高强度划船运动对久坐青年男性餐后血糖、甘油三酯和胰岛素水平的影响

目的:探讨3分钟重复高强度间歇划船运动是否可以影响久坐青年男性高脂饮食后的血糖、甘油三酯和胰岛素的水平。方法:选择18名青年男性随机分为运动组和对照组。第1天,运动组进行17RPE的半小时间歇性高强度运动,对照组未做运动;第2天行75 g口服葡萄糖耐量试验(OGTT)并进食高脂食物,保持休息状态8个小时。间隔1周后两组对换,重复试验。期间采集静脉血监测空腹和餐后血糖、甘油三酯和胰岛素的变化,计算曲线下面积(AUC)和稳态模型评估的胰岛素抵抗指数(HOMA-IR)、β细胞功能指数(HOMA-β),评价胰岛素敏感性和胰岛β细胞功能。结果:在高脂饮食前14个小时进行高强度划船运动(运动能耗约为900 k J)可以显著降低空腹(P=0.004)和高脂餐后甘油三酯(P=0.005),而空腹和餐后的血糖及胰岛素水平没有显著变化(P>0.05)。结论:半小时间歇性高强度划船运动可以显著降低空腹和高脂餐后甘油三酯水平。     

不同糖调节受损人群的餐后血糖波动特点研究

目的 采用动态血糖监测系统(CGMS)研究不同糖调节受损人群的餐后血糖波动特征.方法 根据连续2次75g口服葡萄糖耐量检查(OGTT)结果,选取北京地区稳定人群中正常糖耐量(NGT)组22例,单纯空腹血糖受损(HFG)15例、单纯糖耐量低减(I-IGT)19例、空腹血糖受损合并糖耐量低减(IFG/IGT)组11例,新诊断2型糖尿病(T2DM)组21例.所有受试对象均行72hCGMS监测,分析比较各组餐后血糖峰值(PPG)、达峰时间(△t).餐后血糖波动幅度(PPGE)、餐后血糖波动持续时间(DPE)、曲线下面积(AUC)和其增量(△AUC).结果 I-IGT、IFG/IGT和T2DM组的餐后PPG、餐后PFGE较NGT或I-IFG明显升高,HGT和T2DM组DPE明显延长,T2DM组△t较NGT组明显延迟(P<0.05);从NGT、I-IGT、IFG/IGT到T2DM组,餐后血糖对全天高血糖的贡献率(△PAUCI)逐渐下降;且I-IFG、IRG/IGT和T2DM组较NGT有显著性差异(P<0.05);当糖化血蛋白(HbA1C)≥7%时,空腹对全天高血糖的贡献率首次逆转为大于餐后贡献率,且与HbA1C<5.5%组比较,△PAUC1开始有显著性差异;HbA1C与餐后总曲线下面积(AUC1)、全天总曲线下面积(AUC2)、空腹总曲线下面积(AUC3)、OGTT葡萄糖负荷后2h血糖(2hPBG)和3餐血糖峰值均值(MPPG)显著相关(γ分别为0.743、0.687、0.504、0.708和0.732,P<0.001);以HbA1C为因变量,以曲线下面积和血糖水平为自变量分别进行多元逐步回归分析,只有AUC1、AUC2和2hPBG、中餐后PPG最终分别进入2个方程(决定系数r2为0.552和0.614,P<0.01).结论 IGR三组分中I-IFG的餐后特征与NGT最为接近,I-IGT组与T2DM最相似;除I-IFG组外,随着糖调节受损程度的加重,餐后血糖对全天高血糖的贡献率逐渐下降;当HbA1C<7%时,应以控制餐后血糖为主,餐后2h血糖为推荐的简单评价指标;而HbA1C≥7%时,还应重视空腹血糖.     

迷迭香提取物及大强度耐力训练对大鼠体内糖储备的影响

目的:探讨迷迭香提取物对大强度耐力训练大鼠糖储备的影响.方法:采用SD大鼠进行大强度耐力训练,同时服用迷迭香提取物,7周后取材测定血糖、肝糖原、肌糖原、血清胰岛素、胰高血糖素.结果:安静状态下,服用迷迭香提取物的大鼠血糖、肝糖原、肌糖原和胰高血糖素水平均有所提高,但与安静对照组相比无显著性差异(P>0.05);胰岛素水平明显升高,与安静对照组相比有显著性差异(P<0.05).通过大强度耐力训练,服用迷迭香提取物的大鼠血糖、肝糖原、肌糖原胰岛素和胰高血糖素水平均显著高于运动对照组(P<0.05).结论:迷迭香提取物可使大强度耐力训练大鼠体内糖储备显著增加,同时可以提高胰岛激素水平,并且这种作用通过训练更加明显.     

