2型糖尿病患者勃起功能障碍相关因素分析

目的 探讨糖尿病性勃起功能障碍(DED)的影响因素.方法 测量2型糖尿病(T2DM)合并勃起功能障碍组(ED组,n=71)和T2DM无勃起功能障碍组(非ED组,n=43)的血压、血脂、血糖、颈内动脉内中膜厚度(IMT)等,并比较两组间糖尿病视网膜病变的发生情况.结果 血清总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)水平ED组明显高于非ED 组(P＜0.05),ED组平均颈内动脉IMT明显厚于非ED组(P＜0.05);ED评分与颈内动脉IMT呈负相关(r=-0.323,P=0.000 1);糖尿病视网膜病变发生率:ED组明显高于非ED组(P＜0.05).结论 TC、LDL-C升高、糖尿病大血管病变及微血管病变都是DED发生的危险因素.     

初发2型糖尿病患者勃起功能障碍与同型半胱氨酸关系的初步探讨

目的 探讨初发2型糖尿病患者勃起功能障碍与血清同型半胱氨酸水平的关系,并分析影响勃起功能的其他因素.方法收集30例初发2型糖尿病合并勃起功能障碍患者[根据国际勃起功能指数(IIEF-5)评分判定],同时收集33例初发2型糖尿病未合并勃起功能障碍患者为对照组,并设正常对照组30例.用特定蛋白分析仪免疫散射比浊法测定血清总同型半胱氨酸,并测定血糖、HbA_(IC)、胰岛素、血脂、尿酸、性激素等指标.结果糖尿病勃起功能障碍组血清总同型半胱氨酸水平[(12.9±1.2)μmol/L]明显高于糖尿病非勃起功能障碍组[(9.9±1.6)μmol/L,P<0.05]及正常对照组[(7.2±1.1)μmol/L,P<0.01];初发2型糖尿病患者IIEF-5评分与总同型半胱氨酸、年龄、吸烟、体重指数、HbA_(IC)、空腹血糖负相关(相关系数分别为-0.574、-0.413、-0.231、-0.242、-0.274、-0.371,P<0.05或P<0.01),与高密度脂蛋白胆固醇呈正相关(相关系数为0.275,P=0.013).结论糖尿病勃起功能障碍是一个多环节、多病因参与的结果,同型半胱氨酸可能是糖尿病性勃起功能障碍一个新的危险因素.     

2型糖尿病勃起功能障碍者内皮细胞舒张功能与IMT的相关研究

收集30例初发T_2DM合并ED患者[根据国际勃起功能指数(IIEF-5)评分判定],同时收集共一级亲组30例,正常对照组30例。采用彩色超声诊断仪检测IMT水平,并测定血糖、胰岛素等指标。结果:内皮细胞舒张功能障碍,在一级亲组已有升高。多因素logistic回归分析显示,cIMTmax与T_2DM勃起功能障碍相关。受试者工作曲线显示cIMTmax对T_2DM ED的诊断切点为1.16mm,其敏感性为75%、特异性为71%。结论 IMT增厚可能参与糖尿病ED的血管内皮损伤过程,cIMTmax是T_2DM ED的独立预测因素。     

2型糖尿病勃起功能障碍者内皮细胞舒张功能与CRP的相关研究

收集30例初发2型糖尿病合并勃起功能障碍患者[根据国际勃起功能指数（IIEF-5）评分判定],同时收集2型糖尿病合并勃起功能障碍者一级亲组30例,初发2型糖尿病未合并勃起功能障碍患者组30,并设正常对照组30例。采用免疫比浊法检测hs—CRP水平,并测定颈动脉内膜中层厚度、血糖、胰岛素、血脂、尿酸、性激素、HbA1C等指标。结果：初发2型糖尿病勃起功能障碍组内皮细胞舒张功能障碍,其一级亲组已有升高。结论糖尿病勃起功能障碍是一个多环节、多病因参与的结果,血浆CRP浓度对于糖尿病勃起功能障碍可提供作为一敏感的诊断标志物。     

