组合式可变应力接骨板固定对实验性山羊股骨骨折愈合影响的研究

摘要：目的 探讨组合式可变应力接骨板固定对实验性山羊股骨骨折愈合的影响。方法 健康成年山羊30只,普通环境下饲养,制作山羊右下肢股骨骨折动物模型,随机分为组合式可变应力接骨板组（实验组）、普通直型接骨 板组（对照组）,每组15只。分别于手术后4周、8周、12周处死山羊,取股骨断端组织进行组织病理学观察。测量2组钢板下面骨皮质厚度及髓腔直径的变化,评估钢板的应力遮挡效应;测量2组骨折断端骨痂中骨小梁密度,评估骨折愈合情况;通过2组的破骨细胞计数,评估骨折愈合过程中骨痂改建情况。结果 4周时,2组的骨皮质厚度与髓腔直径比较差异无统计学意义,实验组4周、8周、12周骨皮质及髓腔直径无明显变化。对照组在治疗8周、12周骨髓腔直径大于实验组,而骨皮质厚度值低于实验组,提示对照组钢板存在应力遮挡效应,实验组钢板未见明显的应力遮挡效应造成的骨质厚度丢失。与对照组相比,实验组4周、8周的骨痂中骨小梁密度较高,差异有统计学意义,实验组较对照组成骨快;与对照组相比,实验组8周的骨小梁周边的破骨细胞计数增多,12周时实验组破骨细胞计数明显低于对照组,差异均有统计学意义。实验组的骨痂改建出现较早,12周时实验组骨痂改建基本结束。结论 组合式可变应力接骨板可促进骨痂的生成,加快骨痂的改建,促进骨折愈合。     

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with coronary heart disease

The aim of this paper was to investigate the change of serum leptin and its relationship with platelet membrane glycoprotein Ib (GP Ib) in patients with coronary heart disease (CHD). The enrolled included 50 patients with CHD (CHD group) and 30 patients without CHD (control group) who were diagnosed by coronary angiography. The positive percentage and the average fluorescence intensity of platelet membrane GP Ib were detected by full-blood flow cytometry. Serum leptin was detected by enzyme linked immunosorbent assay. The positive percentage and the average fluorescence intensity of platelet membrane GP Ib in the CHD group were significantly lower than those in the control group (P < 0.05). After correcting the differences of systolic blood pressure, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting glucose, PPBS, fasting insulin and quantitative insulin sensitive index, serum leptin level in the CHD group was significantly higher than that in the control group (P < 0.05). Single factor correlative analysis revealed that serum leptin in CHD patients was negatively correlated with the average fluorescence intensity of platelet membrane GP Ib (P < 0.05). Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independently negatively correlated with the average fluorescence intensity of platelet membrane GP Ib (P < 0.05). Logistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (P < 0.05). Hyperleptinemia was verified in CHD patients. The increase of serum leptin could affect blood platelet activation. Hyperleptinemia may play an important role in the pathogenesis of CHD. __________ Translated from Tianjin Medical Journal, 2007, 35(2): 81–83 [译自: 天津医药]     

灵宝护心丹治疗心动过缓型心律失常的疗效观察

目的 评价灵宝护心丹治疗心动过缓型心律失常的有效性和安全性。方法 选取2020年11月—2022年12月上海市第六人民医院收治的窦性心动过缓患者100例,随机分为对照组（50例）和治疗组（50例）。对照组患者口服二羟丙茶碱片,100 mg/次,3次/d;治疗组患者口服灵宝护心丹,4丸/次,3次/d。两组患者治疗12周。观察两组患者临床疗效,比较治疗前后两组患者中医证候评分,动态心电图指标平均心率、总心率和最慢心率,及不良反应情况。结果 治疗后,对照组和治疗组总有效率分别为91.11%、97.87%,两组比较差异具有统计学意义（P<0.05）。治疗第4、8、12周后,两组中医症候评分均显著降低（P<0.05）;治疗组患者中医证候评分均低于同期对照组（P<0.05）。治疗第4、8、12周后,两组平均心率、总心率和最慢心率均显著提高（P<0.05）;治疗8、12周后,治疗组平均心率、总心率和最慢心率显著高于同期对照组（P<0.05）。治疗组不良反应总发生率（2.13%）显著低于对照组（11.11%,P<0.05）。结论 灵宝护心丹对心动过缓型心律失常患者具...     

