玫瑰茄的药理作用于临床应用

玫瑰茄广泛分布于全球热带和亚热带地区。其花药食两用，富含维生素C、氨基酸、有机酸 、黄酮类、花青苷类等多种成分，亦作为天然色素的资源植物。玫瑰茄除具有消除疲劳、清 热解暑的功效外，还具有降压、调血脂、抗肥胖、保肝、抗糖尿病并发症等多种药理作用， 用于心脏病、神经疾病和癌症等的治疗。综述了玫瑰茄的药理作用及临床研究进展，为其广 泛应用提供参考。     

洋蓟的化学成分、生物活性与临床研究

洋蓟系药食兼用的功能性植物,其花蕾和茎叶富含酚类化合物、黄酮、花青苷、菊粉和酶类等化学成分,具有利胆、解茎、降血脂、性腺保护和抗氧化等生物活性。介绍近年对洋蓟化学成分、生物活性和临床研究概况。     

马鞭草苷现代药学与生物活性研究进展

马鞭草苷是药用植物马鞭草中的重要活性成分。马鞭草分布广泛,资源丰富,临床应用价值较高。马鞭草苷具有很好的研究开发前景。本文从马鞭草苷的含量测定、分离提取、药动学研究和生物活性等几个方面进行阐述,为马鞭草苷更深入的开发利用提供科学的理论依据。     

064茄属植物化学成分和生物活性

茄属植物含有多种类型的化学成分,主要为生物碱类、黄酮及其苷类、甾类、三萜及其苷类、有机酸及其衍生物等。该属植物及其提取物具有抗真菌、抗肿瘤、抗病毒、抗炎、强心、灭螺等生物活性。     

玫瑰茄花萼中脂肪酸成分的GC-MS分析

目的:采用气相色谱-质谱联用技术(GC-MS)对玫瑰茄花萼中提取的油脂进行脂肪酸组成分析。方法:采用索氏提取法提取玫瑰茄花萼中的油脂,甲酯化后运用GC-MS联用技术进行分离和结构鉴定。结果:玫瑰茄花萼油脂中含有17种脂肪酸,其中主要的脂肪酸为亚油酸(45.03%)、油酸(23.62%)、棕榈酸(22.91%)、硬脂酸(3.41%)、(10E)-10-十九烯酸(1.91%)、棕榈油酸(0.84%)、花生酸(0.53%)和肉豆蔻酸(0.34%)。其中不饱和脂肪酸含量高达71.40%以上。结论:玫瑰茄油脂中富含不饱和脂肪酸,具有较高的营养价值和保健功能。     

玫瑰茄花萼浸取滤液的微核试验

应用微核试验方法,初步探讨了玫瑰茄花萼浸取液对小鼠骨髓细胞的影响,为食用该植物的安全性评价提供资料。     

浅谈玫瑰茄治疗高血压的有效性和安全性

本文从化学成分、药理机制、安全性、毒性等方面探讨了玫瑰茄治疗高血压的有效性和安全性,为以后应用玫瑰茄治疗高血压提供一定的理论依据。     

醉茄的化学成分与药理作用

印度阿育吠陀传统草药醉茄有多种药理活性和治疗用途,主要化学成分为醉茄素类和糖蛋白,就近年来对醉茄提取物及其化学成分的抗肿瘤、调节免疫、保护神经、保护心血管等药理活性研究进行综述,并对今后研发方向进行展望。     

108醉茄的化学成分与药理作用

印度阿育吠陀传统草药醉茄有多种药理活性和治疗用途,主要化学成分为醉茄素类和糖蛋白,就近年来对醉茄提取物及其化学成分的抗肿瘤、调节免疫、保护神经、保护心血管等药理活性研究进行综述,并对今后研发方向进行展望.     

