1%盐酸布替萘芬乳膏治疗体股癣、足癣疗效观察

目的：评价1％盐酸布替萘芬乳膏治疗体股癣、足癣的临床疗效和安全性。方法：采用多中心、随机、双盲、平行对照的方法．试验组外用1％盐酸布替萘芬乳膏,对照组外用1％联苯苄唑乳膏。结果：体股癣患者停药时试验组与对照组痊愈率分别为32．76％和38．98％。有效率分别为93．10％和94．92％;停药2周时,试验组与对照组痊愈率分别为62．07％和64．41％,有效率分别为93．10％和96．61％。足癣患者停药时．试验组与对照组痊愈率分别为29．31％和30．00％．有效率分别为89．66％和85．00％;停药2周时,试验组与对照组痊愈率分别为48．28％和43．33％．有效率分别为91．38％和86．67％。局部不良反应发生率,两试验组为5．13％;两对照组为4．17％。上述各项指标,两组比较差异无统计学意义。结论：1％盐酸布替萘芬乳膏治疗体股癣、足癣安全有效。     

1%盐酸布替萘芬软膏治疗浅部真菌病随机单盲对照多中心临床试验

采用1%盐酸布替萘芬软膏与1%联苯苄唑乳膏治疗219例浅部真菌病,治疗结果表明,二类新药1%盐酸布替萘芬软膏对手足癣和体股癣临床疗效、真菌学疗效、不良反应发生率与对照药1%联苯苄唑乳膏相似。虽然停药后1周试验组手足癣和体股癣治愈率均高于对照组(P<0.05),但两组的有效率均差异无统计学意义(P=1.000)。     

1%盐酸布替萘芬治疗浅部真菌病临床疗效及安全性观察

选择110例体股癣和手足癣患者外用1%盐酸布替萘芬乳膏,2次/d,随访观察症状和体征积分变化情况。结果:盐酸布替萘芬乳膏治疗体、股癣和手、足癣有效率为97.27%,其疗效好,安全性高,值得临床选用。     

利拉萘酯乳膏治疗体股癣及足癣的多中心随机双盲对照观察

目的 探讨2%利拉萘酯乳膏治疗体股癣、足癣的临床疗效和安全性。方法 采用多中心随机双盲阳性药平行对照法，分别在3个中心进行，入选288例患者，2%利拉萘酯乳膏试验组144例，1% 联苯苄唑乳膏对照组144例；每组中体股癣患者各72例，足癣患者各72例。每日涂药1次，足癣疗程4周，每2周复诊1次；体股癣疗程2周，每周复诊1次；停药后2周均再复诊1次。结果 试验组体股癣患者中有１例脱落。停药时体股癣试验组的痊愈率和有效率分别为59.2%和94.4%，足癣试验组分别为41.7%和81.9%，与对照组比较，差异均无统计学意义（P ＞ 0.05）。在用药结束后2周时，体股癣试验组的痊愈率和有效率分别为67.6%和94.4%，足癣试验组分别为54.2%和81.9%，与对照组比较，差异无统计学意义（P ＞ 0.05）。在用药结束后2周，体股癣和足癣试验组符合方案分析集真菌学清除率分别为97.18%和90.28%，试验组和对照组差异均无统计学意义（P ＞ 0.05）。用药后发生的不良反应表现为用药部位红肿、疼痛，其中体股癣试验组不良反应发生率为2.78%。结论 2%利拉萘酯乳膏治疗体股癣、足癣有良好的疗效和安全性。     

盐酸布替萘芬软膏治疗浅部真菌病疗效观察

目的探讨盐酸布替萘芬软膏治疗浅部真菌病的临床疗效。方法使用1%盐酸布替萘芬软膏,早、晚各1次薄薄涂于患处,1～4周判断疗效;并以克霉唑软膏作对照。结果盐酸布替萘芬软膏治疗体股癣痊愈率59.01%,有效率和真菌清除率均95.45%;治疗手足癣痊愈率为44.44%,有效率为92.60%,真菌清除率为88.89%;治疗花斑癣痊愈率为56.25%,有效率为93.75%,真菌清除率93.75%。各病种治疗组与对照组治愈率、有效率及真菌清除率分别比较,差异均有统计学意义(P均<0.05)。结论盐酸布替萘芬软膏治疗浅部真菌病安全、有效。     

