GDxVCC系统检测视网膜神经纤维层在青光眼早期诊断中的价值

目的 比较正常人和不同程度青光眼患者GDxVCC系统检测RNFL参数的不同,评价GDx各参数的敏感性、特异性,探讨GDxVCC系统检测视网膜神经纤维层在青光眼早期诊断中的价值.方法 对35例(35只眼)原发性开角型青光眼、33例(33只眼)慢性闭角型青光眼、27例(27只眼)急性闭角型青光眼以及年龄相匹配的36人(36只眼)正常人进行GDxVCC系统和静态视野检查.GDxVCC系统检查,视盘周围视网膜神经纤维层(retinal nerve fiber layer,RNFL)任一参数与系统内所附中国正常人数据库对比概率＜5%或NFI＞30或视网膜神经纤维标准偏差图上连续有10个超级像素概率＜5%定义为具有青光眼性视网膜神经纤维层结构损害,并判断为青光眼.结果 22只正常眼被判断为非青光眼(61.1%),82只青光眼被判断为青光眼(86.3%),RNFL参数椭圆平均值、上方平均值、下方平均值、TSNIT标准偏差、神经纤维指数,标准偏差图诊断青光眼的敏感性分别为48.4%、56.8%、48.4%、50.5%、62.1%,特异性分别为97.2%、100%、97.2%、94.4%、97.2%、61.1%.GDxVCC系统诊断早期、中期、晚期青光眼的敏感性分别为77.36%、95.83%、100%.结论 GDxVCC系统诊断早期青光眼的敏感性和特异性均高,而且RNFL参数中神经纤维指数的敏感性最高.

Abstract：

Objective To evaluate the usefulness of the scanning laser polarimeter with variable corneal compensation (GDxVCC) for glaucoma detection in a Chinese population,and to investigate the retinal nerve fiber layer (RNFL) thickness difference between normal subjects and glaucoma patients.Methods Thirty-six eyes of 36 normal subjects,33 eyes of 33 primary chronic angle-closure glaucoma patients,27 eyes of 27 primary acute angle-closure glaucoma and 35 eyes of 35 primary open-angle glaucoma patients were studied.The glaucoma patients were age-matched with the normal.The thickness of retinal nerve fiber layer was measured with GDxVCC.An eye was diagnosed as glaucoma,ifone of the parameters showed P＜0.05 on the results of the examination reports including four TSNIT parameters (the average of TSNIT,superior,inferior,and TSNIT Std.Dev.),nerve fiber indicator (NFI) ＞ 30,and at least 10 consecutive defects of superpels showed in deviation map (P ＜0.05).Results Of 22 normal eyes (61.1%) were diagnosed as non-glaucoma and 82 glaucomatous eyes (86.3%) were diagnosed as glaucoma by GDxVCC.Sensitivity of the average of TSNIT,superior,inferior,TSNIT Std.Dev.,NFI and the deviation map were 48.4%,56.8%,48.4%,50.5%,62.1% respectively and specificity were 97.2%,100%,97.2%,94.4%,97.2% and 61.1% respectively.Sensitivity of detection early,moderate and progression glaucoma by GDxVCC were 77.36%,95.83%,100% respectively.Conclusions GDxVCC is a valuable technology to detect retinal nerve fiber layer defect in early glaucoma.It is shown that the NFI has highest sensitivity.     

视网膜神经纤维层检查在青光眼早期诊断中的应用

青光眼是一组以眼压升高、视功能和视神经受损为综合表现的致盲性疾病,严重危害人类的健康。早期诊断常依赖于视野检查,现有研究证实,视网膜神经纤维的受损早于视野缺损,通过视网膜神经纤维层检查有利于青光眼的早期诊断,其检查方法可分形态学检查和厚度测量法两大类。包括：手持检眼镜检查、无赤光眼底照相、视神经纤维分析仪、视网膜厚度分析仪、扫描激光拓扑仪、光学相干断层扫描仪、激光偏振扫描仪等,本文将国内外现状进行综述。     

