临床未触及肿块的乳腺钼靶片内簇状钙化临床意义的研究

目的：探讨临床未触及肿块由钼靶发现乳腺内簇状钙化的临床意义。方法：对临床未触及肿块而钼靶摄影发现乳腺内簇状钙化经我院手术病理证实的７９例病例共８６个病灶,分析其大小、数量、形态及分布情况并作良恶性对照研究。结果：７９例病例８６个乳腺内簇状钙化壮,乳腺癌４１个（占４７.67%)。其中２４个为原位癌或早期浸润性乳腺癌,１４个为浸润性导管癌,良性病变４５个（５２.33%)。结论：根据乳腺内钙化的Ｘ线特征可为临床估计其良恶性几率提供线索。     

钼靶摄影对乳腺钙化的诊断价值

目的：探讨钼靶摄影对乳腺钙化在乳腺良恶性疾病中的价值。方法：对96例经手术或穿刺活检病理证实的良恶性钙化钼靶X线片进行回顾性分析。结果：96例乳腺钙化中，良性病变为64例，占67％，恶性病变为32例，占33％。结论：良性钙化一般具有颗粒较粗、数目较少、密度较高、分布相对较局限的特点，但如出现双侧乳腺弥散性钙化分布，也不除外良性病变可能，需严密随访或活检证实：恶性钙化一般具有颗粒较细、数目较多、密度较低等特点，尤其是沿导管走形的多形性杆状、线样及分支样钙化，则恶性可能性大；另外，还有一些成簇状分布的泥沙样钙化，则良恶性影像学有重叠，需要活检证实。     

钼铑双靶乳腺摄影中微小钙化灶对乳腺癌的诊断价值

目的探讨钼铑双靶乳腺摄影中微小钙化灶在乳腺癌诊断中的价值。方法对141例乳腺病变者进行回顾分析,92例乳腺癌患者为研究组,49例乳腺良性病变患者为对照组,对比分析两组患者钼铑双靶乳腺摄影中微小钙化灶的特征。结果研究组检出钙化灶78例,检出率为84．8％,对照组检出钙化灶3例,检出率为6．1％,研究组Ⅱ～Ⅴ型钙化灶检出率明显高于对照组。研究组密集细颗粒型、密集混合型及稀疏细颗粒型钙化灶检出率明显高于对照组,颗粒型钙化灶对乳腺癌诊断的特异性为94．2％,敏感度为98．3％,特异性及敏感度均较高。结论微小钙化灶在乳腺癌患者钼铑双靶乳腺摄影中检出率高,其敏感度及特异性均较高,可作为早期乳腺癌的有效诊断措施推广,以降低漏诊率和误诊率,提高诊断率和患者的生存质量。     

乳腺内微钙化在乳腺癌诊断中的价值

目的 探讨微钙化对乳腺癌的诊断价值.方法 收集经手术病理证实并在乳腺钼靶X线摄影片中发现微钙化乳腺疾病患者80例,分析其微钙化的特征在乳腺癌诊断中的价值.结果 乳腺癌内微钙化多成簇分布,大多伴有肿块,形态大小各异,密度不一,单个区域数量大多>20个.结论 乳腺钼靶X线摄影对乳腺癌的诊断具有重要价值.     

乳腺钼靶簇状钙化点在乳腺癌诊断中的临床价值-附60例患者影像病理相关性分析

目的:探讨簇状钙化点特征与临床活检病理结果间的关系.方法:运用Le Gal分型方法分析60例病例中64个经手术病理证实的簇状钙化点病灶特征.结果:60例患者实际活检标本数64个,其中恶性病变27例(占42.19%).乳腺钼靶摄片发现的簇状钙化点按Le Gal标准分型,其中Ⅱ型18例,术后病理证实恶性l例(5.56%);Ⅲ型12例,恶性1例(8.33%);Ⅳ型14例,恶性6例(42.86%);V型20例,恶性19例(95%).结论:Le Gal分型与病理结果之间存在一定的相关性.乳腺钼靶的簇状钙化点Le Gal分型可为临床诊断乳腺癌提供较可靠的诊断依据.     

