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1.
Ahmed Elsammak 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1073-1081
Objectives
To assess the clinical utility of PET-CT in assessment of thoracic involvement in lymphoma patients prior to, during and after finishing treatment and comparing it to contrast enhanced CT (CECT).Patients and methods
PET-CT was performed for 30 patients with lymphoma. Thoracic nodal and extranodal involvement was assessed and compared to contrast enhanced CT.Results
Comparison of CECT and PET-CT in staging and assessment of treatment response reveals significant statistical difference (P?=?.0001 & .04 respectively). CECT shows sensitivity?=?83.3% and specificity?=?75% in evaluation of patients after finishing chemotherapy.Conclusion
PET-CT plays an important role in staging, detection of response to treatment and restaging of lymphoma after finishing chemotherapy. 相似文献2.
Mohamed Ahmed Youssef Mohamed Hasan Elshafey Khaled Mohamed Moghazy Ahmed Abdellateef Elrashedy 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):1083-1092
Objective
The aim of our study was to determine the role of PET-CT in detection of recurrence and metastasis of renal cell carcinoma.Patients and methods
Our study included twenty patients with renal cell carcinoma. All patients were from those attending to radio-diagnosis department in Sharq El Madina Hospital in Alexandria referred for PET/CT study. The following were done for all patients: Careful history taking, clinical examination, ultrasound, enhanced CT and PET/CT.Results
One patient (5%) had positive PET/CT findings at different bone sites with high metabolic activity however these lesions were negative at CECT without any anatomical changes neither lytic nor sclerotic changes could be detected at these bone sites, with sensitivity, specificity and accuracy of PET/CT were 100%, 83% and 95% respectively.Conclusion
PET/CT had advantage to PET and CT alone, making it an appropriate imaging technique in recurrence detection, therapeutic assessment and follow up of patients with renal cell carcinoma. 相似文献3.
Waleed M. Hetta Mostafa Mahmoud Abdelkawi Mohammed H. Abdelbary Marihan A. Nasr 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1049-1055
Purpose
To estimate the accuracy of 18FDG PET/CT in detection of recurrent cancer ovary and to describe the localization of metastases for restaging.Materials and methods
44 female patients with suspicion of ovarian cancer recurrence underwent a PET/CT scan from September 2013 to August 2015.Results
CA-125 levels were elevated in 36 patients, 25 patients presented with alterations on imaging and 18 patients had clinical suspicion of recurrence. Imaging examinations were normal in 10/36 patients with elevated CA-125. 18FDG PET/CT scan was positive in 39/44 patients, and it was negative in 5/44 patients, 4/5 patients continued to be disease free all over the follow-up (true negative), while PET-CT missed recurrence in 1/5 patient (false negative). 1/39 patient was false positive. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of integrated PET/CT were calculated to be 91%, 76%, 96%, 50% and 87%.Conclusion
18FDG PET/CT is an accurate modality for detection of recurrence of ovarian cancer. The accuracy of PET–CT in precise localization of suspicious FDG uptake can lead to proper assessment of disease recurrence, thus allow for restaging of the disease and subsequently optimizing treatment plan for these patients. 相似文献4.
Omar Ahmad Hassanien Hanan Mohamad Saleh Elahwal Manar Hussein Abdelsattar Ekhlas Abdelmonem Ibrahem Nasr Shaban 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):467-473
Purpose
This study aimed at assessment of the role of (PET/CT) in lymphoma after completion of therapy to differentiate post-treatment fibrosis from residual viable tumor and being familiar with the limitations and interpretative pitfalls of PET/CT.Method and materials
The present study was performed on 50 patients(27 males and 23 females).18F-FDG was injected IV one hour before performing the study. Contrast enhanced CT was performed followed by PET.Results
After the end of therapy; PET/CT revealed (38%) of cases showed a partial regression, (28%) of cases showed a progressive disease, (22%) of cases with complete metabolic disease remission, (8%) of cases showed a stationary disease and the remaining (4%) of cases showed mixed response to therapy. CT only agreed with PET/CT in 76% of the cases. Some physiologic uptake often occurs after treatment in (4%) of patients. PET/CT has 100% sensitivity,68.75 % specificity, 87.17% PPV, 100% NPV and 90% accuracy in treatment response of lymphoma; compared to 94.1% sensitivity and 50% specificity, 80% PPV, 80% NPV and 80% accuracy for CECT.Conclusion
PET/CT is a multimodality technique that can accurately monitor the treatment response of lymphoma. It can differentiate residual mass containing viable tumor from post treatment fibrosis. 相似文献5.
