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血管紧张素转换酶基因多态性与疾病易感性的关系 总被引:1,自引:0,他引:1
机体血管紧张素转换酶(ACE)水平受ACE基因插入/缺失(I/D)多态性影响,缺失型纯合子(DD型)ACE接近插入型纯合子(II型)的两倍。DD型为糖尿病肾病,急性心肌梗塞的易患因素。 相似文献
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血管紧张素转换酶基因多态性与疾病易感性的关系 总被引:1,自引:0,他引:1
机体血管紧张素转换酶(ACE)水平受ACE基因插入/缺失(I/D)多态性影响,缺失纯合子(DD型)ACE接近插入型纯合子(II型)的两倍。DD型为糖尿病肾病,急性心肌梗塞的易患因素。 相似文献
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血管紧张素转换酶基因与女性Ⅱ型糖尿病患者冠心病的关系探讨 总被引:3,自引:0,他引:3
目的探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与Ⅱ型糖尿病患者心血管并发症的关系。方法应用聚合酶链式反应(PCR)法对225例Ⅱ型糖尿病患者和100例正常人ACE基因多态性的分布进行研究,并结合临床及生化指标进行分析。结果在Ⅱ型糖尿病患者中,DD型冠心病的发病率明显高于I型和ID型(P<005)。以性别分层后,这种差异只在女性患者中有显著性(P<005)。非条件logistic回归分析证实,在女性Ⅱ型糖尿病患者中,DD基因型为并发冠心病(CHD)的独立危险因素,而在男性患者中未得出同样结论。结论ACE基因插入/缺失多态性是女性Ⅱ型糖尿病患者中合并冠心病的独立危险因素。提示糖尿病患者中,对女性DD型患者早期施以ACE抑制剂可能会防止冠心病的发生。 相似文献
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为研究冠心病患者血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性分布及其与血清ACE水平的相关性,应用多聚酶链反应方法测定了61例冠心病患者和63例健康人群的ACE基因I/D多态性,并采用微量比色法测定其血清ACE水平。结果发现,冠心病患者ACE基因DD型出现频率显著高于对照组,且DD基因型者具有较高的血清ACE水平。提示ACE基因I/D多态性与血清ACE水平密切相关,DD型ACE基因可能是中国人冠心病发病的独立危险因子。 相似文献
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目的:研究血管紧张素转换酶(ACE)基因插入/缺失多态性与盐敏感性高血压病发生的关系。方法:用ACE基因第16内含子多态性两侧的序列设计引物,用多聚酶链反应来检测80例高血压病患者(其中盐敏感性高血压病患者50例,盐不敏感性高血压病患者30例)和90例正常人ACE基因插入/缺失多态性。结果:D及I型等位基因频率在高血压病患者与正常对照组之间无差异,D及I型等位基因频率在盐敏感性高血压病患者与盐不敏感性高血压病患者之间也无差异。结论:ACE基因插入/缺失多态性与中国人高血压病以及与盐敏感性之间无相关关系。 相似文献
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血管紧张素转化酶基因的插入/缺失多态性与其血清水平及心肌梗塞的关系 总被引:6,自引:0,他引:6
旨在探讨中国人中血管紧张素转化酶(ACE)基因的插入/缺失(insertion/deletion,I/D)多态性与血清中ACE水平及心肌梗塞的关系。心肌梗塞患者103例;正常对照96例。位于ACE基因第16内含子的I/D多态性经PCR扩增可分为三种基因型:纯合缺失型(DD),纯合插入型(I),杂合子型(ID)。血清ACE水平在DD、DI、I型分别为28.3±9.9U/ml、24.5±8.4U/ml、19.2±4.8U/ml,即DD>DI>ⅠⅠ。结果显示,心肌梗塞患者的D等位基因的频率(0.61)高于正常对照组(0.48),P<0.01。认为:ACE基因的缺失多态性与中国人血清ACE水平及心肌梗塞相关。 相似文献
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血管紧张素转换酶基因多态性与2型糖尿病患者脑梗塞的关系 总被引:9,自引:0,他引:9
目的探讨血管紧张素转换酶(ACE)基因多态性与2型糖尿病脑梗塞间的关系。方法应用多聚酶链反应(PCR)技术,对109名2型糖尿病患者及52名正常对照者的ACE基因插入/缺失(I/D)型多态性进行检测,并用Logistic多元逐步回归,筛选出2型糖尿病患者脑梗塞的高危因素。结果(1)糖尿病总组ACE基因型频率和等位基因频率与正常对照组无显著性差异(P>0.05)。(2)糖尿病脑梗塞组ACE基因DD型和D等位基因频率显著高于非脑梗塞组(P<0.01)及正常对照组(P<0.05)。(3)多元逐步回归分析显示:ACE基因DD型、D等位基因、脂蛋白(a)及年龄是糖尿病脑梗塞的独立危险因素,而ACE基因II型和I等位基因则为2型糖尿病脑梗塞的保护因子。结论ACE基因I/D多态性与2型糖尿病脑梗塞的发病密切相关。ACE基因 相似文献
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冠心病与血管紧张素转换酶及其基因 总被引:1,自引:0,他引:1
肾素-血管紧张素系统(RAS)与冠心病,MI的关系一直受到重视。随着分子生物学技术的不断进步,血管紧张素转换酶(ACE)的基因结构及功能得以进一步阐明。并发现位于16内含子的CE基因插入/缺乏多态性影响血清ACE活性,与MI具相关性。 相似文献
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血管紧张素转化酶基因插入/缺失多态性与冠心病发病的关系 总被引:2,自引:0,他引:2
目的 :探讨血管紧张素转化酶 (ACE)基因多态性与冠心病 (CHD)发病的关系。方法 :以人基因组DNA为模板 ,应用聚合酶链式反应 (PCR)检测 5 0例CHD组和 5 6例正常对照组ACE基因第 16内含子插入 /缺失 (I/D)多态性 ,并按性别分组计算各组基因型和等位基因频率。结果 :①在CHD组中 ,ACE基因DD基因型和D等位基因频率分别为 36 %和 6 0 % ,正常对照组分别为 16 %和 4 1% ,两者相比差异有统计学意义 (P <0 .0 1)。②男性CHD组DD基因型和D等位基因频率均显著高于对照组 (均P <0 .0 5 )。女性CHD组DD基因型频率显著高于对照组 (P <0 .0 1) ,D等位基因频率与对照组比较差异无统计学意义。结论 :CHD与ACE基因I/D多态性有显著相关性 ,不论男性和女性 ,ACE基因DD基因型均可能是CHD发生发展过程中重要的危险因素之一。 相似文献
