Intraoral onlay block bone grafts versus cortical tenting technique on alveolar ridge augmentations: a systematic review

Background To review systematically the bone gain and superficial resorption rate of the onlay block bone grafts versus the cortical tenting technique, as well as secondarily study the postoperative complications, implant survival and success rates, and peri-implant marginal bone loss.Material and Methods Following the recommended methods for systematic reviews and meta-analyses (PRISMA), an electronic search was performed in the PubMed (MEDLINE), EMBASE and the Cochrane Library of the Cochrane Collaboration (CENTRAL) databases to identify all relevant articles published up to March 2021 on onlay block bone grafts and cortical tenting technique.Results Eighteen papers complied with the inclusion criteria. In onlay grafts, the vertical bone gain mean was 4.24 mm, and resorption 20.91%; and 4.29 mm in the horizontal augmentation with a resorption of 10.28%. The complication rate was 14.8%. The implant survival and success rates were 100% and 92%; and the mean peri-implant bone loss ranged from 0.6 to 1.26 mm.In cortical tenting technique, the vertical bone gain mean was 6.17 mm and the resorption of 9.99%; and 5.55 mm in the horizontal augmentation with a 6.12% of resorption. The complication rate was 24.6%. The implant survival and success rates were 96.63% and 100%; and the mean peri-implant bone loss ranged from 0.27 to 0.77mm.Conclusions Despite the limitations, both techniques offer a predicTable way to reconstruct atrophic alveolar ridges, though the cortical tenting technique seems to achieve a greater bone gain and a lower surface resorption. Current evidence is still limited due to the inadequate follow-up, lack of information referred to methodological quality and sample attrition. Key words:Onlay graft, cortical graft, intraoral bone, augmentation procedure.     

Surgical success of intraoral autogenous block onlay bone grafting for alveolar ridge augmentation

This article evaluates the surgical success of alveolar bone augmentation using intraoral block bone graft prior to dental implantation and measures the amount of bone accumulation using this technique. A consecutive retrospective study was conducted on patients who had onlay bone grafts from 1999 to 2001. Files of 56 healthy patients reporting 64 bone graft operations were reviewed. Medical history, smoking status, area of surgery, bone origin (donor sites) and complications were recorded. Panoramic and tomographic radiographs were measured for the vertical and horizontal bone addition and mesiodistal dimension of the graft. Graft exposure or/and graft removal were defined as failure; hematoma, swelling, inflammation, or temporary paresthesia were defined as complications. The average vertical addition was 5.6 mm measured from the bottom of the vertical lesion before bone grafting to the top of the graft. The average faciolingual addition was 3.8 mm. The mesiodistal graft length ranged from 4 mm to 67 mm (average 15.2 mm). According to our criteria, 56 (87.5%) of the 64 bone grafts were successful, 46 (71.9%) were totally uneventful, and 10 (15.6%) had complications. Smoking and diabetes were associated with a high rate of complications and graft failure. More complications were observed in the vertical than in the horizontal bone grafts. Intraoral bone block graft is a predictable operation with high success rates that provides faciolingual and vertical bone addition. Onlay bone grafting has a low rate of complications and failures. Intraoral bone graft should not be recommended for diabetic patients and smokers.     

块状异质植骨材料用于牙槽嵴骨增量的研究进展

各种原因所致的牙槽嵴骨量不足是口腔种植临床实践中亟需解决的问题之一。与自体骨相比,块状异质植骨材料因其独特的优势成为研究的热点。本文根据目前已经应用或有望应用于牙槽嵴骨增量领域的块状异质植骨材料的性能特点,分类讨论了无机陶瓷类材料、天然有机高分子材料及有机合成高分子材料的应用现状和最新研究进展,并对块状异质植骨材料的研究方向和前景进行了展望。     

Alveolar ridge reconstruction with titanium meshes: A systematic review of the literature