Rana A. Attalla Khalid A. Abo Dewan Dina M. Mohammed Abo Almagd A. Ahmed 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(3):737-746
Aim and objectives
To assess the added value of hybrid FDG PET/CT in evaluation of extranodal lymphoma.Methodology
In this study, PET/CT was done for 50 patients with lymphoma; (36 NHL and 14 HD), to evaluate its value over CT alone in detecting extranodal extension.Results
The commonest extranodal sites affected by lymphomatous infiltration are in the following order: lung, bone, bone marrow, spleen, liver, GIT, head and neck, pleura, cutaneous tissue, peritoneum, brain, muscle and pancreas. Regarding the final outcome of the reviewed 77 extranodal lesions: depending on the criteria accepted as standard reference including histopathological results, clinical or radiological follow up, CT defined 66 (85.7%) studies as positive and 11 (14.3%) as negative. While PET/CT defined 71 (92.2%) studies as positive and 6 (7.8%) as negative. Most of the disagreement between both modalities (PET/CT and CT) could be detected among splenic, bone and bone marrow lesions. PET/CT was more sensitive and specific than CT alone in detecting extranodal lesions with sensitivity 97.22% and specificity 80%.Conclusion
PET/CT is superior over CT alone in detecting extranodal extension especially among splenic, bone and bone marrow lesions. 相似文献6.
Manar Hussein Abdel-Sattar Omar Abdelaziz Amr Othman Othman Sherief Mohamed El-Refaei 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):209-215
Objective
Our aim was evaluate the role the PET/CT in the assessment of response to therapy in patients with Non-Hodgkin extra-nodal lymphoma: in particular, a five-point scale (Deauville criteria), which can be employed for early- and late-therapeutic response assessment.Methods
Sixty patients with pathologically confirmed Non-Hodgkin lymphoma (NHL) were enrolled in this prospective study. All patients underwent the following PET/CT examinations: initial PET/CT for staging, interim PET/CT and end of treatment PET/CT. Response assessment was done using new Cheson’s guidelines and five-point scale (Deauville criteria).Results
All patients were evaluated for response to therapy in the early interim, followed by late interim, as well as end treatment assessment for the overall response. We found good concordance of response assessment according to the Deauville criteria classification with International Harmonization Project (IHP) classification. After early interim 48/60 patients had concordant designations (91.7%, 83.3%, 70%, and 33.3%) and 12 patients had discordant designations. After late interim, 56/60 patients had concordant designations (100%, 100%, 80%, and 50%) and four patients had discordant designations. After end of treatment, 54/60 patients had concordant designations (100%, 100% and 71.4%) and six patients has discordant designations.Conclusion
Response assessment according to the Deauville criteria classification showed good concordance with IHP classification. According to our findings, we recommend the use of Deauville criteria in reporting of PET/CT for staging and assessment of response to treatment. 相似文献7.