乳腺粘液癌的钼靶X线表现

目的：探讨乳腺粘液癌的钼靶X线表现特点以提高临床诊断率。方法：对2006年3月至2008年11月我院诊断的11例乳腺粘液癌患者的X线资料进行回顾分析,11例乳腺粘液癌患者均经术后病理证实。结果：11例乳腺粘液癌中单纯型粘液癌4例,其中中等密度肿块影3例,局限性密度增高1例;混合性粘液癌7例,均为高密度肿块影,其中毛刺样肿块4例,伴有簇样砂粒样钙化2例,侵犯乳头者1例,腋窝淋巴结转移1例。结论：单纯型乳腺粘液癌钼靶X线表现常表现为边缘光滑的肿块,而混合型具有一些典型的恶性征象。     

钼靶X线导丝定位下乳腺活检的临床应用

 目的 对钼靶X线发现钙化灶但不能触及肿块的乳腺病变进行诊断。方法 对26例钼靶X线片显示有恶性可能的钙化灶而临床不能触及肿块的患者，术前在放射科钼靶X线引导下行乳腺细导丝定位，然后在局麻下行乳腺活检。结果 26例采用此方法活检者均成功取出病变组织，并明确诊断。病理结果为乳腺纤维腺瘤4例，乳腺囊性增生10例，乳腺乳头状瘤3例，积乳囊肿1例，导管内癌5例，浸润性导管癌3例。结论 钼靶X线导丝定位下活检，对X线片显示有恶性可能的钙化灶而临床不能触及肿块，可增加活检的准确性，是一种安全有效的诊断方法，对乳腺癌的早期诊断有一定的意义。     

乳腺钼靶片的计算机辅助诊断

全文综述了乳腺钼靶片的计算机辅助诊断的基本过程及临床应用。并对其发展趋势进行了展望。     

乳腺数字钼靶X线摄影的摆位对图像质量的影响

目的 探讨乳腺数字钼靶X线摄影的摆位对图像质量的影响.方法 收集1000例女性患者的4 000幅乳腺数字钼靶X线图像,均为双侧乳腺头尾位(CC位)及内外侧斜位(MLO位)所摄,由1位副主任医师和2位主管技师对上述图像资料进行质量分析,计算甲级片和非甲级片率,并对非甲级片产生的原因进行分析.结果 甲级片3 730幅,非甲...     

乳腺钼靶摄片在中老年女性乳腺癌筛查中的应用分析

目的探讨乳腺钼靶摄片在中老年女性乳腺癌筛查中的应用价值。方法抽取本地1000例中老年女性进行乳腺癌筛查,筛查方法为乳腺钼靶摄片。结果查出7例乳腺癌,占0.7%。与病理诊断符合率为100.0%,病理类型多为浸润性导管癌。所有患者摄片都可见明确肿块影,可见恶性钙化者6例。结论钼靶摄片筛查中老年女性乳腺癌作为一种无创性的检查手段,摄片肿块与钙化现象能为诊断乳腺癌提供可靠依据,可作为大规模人群筛查的主要手段。     

VEGF与肿瘤血管生成拟态关系的研究

Objective  

The aim of this retrospective study was to evaluate the mammographic imaging features (markers) on different types of breast cancer and improve early radiological diagnosis of breast cancer.     

不典型乳腺癌的X线诊断

目的:探讨不典型乳腺癌的临床表现及钼靶X线片特征,提高不典型乳腺癌的诊断水平。方法:15例不典型乳腺癌均为手术病理证实。均为女性,年龄28～66岁,平均45岁。有9例临床可扪及肿块状或结节感,另6例未扪及包块,在X线检查时被发现。15例均拍摄乳腺钼靶X线片。结果:15例X线表现:小结节状肿块影7例,钙化9例,局灶性致密影6例,腺体结构不良4例,血管影增粗3例。结论:不典型乳腺癌的临床及X线表现相对不典型,诊断乳腺癌除了重视特征性征象:肿块影和钙化,还应重视局灶性致密影、局部结构紊乱等间接征象。阅片时应仔细观察,要双侧对比,诊断时应综合分析,结合病人触诊情况,这对提高乳腺癌的诊断率有重要意义。     