Alveolar bone regeneration by means of titanium meshes is a widespread procedure, however to date, only few relevant studies were reported in literature concerning this technique. Consequently, the aim of the present systematic review was to analyze the reliability of the titanium mesh as a barrier, in conjunction with horizontal and vertical ridge reconstruction for implant placement purposes. A total of 17 articles complying with the inclusion and exclusion criteria were reviewed. Three outcome variables were defined: a) horizontal and vertical bone regeneration obtained, b) complication rate, defined as the percentage of membrane exposures and c) evaluation of implant survival, success and failure rate.In regards to the vertical regeneration the mean was 4.91 mm (range: 2.56 - 8.6), while a mean of 4.36 mm (range: 3.75 - 5.65) was calculated for horizontal reconstruction. Considering the exposure rate, a mean of 16.1% was found, nevertheless, implant placement were placed in almost all of the sites. A mean success rate of 89,9%, a mean survival rate of 100% and a failure rate of 0% emerged from the data evaluation. A meta-analysis could not be performed due to the heterogeneity of the data, however the final results were comparable with those reported in case of bone regeneration obtained through other types of non-resorbable membranes. An advantage in favour of the titanium mesh was found in terms of bone loss after exposure, as implant placement was not jeopardized in almost all of the cases. It could be deduced that titanium meshes represented a reliable solution for alveolar ridge reconstruction. The clinical studies currently available in literature have shown the predictability of this technique in both lateral and vertical bone regeneration. Key words:Alveolar ridge reconstruction, bone atrophy, bone regeneration, dental implants, titanium mesh.     

Effect of platelet-rich fibrin on alveolar ridge preservation: A systematic review

BackgroundPlatelet-rich fibrin (PRF) is the second generation of platelet concentrates and is used in many areas of dentistry. However, whether PRF is effective for alveolar ridge preservation remains controversial. The authors conducted research to evaluate the potential of PRF to preserve the alveolar ridge.MethodsA comprehensive literature search was conducted in MEDLINE, Cochrane Central Register of Controlled Trials, and Embase. Only randomized controlled trials were included. A systematic review was made for postoperative pain, soft-tissue healing, bone density, horizontal and vertical ridge dimension changes, and histologic analysis. The meta-analysis was performed on the alveolar osteitis, mesial and distal bone height changes, and bone fill with Review Manager Version 5.3 software.ResultsAmong the 588 eligible articles found in the initial search, 7 published studies from 2012 through 2019 were included. The authors’ qualitative analysis showed that PRF may play a positive role in reducing postoperative pain and ridge dimension changes after tooth extraction. Among the 7 articles, only 2 trials assessed the effect of PRF on the alveolar osteitis, mesial and distal bone height changes, and bone fill. Results of our meta-analysis showed that smaller mesial bone height changes (standard mean difference, –1.07; 95% confidence interval, –1.92 to 0.22) and a greater percentage of bone fill (standard mean difference, 0.82; 95% confidence interval, 0.32 to 1.33) were observed in the PRF group.ConclusionsGiven the potential value of PRF, consideration should be given to PRF after tooth extraction. However, more high-quality trials are necessary to evaluate the exact role of PRF.Practical ImplicationsBased on the authors’ results, the usage of PRF was suggested in alveolar ridge preservation.     

Correction of postsurgical alveolar ridge defect with vertical alveolar distraction of the onlay block graft

ABSTRACT: Alveolar bone augmentation for dental implant rehabilitation is one of the greatest challenges for oral and maxillofacial surgeons. Bringing out an inadequate quantity of vertical bone during augmentation compromises correct implant positioning and the resulting prosthetic restoration. Alveolar distraction osteogenesis is now generally used in correcting alveolar ridge atrophy due to trauma, congenital defects, or periodontal defects. Onlay block grafting is a suitable method for restoring the alveolar bony defects. However, it sometimes can become a complicated procedure to repair the horizontal defect accompanying a vertical defect using only bone blocks. This clinical report presents a successful reconstruction of a severe anterior mandibular alveolar bony defect as a result of impacted teeth extraction and periodontal problem in a 50-year-old healthy female patient. The defect was reconstructed with symphysis graft and platelet-rich fibrin in the first step. Vertical alveolar distraction was performed on the grafted site to maintain the suitable bony height 3 months later. Grafted bony segment distraction and the treatment options in similar cases were also discussed in this clinical report among with the literature.     

Materials and prognostic factors of bone regeneration in periapical surgery: A systematic review