美克治疗体股癣、手足癣、花斑癣和皮肤念珠菌病疗效观察

目的评价美克(1%联苯苄唑乳膏)治疗体股癣、手足癣、花斑癣和皮肤念珠菌病的临床疗效和安全性。方法采用多中心、随机、平行对照的方法,试验组外用美克,对照组外用欣欣(1%盐酸布替萘芬乳膏)。结果体股癣患者停药时试验组与对照组痊愈率分别为42.20%和39.45%,有效率分别为94.49%和91.74%;停药2w时,试验组与对照组痊愈率分别为85.32%和82.56%,有效率分别为97.24%和96.33%。手足癣停药时试验组与对照组痊愈率分别为39.87%和37.34%,有效率分别为85.54%和84.81%;停药2w时,试验组与对照组痊愈率分别为59.49%和58.22%,有效率分别为89.24%和86.70%。花斑癣患者停药时试验组与对照组痊愈率分别为50.72%和52.17%,有效率分别为79.71%和76.81%;停药2w时,试验组与对照组痊愈率分别为66.67%和63.76%,有效率分别为84.05%和81.16%。皮肤念珠菌病患者停药时试验组与对照组痊愈率分别为34.88%和39.53%,有效率分别为72.09%和76.74%;停药2w时,试验组与对照组痊愈率分别为65.11%和67.44%,有效率分别为88.37%和86.04%。局部不良反应发生率各试验组合计为5.27%;各对照组合计为5.54%。上述各项指标,各病种试验组与对照组比较差异均无统计学意义。结论美克治疗体股癣、手足癣、花斑癣和皮肤念珠菌病安全有效。     

1%布替萘芬乳膏治疗体股癣和手足癣疗效观察

目的　探讨 1%布替萘芬乳膏治疗体股癣和手足癣疗效。方法　 82例体股癣和手足癣患者外用布替萘芬乳膏 ,2次 /d ,随访观察症状和体征积分变化情况。结果　布替萘芬乳膏治疗体股癣和手足癣有效率为 93 .9%。结论　布替萘芬乳膏治疗体股癣和手足癣疗效好 ,值得临床选用。     

1%盐酸布替萘芬乳膏治疗浅部真菌病临床观察

目的：评价1％盐酸布替萘芬乳膏治疗浅部真菌病的临床疗效及安全性，并与1％联苯苄唑凝胶进行比较。方法：对83例浅部真菌病患者进行治疗，其中治疗组43例，外用1％盐酸布替萘芬乳膏，每日1次；对照组40例，外用1％联苯苄唑凝胶，每日1次，体股癣疗程2周，手足癣4周。分别于停药及停药2周时观察记录患者的临床表现及治疗效果。结果：1％盐酸布替萘芬乳膏和1％联苯苄唑凝胶临床疗效相似，停药时临床总有效率分别为90．7％和90．0％，真菌总清除率为93．0％和90．0％；停药2周时临床总有效率分别为97．7％和92．5％，真菌总清除率为100．0％和92．5％。不良反应少。结论：1％盐酸布替萘芬乳膏治疗浅部真菌病疗效显著且安全。     

单用盐酸布替萘芬软膏或联合应用20%尿素软膏治疗角化过度型足癣及其进入角质层情况

单独外用传统的抗真菌剂总是不能有效治疗角化过度型足癣。布替萘芬是一种新型的苯甲胺衍生的抗真菌剂 ,作者为了研究盐酸布替萘芬软膏治疗角化过度型足癣情况 ,采用布替萘芬软膏每日 1次外用治疗足癣取得明显疗效 ,并与尿素软膏合用成功治疗了角化过度型足癣。方法 :4 5例角化过度型足癣患者分成 2组 ,Ⅰ组 2 3例患者 ,单用盐酸布替萘芬软膏治疗 ,Ⅱ组有2 2例患者用盐酸布替萘芬软膏与 2 0 %尿素软膏合用。药物应用方法为浴后或睡前每日一次涂于皮损处 ,随机分配受试者。进行了 12周研究 ,同时在一些病例中采用高压液相色谱法检测了药物向…     