有氧运动联合Ala-Gln对2型糖尿病的干预作用及其机制

目的:探讨有氧运动或/和Ala-Gln对2型糖尿病(T2DM)的干预作用、交互作用及其生化机制。方法:将SD大鼠在喂饲高脂膳食的基础上腹腔注射小剂量的STZ复制T2DM大鼠模型后,对T2DM大鼠进行8周的运动训练和/或补充Ala-Gln,检测空腹血糖(FBG)、血清胰岛素(INS)、C肽和胰高糖素样肽-1(GLP-1)含量。结果:(1)与正常大鼠相比,2型糖尿病鼠FBG含量和HOMA-IR显著升高(P<0.05),血清C肽和GLP-1含量显著降低(P<0.05,P<0.01)。(2)有氧运动使FBG含量和HOMA-IR极显著降低(P<0.01),血清C肽含量极显著升高(P<0.01);补充Ala-Gln使FBG含量显著降低(P<0.05),血清INS、C肽和GLP-1含量显著升高(P<0.05,P<0.01,P<0.05);有氧运动联合Ala-Gln对降低FBG含量和HOMA-IR以及升高血清C肽和GLP-1含量均无显著性的交互作用(P>0.05),但对升高血清INS含量具有显著性的交互作用(P<0.05)。结论:有氧运动或补充Ala-Gln通过促进胰岛素的分泌降低T2DM大鼠的血糖水平,且有氧运动联合补充Ala-Gln对促进T2DM胰岛素的分泌具有协同效应。     

有氧运动与抗阻训练联合用于糖尿病周围神经病变的效果分析

目的 初步探究有氧运动联合抗阻训练对糖尿病周围神经病变(Diabetic peripheral neuropathy, DPN)患者的治疗效果。方法 选择60例进行DPN治疗的患者,对照组给予有氧运动,观察组在有氧运动基础上给予中等强度抗阻训练,连续治疗12周,评价不同治疗方法对DPN患者血糖、血脂、胰岛素功能及运动功能的治疗效果。结果 试验前,两组患者各项指标均无显著性差异(P>0.05)。12周运动干预后,两组患者空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素值及密西根糖尿病性周围神经病评分均显著降低(P<0.05),胰岛β细胞功能指数显著升高(P<0.05),观察组对各项指标回调效果显著优于对照组(P<0.05);此外,观察组患者体内TRIG表示水平显著降低(P<0.05),HDL表达水平显著升高(P<0.05)。结论 有氧运动联合抗阻训练可以显著改善DPN患者血糖、血脂、胰岛素功能,进而加快DPN患者运动和平衡功能恢复。     

有氧和抗阻运动对糖尿病前期人群血糖干预效果的比较研究

目的:比较有氧、抗阻运动干预对糖尿病前期(IGR)人群血糖的干预效果,为控制或逆转IGR、预防糖尿病提供实践依据。方法:采用随机对照实验,将研究对象随机分为有氧运动组、抗阻运动组和对照组,分别进行12周的运动干预和健康教育后,随访血糖和体力活动水平。结果:(1)有氧运动和抗阻运动干预均可使IGR人群空腹和口服葡萄糖耐量试验2小时(OGTT2 h)血糖显著下降,其中有氧运动组的下降幅度略大于抗阻运动组,但无显著性差异。(2)有氧运动组有69.2%的研究对象干预后血糖降至正常水平,与对照组比较有非常显著性差异;抗阻运动组转阴率(43.5%)低于有氧运动组、高于对照组(23.8%),但组间均无显著性差异。(3)糖化血清蛋白(GSP)干预前后和组间均无显著性差异。其中,抗阻运动组有65.2%的研究对象GSP降低,与对照组(23.8%)有非常显著性差异,但抗阻运动组GSP均值变化率的标准差较大(20.77%);有氧运动组GSP下降率(38.5%)低于抗阻运动组、高于对照组,但组间均无显著性差异。结论:(1)有氧或抗阻运动均可使IGR人群的空腹和OGTT2h血糖显著下降,并能一定程度地使IGR人群血糖下降至正常水平。(2)有氧和抗阻运动干预均对IGR人群GSP影响不明显。但抗阻运动对IGR人群GSP影响的个体差异相对较大,可使更多的IGR个体GSP得到改善。     