买麻藤属植物化学和药理研究

1.内容简介:免疫性炎症如哮喘、类风湿性关节炎、免疫性肝炎等是一类多发病、常见病,我们以1970年来逐渐明确的新理论即白三烯代谢障碍在上述疾病发生、发展中的重要性为主要指导思想,选择从临床上治疗有效的中草药买麻藤为研究对象。采用先进技术方法(波谱分析:二维谱的应用、NMR、HMBC、NOESY、NOE、差谱二维、单晶X射线、高效液相、细胞生物学、分子生物学、放射受体等)为手段,植化、合成、药理多学科联手攻坚。采用体内、体外相结合的药理方法判断研究     

A review on ethnobotany,phytochemistry and pharmacology of Fumaria indica (Fumitory)

Fumaria indica (Hausskn.) Pugsley (Fumariaceae), known as “Fumitory”, is an annual herb found as a common weed all over the plains of India and Pakistan. The whole plant is widely used in traditional and folkloric systems of medicine. In traditional systems of medicine, the plant is reputed for its anthelmintic, diuretic, diaphoretic, laxative, cholagogue, stomachic and sedative activities and is used to purify blood and in liver obstruction in ethnopharmacology. The whole plant is ascribed to possess medicinal virtues in Ayurvedic and Unani systems of medicine and is also used in preparation of important Ayurvedic medicinal preparations and polyherbal liver formulations. The review reveals that phytochemical constituents of wide range have been separated from the plants and it possesses important pharmacological activities like smooth muscle relaxant, spasmogenic and spasmolytic, analgesic, anti-inflammatory, neuropharmacological and antibacterial activities. The separation of hepatoprotective and antifungal constituents from this plant was also reported newly. This review highlights the traditional, ethnobotanical, phytochemical, pharmacological information available on Fumaria indica, which might be helpful for scientists and researchers to find out new chemical entities responsible for its claimed traditional uses.     

Ixora coccinea Linn.: Traditional uses, phytochemistry and pharmacology

Ixora coccinea Linn.,(Rubiaceae) commonly known as jungle of geranium and red ixora,is an evergreen shrub found throughout India.Depending on the medical condition,the flowers,leaves,roots,and the stem are used to treat various ailments in the Indian traditional system of medicine,the Ayurveda,and also in various folk medicines.The fruits,when fully ripe,are used as a dietary source.Phytochemical studies indicate that the plant contains important phytochemicals such as lupeol,ursolic acid,oleanolic acid,sitosterol, rutin,lecocyanadin,anthocyanins,proanthocyanidins,glycosides of kaempferol and quercetin.Pharmacological studies suggest that the plant possesses antioxidative,antibacterial,gastroprotective,hepatoprotective, antidiarrhoeal,antinociceptive,antimutagenic,antineoplastic and chemopreventive effects,thus lending scientific support to the plant’s ethnomedicinal uses.In the present review,efforts are made in addressing its ethnomedicinal uses,chemical constituents,and validated pharmacological observations.     

Traditional medical uses of Drimia species in terms of phytochemistry,pharmacology and toxicology

Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications, skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects through several in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.     

Plant profile,phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review

More than half of the world''s population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents. Among them, Cordia dichotoma Forst., a small to moderate size plant of family Boragenaceae, commonly called bhokar, lasura, gonda, Indian cherry and shlesmataka. Plant parts such as leaves, fruit, bark and seed have been reported for possessing antidiabetic, antiulcer, anti-inflammatory, immune-modulator and analgesic activity. Screening of fruit, leaves and seed shows the presence of pyrrolizidine alkaloids, coumarins, flavonoids, saponins, terpenes and sterols. Present review focuses on details of geographical distribution, physicochemical parameters, phytoconstituents and pharmacological properties of Cordia dichotoma reported so far.     