1%盐酸布替萘芬乳膏治疗花斑癣疗效观察

目的观察1%盐酸布替萘芬乳膏对花斑癣的治疗效果。方法每日用1%盐酸布替萘芬乳膏均匀涂抹于皮损处1次进行治疗,观察治疗2周、3周、4周时的疗效。结果临床有效率及真菌清除率逐周均有明显提高。2周后有效率为35.29%,真菌清除率为8.82%,4周后有效率为98.53%,真菌清除率为95.59%。结论1%盐酸布替萘芬乳膏治疗花斑癣疗效肯定,安全性高。     

1%联苯苄唑乳膏治疗手足癣及体股癣的临床研究

目的探讨1%联苯苄唑乳膏治疗手足癣及体股癣的临床疗效和安全性。方法采用多中心、随机、单盲、平行对照法,对照药物为1%硝酸咪康唑乳膏。在停药时和停药1周后记录症状及真菌学检查结果,并评价疗效及不良事件。结果1%联苯苄唑乳膏对手足和体股癣临床疗效、真菌学疗效、不良反应发生率与对照药1%硝酸咪康唑乳膏相似。停药1周后试验组手足癣和体股癣治愈率均高于对照组(P<0.05),但两组的有效率差异均无统计学意义(P=1.000)。结论1%联苯苄唑乳膏治疗手足癣及体股癣安全、有效。     

Once-Daily Naftifine Cream 1% in the Treatment of Tinea Cruris and Tinea Corporis

Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily for 4 weeks in this double-blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle-treated patients (79% vs. 31%, p less than 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significantly differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.     

1%联苯苄唑凝胶治疗体股癣和手足癣疗效观察

目的　观察 1%联苯苄唑凝胶治疗体股癣和手足癣的疗效。方法　局部涂搽 ,1次 /d。体股癣连用 1周 ,手足癣连用 2周 ,每周复诊 1次 ,连续 4周。结果　 10 0例中治愈 94例 ,显效 3例 ,治愈率 94 0 % ,有效率 97 0 %。结论　1%联苯苄唑凝胶治疗体股癣和手足癣疗效好 ,易为患者所接受。     

1％联苯苄唑溶液治疗花斑癣的疗效观察

目的 观察1％联苯苄唑溶液对花斑癣的治疗效果。方法 将69例花斑癣患者随机分组,分别使用1％取苯苄唑溶液、2％酮康唑洗剂进行治疗,观察治疗2周、3周、4周的疗效。结果 1％联苯苄唑溶液与2％酮康唑洗剂疗效及不良反应发生率差异均无显著性（P均＞0．05）。结论 1％联苯苄唑溶液治疗花斑癣安全有效。     

Efficacy and Safety of Terbinafine Hydrochloride 1% Cream vs. Sertaconazole Nitrate 2% Cream in Tinea Corporis and Tinea Cruris: A Comparative Therapeutic Trial

Context:

To the best of our knowledge, till date no study comparing the efficacy and safety of terbinafine hydrochloride 1% cream and sertaconazole nitrate 2% cream has been done in localized tinea corporis and tinea cruris.

Aims:

This clinical trial was carried out to study and compare the efficacy of topical terbinafine hydrochloride 1% cream and sertaconazole nitrate 2% cream in localized tinea corporis and tinea cruris and to know the adverse effects of these antifungal creams.

Settings and Design:

In this prospective, single blind, randomized control trial with two arms, patient were randomized into two groups Group A (treatment with terbinafine cream) and Group B (treatment with sertaconazole cream). A total of 38 patients were enrolled for the study, 20 patients in group A and 18 patients in group B. But five patients of group A and three patients of group B were lost for follow-ups. Therefore sample size was of 30 patients with 15 patients in group A and group B each.