Sherif Fathy Abdelrahman Nahla Dessoki Elsayed Safaa Ibrahim Saif El-nasr Amr Abd Elfattah Hassan Gadalla 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):461-466
Aim
To evaluate the value of 18F-FDG (positron emission tomography) PET/CT in assessment patients with fever of unknown origin (FUO) and to compare the findings with the results of the other investigations.Patients and methods
This is perspective study in which 27 patients having FUO underwent 18F-FDG-PET/CT examination, using combined PET/CT with contrast enhanced CT. PET/CT findings were compared with the results of biopsies, immunology, or microbiology around the examination period & for the following 3 month duration, during which patients with negative PET/CT findings were followed also.Results
The cause of FUO was explained according to the PET/CT findings and the other investigations in 27 patients: 6 patients with infections, 2 patients with autoimmune inflammation, 3 patients with solid malignancies, 2 patients with sarcoidosis, 6 patients with vasculitis, 5 patients with lymphoproliferative disease & 3 patients with negative findings. PET/CT findings matched the clinical diagnosis in 23 patients, 4 patients showed negative PET/CT findings (2 patients as true negative & the other 2 patients as false negative that were fatherly diagnosed as lymphoma). The examination sensitivity 95%, specificity 67%.Conclusion
18F-FDG PET/CT can be a useful tool for scanning the whole body to suggest the FUO cause. 相似文献8.
Mohamed Fouad Sherif 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):202-208
Aim
To clarify the role of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG) PET/CT in evaluating of bronchioalveolar carcinoma (BAC) recurrence and its ability to differentiate recurrent pure BAC type from recurrent adenocarcinoma containing BAC.Methods
A prospective study included 24 PET/CT scans (22 patients with known BAC; 14 male; 8 female; age range 49:75 Y.). 15 PET/CT scans performed for suspicious of recurrence and 9 scans for post treatment restating.Results
Among 15 cases with suspicious of recurrence; upstaging detected in 9 cases and downstaging in 1 case. In 9 cases underwent PET/CT scans for restaging after treatment; upstaging in one patient. Sensitivity?=?100%, Specificity?=?83.3%, PPV?=?94.1%, NPV?=?100% and accuracy?=?95.4%. Statistically significant difference was found between FDG uptake in recurrent BAC and primary BAC (P?<?0.0001) and between FDG uptake of recurrent pure BAC type and adenocarcinoma containing BAC (P?<?0.0001).Conclusion
In patients with known BAC, PET/CT proved high accuracy in detection of recurrence lesion sites and higher staging accuracy. [18F]FDG PET/CT scan was able to differentiate between recurrent adenocarcinoma containing BAC and recurrent pure BAC type. 相似文献9.
Mohamad F. Sherif Mohammed M. Dawoud Hanan A. Nagy Amr Abdelaziz Ghannam 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):453-460
Aim and objectives
The aim of this study was to assess the role of 18-F FDG-PET/CT in evaluating the peripheral malignant neuronal affection as well as perineural tumoral spread that occurs in patients with cancers.Methodology
50 patients with clinical symptoms of neurological deficits (34 male and 16 female) were included, their ages ranged from 17 to 74 with a mean of 45?years. PET/CT was done for all patients followed by clinical correlation after anti-inflammatory drugs and chemotherapy.Results
Interpretation of the PET/CT studies and clinical correlation revealed 10 true positive cases with malignant neuronal involvement, 4 false positive cases diagnosed clinically as radiotherapy-induced neuropathy, 34 true negative cases and 2 false negative cases with negative PET/CT study and clinical evidence of nerve affection with sensitivity 83.33%, specificity 89.47%, PPV 71.43%, NPV 94.44% and diagnostic accuracy 88%. P-value?>?0.05 was considered statistically significant.Conclusion
PET/CT has a significant role in detection of neuronal involvement by malignancy in cancer patients. Correlation between PET/CT and clinical outcome after chemotherapy improves the accuracy of diagnosis. 相似文献10.