Objectives: Analyse the effectiveness of different materials and techniques used in guided tissue regeneration (GTR) applied in periapical surgery, comparing the success rate obtained in 4-wall defects and in through-and-through bone lesions as well as to establish prognostic factors. Material and Methods: A Cochrane, PubMed-MEDLINE and Scopus database search (October 2012 to March 2013) was conducted with the search terms “periapical surgery”, “surgical endodontic treatment”, “guided tissue regeneration”, “bone regeneration”, “bone grafts”, “barrier membranes” and “periapical lesions” individually and next, using the Boolean operator “AND”. The inclusion criteria were the use of GTR (bone graft and/or membrane barrier), clinical studies including at least 10 patients, 10 years aged articles published in English or French. The exclusion criteria were case reports and nonhuman studies. Results: 34 publications were selected from a total of 483. 9 of the 34 were excluded. Finally, the systematic review included 25 articles: 2 metaanalysis, 8 reviews, 13 prospective studies and 2 retrospective studies. They were stratified according to their level of scientific evidence using the SORT criteria. The 4-wall periapical and through-and-through lesions improve more their prognosis by combining bone grafts and barrier membranes than using these materials exclusively, respect to the control groups. The results show lower failure rates in 4-wall lesions than in through-and-through lesions using GTR. Conclusions: The combined GTR technique (filling material and membranes) obtains a greater success rate both in 4-wall lesions and in through-and-through lesions, respect to the control groups. The use of regeneration materials seems to be more necessary in through-and-through lesions,> 5mm lesions, lower teeth and apicomarginal lesions as they have the worst healing prognosis. In function of the articles scientific quality, a type B recommendation is given in favour to the use of GTR in association of periapical surgery in case of 4-wall and through-and-through lesions. Key words:Periapical surgery, surgical endodontic treatment, guided tissue regeneration, bone regeneration, bone grafts, barrier membranes.     

Success of dental implants placed in intraoral block bone grafts

BACKGROUND: The purpose of this study was to evaluate the survival and success of dental implants placed in alveolar bone following augmentation using intraoral block bone grafts. METHODS: A consecutive retrospective study was conducted on patients who had onlay bone grafts for vertical or horizontal augmentations followed by dental implantation from 1999 to 2001. Files of 50 healthy patients who received 129 implants in augmented sites were reviewed. Implant survival, radiologic implant success (marginal bone loss), and complications were recorded. RESULTS: Follow-up from time of implantation ranged from 6 to 67 months (mean: 24.3 +/- 11.2 months). Ranges of implant widths and lengths were 3.25 to 4.7 mm and 10 to 16 mm, respectively. The overall survival rate was 96.9% (four implants were removed). Marginal bone loss around implants ranged from 0 to 3.3 mm (average: 0.22 +/- 0.45 mm). Only 5% of the implants presented marginal bone loss > or =1.5 mm over the follow-up time. CONCLUSIONS: Intraoral bone block graft surgery is a predictable operation for the use of dental implants. Implant placement in augmented areas presents high survival and radiologic success rates with minimal bone loss.     

The alveolar bone protective effects of natural products: A systematic review

ObjectivesThis systematic review was carried out to identify which naturally-occurring agents and constituents isolated therefrom have effects in preventing bone loss in a ligature-induced periodontitis model.Materials and methodsEight databases were systematically searched for studies of experimental periodontitis. The data were extracted, analyzed, and the treatment outcomes were given scores based on the level of bone destruction as compared to their untreated induced-periodontitis control.Results294 articles were found, of which 15 met the inclusion criteria. The selected studies tested a multi-herbal formulation; extracts (leaves, barks or fruit) of different plant species; and propolis. The most usual dosing protocol consisted of 3-times-a-day, 11-day treatment. The combined gel of Myracrodruon urundeuva (5%) and Lippia sidoides (0.5%) was the most active treatment, reducing 45–65% bone loss in the region of molars as compared to 73.4% of doxycycline (gold-standard). Ginkgo biloba extract (28–56 mg/kg) and propolis (100–200 mg/kg) prevented bone destruction by 50% and 40–44%, respectively. The other tested samples showed intermediate/weak activity in modulating bone resorption.ConclusionsThe gel of M. urundeuva and L. sidoides, and G. biloba and propolis extracts showed strong alveolar bone protective effectiveness in induced-periodontitis in rats. Further translational research should bridge the gap between the rat study outcomes and the clinical efficacy and long-term toxicity of these formulations in humans. The compilation of the vast literature database presented herein may drive further in vivo and clinical studies with the selected efficacious formulations to subsidize their pharmaceutical application.     