Materials and Methods:

Patients in group A and B were treated with twice daily topical 1% terbinafine hydrochloride and 2% sertaconazole nitrate cream respectively for a total duration of three weeks. Clinical improvement in signs and symptoms of each clinical parameter, namely itching, erythema, papules, pustules, vesicles, and scaling were graded weekly and clinical cure was assessed. KOH mount and culture was done weekly up to 3 weeks to access mycological cure. Fungal culture was done on Sabouraud''s dextrose agar with chloramphenicol and cycloheximide.

Statistical Analysis Used:

Statistical analysis was done using students paired and unpaired t-tests from the data obtained.

Results:

Comparison between Group A and Group B for complete cure (clinical and mycological) showed that at the end of 3 weeks both terbinafine and sertaconazole groups had 100% complete cure. When the two groups were compared for complete cure, at the end of 1^st and 2^nd week, statistically non-significant results were observed (P = 0.461 and P = 0.679 respectively). However, at the end of 2^nd week, complete cure rate for terbinafine was 80% as compared to 73.35% for sertaconazole with no statistical significance. In both Group A and Group B, clinically significant local side effects like erythema, swelling, stinging sensation, or increased itching were not noticed. A majority of our patients in both the group showed Trichophyton rubrum followed by Trichophyton mentagrophytes growth on culture. In Group A, 11 patients showed growth of T. rubrum, 2 patients showed growth of T. mentagrophytes, and 1 patient had only KOH test positive. In Group B, 10 patients revealed growth of T. rubrum, followed by growth of T. mentagrophytes in 3 and Microsporum canis in 2 patients. The therapeutic response is more or less same in infection with different species.

Conclusions:

The newer fungistatic drug sertaconazole nitrate 2% cream was as effective as terbinafine hydrochloride 1% cream which is one of the fungicidal drugs, though terbinafine hydrochloride 1% cream has higher rates of complete cure at the end of 2 weeks as compared to sertaconazole nitrate 2% cream. Both the drugs showed good tolerability with no adverse effects.     

Comparative Study of 2% Sertaconazole Solution and Cream Formulations in Patients with Tinea Corporis, Tinea Pedis Interdigitalis, or a Corresponding Candidosis

Background: Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. Objective: The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% sertaconazole cream formulation in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis. Methods: This was a prospective, open-label, randomized, controlled, parallel-group, multicenter, noninferiority therapy study. Patients received either sertaconazole solution or cream twice daily for 28 days. The full analysis set comprised 160 patients in the solution group and 153 patients in the cream group. The primary efficacy parameter was a combination of culture test result and total clinical score. Efficacy was defined by eradication of the pathogen and reduction of the total clinical score between pretreatment and the final visit. Results: Efficacy was documented in 90.6% of patients using the solution and 88.9% of those using the cream (full analysis set). No adverse events occurred. Conclusion: Solution and cream formulations of 2% sertaconazole applied for 28 days were associated with comparable efficacy and safety in the treatment of fungal skin infections.     

1%环吡酮软膏治疗足癣的疗效观察

目的　观察 1%环吡酮软膏治疗足癣的疗效。方法　足癣患者 83例分两组 ,治疗组 45例外用 1%环吡酮软膏 2次 /d ,对照组 3 8例使用克霉唑软膏 2次 /d。结果　治疗组治愈率 88.89% ,有效率 95.56% ;对照组分别为55.2 6%、68.42 %。两组治愈率、有效率比较 ,差异均具有高度显著性 (P <0 .0 0 1、P <0 .0 1)。结论　 1%环吡酮软膏治疗足癣起效快、疗程短、效果较好     

A Randomized,Double‐Blind Study Comparing the Efficacy of Selenium Sulfide Shampoo 1% and Ciclopirox Shampoo 1% as Adjunctive Treatments for Tinea Capitis in Children

Abstract: Our objective was to compare the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Forty children aged 1–11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8‐week course of ultramicronized griseofulvin dosed at 10–12 mg/kg/day. At weeks 2, 4, and 8, subjects returned to the clinic for evaluation and scalp cultures. Subjects then returned for follow‐up visits 4 weeks after completing treatment. Overall, by 8 weeks, 30 of 33 (90.9%) treated children demonstrated mycological cure. Selenium sulfide shampoo 1% and ciclopirox shampoo 1% were equally effective as adjunctive treatments for tinea capitis in children in our study.