视网膜神经纤维层定量测定在青光眼方面的应用

青光眼的主要病理过程是视网膜节细胞轴突（即视神经纤维）的丢失，故测量视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙｅｒ，ＲＮＦＬ）来确定轴突丢失的程度在青光眼的早期诊断和治疗上具有非常重要的意义。近年来，计算机图像分析技术应用于眼科，它能对ＲＮＦＬ作出客观的量化检测。该文综述有关文献，就ＲＮＦＬ定量测定方法的原理，以及它们在青光眼ＲＮＦＬ损害检测方面的应用情况作一介绍。     

SD-OCT测量视网膜神经纤维层厚度在青光眼诊断中的应用

青光眼是世界上第二大致盲眼病,其早期诊断及远期监测非常重要。光学相干断层成像(opticalcoherencetomo-graphy,OCT)自问世以来,一直广泛地被应用于青光眼的诊断,尤其在视网膜神经纤维层厚度的测量上。频域光学相干断层成像(spectraldomainOCT,SD-OCT)是最新一代的OCT扫描技术,相比之前三代OCT,其技术参数愈加完善,具有分辨率更高、扫描速度更快的特点,理论上其在青光眼的早期诊断和远期随访上的应用价值可能更高。本文就SD-OCT对比前三代OCT在青光眼的早期诊断和监测中的价值作一综述。     

视网膜神经纤维层检查在青光眼早期诊断中的应用分析

目的:应用无赤光眼底照相及图像处理技术观察视网膜神经纤维层(RNFL)形态,并与视野检查结果进行对比分析,探讨RNFL检查在青光眼早期诊断中的临床意义。方法:选30例(55眼)门诊可疑的青光眼患者,进行无赤光眼底照相及视野检查,经Photoshop图像处理软件对眼底图像进行处理后观察,并与视野检查结果进行统计学检验及对比分析。结果:以无赤光眼底照相及图像处理技术观察RNFL形态方法的敏感性为94%,阳性率为78%,视野检查的阳性率为67%,经卡方检验,差异有统计学意义(χ2=15.0349,P=0.0001),提示RNFL观察的阳性率高于视野检查,结合临床,认为RN-FL观察法实际上是较视野检查更早的发现了神经纤维的损害。结论:应用无赤光眼底照相及图像处理技术观察RNFL形态,灵敏度较高,能够较视野检查更早的发现神经纤维的损害,为青光眼早期诊断、随访监测及治疗方案提供参考,且方法简单易行,适于普及,值得在青光眼早期诊断中推广应用。     

青光眼的视网膜神经纤维层缺损及视盘参数改变

青龙眼的主要病理过程是视网膜神经纤维及视乳头盘沿的丢失。青光眼的视网膜神经纤维层缺损可分为局部缺损和弥漫缺损，这两作缺损的存在可能预示着存在两种或多种造成青光眼视神经损害的机制。本文总结分析了75例开角型青光眼及慢性闭角型青光眼病人131只眼的彩色立体眼底象．根据视网膜神经纤维层损害形态的不同，将131只限分为局限性RNFLD；弥漫性RNFLD；混合性RNFLD三组。对各组眼的视盘参数进行定最测量并参照Airaksinen法对视网膜神经纤维层进行半定量评估，根据视杯扩大的形态及盘沿面积的大小将各组中的病眼分为0、Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ几个阶段，采用SYSTAT统计软件对三组病人的c／D、沿盘面积比进行对比分析；且对各级RNFLD的半定量值与盘沿面积进行直线相关及回归分析。结果表明三组间的C／D及沿盘面积比存在着相当显著性差异（P＝0．000），且局部缺损组主要处于青光眼的早期和中期，混合缺损组主要分布于中期，弥漫缺损组主要分布于中晚期。视网膜神经纤维层缺损的半定量值与盘沿面积低度相关。青光眼视网膜纤维层缺损的不同形态表现，不同缺损形态组的视盘参数的差异及视杯扩大形式的差异，可能预示着存在多种造成青光眼视神经损害的机制。     