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目的探讨高血压人群中血管紧张素转换酶(ACE)基因多态性及β1肾上腺素能受体(ADRB1)基因多态性与冠状动脉(冠脉)狭窄程度的相关性。方法选取2017年7月至2019年4月于徐州医科大学附属医院心血管内科住院的280例高血压患者的临床资料进行回顾性分析,行冠脉造影或冠脉CT血管造影(CTA)检查判定其是否患有冠心病(CHD),并依据结果判定其冠脉病变支数及给予Gensini评分。根据冠脉检查结果将上述患者分为CHD组(n=145)和对照组(n=135)。所有入选病例均给予了ACE及ADRB1基因多态性检测,并根据结果分为ACE II型纯合子、ID型杂合子、DD型纯合子和ADRB1 GG型纯合子、GC型杂合子、CC型纯合子。结果在研究的高血压人群中,ACE DD基因型携带者在冠脉病变支数中的多支病变组及Gensini得分分组中的重度病变组的占比明显高于ACE II及ACE ID基因型(P<0.05);ADRB1基因多态性在冠脉病变支数分组及Gensini得分分组的对比中无明显相关性(P>0.05);CHD组与对照组一般临床资料对比中显示年龄、高密度脂蛋白胆固醇(HDL-C)和糖尿病与CHD存在相关性,且有统计学意义(P<0.05)。结论ACE基因多态性与高血压人群冠状动脉狭窄程度密切相关,ADRB1基因多态性无明显相关性。 相似文献
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血管紧张素转换酶基因多态性对冠心病患者血管内皮舒张功能的影响 总被引:2,自引:0,他引:2
目的:观察血管紧张素转换酶(ACE)基因多态性对冠心病患者内皮功能的影响及其抑制剂的干预作用.方法:选取冠心病患者(冠心病组)68例,对照组69例,聚合酶链反应(PCR)检测ACE基因插入/缺失(L/D)多态性,超声检测肱动脉内皮功能.结果:冠心病组DD基因型明显高于对照组.冠心病组ACE各基因型内皮依赖性舒张功能均低于对照组,DD基因型最为明显;非内皮依赖性舒张功能差异无显著性.血管紧张素转换酶抑制剂(ACEI)治疗后冠心病组各型肱动脉内皮依赖性舒张功能与治疗前比较均有显著性改善,其中DD基因型改善最为明显.结论:冠心病患者血管内皮功能异常与ACE基因I/D多态性相关.ACEI可以改善内皮功能,特别是对DD基因型患者改善更为明显. 相似文献
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ACE gene polymorphism and coronary restenosis. 总被引:3,自引:0,他引:3
In humans, circulating levels of angiotensin-converting enzyme (ACE) are linked with an insertion (I)/deletion (D) polymorphism in the ACE gene: DD genotype bearers have higher levels of ACE than either ID or II genotype bearers. Recent studies have suggested that the ACE DD genotype might be associated with a higher risk of coronary artery disease. The aim of this paper is to review studies on the influence of the I/D polymorphism on coronary restenosis. The renin-angiotensin system has been implicated in the pathogenesis of neointimal hyperplasia in experimental models. In humans, the I/D polymorphism is not associated with restenosis after balloon angioplasty, but is strongly associated with restenosis after coronary stent implantation. This may be explained by the fact that the contribution of neointimal hyperplasia to restenosis is much more important after coronary stent implantation than after balloon angioplasty. 相似文献
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Koch W Mehilli J von Beckerath N Böttiger C Schömig A Kastrati A 《Journal of the American College of Cardiology》2003,41(11):1957-1961
OBJECTIVES: We tested the hypothesis that patients with the DD genotype of the angiotensin I-converting enzyme (ACE) gene who are treated with ACE inhibitors are at a higher risk of restenosis after coronary stent placement than patients who do not receive ACE inhibitors. BACKGROUND: Two recent studies with a limited series of patients carrying the DD genotype suggested an unfavorable impact of the use of ACE inhibitors on the restenotic process after implantation of stents in coronary arteries. Because these findings may question the use of ACE inhibitors after coronary stenting, we examined this important issue in a large series of patients. METHODS: We determined the ACE gene I/D genotype of 2,222 consecutive patients with symptomatic