初发2型糖尿病患者勃起功能障碍与内皮细胞舒张功能关系

收集30例初发2型糖尿病合并勃起功能障碍患者[根据国际勃起功能指数（HEF-5）评分判定],同时收集2型糖尿病合并勃起功能障碍者一级亲组30例,初发2型糖尿病未合并勃起功能障碍患者组30,并设正常对照组30例。用彩色多普勒超声显像仪进行血管内皮功能的检测。结果：初发2型糖尿病勃起功能障碍组内皮细胞舒张功能障碍,其一级亲组已有降低,初发2型糖尿病患者IIEF-5评分与年龄、吸烟、体重指数、HbA1C、空腹血糖负相关,与高密度脂胆固醇呈正相关。结论糖尿病勃起功能障碍是一个多环节、多病因参与的结果,血管内皮细胞舒张功能障碍可能是其一个危险因素。     

2型糖尿病并发脑梗死患者血脂水平的变化

目的 观察2型糖尿病并发脑梗死(cerebral infarction,CI)患者的血糖、血脂水平.方法 将48例2型糖尿病并发CI患者,68例2型糖尿病患者与78例正常人对照,分别测空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C).结果 2型糖尿病合并CI患者的血糖、血脂水平均较正常对照组明显增高(P<0.05);并发CI组患者的血糖、低密度脂蛋白-胆固醇较未合并CI的糖尿病组也明显增高(P<0.05).结论 糖尿病患者糖代谢紊乱,血脂异常可能是其易发生CI的主要因素.     

2型糖尿病患者视网膜病变与颈动脉内膜中层厚度的关系

目的 探讨2型糖尿病患者视网膜病变(DR)与颈动脉内膜中层厚度(IMT)之间的关系.方法 选取2008、2009年在哈尔滨医科大学附属第四医院内分泌科确诊的2型糖尿病患者123例作为观察对象,根据眼底检查结果 分为DR组和非DR(NDR)组.采集病史(病程、吸烟、家族史等),同时检测颈动脉IMT、收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、体质量指数等指标.两组颈动脉IMT增厚发生率的比较采用χ2检验,两组平均颈动脉IMT值的比较采用独立样本t检验:应用Logistic回归分析糖尿病DR病变的影响因素.结果 ①DR组IMT增厚的发生率为50.98%(26/51),NDR组为33.33%(24/72),两组比较差异有统计学意义(χ2=3.85,P<0.05).②DR组平均颈动脉IMT值为(1.01±0.23)mm,NDR组为(0.91±0.24)mm,两组比较差异有统计学意义(t=-2.21,P<0.05).③单因素分析糖尿病DR病变的影响因素为;吸烟(χ2=6.20,P<0.05),病程(t=-4.13,P<0.01),高密度脂蛋白胆固醇(t=4.49,P<0.01),颈动脉IMT(t=-2.21,P<0.05),收缩压(t=-2.37,P<0.05).④Logistic回归分析糖尿病DR病变的影响因素为:病程、高密度脂蛋白胆固醇、颈动脉IMT、吸烟(χ2值分别为7.77、12.77、6.05、4.15,P均<0.01或0.05).结论 2型糖尿病DR病变患者颈动脉IMT增厚的比例明显增加,且平均颈动脉IMT厚度亦明显增加.2型精尿病合并DR病变与其颈动脉IMT厚度之间关系密切.     

糖尿病性勃起功能障碍与血管内皮功能的相关性

勃起功能障碍(ED)是糖尿病常见的慢性并发症之一,其发病机制目前尚未明确,有研究表明血管内皮功能障碍是ED发生的基本病理生理机制[1].本文旨在分析糖尿病性ED与血管内皮功能相关性. 1资料与方法 1.1 临床资料2008年4月至2010年7月本院住院的男性2型糖尿病患者84人,年龄24～45[平均(34.6±9.7)]岁,均符合WHO 1999年2型糖尿病诊断标准.其中糖尿病合并ED组43人,糖尿病无ED组41人.两组患者年龄、收缩压(DBP)、舒张压(SBP)、体重指数(BMI)等一般资料比较差异无统计学意义(P＞0.05).     