OCT检测视网膜神经纤维层厚度及视盘参数在青光眼早期诊断应用

目的 通过光学相干断层成像术(OCT)检测视网膜神经纤维层(RNFL)厚度及视盘结构参数,结合视野改变,探讨OCT在青光眼早期诊断中的应用价值.方法 采用OCT对34只眼疑似闭角型青光眼(SG)患者、36只眼慢性闭角型青光眼(CACG)早中期患者、10只眼正常人行RNFL及视盘扫描,观察各组的RNFL厚度及视盘结构的图像特征;将各象限RNFL厚度和平均RNFL厚度的均数进行总体比较及任意两组间比较;将视乳头水平、垂直杯盘比及杯/盘面积比的均数进行比较;将平均RNFL厚度与视野指数进行相关分析.结果 三组间各象限RNFL厚度、平均RNFL厚度、视盘参数差异有统计学意义(P<0.05);正常人与SG组下方、上方及平均RNFL厚度差异有统计学意义(P<0.05);正常人与CACG早中期组各象限RNFL厚度及平均RNFL厚度差异均有统计学意义(P<0.05);CACG早中期组与SG组上方、下方、鼻侧及平均RNFL厚度差异有统计学意义(P相似文献   

OCT检测青光眼视网膜神经纤维层局部缺损的临床研究

背景传统眼底照相的方法诊断视网膜神经纤维层（RNFL）局部缺损依赖于检查者的主观经验,而光学相干断层扫描（OCT）可以客观判断RNFL的局部缺损,新的频域OCT对RNFI,缺损的显示更直观。目的评价频域OCT、时域OCT对青光眼RNFL局部缺损的诊断价值及其与眼底彩色照相的一致性。方法由2位青光跟专家通过眼底彩色照相一致确认存在RNFL局部缺损的青光眼患者55例55眼和正常对照41名41眼纳入研究,分析眼底彩色照相、频域CirrusHD-OCT、时域Stratus OCT分别检测的RNFL局部缺损的位置和宽度,进行三者检测结果的一致性和相关性研究,评价OCT对RNFL局部缺损的诊断价值。结果确认青光眼患者55眼中共有RNFL局部缺损75处,分别位于颞上和颞下象限。CirrusHD-OCT和Stratus OCT检测RNFL损害的灵敏度分别是88．O％和69．3％,特异度分别是927％和97．6％。CirrusHD-OCT和Stratus OCT检测RNFL缺损的位置均与眼底彩色照相结果的检测值呈高度正相关（r=0．993、r=0．992,P〈0．01）;二者检测的RNFL缺损宽度与眼底彩色照相结果的检测值呈正相关（r=0．420、r=0．432,P=0．019、P=0．002）,CirrusHD-OCT和Stratus OCT检测RNFL缺损宽度与眼底彩色照相的检测值比较差异均无统计学意义（CirrusHD-OCT：P=0．114;Stratus OCT：P：0．074）。CirrusHD-OCT和Stratus-OCT检测RNFL缺损宽度值差异有统计学意义（P：0．002）。结论频域OCT和时域OCT均具有较好的诊断RNFL局部缺损的价值,与眼底彩色照相检测值有较好的一致性。     

剥脱性青光眼患者视网膜神经纤维层厚度变化分析

目的：比较维吾尔族假性剥脱综合征(PEX)患者、剥脱性青光眼(PEXG)患者视网膜神经纤维层(RNFL)厚度,为早期诊断剥脱性青光眼提供理论依据。

方法：回顾性病例对照研究。选取2018-04/ 2020-06在我院就诊治疗的维吾尔族假性剥脱综合征患者70例70 眼,剥脱性青光眼患者 80例80 眼,按照视野缺损分期分为早中期剥脱性青光眼患者56眼、晚期剥脱性青光眼患者24眼,选取同期本院收治的维吾尔族年龄相关性白内障病例60例60 眼作为对照组。比较四组患者视盘不同位置RNFL厚度。

结果：对照组、假性剥脱综合征组及剥脱性青光眼组患者视野缺损(MD)逐渐加重且剥脱性青光眼组患者MD显著高于假性剥脱综合征组(P<0.01); 假性剥脱综合征组、早中期剥脱性青光眼组及晚期剥脱性青光眼组视盘不同位置RNFL厚度较对照组均变薄(均P<0.01); 假性剥脱综合征组患者视盘平均RNFL、下方、上方RNFL厚度均低于对照组(均P<0.01)); 晚期剥脱性青光眼组患者视盘各个位置RNFL厚度明显低于早中期剥脱性青光眼患者(均P<0.01)。