睡眠剥夺对健康青年糖代谢的影响

目的 研究睡眠剥夺对健康青年志愿者糖代谢的影响. 方法 对象为40名血糖代谢正常的青年健康志愿者,其中男22名,女18名,年龄19～35岁.于睡眠剥夺前后行口服葡萄糖耐量试验,取血测定血糖和胰岛素,用稳态模式评估法2公式计算胰岛素抵抗指数、胰岛素敏感指数和胰岛β细胞功能. 结果 睡眠剥夺后与睡眠剥夺前空腹胰岛素水平差异无统计学意义(P>0.05).睡眠剥夺后空腹血糖、糖负荷后2 h血糖、胰岛素抵抗指数均显著高于睡眠剥夺前测定值(t=2.189～7.721,P<0.05),胰岛素敏感指数、胰岛β细胞功能睡眠剥夺后均显著低于睡眠剥夺前测定值(t=2.189、6.575,P<0.05). 结论 睡眠剥夺后胰岛β细胞功能受抑,胰岛素抵抗发生.睡眠剥夺影响机体糖代谢,对飞行人员应该进行应对性预防研究.     

高血压病患者胰岛素抵抗及药物干预的观察

对26例高血压病(EH)患者用口服葡萄糖进行糖耐量试验及胰岛素(IS)释放试验。结果显示EH患者糖耐量普遍减低,存在胰岛素抵抗和高胰岛素血症。EH患者舒张压与血胰岛素水平显著正相关,P值分别<0.01、<0.05。收缩压与血IS水平部分呈正相关,降压治疗8周后硝苯吡啶组(Ⅰ)血糖(GS)无明显改变。糖负荷后60min、120min血IS水平及IS释放曲线下面积Ⅰ降低(P<0.05).巯甲丙脯酸组(Ⅱ)GS、糖耐量曲线下面积及血IS释放曲线下面积、IS/GS比值均较治疗前明显降低,P值分别<0.05、<0.01。表明巯甲丙脯酸有明显的改善胰岛素敏感性及糖代谢效应。其机制与增加骨骼肌血流、抑制肾素血管紧张素系统、减慢缓激肽的释放有关。硝苯吡啶对EH患者血糖无明显影响,对血IS水平影响有待进一步探讨。     

不同海拔地区藏族中、青年心脏病和高血压患病状况及高血压相关影响因子分析

目的:了解不同海拔地区藏族中、青年心脏疾病与高血压患病情况以及与高血压有关的降钙素基因相关肽和胰岛素样生长因子Ⅱ水平.方法:采用流行病学方法,调查研究不同海拔地区藏族中、青年心脏病和高血压患病情况,采用放射免疫法测定与高血压相关因素. 结果:不同海拔地区藏族中、青年心脏疾病与高血压患病情况均有显著性差别(P<0.05);高血压和心脏病患病率分别10.01%和13.97%,男性患病率高于女性,不同海拔藏族中、青年高血压患者降钙素基因相关肽和胰岛素样生长因子Ⅱ水平均有显著性差别(P<0.05).结论:加强藏族中、青年人群的心脏病和高血压的检查,积极鼓励进行健康检查和健康教育.降钙素基因相关肽和胰岛素样生长因子Ⅱ水平在不同海拔的藏族中、青年中的变化反映了生活在高原地区人群机体具有一定的自我保护反应.     

二甲双胍和蕲蛇酶联合治疗无症状期2型糖尿病疗效观察

目的 :观察二甲双胍和蕲蛇酶联合用药对 2型糖尿病的治疗作用。方法 :选择 2型糖尿病 10 8例 ,随机分为单纯口服二甲双胍与二甲双胍和蕲蛇酶联合用药组 ,两组均治疗 2 0天后 ,比较馒头餐糖耐量试验、血糖、糖化血红蛋白等相关生化指标改善情况。结果 :二甲双胍和蕲蛇酶联合用药在空腹血糖、空腹胰岛素、餐后C肽值比空腹C肽值高出的倍数、胰岛素敏感指数、末梢血糖化血红蛋白、OGTT血糖、胰岛素曲线下面积等值较单纯口服二甲双胍下降明显 (P <0 0 1)。结论 :联合用药能显著提高胰岛素敏感性和降低血压、胆固醇的作用优于单纯服用二甲双胍     