嵌贴式植骨术在牙槽嵴严重吸收患者牙种植术中的应用

目的:总结嵌贴式植骨方法进行缺牙后重度吸收牙槽嵴骨增量的植骨技术及其效果。方法:15例重度吸收牙槽嵴患者接受了嵌贴式植骨术,分别于植骨12～24周后植入种植体,共植入26枚种植体。术后16～24周行种植体基台连接术及烤瓷冠或烤瓷桥修复。结果:术后12周复诊二期植入种植体者,术中见植骨块吸收很少,所有患者均成功完成了种植修复。15例植骨患者中,3例出现术后感染,但仍获一定程度的骨增量效果,12例无并发症。所有病例修复后追踪24～48周,无种植体脱落。结论:嵌贴式植骨技术应用于严重吸收牙槽嵴骨增量操作简单,效果可靠。     

Immediate bleeding complications in dental implants: A systematic review

Objective: A review is made of the immediate or immediate postoperative bleeding complications in dental implants, with a view to identifying the areas of greatest bleeding risk, the causes of bleeding, the length of the implants associated with bleeding, the most frequently implicated blood vessels, and the treatments used to resolve these complications.Material and Methods: A Medline (PubMed) and Embase search was made of articles on immediate bleeding complications in dental implants published in English up until May 2014. Inclusion criteria: studies in humans subjects with severe bleeding immediately secondary to implant placement, which reported the time until the hemorrhage, the implant lenght, the possible cause of bleeding and the treatment. Exclusion criteria: patients receiving anticoagulation treatment.Results: Fifteen articles met the inclusion criteria. The area with the largest number of bleeding complications corresponded to the mandibular canine. The cause of bleeding was lingual cortical bone perforation during implant placement, with damage to the sublingual artery. The implants associated with bleeding were those measuring 15 mm in length or more. Management focused on securing the airway (with intubation or tracheostomy if necessary), with bleeding control.Conclusions: It’s important to pay special attention when the implants are placed in the mandibular anterior zone, especially if long implants are used. The most frequently cause of bleeding was the perforation of the lingual plate. Treatment involves securing the airway, with bleeding control. Key words:Hemorrhage, complications, immediate, bleeding, dental implants.     

The use of intraorally harvested autogenous block grafts for vertical alveolar ridge augmentation: a human study

This study presents a clinical, radiographic, laboratory, and histologic/histomorphometric analysis of the use of mandibular block autografts for vertical alveolar ridge augmentation. Twelve patients were included in the study. The autogenous block autografts were fixated at the recipient sites with screws, and a mixture of autogenous bone marrow and inorganic bovine mineral (Bio-Oss) was used at the periphery. At re-entry surgery, all the grafts appeared well incorporated at the recipient sites. Radiographic measurements revealed an average of 5.75 +/- 1.29 mm vertical ridge augmentation at 1 month after surgery and 4.75 +/- 1.29 mm at 4 to 6 months after surgery. This indicated 17.4% resorption. Laboratory volumetric measurements revealed an average of 0.84 +/- 0.34 mL of alveolar ridge augmentation 1 month after surgery and 0.71 +/- 0.28 mL at 6 months postoperatively. The resorption rate according to the laboratory volumetric measurements was 15.5%. Linear laboratory measurements revealed 5.92 +/- 1.38 mm of vertical ridge augmentation 1 month postoperatively and 4.08 +/- 1.01 mm at 4 to 6 months after surgery. Histologic evaluation of the block autografts indicated signs of active remodeling activity in 10 of the 12 specimens. In one case the block graft became exposed and infected, and in another case the block autograft became dislodged during implant placement surgery. Histomorphometric analysis of the peripheral particulate bone indicated bone present at 33.99% +/- 8.82% of the graft surface, while 42.43% +/- 11.06% of the area was occupied by fibrous tissue and 23.89% +/- 9.12% was made up of residual Bio-Oss particles. Residual Bio-Oss particles were in tight contact with newly formed bone along 58.57% +/- 15.22% of their perimeter.     

Clinical results of alveolar ridge augmentation with mandibular block bone grafts in partially edentulous patients prior to implant placement

A group of 15 partially edentulous patients who needed alveolar ridge augmentation for implant placement, were consecutively treated using a two-stage technique in an outpatient environment. A total of 18 alveolar segments were grafted. During the first operation bone blocks harvested from the mandibular ramus or symphysis were placed as lateral or vertical onlay grafts and fixed with titanium osteosynthesis screws after exposure of the deficient alveolar ridge. After 6 months of healing the flap was re-opened, the screws were removed and the implants placed. Twelve months after the first operation implant-supported fixed bridges could be provided to the patients. Mean lateral augmentation obtained at the time of bone grafting was 6.5 +/- 0.33 mm, that reduced during healing because of graft resorption to a mean of 5.0 +/- 0.23 mm. Mean vertical augmentation obtained in the 9 sites where it was needed was 3.4 +/- 0.66 mm at bone grafting and 2.2 +/- 0.66 mm at implant placement. Mean lateral and vertical augmentation decreased by 23.5% and 42%, respectively, during bone graft healing (before implant insertion). Mandibular sites showed a larger amount of bone graft resorption than maxillary sites. All the 40 implants placed were integrated at the abutment connection and after prosthetic loading (mean follow-up was 12 months). No major complications were recorded at donor or recipient sites. Soft tissue healing was uneventful, and pain and swelling were comparable to usual dentoalveolar procedures. A visible ecchymosis was present for 4 to 7 days when the bone was harvested from the mandibular symphysis. From a clinical point of view this procedure appears to be simple, safe and effective for treating localised alveolar ridge defects in partially edentulous patients.     