结论：维吾尔族假性剥脱综合征患者早期RNFL厚度较未患有剥脱综合征人群开始变薄,早期对于假性剥脱综合征患者RNFL进行检测有助于剥脱性青光眼疾病诊断并进行治疗。     

不同程度近视患者视网膜神经纤维层厚度、黄斑外环区视网膜厚度观察

目的　观察不同程度近视患者视盘旁视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙ-ｅｒ,ＲＮＦＬ）厚度、黄斑外环区视网膜厚度变化,并分析其特点。方法　参与检测的受检者共２０９例３９９眼分４组,分别为中低度近视组５２例（９８眼）、高度近视组４７例（９１眼）、高度近视青光眼组５７例（１０４眼）及５３人（１０６眼）健康志愿者为正常对照组。采用光学相干断层扫描仪测量视盘旁上方、颞侧、下方、鼻侧四个象限的ＲＮＦＬ厚度,视盘周围全周ＲＮ-ＦＬ厚度,黄斑外环区四个象限的视网膜厚度。采用Ｐｅａｒｓｏｎ相关分析法分析近视患者屈光度数与ＲＮＦＬ厚度及黄斑外环区视网膜厚度的相关性。结果　各组视盘旁ＲＮＦＬ厚度以上象限和下象限较厚,其次为颞侧象限,而鼻侧象限最薄。正常对照组与中低度近视组各象限ＲＮＦＬ厚度比较差异无统计学意义（Ｆ＝１．７３２,Ｐ＞０．０５）,其余各近视眼组患眼各象限ＲＮＦＬ厚度均有差异（Ｆ＝３６１．７１、４７８．９２、３９５．１６,均为Ｐ＜０．０５）。近视患者屈光度数与上、下、鼻侧ＲＮＦＬ厚度呈负相关（ｒ＝－０．２７９、－０．３１９、－０．２１３,均为Ｐ＜０．０５）,与颞侧象限ＲＮＦＬ厚度呈正相关（ｒ＝０．３２６,Ｐ＜０．０５）。高度近视青光眼组与高度近视眼组之间比较黄斑外环区颞侧、上方视网膜厚度减少,差异有统计学意义（Ｆ＝４７５．１２,Ｐ＜０．０５）。结论　光学相干断层扫描能够检测高度近视青光眼的ＲＮＦＬ厚度及黄斑外环区厚度的变化,为青光眼的早期诊断提供了一定的帮助。     

应用GDx VCC检测原发性开角型青光眼视网膜神经纤维层

目的 采用GDx VCC检测青光眼和正常人视网膜神经纤维层厚度(retinal nerve fiber layer,RNFL),并进行对比分析.方法 选择正常人44人44眼,原发性开角型青光眼患者45例45眼行GDx VCC检查.将获取的参数(椭圆平均值、上方平均值、下方平均值、TSNIT标准差、眼间对称性、视神经纤维指征)进行分析.结果 所有参数在正常人组与青光眼组比较中均有统计学意义(P＜0.01).GDxVCC不同参数检测青光眼RNFL缺损敏感性为68.9%～82.2%,特异性84.1%～100.0%.其中下方平均值、视神经纤维指征ROC曲线下面积为0.959、0.964.结论 GDx VCC在RNFL检查中有较高的敏感性和特异性,可客观反应受检者的RNFL情况,对于青光眼的早期诊断有一定的临床价值.     