男性高血压患者非杓型血压与勃起功能障碍及内皮损害的关系

目的 探讨男性高血压患者非杓型血压与勃起功能障碍(ED)、血一氧化氮、内皮型一氧化氮合酶(eNOS)及循环内皮微粒的关系。方法 选择2019年1月-2021年5月,天津市第一中心医院心内科门诊和住院的首次诊断原发性高血压、剔除糖尿病、年龄40～60岁的男性患者190例作为研究对象,根据夜间收缩压下降率是否≥10%分为杓型组(n=120)和非杓型组(n=70)两组,采用勃起功能障碍国际指数问卷表-5和RigiScan阴茎硬度测量仪进行夜间勃起功能监测评估ED;酶联免疫吸附试验(ELISA)法测定血浆一氧化氮、eNOS,流式细胞技术测定血浆内皮微粒水平。结果 与杓型组比较,非杓型组ED发生率上升(50.00%比32.50%,χ²=5.694,P=0.017);非杓型组血浆一氧化氮浓度[(60.09±3.56)比(62.34±4.06)μmol/L,t=3.817]、eNOS浓度[(19.76±2.98)比(21.33±2.48)μmol/L,t=3.914]下降,血浆内皮微粒[(6.08±1.22)%比(5.04±1.41)%,t=5.173]上升(均P<0.0...     

老年性勃起功能障碍的临床特点

目的 通过对老年性勃起功能障碍(ED)患者回顾性研究,探讨其发病规律和临床特点.方法 将ED患者分为2组,老年性ED组(49例)和非老年性ED组(425例).统计各组患者年龄、病程、既往病史(糖尿病、高血压、高血脂)以及国际勃起功能指数评分表(IIEF-5)、夜间阴茎涨大试验(NPT)、阴茎海绵体注射试验(ICI)结果.结果 与非老年性ED患者相比,老年性ED患者病程长,同时患有糖尿病、高血压、高血脂的患者比例明显升高(分别为61%、78%、37%).老年性ED患者IIEF-5评分明显降低,患有重度ED比例明显升高.老年性ED患者平均夜间勃起事件明显减少,每次勃起平均时间明显减少,平均阴茎容量峰/基线比率也明显降低.注射前列地尔后,阴茎海绵体动脉收缩期峰值流速(PSV)及阻力指数(RI)明显小于非老年性ED患者,舒张末期流速(EDV)高于非老年性ED患者.结论 老年性ED以器质性病变为主,病程长,程度重,其中尤以血管性ED发病率较高.血管病变导致的阴茎海绵体动脉供血不足和静脉关闭不全是老年性ED发病机制中重要环节.     

老年高血压患者血压昼夜节律与颈动脉粥样硬化的相关性研究

目的探讨老年高血压患者血压昼夜节律与颈动脉粥样硬化的相关性。方法2003￣2004年来我院老年高血压患者共72例(男68例女4例),根据动态血压监测(ABPM)结果分为正常昼夜节律组,即杓型组(n=37,男35例女2例)和异常昼夜节律组,即非杓型组(n=35,男33例女2例)。对所有患者均行颈动脉超声检查,测定右侧颈总动脉(RCCA)、颈内动脉(RICA)内膜中层厚度(IMT)、管腔内径(D),并计算各自的IMT/D值,测定右侧颈动脉分叉处(RBIF)的IMT,观察并记录双侧颈动脉系统斑块的大小、数量。结果(1)两组年龄(Age)、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、全天平均收缩压(24hMSP)、全天平均舒张压(24hMDP)比较均无显著性差异(P>0.05)。(2)两组的RCCA及RICA的IMT、D、IMT/D比较均无显著性差异(P>0.05)。而右颈动脉分叉处IMT,非杓型组明显高于杓型组(P<0.001)。(3)两组总斑块检出率无显著差异,但多发性斑块检出率非杓型组显著高于杓型组(P<0.05)。结论老年高血压患者血压昼夜节律与颈动脉粥样硬化明显相关,异常的血压昼夜节律提示可能存在更严重的靶器官损害。     

Are serum adiponectin concentrations in a population sample of 64‐year‐old Caucasian women with varying glucose tolerance associated with ultrasound‐assessed atherosclerosis?

