有较高的正确率,其特征有助于与胆囊癌鉴别。 相似文献
18.
Adenocarcinoma is the usual histological presentation of the very rare gallbladder carcinoma. Adenosquamous cell carcinoma accounts for less than 3.5% of gallbladder carcinomas, and is characterised by invasive growth, a reduced tendency for lymph node metastasis, an increased tendency for hepatic infiltration or liver metastasis, and a poorer prognosis than adenocarcinoma. We present two cases. The first patient presented to our institution with increased bilirubin levels and dilated intra- and extrahepatic bile ducts. Adenosquamous carcinoma of the gallbladder was diagnosed on the post-operative pathological specimen. After surgery, bilirubin levels decreased, but hepatic metastases occurred that did not respond to conventional chemotherapy. The second patient was admitted to our hospital with jaundice and abdominal pain. Abdominal computed tomography (CT) imaging showed marked thickening of the gallbladder with direct extension of a mass into the left liver lobe. Cytology specimens obtained with an endoscopic retrograde cholangiopancreatography (ERCP) procedure revealed a malignant epithelial tumour. The patient underwent surgery but the tumour was incompletely resected. A regimen of oral UFT (Tegafur + uracil) chemotherapy was begun. Serum bilirubin levels increased due to occlusion in the surgical area 15 weeks after the start of chemotherapy. 相似文献
19.
Hamada T Yamagiwa K Okanami Y Fujii K Nakamura I Mizuno S Yokoi H Isaji S Uemoto S 《World journal of gastroenterology : WJG》2006,12(9):1472-1475
A 49-year-old Japanese woman was referred to our department because of high fever and a huge abdominal mass. Computed tomography (CT) and magnetic resonance (MR) imagings revealed a tumor, about 30 cm in diameter, occupied the right hepatic lobe and the peritoneal cavity. Abdominal angiography showed that the tumor was fed mainly by the cystic artery. We pre-operatively diagnosed angiosarcoma of the gallbladder and performed tumor resection with cholecystectomy because the tumor was almost casplated, however the posterior wall of the gallbladder attached to the tumor firmly. Histologically, the tumor was composed of spindle cells including lipoblasts with cellular pleomorphism, which were also detected in the muscular layer of the gallbladder. We finally diagnosed pleomorphic liposarco-ma of the gallbladder. At 10 mo and 29 mo after the first operation, she underwent two more operations because of recurrence. Now she has a good quality of life 3 years and 6 mo after the first operation. 相似文献
20.
Gallbladder carcinoma as an incidental finding] 总被引:1,自引:0,他引:1
Between March 1982 and December 1990, 903 patients underwent elective cholecystectomy. In 40 patients cholecystectomy was performed for gallbladder carcinoma. 15 malignomas (1.7%) were found incidentally. Preoperatively no anamnestic or diagnostic tumor signs were found in this group of patients. An en-bloc-resection of the gallbladder with resection of the bordering liver segments was performed when gallbladder carcinoma was diagnosed intraoperatively. When the diagnosis was established by postoperative histology, a relaparotomy with liver resection and lymphnode-dissection was done, except in one case (T-1a stage). Histology showed adenocarcinoma in 11 out of 15 cases. No significant difference in the course of the disease was observed in patients with gallbladder carcinoma of different types. The hospital mortality rate was 0% after curative and palliative surgical treatment of gallbladder carcinoma. Patients with T-1 and T-2 stage have survived without tumor-recurrence up to now. The median survival time after surgery for gallbladder carcinoma in T-3 stage was 17 months, and 8 months in T-4 stage. The morbidity rate after elective cholecystectomy is low and hospital mortality is 0%. According to the short survival times in advanced stages of gallbladder carcinoma, a prompt cholecystectomy in symptomatic gallbladder lithiasis or chronic cholecystitis is advocated. 相似文献