Detecting optic nerve head deformation and retinal nerve fiber layer thinning in glaucoma progression

The application of digital imaging technologies including confocal scanning laser ophthalmoscopy (CSLO), optical coherence tomography (OCT), and scanning laser polarimetry (SLP) has significantly improved the detection of optic nerve head (ONH) deformation and progressive retinal nerve fiber layer (RNFL) thinning for assessment of glaucoma progression. Algorithms for change analysis such as topographic change analysis and guided progression analysis perform event analysis of serial ONH surface height topology maps and RNFL thickness/RNFL retardance maps, respectively, providing a topographical display of the location of significant change. With spectral-domain OCT, it is feasible to delineate and measure the lamina cribrosa surface depth in addition to ONH surface depth and RNFL thickness. Growing evidence from experimental and clinical studies indicates that ONH and lamina cribrosa deformation can be observed prior to detectable RNFL thinning and functional loss in glaucoma. These findings lend support to the notion that upon detection of ONH/lamina cribrosa deformation, a time window for therapeutic intervention for better outcomes may exist. The ONH and the lamina cribrosa are therefore important targets for monitoring glaucoma progression. This review summarizes the latest findings comparing the performance of OCT, CSLO, and SLP for detection of progressive ONH and RNFL damages in glaucoma patients and the clinical implication and limitations of studying the morphological alteration of the ONH, lamina cribrosa, and RNFL in the assessment of glaucoma progression.     

Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls

AIM: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3.0 D, up to -6.0 D) and high myopia (HM; SE greater than -6.0 D). The control group consisted of emmetropic (EM) patients (SE from +0.5 D to -0.5 D). A Zeiss Cirrus HD-OCT machine was used to measure the peripapillary RNFL thickness of both eyes of each subject. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance. RESULTS: A total of 403 eyes of 403 subjects were included in this study. The mean age was 31.48±10.23y. There were 180 (44.7%) eyes with EM, 124 (30.8%) with LM, 73 (18.1%) with MM and 26 (6.5%) with HM. All groups of myopia severity had a thinner average RNFL than the EM group, but after controlling for gender, age, and axial eye length, only the HM group differed significantly from the EM group (P=0.017). Likewise, the superior, inferior and nasal RNFL was thinner in all myopia groups compared to controls, but after controlling for confounders, only the inferior quadrant RNFL was significantly thinner in the HM group, when compared to the EM group (P=0.017). CONCLUSION: The average and inferior quadrant RNFL is thinner in highly myopic eyes compared to emmetropic eyes. Refractive status must be taken into consideration when interpreting the OCT of myopic patients, as RNFL thickness varies with the degree of myopia.     

Evaluation of ganglion cell-inner plexiform layer thickness in the diagnosis of preperimetric glaucoma and comparison to retinal nerve fiber layer

Purpose:The aim of this study was to evaluate the diagnostic ability of optic nerve head (ONH), RNFL, and GC-IPL parameters in differentiating eyes with PPG from normals.Methods:This was a retrospective, cross-sectional, observational study. We studied 73 eyes of 41 patients and compared them to 65 eyes of 34 normal persons. Each patient underwent detailed ocular examination, standard automated perimetry, GC-IPL, ONH, and RNFL analysis. PPG was defined as eyes with normal visual field results and one or more localized RNFL defects that were associated with a glaucomatous disc appearance (e.g., notching or thinning of neuroretinal rim) and IOP more than 21 mm Hg. Diagnostic abilities of GC-IPL, ONH, and RNFL parameters were computed using area under receiver-operating curve (AUROC), sensitivity and specificity, and likelihood ratios (LRs).Results:All GC-IPL parameters differed significantly from normal. The ONH, RNFL, and GC-IPL parameters with best area under curves (AUCs) to differentiate PPG were vertical cup to disc ratio (0.76), inferior quadrant RNFL thickness (0.79), and inferotemporal quadrant GC-IPL thickness (0.73), respectively. Similarly, best LRs were found for clock hour 5, 6, and 12 thicknesses among RNFL; inferior sector and inferotemporal sector thicknesses among GC-IPL parameters.Conclusion:Diagnostic abilities of GC-IPL parameters were comparable to RNFL parameters in differentiating PPG patients from normals. The likelihood of ruling in a disease was greater with GC-IPL parameters.     

