带蒂TRAM皮瓣乳房重建体会

目的:探讨带蒂横向腹直肌肌皮瓣(TRAM)皮瓣在乳腺癌根治术后乳房重建中的临床效果及其常见并发症。方法:自2003年7月至2005年4月从本院乳腺外科选择5例患者,在乳腺癌根治术后一期或二期应用带蒂TRAM皮瓣进行乳房重建。结果:应用该方法重建乳房的5例患者,术后3例患者出现部分皮瓣的坏死,通过清创缝合后均愈合,愈合后乳房形态仍良好;随访1～2年无局部复发及远处转移情况,重建的乳房与健侧基本对称。结论:部分皮瓣的坏死是应用带蒂TRAM皮瓣重建乳房常见的并发症,应用带蒂TRAM皮瓣在乳腺癌根治术后行乳房重建是一种安全有效的治疗方法。     

背阔肌肌皮瓣在乳房修复和重建中的应用

目的通过背阔肌肌皮瓣在乳腺癌术后Ⅰ期乳房修复和重建的研究,探讨适合中国女性乳腺癌患者的乳房再造方式.方法20例患者采用背阔肌肌皮瓣带蒂转移乳房再造;11例联合假体置入乳房再造.结果再造手术均取得成功,患者满意度高,可接受度100%.结论乳腺癌术后Ⅰ期背阔肌肌皮瓣乳房再造能同时满足肿瘤治疗和形体美容的要求,提高患者生活质量,背阔肌肌皮瓣再造对中国女性适用性好,值得推广.     

乳腺癌改良根治术后一期乳房再造术中应用背阔肌肌皮瓣的价值

目的探讨在乳腺癌改良根治术后一期乳房再造术中应用背阔肌肌皮瓣的安全性及可行性。方法选取2012年10月至2016年10月收治的乳腺癌患者90例,将其随机分为两组,各45例。对照组单用乳腺癌改良根治术,观察组术后行一期背阔肌肌皮瓣乳房再造术。评估观察组乳房美容效果,比较两组术后恢复情况、并发症发生率。结果观察组乳房美容优良率为95.56%,对照组患侧乳房完全缺失。两组术后恢复情况及并发症发生率相近,差异无统计学意义(P>0.05)。结论在乳腺癌改良根治术后一期乳房再造术中应用背阔肌肌皮瓣安全可行,操作相对简单,乳房美容效果较佳。     

股薄肌皮瓣转移修复女性外阴恶性肿瘤根治术后的组织缺损

利用带血管蒂股薄肌皮瓣转移修复女性外阴恶性肿瘤根治术后的组织缺损３例，缺损面积最大１４ｃｍ×７ｃｍ，肌皮瓣面积最大１６ｃｍ×９ｃｍ。肌皮瓣全部一期成活。讨论了带血管蒂股薄肌皮瓣转移或移植时应注意的问题。     

乳腺癌简化根治术后乳房再造术93例

目的比较乳腺癌简化根治术后在不同时期、应用不同手术方式乳房再造的疗效,探讨其最佳时机和最佳适应证。方法乳腺癌患者93例,根据适应证不同分别应用背阔肌肌皮瓣,或加硅凝胶假体和带蒂下腹部横行腹直肌肌皮瓣行乳癌简化根治术后即时或延期乳房再造。结果应用背阔肌肌皮瓣或加硅凝胶假体再造乳房者大部分获Ⅰ期愈合,应用带蒂下腹部横行腹直肌肌皮瓣再造乳房者有部分发生不良反应,经积极处理后愈合。结论手术时机的选择主要由患者意向决定,即时和延时再造乳房结果差异无统计学意义。     

保留乳头乳晕复合体乳腺癌改良根治术后背阔肌肌皮瓣乳房再造

目的研究保留乳头乳晕复合体乳腺癌改良根治术后背阔肌肌皮瓣乳房再造安全性与美观性。方法 2005年1月-2011年4月30例早期乳腺癌,在保留乳头、乳晕改良根治术的同时进行背阔肌肌皮瓣乳房再造。结果 30例手术均成功,术后1例出现乳头部分坏死,术后1例出现再造乳房僵硬,术后腋窝形态美观,腋窝无1例积液,5d拔出引流管,20例患者术后半年左右乳头恢复感觉。术后患者均随访1-5年,术后无1例出现局部复发,1例4年后出现肺部转移。重建的乳房形态完美,增加了美感,减轻了患者的精神负担。结论保留乳头乳晕复合体乳腺癌改良根治术后背阔肌肌皮瓣乳房再造,不但有改良根治术相同的安全性,而且有更好的美观性,可望作为早期乳腺癌手术治疗的常规选择术式。     

带蒂背阔肌肌皮瓣修复乳腺癌胸壁组织缺损1例的护理

<正>乳腺癌错过早期治疗机会致肿瘤逐渐增大侵袭胸壁或乳腺癌复发胸壁转移,治疗上可行连同胸壁组织的广泛切除并一期给予皮瓣修复术,术后5年生存率达43%～57%[1]。背阔肌肌皮瓣的供血来自胸背动脉[2],以胸背动脉为蒂的背阔肌肌皮瓣,切取面积大,转移覆盖范围广,临近乳房,是胸壁缺损的优良供区。现就我科成功应用该皮瓣1例的护理体会汇报如下。     