Ahmed Mohamed Wafaie Kareem Mohsen Moussa Eman Mahmoud Ebeid 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):190-195
Objectives
Our aim in this study was to evaluate the efficiency of combined positron emission tomography and computed tomography (PET/CT), in the detection of the primary tumor origin in patients with cancer of unknown primary (CUP).Methods
PET/CT were performed for 52 patients with CUP. These patients presented with metastatic lesions that were proven pathologically, and no primary site was detected by previous investigations.Results
The number of patients with true positive primary tumor sites was 29 (55.8%), 4 patients with false positive results (7.7%), 9 patients with true negative results (17.3%) and 10 patients with false negative results (19.2%). The sensitivity was 74.4%, specificity was 69.2% and accuracy was 73.1%. Our positive predictive value in this study was 87.9% and our negative predictive value for this study was 47.4%.Conclusions
This study showed an advantage of PET/CT in the detection of the site of the primary tumor in patients diagnosed with CUP. 相似文献11.
Tamer W. Kassem Nayef K. Ramadan Sameh A.Z. Hanna 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):492-498
Objective
The aim of this study was to evaluate the role of PET/CT in post-operative assessment and therapeutic follow up of renal cell carcinoma (RCC).Patients and methods
30 patients having pathologically proven RCC underwent PET/CT examination following a preset protocol as baseline study within 1?month post radical nephrectomy. They all had a second PET/CT examination following the same protocol after 6 to 12?months as systematic follow up or to assess the therapeutic response.Results
13 out of 30 patients (43.3%) were performing their regular follow up post radical nephrectomy, 14 cases (46.7%) were under chemotherapy while 3 cases (10%) were receiving combined chemo and radiotherapy.In first setting follow up examination 18F-FDG PET/CT showed 17 true positive (TP), 12 true negative (TN) and 1 false negative (FN) cases while CT showed 11 TP, 11 TN, 7 FN and 1 false positive (FP) cases. 18F-FDG PET/CT vs. CT revealed sensitivity, specificity and accuracy of 94.4% vs. 61.1%, 100% vs. 91.7% and 96.7% vs.73.3% respectively.Conclusion
18F-FDG PET/CT is more accurate than CT in post-operative and therapeutic follow up of renal cell carcinoma. 相似文献12.
Ekhlas Abdelmonem Ibrahem Nasr Shaban 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):1052-1059
Objective
The goal of this study was to highlight the usefulness of fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography (18-F-FDG PET/CT) in soft tissue sarcoma (STS) follow-up to distinguish fibrosis from residual/recurring viable tumours and to detect distant metastases.Methods
Twenty-three patients with confirmed STS underwent PET/CT scans. Bone and visceral sarcomas were excluded. Detailed case-based and statistical analyses were performed. Final diagnosis was confirmed by clinical or radiological examination and/or biopsy.Results
The most common pathological diagnoses were synovial sarcomas (26.1%). PET/CT detected local disease recurrence in 8 cases. True positives for local disease were detected in 6 cases, and false negatives occurred in 2 cases (well-differentiated liposarcoma and low-grade synovial sarcoma). Distant disease was negative in 14/23 cases, and 2 cases were false negatives. Overall, PET/CT had 80% sensitivity, 87.5% specificity, 92.3% PPV, 70% NPV and 82.6% accuracy in STS treatment response follow-up.Conclusion
18-F-FDG PET/CT is a useful imaging modality for STS follow-up and is effective in guiding biopsies. Locoregional and distant metastatic spread can be detected using PET/CT, with some limitations. 相似文献13.
Ekhlas Abdelmonem Ibrahem Nasr Shaban 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1057-1063
Purpose
The aim of this study is to clarify the role of 18-F-FDG PET/CT over CT alone in the detection of primary, recurrent and metastatic disease in renal cancers patients.Patients and methods
In this study; 18-F-PET/CT scans were performed for 25 patients (19 males and 6 females) with renal cancer. A patient-based analysis was performed in a dedicated manner to pick up lesions on CT, PET and PET/CT fused images. Statistical analysis was calculated. A final diagnosis of disease extent was affirmed by clinical, radiologic workup and histopathological correlation.Results
PET/CT has 100% sensitivity, 93% specificity, 100% PPV, 91% NPV and 96% accuracy; compared to 100% sensitivity and 70% specificity, 83% PPV, 100% NPV and 88% accuracy for CT in diagnosis of primary, recurrent and metastatic disease in renal cancer.Conclusion
Incorporated 18-F FDG PET/CT is a very versatile and accurate imaging technique for renal cancers. It significantly improves the accuracy and predictive values over CT alone for detection of primary, recurrent and metastatic disease in renal cancer thus change the treatment decision. 相似文献14.