coronary artery disease who underwent stent implantation. The patients with the DD genotype (n = 612) constituted the study population. The primary end point was in-stent restenosis, which was assessed as angiographic restenosis (> or =50% diameter stenosis at six-month follow-up) and clinical restenosis (need for target vessel revascularization due to symptoms or signs of ischemia in the presence of angiographic restenosis over one year after the intervention). RESULTS: Of the 612 patients with the DD genotype, 403 (65.8%) were treated with ACE inhibitors and 209 (34.2%) did not receive ACE inhibitors. The angiographic and clinical restenosis rates were not significantly different between the group treated with ACE inhibitors and the group not receiving ACE inhibitors (p = 0.55). Continuous measures of restenosis, minimal lumen diameter, diameter stenosis, late lumen loss, and loss index were also similar in both groups (p > or = 0.55). In addition, one-year survival free of myocardial infarction was not significantly different between the two groups (p = 0.27). CONCLUSIONS: In contrast to previous reports, our study provides evidence that patients carrying the DD genotype are not exposed to an increased risk of restenosis after stent placement when treated with ACE inhibitors. 相似文献
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Isabel Mendon?a Isabel A Freitas Célia A Sousa Susana Gomes Paula Faria António Drumond Gra?a Silva Jorge J Araújo Sónia Freitas Ilídio Ornelas Gra?a Andrade Ana P Coelho P Marques Silva Almada Cardoso António A Brehm R Palma dos Reis 《Revista portuguesa de cardiologia》2004,23(12):1593-1601
BACKGROUND: A family history of coronary heart disease (CHD) is a strong risk marker for the disease, independently of classical risk factors. It could be decoded by recognizing the polymorphisms associated with increased risk. Renin-angiotensin system genes are candidate genes in CHD and the deletion allele of the angiotensin converting enzyme (ACE) has been reported as deleterious. However, there is disagreement as to the role of the insertion/deletion polymorphism of the ACE gene in coronary risk. AIM: To evaluate whether ACE gene polymorphisms constitute a CHD risk factor. METHODS: We conducted a population-based case-control study of 301 subjects with a history of myocardial infarction or angiographic evidence of coronary heart disease and 510 age- and gender-matched controls, without CHD, living in a region with high CHD mortality rates. Blood samples were taken, DNA extracted and genotypes determined by the polymerase chain reaction (PCR). Amplification products were identified by agarose gel electrophoresis. STATISTICAL ANALYSIS: The Data were evaluated by SPSS for Windows, using the Student's t test, the chi-square test, odds ratios and 95% confidence intervals. RESULTS: The prevalence of the DD, ID and II genotype was 41.2%, 46.3%, 12.5% in the cases and 28.1%, 55.2% and 16.7% in the control group. The frequency of the DD genotype was significantly higher in the