Effects of acute aerobic exercise on high-molecular-weight adiponectin

INTRODUCTION: Few studies have reported the response of high-molecular-weight (HMW) adiponectin to acute aerobic exercise. PURPOSE: The purpose of this study was to investigate the influence of acute aerobic exercise on HMW adiponectin in healthy men. METHODS: Eight healthy men (age, 24.9 +/- 1.8 yr; BMI, 21.9 +/- 0.5 kg x m) participated in this study. They performed two trials. Trial 1 [exercise trial (EX)] consisted of 60-min stationary cycle exercise (50% peak oxygen uptake) followed by 30-min rest. Trial 2 [control trial (CON)] was 90-min rest. Blood samples were drawn to assess hormones (catecholamine and insulin), metabolites (free fatty acid [FFA], glycerol, and glucose), and total and HMW adiponectin concentration. RESULTS: There were significant trial x group interactions in serum FFA and glycerol concentrations (P < 0.05). Serum FFA and glycerol concentrations were higher in EX than in CON (P < 0.05). There were significant trial x group interactions in plasma insulin and glucose concentration (P < 0.05). Plasma insulin and glucose concentrations were lower in EX than in CON (P < 0.05). Total adiponectin, HMW adiponectin concentration, and the ratio of HMW to total adiponectin concentration, however, were unchanged during aerobic exercise and postexercise. Also, those changes did not differ between EX and CON. CONCLUSION: Our results indicate that total adiponectin and HMW adiponectin concentrations are not regulated by the change of hormones or metabolites during acute moderate-intensity aerobic exercise and postexercise in healthy young men.     

不同运动因素对2型糖尿病患者早餐后糖代谢的影响

目的:观察不同步行强度、起始和持续时间对2型糖尿病患者餐后血糖与胰岛素水平的影响。方法:12名2型糖尿病患者进行每次间隔1周的1次静息和4次运动实验,测定空腹及标准早餐后各时点的血糖及胰岛素;采用三因素两水平正交设计,混合模型分析。结果:运动可显著降低2型糖尿病患者餐后峰值血糖和血糖曲线下面积(GlucoseAreaUndertheserumconcentrationCurve,GAUC),但对胰岛素曲线下面积(InsulinAreaUndertheserumconcentrationCurve,IAUC)影响不显著(P>0·05),其中运动强度为3·3代谢当量(MetabolicEquivalentsMETs)、持续时间40min、血糖峰值前30min运动的峰值血糖显著低于静息值(P<0·05);糖尿病史>5年组和BMI>26组运动实验峰值血糖和GAUC显著降低(P<0·05)。结论:单次步行可显著降低2型糖尿病患者餐后峰值血糖和GAUC,但对IAUC影响不明显;糖尿病病史长、体形肥胖的患者运动降糖效果更显著。     

Metabolic responses to exercise after carbohydrate loads in healthy men and women

PURPOSE: This study aimed to investigate gender differences in i) pancreatic insulin secretory (beta-cell sensitivity) and whole body insulin sensitivity responses to an intravenous carbohydrate (CHO) load, and (ii) metabolic responses to exercise after both intravenous and oral CHO loads. METHODS: Seven untrained healthy men and seven age-, body mass-, and VO2max-matched women performed two trials. In one trial they cycled for 60 min at 50% VO2max, starting 60 min after ingestion of a carbohydrate-rich meal (ME trial). In the other trial, subjects were infused with 20% dextrose solution to maintain blood glucose concentration at approximately 8 mmol x L(-1) for 60 min (INF trial), then the infusion rate was maintained constant during the following 60 min while exercising at 50% VO2max. RESULTS: There was no gender effect on beta-cell sensitivity (serum insulin: 161 +/- 37 and 159 +/- 28 pmol x L(-1) for men and women, respectively) and whole body insulin sensitivity (155 +/- 24 and 135 +/- 29 mg x KgFFM(-1) x min(-1) per pmol x L(-1) x 100 for men and women, respectively). This may explain the similarity in glycemic, substrate oxidation and other metabolic responses to exercise after both intravenous and oral CHO loads in men and women. CONCLUSION: These results suggest that moderate exercise performed in the postprandial state presents a similar challenge to the ability of healthy, untrained men and women to perform exercise without a substantial decline in plasma glucose concentration below fasting values.     