阔筋膜张肌肌皮瓣修复腹股沟恶性肿瘤切除后缺损的临床探讨

目的探讨阔筋膜张肌肌皮瓣带蒂转移修复腹股沟区域恶性肿瘤切除后巨大软组织缺损的临床疗效。方法2006年1月-2010年1月，我科收治腹股沟区域恶性体表肿瘤6例，行扩大切除术后形成继发软组织缺损，缺损范围10．0cm×8．5cm-27．Ocm×17．5cm，采用同侧阔筋膜张肌肌皮瓣带蒂转移修复。结果6例患者皮辩全部成活，且一期愈合；术后随访1年以上，2例出现肿瘤局部复发，修复后外形满意，惠侧肢体功能良好，生活质量明显提高。结论阔筋膜张肌肌皮瓣可以满意修复腹股沟区域恶性体表肿瘤切除后的软组织缺损，有效保护腹股沟区域重要神经血管，是一种简便，安全，有效的治疗方法。     

乳腺癌根治术后部分筋膜法TRAM瓣Ⅰ期乳房再造术临床应用

目的 探讨乳腺癌根治术后部分筋膜法横行腹直肌肌皮瓣（TEAM）乳房再造的手术方法的临床应用。方法对32例乳腺癌根治术患者行部分筋膜法TEAM瓣Ⅰ期乳房再造术。结果32例中,左侧腹直肌蒂者16例,右侧蒂14例,双侧蒂1例。术后所有病例的TEAM瓣均存活,仅1例发生皮瓣边缘坏死。再造乳房与对侧基本对称26例,不对称6例中,4例为对侧乳房中度以上下垂,2例为再造乳房偏小。24例乳房下皱褶与健侧相应,有对称感;6例乳房下极偏低。供区愈合延迟、线头反复排出5例、供区切口旁脂肪液化2例、供区瘢痕增生5例等术后并发症。结论部分筋膜法TEAM瓣再造乳房术式有较好的可操作性,能降低术后腹壁并发症发生率,值得推广应用。     

乳腺癌根治术后部分筋膜法TRAM瓣Ⅰ期乳房再造术临床应用

目的 探讨乳腺癌根治术后部分筋膜法横行腹直肌肌皮瓣(TRAM)乳房再造的手术方法的临床应用.方法 对32例乳腺癌根治术患者行部分筋膜法TRAM瓣Ⅰ期乳房再造术.结果 32例中,左侧腹直肌蒂者16例,右侧蒂14例,双侧蒂1例.术后所有病例的TRAM瓣均存活,仅1例发生皮瓣边缘坏死.再造乳房与对侧基本对称26例,不对称6例中,4例为对侧乳房中度以上下垂,2例为再造乳房偏小.24例乳房下皱褶与健侧相应,有对称感,6例乳房下极偏低.供区愈合延迟、线头反复排出3例、供区切口旁脂肪液化2例、供区瘢痕增生5例等术后并发症.结论 部分筋膜法TRAM瓣再造乳房术式有较好的可操作性,能降低术后腹壁并发症发生事,值得推广应用.     

Breast

<正>209026 Relationship between breast cancer-related lymphoedema and VEGF-C and VGGFR-3/He Jianye (贺建业,DeptGen Surg,Anzhen Hosp,Cap Univ Med Sci, Beijing 100029)…∥Chin J Gen Surg. -2009,24(11). -900～903 Objective To study the distributionand clinicopath-ological characteristics between VEGF-C and peritumoral lymph vessels density (PlND) in breast cancer tissue,and to investigate the development and the mechanism of breast cancer-related lymphoedema(BCRL).     

Breast

Effect of PTEN on the cell growth and P13K/ AKT signal pathway in Tamoxifen-resistant breast cancer cell-line LCC2;Pacilitaxel in association with gemcitabine for anthracycine-resistant advanced breast cancer;Effect of uroacitides on the cell cycle progression and the expression of Cyclin D1 of breast cancer cells ; Relationship between expression of focal adhesion kinase, tumor suppressor gene PTEN-encoding protein and biological behaviors in breast carcinoma;……     

Breast

Significance of multidisplinary surgery in chest wall resection and reconstruction for selected patients with breast cancer, Relation between c-erbBl,c-erbB2,MAPK expression and resistance to tamoxifen in breast cancer cells in vitro, Observation and clinical significance of adjuvant chemotherapy-induced amenorrhea in premenopausal breast cancer patients,Effects of Syk （L） nuclear translocation on breast cancer cell invasion,     

Breast

<正>210378 Expression and significance of stromal CD10 and Ezrin inductal carcinoma in situ and invasive ductal carcinoma of breast/Zhang Rongju(张荣菊,Breast Cancer Research Key Lab Educat Minis Nation,Oncol Key Lab Tianjin,Tianjin Cancer Inst Cancer Hosp,Tianjin Med Univ,Tianjin 300060)…Chin J Exp Surg.-2010,27(6).-705～707     