OBJECTIVE: To examine whether serum adiponectin concentrations were associated with subclinical atherosclerosis assessed as intima media thickness (IMT) in the carotid arteries in Caucasian women with varying degrees of glucose tolerance. RESEARCH DESIGN AND METHODS: From a population-based cohort of 64-year-old Swedish women, 533 subjects with type 2 diabetes (DM2, n=177), impaired glucose tolerance (IGT; n=178) or normal glucose tolerance (NGT, n=178) were recruited. Anthropometrics, usual cardiovascular risk factors were examined and ultrasound examination of the carotid arteries was performed. RESULTS: Women with low adiponectin concentrations were characterized by thick IMT, higher prevalence of DM2, history of previous myocardial infarction, angina pectoris, anti-hypertensive treatment and high body mass index (BMI), waist circumference, plasma insulin, serum triglycerides, fasting glucose, HbA1c, and low serum HDL cholesterol levels. Carotid IMT correlated with HbA1c (r=0.24, P<0.001), waist circumference (r=0.22, P<0.001), plasma insulin (r=0.19, P<0.001), BMI (r=0.18, P<0.001), DM2 (r=0.16, P<0.001), systolic blood pressure (r=0.16, P<0.001), blood glucose (r=0.16, P<0.001), triglycerides (r=0.15, P<0.001), and reversely to adiponectin (r=-0.11, P=0.01), HDL cholesterol (r=-0.13, P=0.004), and alcohol intake (r=-0.087, P<0.05). A more detailed analysis of underlying associations was difficult due to a high co-linearity between these variable. CONCLUSIONS: Low serum adiponectin concentrations were associated with increased carotid artery IMT, and several risk factors for cardiovascular diseases, mainly those constituting the metabolic syndrome.     

Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index,gender, and other cardiovascular risk factors

OBJECTIVE: Increased cardiovascular mortality and carotid atherosclerosis have been observed in hypopituitary patients with untreated GH deficiency (GHD), but results are contradictory and relations to cardiovascular risk factors are not clear. The aim of this study was to investigate intima-media thickness (IMT) in relation to cardiovascular risk factors in adults with GHD. DESIGN: Cross-sectional observational study of 21 men and 13 women with GHD, but without cardiovascular disease, compared to two healthy control groups matched for age, sex and smoking habits. One control group was matched for body mass index (BMI) and the other group was nonobese. MEASUREMENTS: IMT of the carotid and femoral arteries, blood pressure, blood samples and anthropometric data. RESULTS: Patients had 12% thicker composite carotid IMT [(IMT of common carotid artery + IMT of bulb)/2] compared to nonobese controls (P = 0.022), but IMT was not different compared to BMI-matched controls. Femoral IMT did not differ between patients and controls. Patients had higher waist : hip ratio (WHR), heart rate, serum triglycerides and fasting insulin concentrations in combination with lower high-density lipoprotein (HDL) cholesterol and smaller low-density lipoprotein (LDL) peak particle size compared to both nonobese and to BMI-matched controls. This cardiovascular risk pattern was more pronounced in female patients than in male patients compared to their gender controls. Carotid IMT was related to age, serum cholesterol, LDL cholesterol and smoking in the patient group. Only age was independently related to carotid IMT in multivariate analysis. CONCLUSIONS: These results indicate that high BMI in GH-deficient patients contribute to their increased intima-media thickness. However, several cardiovascular risk factors are present in this patient group independent of their increased BMI, especially in women.     

颈动脉粥样硬化与血管性痴呆的相关性分析

目的探讨颈动脉粥样硬化对血管性痴呆发生、发展的影响。方法对61例血管性痴呆（VaD）患者（VaD组）及70例健康体检者（对照组）行高频超声检查,测定其颈总动脉、颈内动脉内-中膜厚度（IMT）及内径,颈动脉粥样硬化斑块的发生情况及斑块性质,采用全自动生化分析仪测定血TC、TG、HDL—C及LDL-C水平。结果VaD组颈总动脉IMT及颈内动脉IMT均明显大于对照组,颈总动脉及颈内动脉内径均明显小于对照组（P均〈0．05）;VaD组斑块发生率明显高于对照组（P〈0．05）;TC、TG、LDL-C水平均明显高于对照组、HDL-C明显低于对照组（P均〈0．05）。结论颈动脉粥样硬化形成与VaD的发生密切相关。     