氨磺必利联合奥氮平改善精神分裂症患者认知功能的疗效观察

目的观察氨磺必利联合奥氮平改善精神分裂症患者认知功能的临床疗效。方法将2013年10月—2015年10月在上海市宝山区精神卫生中心住院的精神分裂症患者61例随机分为对照组(31例)和治疗组(30例),对照组口服奥氮平片,起始剂量10 mg/d,依患者病情及症状,1周内增加至15~20 mg/d,平均给药剂量(18.75±1.13)mg/d;治疗组在对照组基础上口服氨磺必利片,起始剂量0.1 g/d,根据具体病情,1周内增加至0.1~0.3 g/d,平均给药剂量(0.26±0.06)g/d。两组均连续治疗8周。比较两组治疗前后的阳性症状与阴性症状量表(PANSS)、韦氏记忆量表(WMS)、威斯康星卡片分类测验(WCST)评定。结果治疗4周后,两组的阳性症状评分、一般精神病理症状评分和总分较治疗前均显著改善(P0.05、0.01);且治疗组阴性症状分值和总分改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗8周后,两组的阳性症状评分、阴性症状评分、一般精神病理症状评分和总分均较治疗前显著改善,同组治疗前后差异有统计学意义(P0.05)。两组治疗后比较差异无统计学意义。治疗8周后,两组的正确数、完成分类数显著升高,随机错误数显著降低,两组比较差异具有统计学意义(P0.05);且治疗组的WCST评分改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗8周后,两组的WMS评分差异无统计学意义。结论氨磺必利联合奥氮平能够显著改善精神分裂症患者的认知功能,具有一定的临床推广应用价值。     

活血止痛软胶囊联合骨肽治疗膝骨性关节炎的临床研究

目的探讨活血止痛胶囊联合骨肽注射液治疗膝骨性关节炎的临床疗效。方法选取2015年1月—2016年1月在内江市第一人民医院骨科接受治疗的膝骨性关节炎患者78例,根据治疗方案的不同分为对照组(39例)和治疗组(39例),对照组关节腔注射骨肽注射液,30 mg/次,1次/周;治疗组在此基础上口服活血止痛胶囊,6粒/次,2次/d。两组患者均连续治疗4周。比较两组患者治疗前后总有效率。观察两组治疗前后Lequesne指数和视觉模拟分数变化情况,同时检测两组治疗前后血清IL-1β、TNF-α、MMP-9和NO水平改变。结果治疗后,对照组和治疗组总有效率分别为79.49%和94.87%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者Lequesne指数和视觉模拟分数均明显降低(P0.05),但治疗组降低的更明显,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血清IL-1β、TNF-α、MMP-9和NO水平均明显降低(P0.05),但治疗组降低的更明显,两组比较差异具有统计学意义(P0.05)。结论活血止痛胶囊联合骨肽注射液治疗膝骨性关节炎疗效显著,可明显改善患者膝关节功能和减轻关节疼痛及降低血清炎性因子水平,具有一定的临床推广应用价值。     

跌打七厘片对小鼠骨折愈合的影响

目的 研究跌打七厘片对小鼠骨折愈合的影响。方法 将100只C57BL/6小鼠随机分为空白对照组20只、假手术组20只、造模组60只。造模组制备股骨骨折模型,造模后再随机分为模型组和跌打七厘片低、高剂量（405.5、1 621.8 mg·kg^-1）组,每组20只。每天1次,连续ig给药28 d。每周通过骨组织形态学和苏木精伊红（HE）染色观察骨痂形态改变、微计算机断层扫描分析（Micro-CT）检测愈合骨的骨体积分数（BV/TV）,生物力学三点弯曲实验检测愈合骨的最大负载,全自动生化仪检测小鼠血清钙（Ca）、磷（P）、碱性磷酸酶（ALP）的水平。结果 HE染色、Micro-CT结果显示,造模后第14天,与模型组比较,跌打七厘片组有较多的软骨细胞浸润,钙化编织骨骨量多,新生骨痂骨量明显较多;造模后第28天,模型组骨折断端仍有未连接,而跌打七厘片组的骨折断端均已连接,钙化编织骨转化为层状骨,逐渐恢复骨的基本形态,有更多的新生骨痂及钙化程度,高剂量组骨折断端被钙化新生骨完全填充并与周围骨皮质相联合。造模后第14天,跌打七厘片高剂量组的BV/TV、最大负载显著高于模型组（P<0.05）;造模后第28天,低、高剂量组的BV/TV、最大负载均显著高于模型组（P<0.05）。造模后小鼠血清Ca水平各组之间没有明显差异。造模后小鼠血清P、ALP水平呈上升趋势,并在21 d达到高峰,与模型组比较,第14、21天跌打七厘片低剂量组和第7、14、21、28天的高剂量组血清P水平显著升高（P<0.05）,第14、21、28天的高剂量组血清ALP水平显著升高（P<0.05）。结论 跌打七厘片可以提高成骨活性及钙盐沉积,以增加骨痂水平增强骨强度,有利于小鼠骨折愈合。     