Flapped versus flapless alveolar ridge preservation: a systematic review and meta-analysis

Alveolar ridge preservation (ARP) procedures can limit bone changes following tooth extraction. Flapped and flapless surgical approaches have been used for ARP; however, there is a lack of strong scientific evidence regarding their specific influences on the clinical outcomes of ARP. The aim of this systematic review and meta-analysis was to evaluate the effects of flapped and flapless surgical approaches on the dimensional changes of hard and soft tissues and patient-reported outcomes following ARP. Electronic databases were searched to identify randomized controlled trials (RCTs) that compared flapped ARP by means of a coronally advanced flap to flapless ARP where barrier membranes were left exposed. The risk of bias was assessed using the Cochrane Collaboration Risk of Bias tool. Data were analysed using a statistical software program. A total of 754 studies were identified, of which five studies with 149 extraction sockets in 128 participants were included. Overall, meta-analysis did not show any significant differences in the changes in ridge width or height between flapped and flapless ARP. The use of flapless ARP was associated with significantly less postoperative pain, thicker labial soft tissues, and marginally more favourable changes in width of the keratinized tissues compared to the flapped approach. The short-term hard tissue changes following ARP with a flapped or flapless approach are comparable. Postoperative pain and labial soft tissue changes are more favourable following ARP using a flapless approach. Further evidence from long-term RCTs is still required to substantiate the current findings.     

Maxillary alveolar ridge reconstruction with nonvascularized autogenous block bone: clinical results.

PURPOSE: The purposes of this study were to evaluate the clinical success of bone reconstruction of the severely atrophic maxilla using autogenous bone harvested from the anterosuperior edge of iliac wing and to analyze the clinical success and the marginal bone level of dental implants placed 4 to 5 months after bone grafting and before prosthetic rehabilitation. PATIENTS AND METHODS: Fifty-six patients (18 men, 38 women) aged 27 to 63 years were included in the study and required treatment for maxillary atrophy. All patients selected were scheduled for onlay bone graft and titanium implants in a 2-stage procedure. The dental implants were inserted 4 to 5 months after grafting. RESULTS: No major complications were observed from the donor sites. A total of 129 onlay bone grafts were used to augment 56 severely resorbed maxillas. Three out of 129 bone grafts had to be removed because of early exposure occurring with bone grafts placed to increase the vertical dimension of the alveolar ridge. One hundred sixty-two implants were placed in the area of bone augmentation. Seven implants failed to integrate and were successfully re-placed without any need for additional bone grafting. The clinical measurements for bone resorption around implants revealed a mean bone loss of 0.05 mm (+/- 0.2); the marginal bone level evaluated with periapical radiographies was 0.3 mm (+/- 0.4) at implant placement and 0.1 mm (+/- 0.3) 6 months after placement. CONCLUSION: The success rate of the block grafts was very good. The clinical and radiographic bone observations showed a very low rate of resorption after bone graft and implant placement. Therefore, on the basis of this preliminary study, iliac bone grafts (from the anterosuperior edge of the iliac wing) can be considered a promising treatment for severe maxillary atrophy.     

An intraoral anastomosing technique for microvascular bone flaps in alveolar ridge reconstruction: First clinical results

The main indication for microvascular reconstruction of the face is to achieve the best possible functional and aesthetic outcome. In several cases of reconstruction of the alveolar ridges of the mandible or maxilla, extraoral scars might have been avoided if microvascular anastomoses had been performed without using the extraoral approach. In 9 patients with severe defects of the alveolar ridge of the mandible or maxilla caused by trauma, tumour resection, atrophy or partial loss of premaxilla, reconstruction was performed using six microvascular corticocancellous femur flaps, two iliac crest flaps and one osteoperiosteal fibula flap. In every case, an intraoral approach was used to prepare the transplant bed and the facial vessels. The anastomoses were carried out via this intraoral approach between the donor vessels and the facial vessels. The patients were followed up radiologically and clinically for 6–24 months postoperatively. There was no flap loss or severe complication postoperatively. All patients had good functional and aesthetic results, were treated successfully with dental implants 4–6 months after microvascular reconstruction, and were subsequently fitted with implant-retained prostheses. Intraoral anastomosing of microvascular bone flaps is a reliable technique for microvascular reconstruction of the alveolar ridge. Extraoral scars can be avoided.     