Ekhlas Abdelmonem Ibrahem Nasr Shaban 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):196-201
Aims
The point of this research is to investigate the potential role of (18-F-FDG/PET) in the identification of hepatocellular carcinoma (HCC) and its metastases.Patients and method
The present study was performed on 22 patients (15 newly diagnosed, 7 previously treated).18F-FDG was injected IV 1?h before the scan. Non-contrast-enhanced CT was performed trailed by PET in the same session. PET/CT scans were performed on (Philips Gemini-NM system). The whole study took around 20–30?min.Results
PET/CT revealed increased local liver tumor 18-F-FDG uptake in 13/17 of those patients (6 solitary uptakes and 7 multi-nodular uptakes). Primary tumor SUV max. extended from 3 to 11 (mean 6.1) and liver tumor background ratio (TBR) varied from 0.4 to 3 (mean 2.05). 18-F-FDG PET/CT showed extrahepatic metastasis in 6 newly diagnosed patients. It also showed local tumor recurrence in 4 treated patients; 3 of them with no metastasis and 1 previously treated patient had local recurrence and distant metastasis. PET/CT has 76.5% sensitivity, 60% specificity, 86.7% PPV, 42.9% NPV and 59% accuracy in defining HCC and its extrahepatic metastases.Conclusion
This study affirms the achievability of 18-F-FDG PET/CT for identification of primary HCC and its extrahepatic metastases. 相似文献15.
Adel Ali Ramadan Mohamed Samir Shaaban Alaa Magdy El-Sayed 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1097-1104
Background
Urinary tract injuries occur in 3–10% of abdominal trauma. Early recognition and diagnosis of ruptured bladder is essential to lower this mortality rate. CT is the method of choice for the evaluation of patients with blunt or penetrating abdominal and/or pelvic trauma. Imaging in patients with suspected bladder injury with CT cystography may be performed using either an intravenous or retrograde technique.Aim of work
The aim was to evaluate the role of CT in diagnosing traumatic urinary bladder injuries.Materials and methods
The study was carried out on 32 patients with suspected traumatic urinary bladder injury. All patients were subjected to contrast-enhanced CT study and classified according to Sandler et al. classification of urinary bladder injuries.Results
All patients were classified according to the type of the encountered urinary bladder trauma. Type I injury was diagnosed in 3.1% of patients, type II in 18.8%, type III in 3.1%, type IVa in 12.5%, type IVb in 43.7% and type V in 18.8%. 21.8% of patients were managed conservatively, while 78.2% of patients underwent surgical repair.Conclusion
CECT well demonstrated traumatic urinary bladder injuries. 相似文献16.
Susan Adil Ali Maged Abd Elgalil Hamed 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(3):671-676
Purpose
to assess the efficacy of FDG PET/CT in detecting unexpected additional primary malignant neoplasms in patients being evaluated by PET/CT for known malignancies compared to conventional staging work-up (CSW).Patients and methods
Of 1889 patients referred for whole-body FDG PET/CT in the period from February 2015 to May 2016, only 273 were included in this prospective study. Patients included are those with histopathologicaly proven primary malignancy and sent for initial tumor staging before treatment within 1 month of CSW that was performed for the patients according to the site and cell type of the primary tumor. Histopathologic examination was performed for lesions indicating additional primary cancer detected by either PET/CT or CSW.Results
In 13 out of 273 patients included in the study (4.76%) only were proved to have additional primary cancer, the PPV of PET/CT for detecting an additional primary cancer was 56.5%. Also, it showed high sensitivity of 89.2%, which was significantly higher than 23% from the CSW (P < 0.005).Conclusion
PET/CT is more accurate than CSW for detecting additional primary cancer with a higher sensitivity and positive predictive value, which consequently affect further management. 相似文献17.