一氧化氮供体型与传统型NSAID对小鼠骨折骨愈合的影响分析

目的对比分析骨科术后氟比洛芬酯和NO-氟比洛芬酯对小鼠骨折损伤模型的干预结果,探讨一氧化氮供体型非甾体抗炎药（NSAID）对骨愈合的治疗作用。方法 4月龄,体重相近,雄性BALB/c小鼠45只分成3组进行腓骨骨折造模。造模后,A、B两组分别注射氟比洛芬酯和NO-氟比洛芬酯50mg/kg,C组注射等量的0.9%氯化钠溶液。术后2周、4周X线观察,术后4周测量骨折处骨密度、组织学观察。结果术后X线示,2周时各组小鼠骨折处两端可见骨痂生长,骨折线模糊,其中B组骨痂范围较其余两组较大。4周时骨痂完全包裹骨折区域,A组和B组小鼠骨折线完全消失,C组有4只小鼠骨折线仍可见;术后应用一氧化氮型非甾体药物组的小鼠骨密度明显高于其余两组,差别具有统计学意义（P〈0.01）;小鼠术后4周处死,患肢下肢整体观察中得到,B组小鼠的骨骼肌比A组和C组略有肥大。结论应用一氧化氮供体型NSAID在减少小鼠不良反应的同时能够在一定程度上促进骨折愈合。     

麦角甾苷促进大鼠骨折愈合及对骨形态发生蛋白/Runx2通路的影响

目的探讨麦角甾苷促进大鼠骨折愈合及对骨形态发生蛋白(BMP)/Runx2通路的影响。方法将72只雄性SD大鼠随机分为对照组、模型组、阳性组和麦角甾苷低、中、高剂量组,除对照组外,其余各组均制备大鼠胫骨骨折模型,造模后阳性组腹腔注射复方骨肽(5 mg/kg),麦角甾苷低、中、高剂量组腹腔注射麦角甾苷(20,40,80 mg/kg),对照组和模型组腹腔注射等量生理盐水。术后4,8周在各组大鼠中随机取6只进行X线摄片和骨生物力学检测,测定血清中碱性磷酸酶(ALP)和骨Gla蛋白(BGP)含量及骨痂组织中BMP、骨形态发生蛋白受体瘤基因(BMPRIB)、骨形态发生蛋白受体(BMPR)Ⅱ和Runx2 m RNA表达水平。结果给药4周后,阳性药组和麦角甾苷中、高剂量组大鼠骨折线完全消失,骨折应力和骨折碎力较模型组均明显上升,模型组骨折线模糊。给药8周后,阳性组和麦角甾苷各剂量组骨折完全愈合,骨折应力和骨折碎力恢复正常;模型组骨折线消失,骨痂减少。给药4周后,阳性组和麦角甾苷各剂量组ALP和BGP含量,BMP,BMPRIB,BMPRⅡ和Runx2 m RNA相对表达水平较模型组明显上升(P <0. 05);给药8周后,模型组、阳性组和麦角甾苷各剂量组ALP和BGP含量,BMP,BMPRIB,BMPRⅡ和Runx2 m RNA相对表达水平较对照组均明显下降(P <0. 05),但均仍明显高于模型组(P <0. 05);各麦角甾苷剂量组反应呈剂量依赖性。结论麦角甾苷具有明显促进骨折愈合作用,其机制可能与激活BMP/Runx2通路有关。     

阿仑膦酸钠对骨折愈合的影响

目的 研究阿仑膦酸钠对骨折愈合的影响。方法 48只日本大耳白兔随机分为对照组和实验组各24只。48只大白兔建立单侧尺桡骨骨折模型并夹板固定，实验组犬白兔给予0．05％阿仑膦酸钠溶液2mL。于实验第2，3，4和6周分别取实验组和对照组大白兔各4只，取骨折标本分别摄X线片、测定骨密度及行常规病理切片检查，观察骨痂生长情况、骨痂的骨密度的区别及常规病理切片的变化。结果实验组与对照组比较骨折端骨痂的骨密度降低，差异有显著性（P〈0．05），骨痂塑形减慢，骨折线消失延迟。结论 阿仑膦酸钠对骨折愈合有抑制作用。     