青光眼视网膜神经纤维损害激光偏振光扫描测量的价值

目的:探讨青光眼的视网膜神经纤维层缺损特征,评价激光偏振光扫描测量仪(GDxVCC)在青光眼早期诊断方面的应用价值。方法:采用激光偏振光扫描测量仪(GDxVCC,美国)对60例110眼正常人及46例85眼青光眼患者视网膜后极部水平方向40°、垂直方向20°范围进行激光偏振光扫描测量视网膜神经纤维层厚度(RNFL),同时进行中央30°视网膜光阈值检查(Humphrey视野分析仪,Central30-2thresholdtest,美国),并对结果进行统计分析。结果:正常眼RNFL厚度与性别、眼别无关,而与年龄呈负相关;各期青光眼患者的RNFL均值显著低于正常对照组(年龄匹配,P<0.01);早期、进展期、晚期青光眼患者的RNFL厚度均值比较也有显著性差异(P<0.001)。GDxVCC检测RNFL厚度值与Humphrey视野检查指数平均缺损值(MD)具显著正相关性(r=0.795,P<0.001)。青光眼的视网膜神经纤维层图像可表现为局限性变薄或缺损(85.2%)、弥漫性变薄(6.6%)、弥漫性变薄并局限性缺损(8.2%),以鼻上方的局限性变薄或缺损最常见(56.7%)。有23.3%的早期青光眼患者视野检测正常而GDxVCC检测发现有不同程度的视网膜神经纤维层缺损。结论:GDxVCC能准确定量检测RNFL厚度值,视网膜神经纤维层的检测能比视野检测更早地发现青光眼的视神经的损害,因而可作为青光眼患者早期诊断的重要指标之一。随着青光眼患者病情的发展,RNFL厚度逐渐变薄,视野的平均缺损值逐渐增加。GDxVCC联合视野检查对于追踪青光眼患者的病情变化,确立靶眼压的水平,制定个性化的治疗方案有着重要的价值。     

近视眼神经纤维层光学相干断层扫描检测的临床研究

目的研究人视网膜神经纤维层厚度随近视眼屈光度加深而变化的特点及临床意义。方法将近视眼108例(197眼)和正常对照者42例(60眼)分为低度近视组、中度近视组、高度近视组和正常对照组,应用光学相干断层扫描仪进行以视盘为中心,直径3.46mm圆周的视网膜神经纤维层(retinal nerve fiberlayer,RNFL)厚度测量,计算各组平均RNFL厚度及鼻、颞、上、下4个象限的RNFL厚度,各近视组分别与正常组对比,并进行统计学分析。结果低度、中度近视患者平均RNFL分别为(119.33±37.23)μm、(117.84±36.57)μm,已变薄但与正常人(123.74±35.68)μm无显著差异(P>0.05);高度近视平均神经纤维层厚度为(112.89±37.09)μm明显变薄,与正常人相比有显著性(P<0.01)。近视眼各象限RNFL最早变薄的是鼻侧,低度近视即与正常人有显著性差异(P<0.01)。高度近视眼鼻、下、上方RNFL均明显变薄(P<0.01),而颞侧RNFL反而增厚,与正常人相比差异具有显著性(P<0.01)。结论近视眼中平均RNFL厚度变薄,随着近视度数的加深,近视眼RNFL厚度变薄越来越明显。分区分析上、下、鼻侧变化与平均相一致,而颞侧增厚,这可能是近视眼RNFL的特点。这些特点对临床疾病的诊断具指导意义。     

Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia

AIM: To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS: This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the optic disc using Stratus and Spectralis OCT. Areas under the receiver operating characteristic curve (AUROC) and the sensitivity at specificity of >80% and >95% for p-RNFL parameters obtained using the two devices to diagnose glaucoma were analysed and compared. RESULTS: In Spectralis OCT, p-RNFL thickness parameters with the largest AUROC were the temporal-inferior sector (0.974) and the inferior quadrant (0.951), whereas in Stratus OCT, the best parameters were the 7-o’clock sector (0.918) and the inferior quadrant (0.918). Compared to the Stratus OCT parameters, the Spectralis OCT parameters demonstrated generally higher AUROC; however, the difference was not statistically significant. CONCLUSION: The best p-RNFL parameters for diagnosing glaucoma in patients with high myopia were the temporal-inferior sector on Spectralis OCT and the 7-o’clock sector on Stratus OCT. There were no significant differences between the AUROCs for Spectralis OCT and Stratus OCT, which suggest that the glaucoma diagnostic capabilities of these two devices in patients with high myopia are similar.