Dental implants and onlay bone grafts in the anterior maxilla: analysis of clinical outcome

PURPOSE: Loss of alveolar bone in the anterior maxilla may preclude implant placement or compromise positioning and thus diminish the final esthetic result of the restoration. Bone augmentation can overcome such difficulties but may affect osseointegration. The aim of this study was to report the outcome of buccal onlay bone grafting in the anterior maxilla in routine dental implant practice. MATERIALS AND METHODS: Seventeen consecutive patients (12 men and 5 women, mean age 31.4 years) received autogenous bone grafts from the mandibular symphysis to the anterior maxilla. A total of 35 Br?nemark System MK II implants were placed in grafted bone. RESULTS: Fifteen patients had a mean period of graft consolidation of 19.7 weeks (range 13 to 32 weeks). Two patients had simultaneous graft and implant placement; 1 implant failed to Integrate in this group. This represents a survival rate of 97.1% of implants in functional loading after a mean follow-up period of 153.6 weeks from occlusal loading (range 74 to 283 weeks). DISCUSSION AND CONCLUSION: Mandibular block onlay grafts appear to be a predictable method for augmenting the width of the anterior maxilla prior to implant placement.     

Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis

Background

The real clinical utility of genetic testing is the prognostic value of genetic factors in the clinical outcome of periodontal treatment and the tooth survival. A meta-analysis was undertaken to estimate the effect of a susceptible genotype to periodontitis on the clinical outcomes of non-surgical periodontal therapy and the tooth survival.

Material and Methods

A systematic search of MEDLINE-Pubmed, Cochrane Library and Scopus was performed. Additionally, a hand search was done in three journals. No specific language restriction was applied. Two reviewers screened independently titles and abstracts or full text copies. Quality assessment of all the included studies was held.

Results

Initial screening of electronic databases resulted in 283 articles. Ten studies met the inclusion criteria, nine of them examined the clinical outcome, while the other one investigated the tooth survival in susceptible individuals after non-surgical periodontal therapy. Eight of included studies were selected for the meta-analysis. IL-1 positive genotypes increase the risk of tooth loss, while no association found between the bleeding on probing (BOP), clinical attachment loss (CAL) and plaque index (PI) with the genotype status. Probing pocket depth (PPD) reduction in the first three months and in long-term results found to have a significant association with the genotype.

Conclusions

There is no difference in the clinical measurements after non-surgical periodontal treatment, apart from PPD. More publications are needed to identify a cause-effect relationship. Key words:Periodontal disease, periodontitis, periodontal therapy, clinical outcome, tooth loss, susceptibility, polymorphism, genotype, meta-analysis, systematic review.     

Antiepileptic drugs for the treatment of neuropathic pain: A systematic review

Many therapies have been proposed for the management of neuropathic pain, and they include the use of different antiepileptic drugs. However, the lack of high quality studies indicates that results on the different neuropathic disorders under study do not recommend a particular drug treatment. This study makes a systematic review of the published literature on the use of several antiepileptic drugs to treat neuropathic pain, and has the objective of considering both its clinical characteristics and pharmacological use, which will depend on their level of scientific evidence and will follow the principles of evidence-based dentistry. The articles were stratified according to their scientific evidence using the SORT criteria (Strength of Recommendation Taxonomy), and it included those articles that only have level 1 or 2. Randomized clinical trials were stratified according to their level of quality using the JADAD scale, an instrument described by Jadad et al. (7). to assess the quality of clinical trials, while studies with a level below 3 were discarded. Recently, type A or B recommendations are given in favor or against the use of antiepileptic drugs to treat neuropathic pain on the basis of their scientific quality. Key words:Neuropathic pain, antiepileptic drugs (AEDs), trigeminal neuralgia, glossopharyngeal neuralgia, post- herpetic neuralgia, burning mouth syndrome, persistent idiopathic facial pain.