The CD147/MMP‐2 signaling pathway may regulate early stage cardiac remodelling in spontaneously hypertensive rats

Previous studies have reported that decreased matrix metalloproteinase‐2 (MMP‐2) is associated with early stage (age 8–16 weeks) ventricular remodelling in spontaneously hypertensive rats (SHR). We hypothesized that inhibited CD147/MMP‐2 signalling might down‐regulate MMP‐2 expression and augment remodelling in spontaneously hypertensive rats. Twenty‐nine male SHR (8 weeks) were randomly assigned to SHR, CD147, and CD147+DOX groups. The control group included eight age‐matched WKY rats. CD147 and CD147+DOX groups received recombinant human CD147 (600 ng/kg in 1.5 mL saline, weekly). The SHR and WKY groups received the vehicle. The CD147+DOX group also received doxycycline, an inhibitor of MMPs (daily, 30 mg/kg in 1.5 mL saline, iG). On day 56 echocardiography and left ventricular mass index (LVWI) measurements were collected and histological sections were stained for cell and collagen content. Myocardium MMP‐2, TIMP‐1, CD147, and collagens types I and III were estimated by western blot. CD147 and the ratio of MMP‐2/TIMP‐1 were lower in SHR than WKY rats (P<.05). Myocyte hypertrophy, partial fibre breaks, plasmolysis, necrosis and collagen content (collagen volume fraction [CVF], I and III) in SHR were above control levels (P<.05). CD147 rats showed CD147, MMP‐2 and MMP‐2/TIMP‐1 were increased (P<.05), CVF, LVWI, and collagen I and III were decreased (P<.05) and myocyte morphology was improved. CD147 levels did not differ between CD147+DOX and CD147 groups, CVF, collagens type I and III and partial fiber breaks were more abundant in CD147+DOX (P<.05). In summary, an inhibited CD147/MMP‐2 pathway was associated with early stage cardiac remodelling, and CD147 supplementation may attenuate this response.     

载药磷酸钙骨水泥促进骨质疏松大鼠骨折愈合的研究

目的研究磷酸钙骨水泥(Calcium Phosphate Cement, CPC)与重组人骨形态发生蛋白-2(Recombinant Human Bone Morphogenetic Protein-2, rhBMP-2)复合材料对骨质疏松大鼠骨折愈合的影响.方法取4月龄雌性大鼠60只,双侧卵巢切除后形成骨质疏松动物模型.然后制作右侧股骨远端松质骨骨折,将上述动物随机分成3组,每组20只:①克氏针组:从髁间窝穿入直径1 mm克氏针固定;②CPC组:将CPC从12号针头注入骨髓腔,手法固定至骨水泥凝固;③CPC-BMP组:将CPC与rhBMP-2复合材料用12号针头注入骨髓腔,手法固定至骨水泥凝固.术后第 2、4、6、8 wk,3组各取5只动物处死,行碱性磷酸酶测定,骨痂直径测量.结果在上述4个时间点,与克氏针组和CPC组比较,CPC-BMP组的碱性磷酸酶值、骨痂直径,均高于上述两组,差异具有显著性意义.结论于骨折部位局部髓腔内注射CPC-BMP复合材料,可以促进骨质疏松大鼠骨折的愈合.     

鲑鱼降钙素联合碳酸钙D3片治疗绝经妇女桡骨远端骨折的疗效观察

目的评估鲑鱼降钙素鼻喷剂联合碳酸钙D3片治疗绝经妇女桡骨远端骨折的临床疗效。方法选取2012年12月—2014年12月在陕西省核工业二一五医院骨科接受掌侧钢板内固定的桡骨远端骨折绝经妇女59例,所有患者随机分为对照组(26例)和治疗组(33例)。对照组口服碳酸钙D3片,1片/次,1次/d。治疗组在对照组治疗基础上给予鲑鱼降钙素鼻喷剂,200 IU/d。两组均连续治疗3个月,并随访6个月。比较视觉模拟评分(VAS)、骨密度值、腕关节功能。结果治疗3 d、1个月、3个月、随访6个月,两组患者的VAS评分均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗1、3个月后,治疗组患者的VAS评分改善程度明显优于同期对照组,两组比较差异有统计学意义(P0.05)。治疗3个月、随访6个月,治疗组的骨密度值均较治疗前显著增高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组患者的骨密度值改善程度明显优于同期对照组,两组比较差异具有统计学意义(P0.05)。而对照组的几乎没有变化。治疗后,对照组和治疗组患者腕关节功能评分优良率分别为61.5%、87.9%,两组优良率比较差异具有统计学意义(P0.01)。结论鲑鱼降钙素联合碳酸钙D3片治疗绝经妇女桡骨远端骨折具有较好的疗效,能够增加骨密度,促进腕关节功能恢复,具有一定的临床推广应用价值。     