cases than in the controls (41.2% vs. 28.1%, odds ratio 1.79, 95% CI 1.31 to 2.4, p < 0.0001). By contrast, the ID and II genotypes' prevalence was higher in the control group (55.2% vs. 46.3%, p = 0.002 and 16.7 vs. 12.5%, p = NS, respectively) compared to the case group. CONCLUSIONS: This study clearly shows that the ACE DD polymorphism is strongly linked to CHD, and if our data are confirmed in a larger population sample, more aggressive vascular prevention could be justified in patients carrying the DD genotype. 相似文献
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Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease 总被引:6,自引:0,他引:6
Buraczyńska M Pijanowski Z Spasiewicz D Nowicka T Sodolski T Widomska - Czekajska T Ksiazek A 《Kardiologia polska》2003,58(1):1-9
BACKGROUND: Renin-angiotensin system genes are candidate genes in cardiovascular system diseases. Angiotensinconverting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R) gene polymorphisms are considered risk factors in coronary heart disease (CHD). AIM: To evaluate the involvement of the ACE, AGT and AT1R genetic variants in predisposition to CHD as well as their association with other known risk factors. METHODS: The study included 400 male subjects (200 with CHD and 200 healthy individuals). Genotypes were determined by a polymerase chain reaction (PCR). For the AGT and AT1R genes a restriction analysis of the PCR product was performed. The allele frequency and genotype distribution were compared between groups. RESULTS: The allele and genotype frequencies of the ACE gene were similar in both groups, however, a significantly higher frequency of the DD genotype was observed in the presence of hyperlipidemia (39% vs 24% in non-hyperlipidemic subjects, p<0.01). The AGT gene polymorphism was associated with the development of CHD. The T allele was significantly more frequent in patients than in the control group (55% vs 44%, p<0.05). The heterozygous MT genotype was observed in 61% of patients compared to 40% in the controls (p<0.05). The A1166C polymorphism of the AT1R gene was also associated with CHD as well as with age at the onset of disease. The frequency of the C allele was 29% compared to 21% in the control group (p<0.01) and the frequency of the CC homozygote was almost three times higher in patients. CONCLUSIONS: There is an association between molecular variants of the angiotensinogen and angiotensin II type 1 receptor and increased risk of CHD. The DD genotype of the ACE gene polymorphism and the TT genotype of the AGT gene polymorphism were significantly more frequent in patients with hyperlipidemia. The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers. 相似文献
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目的探讨血管紧张素转换酶(ACE)基因I/D多态性与冠心病及冠脉病变严重程度的关系.方法对122例冠心病患者进行冠状动脉造影,判定冠脉病变支数(狭窄程度≥75%)和危险记分.用聚合酶链式反应(PCR)技术检测病例组和80例健康人群ACE基因多态性.结果ACE基因型分布和等位基因频率在病例组和对照组间差异有显著性,病例组DD基因型(38.5%)和D等位基因频率(55%)显著高于对照组(13.7%,41%;P<0.05).冠脉病变支数和危险记分在ACE基因型间差异无显著性(P>0.05).结论ACE基因多态性中DD型和D等位基因是冠心病发病的独立危险因素,但与冠脉病变严重程度不相关. 相似文献