Plant profile,phytochemistry and pharmacology of Avartani (Helicteres isora Linn.): A review

Plants are used as medicine since ancient time, in organized (Ayurveda, Unani & Siddha) and unorganized (folk, native & tribal) form. In these systems, drugs are described either in Sanskrit or vernacular languages. Avartani (Helicteres isora Linn.) is a medicinal plant which is used in several diseases. It is commonly known as Marodphali, Marorphali, Enthani etc. due to screw like appearance of its fruit. Avartani is used as a folk medicine to treat snake bite, diarrhoea and constipation of new born baby. In the research, antioxidant, hypolipidaemic, antibacterial and antiplasmid activities, cardiac antioxidant, antiperoxidative potency, brain-antioxidation potency, anticancer activity, antinociceptive activity, hepatoprotective activity, anti-diarrheal activity and wormicidal activity in this plant were reviewed.     

艾滋病的虚证表现及其形成机理探讨

通过对艾滋病的症状、病机、病理组织学、治疗效果等角度的分析探究,发现艾滋病的病理变化是一个逐渐致虚的过程,并且从虚治疗效果显著。因此,艾滋病的证型以虚为主。     

酸角的诱变性与抗诱变性研究

目的 :探讨酸角的食用安全性及保健作用。方法 :用体内微核实验方法进行酸角的诱变性与抗诱变性试验。结果 :酸角各剂量组小鼠骨髓多染红细胞微核发生率与对照组无显著性差异 (P >0 .0 5 ) ,酸角在 5 0 0 0mg/kg剂量对环磷酰胺 10mg/kg、2 0mg/kg剂量所诱发的小鼠骨髓多染红细胞微核率增加有一定抑制作用 ,微核率分别下降了 2 7.97%和 38.85 % ,但对丝裂霉素C的诱变性拮抗作用不明显 (P >0 .0 5 )。结论 :酸角不具有诱变性 ,在动物体内对CP所诱发的微核增高有降低趋势 ,是一种待进一步开发的安全饮料。     

淫羊藿苷的分离纯化工艺研究

目的 :研究大孔吸附树脂分离纯化淫羊藿苷的工艺条件、树脂前处理的方法。方法 :用HPLC法测定淫羊藿苷含量 ,以淫羊藿苷洗脱率和纯度为考察指标 ,确定DM 130型大孔吸附树脂分离纯化淫羊藿苷的吸附性能和洗脱参数。结果 :DM130型大孔吸附树脂吸附容量以干树脂计为 5 .0 3mg·g-1,用纯化水和不同体积分数的乙醇依次洗脱 ,以 6 0 %乙醇洗脱效果最佳 ,洗脱率达 90 .0 3% ,总干燥物中淫羊藿苷含量达 6 0 .30 %。结论 :大孔吸附树脂对淫羊藿苷有较好的分离纯化作用 ,且工艺简单 ,成本低 ,适宜于工业化生产。     

HUN的毒性和致突变性研究

对ＨＵＮ（植物杀虫剂）进行了经口、皮和呼吸道的急性毒性实验（霍恩氏法和寇氏法），蓄积毒性试验（剂量递增法）和致突变试验（Ａｍｅｓ试验、小鼠骨髓细胞微核试验和精子畸变试验）。结果表明：ＨＵＮ的大鼠经口ＬＤ５０为３１６ｍｇ／ｋｇ，经皮ＬＤ５０为５８４ｍｇ／ｋｇ；小鼠经口ＬＤ５０为２６５．５ｍｇ／ｋｇ，经呼吸道ＬＤ５０为１７９６．４ｍｇ／ｋｇ，蓄积系数为１．９。致突变试验结果表明，Ａｍｅｓ试验各浓度组加Ｓ９与不加Ｓ９活化，其ＭＲ值均小于２。微核试验和精子畸变试验，各剂量组微核发病率和精子畸变率与阴性对照组比较均无显著性差异（Ｐ＞０．０５）。结果提示：ＨＵＮ为中等毒性和高蓄积性的化学物质。各项致突变试验结果均表明ＨＵＮ无致突变性，是一种较理想的植物杀虫剂。