轻中度创伤性脑损伤患者记忆受损与血清Tau蛋白的关系

目的 探讨轻中度创伤性脑损伤（TBI）患者记忆受损与血清Tau蛋白的关系。方法 选取安徽医科大学第一附属医院2016年6月至2017年6月收治的TBI患者60例为研究对象,依据患者入院时格拉斯哥昏迷评分（GCS）分为轻度TBI组（30例）与中度TBI组（30例）。另选取20名志愿者为健康对照组。在入院时、伤后第72小时、2周、6周和3个月时,采用ELISA法检测受试对象的血清Tau蛋白浓度,同时运用神经心理学测试量表对受试对象记忆认知特点进行评估。结果 入院时,TBI组患者血清Tau蛋白浓度为（574.3±270.1） pg/mL、健康对照组为（79.9±36.3） pg/mL,两组差异有统计学意义（t=13.807,P<0.05）。伤后第72小时,中度TBI组患者血清Tau蛋白浓度为（1 051.2±333.9） pg/mL、轻度TBI组为（805.2±400.2） pg/mL,两组差异有统计学意义（t=2.585,P=0.012）。伤后3个月,TBI组患者血清Tau蛋白浓度为（100.8±35.6） pg/mL,与健康对照组相比,差异无统计学意义（t=2.001,P=0.051）。TBI组患者记忆受损明显,且伤后第72小时患者记忆认知水平处于最低,至伤后6周,TBI组患者记忆受损逐渐恢复至健康对照组水平,两组差异无统计学意义（P>0.05）。伤后第72小时和伤后2周,TBI组患者血清Tau蛋白浓度与神经心理学测试评分呈负相关（P<0.05）。结论 早期检测TBI患者的血清Tau蛋白浓度不仅可以评估患者的受伤程度,而且能够有效地反映患者记忆受损的程度。     

Low‐intensity endurance exercise plus nandrolone decanoate modulates cardiac adiponectin and its receptors

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弹性髓内钉对儿童前臂骨折临床疗效及并发症的影响

目的 探究弹性髓内钉（ESIN）对儿童前臂骨折手术效果及并发症的影响。方法 选取2015年12月至2018年12月安徽省太和县中医院行ESIN治疗的40例患儿为ESIN治疗组,选择同期行钢板手术治疗的40例患儿为钢板治疗组。术中记录两组患儿手术切口长度、术中出血量情况;术后4周内观察患儿骨折部位骨痂形成占比情况、骨折愈合时间、关节功能评价、术后并发症发生情况以及临床疗效。结果 ESIN治疗组患儿术中切口长度及出血量均低于钢板治疗组（P<0.05）;ESIN治疗组骨折4周内骨痂形成占比情况、骨折愈合时间、关节功能与治疗总有效率均优于钢板治疗组（P<0.05）;ESIN治疗组患儿术后并发症发生率较钢板治疗组高,但两组差异无统计学意义（P>0.05）。结论 ESIN治疗儿童前臂骨折具有创伤小、愈合时间短、术后关节功能评价较好等特点,但该法可能出现的术后并发症需予以重视。     

Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice treated by percutaneous transhepatic biliary external and internal drainage