Unaltered insulin sensitivity after resistance exercise bout by postmenopausal women

PURPOSE: The major aims of this study were to determine whether a single session of resistance exercise would alter insulin sensitivity, glucose effectiveness, and C-peptide response to glucose challenge in a group of previously sedentary, postmenopausal women. METHODS: Ten postmenopausal women (aged 57.5 +/- 1.6 yr) were studied. Each participant underwent two frequently sampled intravenous glucose tolerance tests (FSIVGTT): without prior exercise (no exercise), and postexercise (15 h after a session of resistance exercise: three sets of 10 repetitions performed at 50%, 75%, and 100% of 10-repetition maximum for 7 exercises). Insulin sensitivity and glucose effectiveness were determined according to Bergman's minimal model procedure. In addition, C-peptide concentration and glucose disappearance were measured. RESULTS: There was no significant difference between trials for insulin sensitivity, glucose effectiveness, glucose disappearance, or area under the curve (AUC) for glucose or insulin during the glucose challenge. AUC for C-peptide tended (P = 0.059) to be 10% higher in the postexercise versus no exercise trial, and C-peptide values were significantly (P < or = 0.02) higher at several time points (60, 70, 140, and 180 min) during the postexercise compared with no exercise trial. CONCLUSIONS: In contrast to previously reported results with young men and women after a single bout of endurance exercise, insulin sensitivity was unaltered by a single session of resistance exercise in postmenopausal women. Higher plasma C-peptide values concomitant with unchanged insulin values provide evidence that resistance exercise may have induced a slightly higher insulin secretion and a proportional increase in insulin clearance.     

Acute effects of moderate intensity resistance exercise on bone cell activity

Resistance exercise has positive effects on bone mass, but little is known about the mechanisms by which this occurs. The purpose of this study was to determine if a single bout of moderate intensity resistance exercise alters biochemical markers of bone cell activity. Indices of bone turnover were measured in nine healthy, untrained men (21.9 +/- 1.2 yrs old), before and following a single 45 minute session of resistance exercise, and during a control trial. A cross-over design was used so that all participants performed both trials in random order. Blood samples were collected immediately before, immediately after, and at 1, 8, 24, and 48 hours post exercise and analyzed for bone-specific alkaline phosphatase (BAP), type I collagen propeptide (PICP), and type I collagen N-telopeptide (sNTX). Urine from the second morning void was collected over four days (day before, day of, and two days following exercise) and analyzed for type I collagen N-telopeptide (uNTX). Exercise resulted in a significant increase (p < 0.05) in the ratio of biochemical markers of bone formation to bone resorption eight hours post exercise, largely due to a decrease in sNTX. Markers return to baseline within 24 hrs. These data suggest that moderate intensity resistance training acutely reduces bone resorption, leading to a favorable change in overall bone turnover, for at least 8 hours post exercise in untrained young men. Further work is needed to determine if long-term benefits to bone strength follow with persistent training.     

Effect of confinement in small space flight size cages on insulin sensitivity of exercise-trained rats

Previous studies on men under conditions of total bed rest, and laboratory animals under limited physical activity, have shown resistance to insulin-induced glucose uptake and, conversely, increased sensitivity to insulin with exercise training. To determine whether the beneficial effects of exercise training on increasing insulin sensitivity are lost following end of exercise and confinement in small cages, oral glucose tolerance tests (OGTT) were given to control and exercise-trained rats before and after placement in small space flight size cages (11 X 4 X 4 1/2 in) for 7 d. The product of the area of the insulin and glucose curves of the OGTT (IG index) provides a measure of insulin resistance. Values obtained, before confinement, were one-half as high in exercise-trained rats as those in control rats (p less than 0.001), reflecting increased sensitivity to insulin with exercise training. After 7 d confinement, the IG index was not significantly different from initial values for both control and exercise-trained rats. These findings indicate that increased insulin sensitivity in exercise-trained rats persists 7 d after cessation of running activity. Furthermore, the data suggest that exercise training, before flight, may be beneficial in minimizing the loss of insulin sensitivity expected with decreased use of gravity dependent muscles during exposure to hypogravity in space flight.     