三阴性乳腺癌X线特征分析

目的:探讨三阴性乳腺癌的X线特征。方法:收集经手术病理证实为乳腺癌的202例患者资料,根据雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体（HER-2）表达情况将其分为三阴性乳腺癌（TNBC）与非三阴性乳腺癌（NTNBC）,比较两组病例腺体分型、病灶是否单发、肿块情况及有无钙化。结果:202例乳腺癌TNBC有34例,NTNBC有168例。两组病例肿块边缘及有无钙化差异有统计学意义(P均＜0.05)。腺体分型、是否单发、肿块的大小、肿块的形态、肿块的密度差异无统计学意义。结论:TNBC有一定特征,大多为单发肿块,与NTNBC相比肿块边缘更易表现为清晰光滑,钙化相对少见的征象。     

Breast Pain Associated with Mammographic Compression

Firm breast compression during film-screen mammography is necessary to achieve optimum image quality while minimizing radiation time. Of 374 women who fully completed a questionnaire following mammography, 225 (60%) reported no pain, 115 (31%) moderate pain and only 3 (1%) reported severe pain. Only one patient stated that the pain from the procedure would prevent her from having a further mammogram. Underlying breast disease (usually fibmystic disease) is associated with a greater incidence and severity of breast pain, but, no relationship has been demonstrated with regards to the patient's age, hormonal status, menstruation or caffeine intake. The high level of acceptance of firm compression by women in our study indicates that undue concern regarding patient discomfort should not deter people from referral for mammography or from the application of firm compression.     

Mammographic features of adenoid cystic carcinoma

Adenoid cystic carcinoma of the breast accounts for < 1% of breast malignancies. This case report describes the mammographic features and the pathology. Adenoid cystic carcinoma is a well-circumscribed carcinoma that has a relatively good prognosis.     

The Impact of Mammographic Breast Cancer Screening in Singapore: A Comparison Between Screen-detected and Symptomatic Women

Background: Breast cancer is the leading cause of cancer death amongst Singapore women. There are few studies evaluating the impact of mammographic screening among Asian women. This study aimed to examine differences in disease stage at presentation and outcome between breast cancer patients who were detected by screening (screen-detected) and those who presented symptomatically (symptomatic) from the experience of a regional hospital in Singapore. We also sought to identify the demographic profile of patients who were less likely to be screen detected. Methods: Retrospective data fpr female patients diagnosed with primary breast cancer and treated from January 2002 - December 2008 were analyzed. Univariate and multivariate analyses were performed to examine the profile of symptomatic as opposed to screen-detected patients and factors that influence presentation at an early disease stage. Survival and recurrence rates were computed by Kaplan-Meier method and compared by log rank test. Results: The study population consisted of 82 screen-detected and 679 symptomatic patients. The screen-detected patients were more likely to present at an earlier stage and have better overall cancer-specific survival as compared to symptomatic patients. Malay women and those without a family history of breast cancer were less likely to be detected by screening. Conclusions: Mammographic screening appeared to enable the detection of oncologically more favorable lesions and conferred better overall cancer-specific survival in Singapore women. There is possibly room for more targeted education efforts to reach out to Malay women and those without a family history of breast cancer to enable earlier disease detection among these individuals through regular breast cancer screening.     

Screen‐detected breast carcinoma with macroscopic dystrophic calcification: A pictorial essay with radiolological pathological correlation

Breast calcifications are among the most common abnormal radiographic findings detected at screening mammography. This essay illustrates the clinico‐pathological features of nine screen‐detected breast carcinomas, which had benign‐appearing macrocalcifications, as a radiographically dominant presenting feature. We aimed to demonstrate that benign‐appearing calcifications within a breast lesion are not diagnostic of a benign process if the other imaging characteristics of the lesion are suspicious of malignancy.     

乳腺钙化在乳腺癌诊断中的意义

将１８４例乳腺疾病患者分为乳腺癌组与非癌组，观察和比较两组钙化出现的频率和形态特征，分析乳腺癌组的钙化与病理分型，钙化与乳腺肿块的关系。乳腺癌组Ｘ线摄影显示钙化者为６４％（６０／９３），非癌组为２８％（２６／９１）。有钙化者患乳腺癌的相对危险性（ＲＲ）是没有钙化的４．５倍（Ｐ＜０．０１）。在显示钙化的乳腺癌组，４７％为浸润性导管癌，没有显示钙化的乳腺癌中，浸润性导管癌为２４％（Ｐ＜０．０５）；仅显示钙化但不伴有明显肿块影的占３８％（２３／６０）。典型的恶性钙化如泥沙样，细线样钙化有助于对Ｘ线摄影未显示肿块影的乳腺癌的诊断。