乳腺癌术后的乳房重建

乳房重建能纠正乳房切除术后的形体畸变和减少负面情绪影响,并且不影响乳腺癌的预后及监测。是否进行重建和重建策略的制订需要个体化,必须考虑患者的形体特点、全身情况、乳腺癌治疗计划和个人喜好。乳房重建大体分为假体重建和自体组织重建。假体重建中使用盐水或硅胶假体同样安全有效;自体组织重建通常使用腹部皮瓣,其中腹部游离皮瓣技术能有效保留腹部肌肉,减少术后腹部并发症。无论是假体重建或自体组织重建都有其优缺点,都需考虑后续放疗的影响。     

Breast

<正>209169 Analysis of the treatment and prognosis of recurrent breast phyllodes tumor/Fang Yi(Dept Abdomin Surg,Oncol Cancer Hosp(Institute),Chin Acad Med Sci,Beijing 100021)…∥Chin J Oncol.-2009,31(1).-72~74Objective To explore the methods of diagnosis,treatment and prognosis for patients with recurrent breast phyllodes tumor.Methods Clinicopathological data of 26 patients with pathologically proven recurrent phyllodes tumors treated from March 1972 to June 2006 were retrospectively analyzed.Results The mean age of the 26 cases was 45 years,and the median follow-up duration was 83 months.The mean overall survival time of this series was 96 months.The primary breast phyllodes tumor was ≥5 cm in 10 cases with a recurrence rate of 60.0%(6/10 cases);<5 cm in 16 cases with a recurrence rate of 31.3% 5/16(cases).After surgical removal of the breast primary tumor,the recurrent tumor was ≥5 cm in 14 cases with a re-recurrence rate of 35.7%(5/14 cases);<5 cm was in 12 cases with a re-recurrence rate of 50.0% (6/12 cases).There was no statistically significant relationship between the(primary and reccurent)tumor size and recurrence rate(P=0.094,P=0.383)or prognosis,(P=0.142,P=0.486).The benign or malignant nature of the breast phyllodes tumor was singificantly correlated with the rate of local re-recurrence(P=0.046)and prognosis(P=0.028).     

Breast

Technique investigation of endoscopic axillary lymph node dissection by liposuction , The study on sentinel lymphatic channels by us. ing methylene blue in breast cancer patients , A study of the combination of vinorelbine and epirubicin as ncoadjuvant chemotherapy regimen in the treatment of locally advanced breast cancer , Epidermal growth factor receptor signaling pathway in tamoxifen-resistant breast cancer cells     

Breast

A retrospective study of 129 cases with immediate breast reconstruction after skin-sparing mastectomy for breast cancer; Expression of imprinted tmnor suppressor gene SLC22A18 in breast cancer; WWOX gene expression and aberrant CpG island hypermethylation of WWOX gene in breast cancer; Are there other axillary lymph node metastasis than positive sentinel lymph nodes containing micrometasrases and isolated tumor cells in patients with breast cancer.     

Breast

<正>209325 Clinical characteristics and survival in the operable breast cancer patients with different molecular subtypes/Zhang Huiming(张慧明,Dept Abdom Surg Oncol,Cancer Hosp(Inst),Chin Acad Med Sci Peking Union Med Col,Beijing 100021)…∥Chin J Oncol.-2009,31(6).-447～451Objective According to the immunohistochemical (IHC)test of ER,PR and HER-2,breast cancer can be divided into 4 different molecular subtypes:Luminal A subtype (ER or PR positive and HER-2 negative),Luminal B subtype (ER or PR positive and HER-2 positive),HER-2 sutype (ER and PR negative,HER-2 positive) and Basal-like subtype (ER,PR and HER-2 negative).This study was to analyze the clinical features of different breast cancer subtypes,and try to find the evidence of combined and individualized treatment for patients with breast cancer.Methods The data of 408 surgically treated breast cancer patients in the Cancer Hospital of Chinese Academy of Medical Sciences from January 1,2002 to December 31,2002 were collected and retrospectively analyzed.The clinicopathological features and recurrence,metastasis as well as survival of these four subtypes were compared.Results Of the 408 cases,Luminal A subtype accounted for 60.8% (248/408),Luminal Bsubtype 7.8% (32/408),HER-2 subtype 12.5%(51/408),and Basal-like subtype 18.9%(77/408).Basal-like subtype had less lymph mode metastases than other subtypes(P<0.05).HER-2 subtypes consisted of less patients aged 45 years or younger than other subtypes(P<0.05).Luminal B subtype contained less advanced cases than other subtypes(P<0.01).By August 2008,the median time of follow-up was 64 months (range,3-79 months).Fifty-eight cases presented local recurrence or metastasis,and 51 of them died of the disease.The 5-year overall survival rates (OS) for patients with Luminal A,Luminal B,Basal-like and HER-2 subtype were 89.83%,86.15%,79.85% and 86.70%,respectively.The 5-year disease-free survival (DFS) rates of the four subtypes were 83.52%,68.88% and 75.83%,respectively.The rate of local recur