The aim of this article was to study the influence of immunity function of advanced malignant obstructive jaundice (MOJ) treated by percutaneous transhepatic biliary external and internal drainage. Ninety-six cases of MOJ were divided into two groups according to the different ways of biliary drainage. Fifty-two external drainage tubes were placed in 41 cases of percutaneous transhepatic biliary external drainage group and 66 metal stents were placed in 55 cases of percutaneous transhepatic biliary internal drainage group. Liver function, serum TNF-α and cellular function were examined one day before operation and one week after operation and liver function was re-examined two weeks after operation, in order to observe the change and analyze the association among them and compare with the control group. All patients’ conditions were improved after operation. In the percutaneous transhepatic biliary external and internal drainage groups, the total level of bilirubin decreased from (343.54±105.56) μmol/L and (321.19±110.50) μmol/L to (290.56±103.46) μmol/L and (283.72±104.95) μmol/L after operation respectively, which were significantly lower than pre-operation (P<0.05), but there was no significant difference between the two groups (P>0.05). Serum alanine aminotransferase (ALT) of all patients one week after operation was significantly lower than that before operation. TNF-α in percutaneous transhepatic biliary external and internal groups decreased from (108.58±19.95) pg/mL, (109.98±16.24) pg/mL of pre-operation to (104.32±19.59) pg/mL, (83.92±13.43) pg/mL of post-operation respectively, there was notable improvement (P<0.01) in internal drainage group after operation. Patients’ serum CD4, CD3 and CD4/CD8 were notably increased, but CD8 was notably decreased (P<0.05). There was no difference in external drainage group (P>0.05). There was a significant difference between the two groups. Serum TNF-α and ALT had positive correlation. Percutaneous transhepatic biliary internal or external drainage was an effective and important method to treat MOJ. Patients’ immune function was weak when they suffered MOJ, but body’s cellular immune function can be notably improved after internal biliary drainage.     

接骨七厘片联合鹿瓜多肽治疗四肢骨折的疗效观察

目的探讨接骨七厘片联合鹿瓜多肽治疗四肢骨折的临床有效性与安全性。方法选取2012年6月—2015年6月天津市第五中心医院收治的四肢骨折患者82例,根据用药方案不同分成对照组和治疗组,每组各41例。对照组患者静脉滴注注射用鹿瓜多肽,24 mg加入生理盐水,1次/d;治疗组患者在对照组基础上口服接骨七厘片,5片/次,2次/d。两组患者均连续治疗8周。观察两组患者临床疗效,比较治疗前后两组患者四肢骨折愈合时间、视觉模拟评分(VAS)评分和SF-36评分。结果治疗后,对照组临床总有效率为78.05%,显著低于治疗组的95.12%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患者胫骨干、尺桡骨、股骨干、肱骨干骨折愈合时间均明显短于对照组患者,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者VAS评分显著降低,SF-36评分显著升高,同组比较差异具有统计学意义(P0.05);且治疗组患者VAS评分和SF-36评分改善情况明显优于对照组(P0.05)。结论接骨七厘片联合鹿瓜多肽治疗四肢骨折可显著提升患者的临床有效率,改善患者的疼痛症状与生活质量。     

天舒胶囊联合氟桂利嗪治疗前庭性偏头痛的疗效观察

目的 探讨天舒胶囊联合氟桂利嗪治疗前庭性偏头痛的临床效果.方法 选取2019年1月—2021年6月天津市第三中心医院分院中医科诊治的120例前庭性偏头痛患者,按随机数字表法分为对照组和治疗组,每组各60例.对照组患者口服盐酸氟桂利嗪胶囊,10 mg/次,1次/d.治疗组在对照组基础上口服天舒胶囊,4粒/次,3次/d.两...     

Clinical trial: controlled,open, randomized multicentre study comparing the effects of treatment on quality of life,safety and efficacy of budesonide or mesalazine enemas in active left‐sided ulcerative colitis

Aliment Pharmacol Ther 2010; 32: 368–376

Summary

Background Therapy for active left‐sided ulcerative colitis usually involves topical application of mesalazine (mesalamine) or budesonide. Aim To compare the efficacy and safety of budesonide enema and mesalazine enema in the treatment of active left‐sided ulcerative colitis. Methods A total of 237 patients with mild–moderate ulcerative colitis were randomized open 1:1 to receive either budesonide (n = 118) or mesalazine enemas (n = 119) for 8 weeks. Efficacy variables were clinical activity index, endoscopic, histological index and IBDQ scores after 4 and 8 weeks. Results Clinical remission (intention‐to‐treat analysis) at week 4 was 63.5% for budesonide enemas and 77.2% for mesalazine enemas (P < 0.05). The respective values for the per protocol population (PP) were 59.9% examined in the budesonide group and 77.5% in the mesalazine group (P < 0.02). At the final visit (W8), clinical remission was diagnosed in the ITT analysis for 64.4% of the budesonide group and 77.4% of the mesalazine group (P < 0.05). The respective values for the PP analysis were 59.5% in the budesonide group and 75.3% in the mesalazine group (P < 0.02). Conclusions Compared with budesonide, mesalazine enema was associated with a significantly higher remission rate; this was supported by favourable trends in endoscopic, histological remission rates and the IBDQ score.