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选择蛋白(selectin)是细胞黏附分子中的一个家族。包括3个成员:L-选择蛋白、P-选择蛋白和E-选择蛋白。选择蛋白分子具有糖链结合活性。能通过其分子中的凝集素样结构域与糖蛋白、糖脂或蛋白多糖上的糖配体(1igand)特异结合。在炎症发生时介导白细胞与血管内皮问的起始黏附.在淋巴组织中介导淋巴细胞的归巢.乃至在肿瘤的转移过程中发挥作用。另外。选择蛋白及其配体也可作为信号分子促进肿瘤的转移。因此,通过抑制选择蛋白与其配体的相互作用,或阻断选择蛋白的表达。可以作为防治肿瘤转移的一条重要思路。本研究就选择蛋白及其配体的分子结构、功能特点与肿瘤转移的相关性作一综述。 相似文献
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组织损伤和炎症反应的必要步骤是白细胞跨内皮迁移至血管壁间隙,白细胞与血管内皮的黏附是此过程早期重要的一步。白细胞与血管内皮黏附分子的相互作用是组织损伤和炎症反应过程的重要分子基础。炎症的重要特征就是白细胞黏附。炎症时血管内皮细胞被激活而出现选择素分子,与白细胞膜上的配体反应,使白细胞在血管内皮上滚动。炎症性物质激活白细胞后,其表面的黏附分子受体即为激活型,血管 相似文献
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肿瘤的转移是多因素参与的复杂过程,包括肿瘤细胞侵袭周围组织、从原发灶脱离进入循环系统、逃避免疫监视以及在远隔器官形成与原发瘤同样类型的转移灶。在此过程中细胞粘附分子发挥着重要作用,粘附分子是由细胞产生,存在于细胞表面,介导细胞与细胞间或细胞与基质间相互接触和结合的一类分子。选择素是细胞粘附分子中的一个家族,包括P-选择素、L-选择素和E-选择素,主要参与细胞间选择性识别、粘附,并在肿瘤转移、炎症反应、血栓形成及其他疾病中起重要作用[1]。现就P-选择素的结构、生理功能及其与肿瘤转移关系的相关研究作一综述。1 P-选… 相似文献
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晚期糖基化终末产物受体及其抑制剂的研究进展 总被引:1,自引:0,他引:1
晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)是一种多配体的膜受体,与配体结合后可启动多条信号通路,引起细胞内氧化应激和炎症反应等,导致细胞功能紊乱。RAGE在糖尿病并发症、炎症、阿尔采末病和肿瘤等疾病的发生和发展中起重要作用。应用可溶性RAGE(sRAGE)、抗RAGE抗体或干扰RAGE与配体结合的抑制剂阻断RAGE的活化,是防治上述疾病的新策略。该文对RAGE配体与疾病的关系和RAGE-配体激活的信号通路进行阐述,并对近年来关于RAGE抑制剂的研究进展进行总结。 相似文献
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骨保护素(OPG)是肿瘤坏死因子(TNF)超家族的一种可溶性分泌型糖蛋白,与核因子 κB 受体活化因子配 体(RANKL)、核因子 κB 受体活化因子(RANK)以及肿瘤坏死因子相关凋亡诱导配体(TRAIL)共同组成骨保护素系 统。大量临床及实验研究证实骨保护素系统参与内皮功能调节、炎症反应、氧化应激及细胞凋亡等生理过程,其有 望成为冠心病发生、发展、严重程度及其远期预后的生物学标志物,为冠心病的早期诊断及治疗提供新的可行途径。 本文就骨保护素系统在冠心病发生、发展中的生物学效应、作用机制及未来的临床应用前景进行综述。 相似文献
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慢性阻塞性肺疾病 (COPD)是一种气道炎症性疾病 ,系白细胞与气管壁相互作用的结果 ,炎症过程受细胞因子的调节。 E-选择素 (E- selectin,E- SL T)是介导内皮细胞与白细胞等黏附作用的重要分子基础。为了探讨可溶性 E-选择素 (s E- SL T)在 COPD的临床意义 ,我们对比分析了2 0 0 相似文献
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The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties. 相似文献
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Larks and owls and health, wealth, and wisdom 总被引:1,自引:0,他引:1
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《Journal of addictive diseases》2013,32(3):73-87
Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder. 相似文献
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Z J Witczak 《IDrugs : the investigational drugs journal》1998,1(1):30-31
The American Chemical Society Symposium "Glucosidase and fucosidase inhibitors" took place on 1 April 1998 and was organized by Professors Zbigniew J Witczak (UConn, School of Pharmacy, CT, USA), Kuniaki Tatsuta (Waseda University, Tokyo, Japan) and Waldemar Priebe, MD (Anderson Cancer Center, University of Texas, USA). Professor Witczak provided introductory remarks including the status of existing glucosidase inhibitors, and chaired the morning session, which consisted of six lectures. The symposium was well received, and was particularly attractive for those interested in networking, as attendance was about sixty. In addition, some participants and attendees presented posters on the subject during the regular poster session organized by the Division of Carbohydrate Chemistry. 相似文献