中晚期妊娠妇女口服葡萄糖耐量试验血清胰岛素检测及其临床意义

目的探讨口服葡萄糖耐量试验血清胰岛素检测的临床意义。方法测定70例门诊非妊娠健康查体妇女(对照组)、70例中晚期妊娠妇女(观察组)的空腹血糖和胰岛素,然后对两组进行葡萄糖耐量试验并测定胰岛素。结果空腹血糖妊娠组明显低于非妊娠组,但糖耐量试验1h血糖妊娠组高于非妊娠组,且差异显著(P<0.05)。DGTT试验中妊娠组血清胰岛素明显高于非妊娠组(P≤0.01)。口服葡萄糖后血糖及胰岛素浓度持续增高且表现有高峰迟缓现象。结论中晚期妊娠妇女行糖耐量检查,对判断其糖耐受能力有重要临床意义。     

Acute effects of exercise on glucose tolerance in non-insulin-dependent diabetes

The evidence that exercise reduces resistant to the action of insulin has generated interest in the possibility that endurance exercise training may be a worthwhile primary therapeutic intervention in the treatment of mild non-insulin-dependent diabetes mellitus (NIDDM). Unfortunately, the results of several studies of exercise training in NIDDM have been discouraging since improvements in oral glucose tolerance (OGT) did not occur or were quite modest even though insulin resistance was reduced. Recently it was determined that 12 months of endurance exercise training at 75-90% of VO2max could normalize OGT in men with mild NIDDM when the post-training OGTT was performed within 18 h of the last bout of exercise. This, coupled with the fact that the enhanced action of insulin is lost in trained persons within a few days of cessation of training, suggests that improved glucose tolerance in NIDDM patients may be partly due to the persistent effects of the last bouts of exercise. Acute exercise in the form of 7 d of intense walking/cycling has been shown to improve glucose tolerance despite a significantly smaller increase in plasma insulin levels during the OGTT in NIDDM. Apparently, the improvement in OGT was due to a decrease in resistance to insulin over the short term since no changes in body weight, body fat, or VO2max took place. Thus, acute exercise of sufficient intensity and duration can increase peripheral insulin action and may contribute to the effects of long-term exercise training on improvement in OGT and the amelioration of insulin resistance in patients with NIDDM.     

Effects of short-term exercise training on plasminogen activator inhibitor (PAI-1)

PURPOSE: To observe the effects of exercise training on plasminogen activator inhibitor, type-1 (PAI-1), tissue plasminogen activator (tPA), and associated metabolic variables in sedentary men and women. METHODS: A randomized, controlled experimental design was used to examine the influence of 10 d of moderate-intensity exercise training on measures of fibrinolysis. Sixteen men and 16 women between the ages of 50 and 70 yr were randomly assigned to exercise (EX) and control groups (CON) that were balanced for gender and hormone replacement therapy. Blood samples were collected on days 1, 2, 11, and 12 for measurement of plasma PAI-1, tPA, insulin, glucose, and triglyceride. Subjects in EX performed 50 min of treadmill walking at an intensity corresponding to 65% of heart rate reserve each day for 10 consecutive days. RESULTS: There were no significant changes in PAI-1, tPA, or associated metabolic variables between EX and CON during the intervention period. Within EX subjects, those with higher body fatness had a significant decrease in insulin and triglyceride compared with those with lower body fatness. However, no changes in fibrinolytic measures were observed within these subgroups. CONCLUSIONS: Short-term exercise training does not change PAI-1 levels in normal, asymptomatic men and women. In addition, modest decreases in insulin and triglyceride in individuals with elevated body fatness do not result in changes in PAI-1 after short-term training. It appears likely that decreases in PAI-1 with exercise training require decreases in adiposity and/or marked changes in metabolic variables.     

Effects of intermittent games activity on postprandial lipemia in young adults

PURPOSE: To investigate whether a single session of intermittent games activity would reduce postprandial lipemia. METHODS: Twelve male volunteers completed three 2-d trials: rest, continuous exercise, and intermittent games activity. Trials were performed a minimum of 6 d apart in a balanced crossover design. In the rest trial, subjects took no exercise on day 1. On day 1 of the continuous and intermittent games trials, subjects completed four blocks (approximately 15 min per block) of uphill treadmill walking or intermittent games activity with 3 min of rest between each block. On day 2, subjects came to the laboratory for an oral fat tolerance test (blood taken fasted and for 6 h following a high-fat test meal (1.25 g of fat and 1.07 g of carbohydrate per kilogram of body mass)). RESULTS: The intermittent games protocol elicited a higher exercise intensity than the continuous trial (lactate: 4.3+/-0.6 vs 2.4+/-0.3 mmol.L; % VO2max: 72+/-2 vs 62+/-1, respectively; mean+/-SE). The total area under the plasma triacylglycerol (TAG) concentration versus time curve was lower in both the intermittent games (25%, P=0.001) and the continuous (19%, P=0.028) trials than in the rest trial. CONCLUSION: These findings show for the first time that intermittent games activity can reduce postprandial lipemia, and confirm that continuous exercise reduces postprandial lipemia in young adults.