Tamer W. Kassem 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(2):537-545
Objective
The aim of this study was to compare the diagnostic performance of positron emission tomography/computed tomography (PET/CT) scan and CT scan in follow up of proven gynecological malignancies omental deposits in first setting follow up after treatment.Patients and methods
60 female patients having proven omental deposits from gynecological malignancies underwent PET/CT examination following a preset protocol as baseline study. 34 cases of them had a second PET/CT examination following same protocol after 5–11 months considered as first setting follow up study aiming to assess therapeutic response.Results
Out of 34 cases 2 cases (6%) showed only newly developed lesions, 8 cases (23.5%) showed progression, 8 cases (23.5%) showed mixed response and 16 cases (47%) showed regression or complete resolution. In first setting follow up examination 18F-FDG PET/CT showed 31 TP, 2 TN and 1 FN cases while CT showed 29 TP, 2 TN, 2 FN and 1 FP cases. 18F-FDG PET/CT vs. CT revealed sensitivity, specificity and accuracy of 96.88% vs. 93.55%, 100% vs. 66.67% and 97.06% vs. 91.18% respectively.Conclusion
18F-FDG PET/CT is more accurate than CT in assessment of therapeutic response of proven gynecological malignancies omental deposits in first setting follow up. 相似文献18.
Rania Refaat Hesham Elghazaly 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1065-1071
Background
Metastatic adrenal disease can occur in a wide diversity of malignancies. Distinguishing benign from metastatic adrenal masses in oncologic patients is vital.Objective
To appraise the 18F-FDG PET/CT performance for distinguishing benign from metastatic adrenal masses.Material and methods
In the current prospective study, 21 patients with proven extra-adrenal primary malignancy, having adrenal masses?≥10?mm on the axial CT images of their PET/CT examinations, were enrolled. Positive PET findings for malignancy were considered if the mass showed FDG uptake equivalent to or more prominent than the FDG liver uptake. Alternatively, negative PET findings for malignancy were considered if the mass showed FDG uptake not as much of the FDG liver uptake. Afterward, the obtained results were correlated with serial imaging follow-up or histopathological diagnosis by surgery or percutaneous biopsy as the diagnostic standard of reference.Results
An overall number of 24 adrenal masses was diagnosed. Positive PET/CT results were found in 14 adrenal masses. All were finally considered to be metastases by serial imaging follow-up (n?=?8) and histopathological analysis by surgery (n?=?1) and percutaneous biopsy (n?=?5). Accordingly, no false positive result was obtained. Negative PET/CT results were observed in 10 adrenal masses, 9 of them were finally confirmed to be benign by serial imaging follow-up. The remaining mass was finally confirmed to be metastasis by percutaneous biopsy and hence, it represented the false negative result. 93% sensitivity, 100% specificity and 96% accuracy for identifying adrenal metastases were obtained.Conclusion
18F-FDG PET/CT is a precise, non invasive modality for distinguishing benign from metastatic adrenal masses in oncologic patients. 相似文献19.
Hala Yehia Yousef Haitham A. Dawood Nesreen Mohey 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):927-930
Aim of the work
To evaluate the role of diffusion weighted imaging (DWI) in the planning for CT guided biopsy of lung and mediastinal lesions.Subjects and methods
This cross sectional study included 23 patients with mean age was 42.7?years came with clinical and imaging suspicion of chest malignancy, referred for CT guided transthoracic biopsy. DWI and apparent diffusion coefficient (ADC) were evaluated for all patients to choose the area of maximum restriction.Results
The study showed that with DWI guidance; all the biopsy specimens were diagnostic and provide adequate material for analysis.Conclusion
DWI and measurement of ADC value has a very helpful role in the pre-procedural planning of transthoracic biopsies. 相似文献20.
Enas A. Azab 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):948-952