血清晚期氧化蛋白产物与2型糖尿病患者动脉粥样硬化的关系

目的 探讨血清晚期氧化蛋白产物与2型糖尿病患者动脉粥样硬化性大血管并发症的关系.方法选择90例2型糖尿病患者和60例健康对照者,用酶联免疫吸附法及分光光度法分别检测血清基质细胞衍生因子1α生及晚期氧化蛋白产物水平,采用高分辨超声测定大动脉内膜中膜厚度.结果 2型糖尿病患者血清晚期氧化蛋白产物和基质细胞衍生因子1α水平明显高于健康对照者(P<0.05或P<0.01),2型糖尿病患者高晚期氧化蛋白产物组基质细胞衍生因子1α、空腹血糖、糖化血红蛋白及血清甘油三酯水平和体质指数与正常晚期氧化蛋白产物组比较显著升高(P<0.05),2型糖尿病患者中动脉粥样硬化组晚期氧化蛋白产物及基质细胞衍生因子1α水平明显高于非动脉粥样硬化组(P<0.01或P<0.05).单因素相关分析显示,血清晚期氧化蛋白产物水平与基质细胞衍生因子1α呈正相关(r=0.295,P=0.03),与空腹血糖、糖化血红蛋白、甘油三酯及体质指数呈正相关(r=0.286,P=0.03;r=0.310,P=0.01;r=0.461,P=0.001;r=0.257,P=0.04).结论 2型糖尿病患者蛋白氧化损伤增强,血清晚期氧化蛋白产物增加促进血管内皮细胞基质细胞衍生因子1α表达,晚期氧化蛋白产物增加可能与2型糖尿病动脉粥样硬化相关.     

Cardiovascular risk profile of asymptomatic healthy young adults with increased femoral artery intima-media thickness: The Bogalusa Heart Study

BACKGROUND: Femoral artery intima-media thickness (IMT), like carotid IMT, is a surrogate indicator of atherosclerotic coronary and peripheral vascular diseases in middle-aged and older adults. This study examined the cardiovascular disease risk profile of asymptomatic young adults with increased femoral artery IMT. METHODS: Femoral artery IMT was measured by B-mode ultrasonography in 1080 black and white subjects (aged 24-43 years; 71% white, 43% male) enrolled in the Bogalusa Heart Study. Individuals in the top (n=54) versus bottom fifth (n=54) percentiles distribution of femoral IMT were compared for traditional cardiovascular risk factors profile. Univariate analysis compared the two groups, t-tests and chi tests were performed. RESULTS: The top and bottom fifth percentiles of IMT differed with respect to age (P<0.001), systolic blood pressure (P<0.05), diastolic blood pressure (P<0.05), total cholesterol (P<0.01), low-density lipoprotein (LDL) cholesterol (P<0.001), non-high-density lipoprotein (HDL) cholesterol (P<0.01) and smoking status (P<0.01). In terms of prevalence of clinically defined traditional risk factors, individuals at the top versus bottom fifth percentile of IMT distribution had significantly higher prevalence of high LDL cholesterol (>OR=130 mg/dL), non-HDL cholesterol (>OR=160 mg/dL), and cigarette smoking. The odds ratio for individuals with three or more risk factors versus no risk factors having IMT in the top fifth percentile was 4.7 (P=0.01). CONCLUSION: The observed adverse effect of cardiovascular risk factors on IMT of femoral artery, a surrogate measure of coronary and peripheral atherosclerosis, in asymptomatic young individuals underscores the need for risk factors profiling in early life. These observations have important implications in preventive medicine.     

Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects

OBJECTIVE: To examine the relationship between markers of systemic inflammation and carotid atherosclerosis in patients with rheumatoid arthritis (RA) and healthy controls. METHODS: Carotid artery intima-media thickness (IMT) and carotid plaque were measured using high-resolution B-mode ultrasound in 204 patients with RA, ages 40-85, and 102 age- and sex-matched healthy persons. No subject in either group had ever smoked cigarettes. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were used to measure systemic inflammation. The relationship of the carotid artery IMT and carotid plaque to inflammation markers was examined, adjusting for age, sex, RA versus control status, and the cardiovascular (CV) risk factors hypercholesterolemia, systolic blood pressure, diabetes mellitus, and body mass index (BMI). RESULTS: A significant linear trend for increased carotid artery IMT was associated with increasing ESR and CRP categories (r = 0.16, P = 0.004 for ESR, and r = 0.13, P = 0.02 for CRP). These trends did not differ among RA cases and controls, and were independent of age, sex, and CV risk factors. The difference in carotid artery IMT between the lowest and highest categories of ESR was 0.221 mm (95% confidence interval [95% CI] 0.767-1.020, P = 0.02). The difference between extreme CRP categories was 0.275 mm (95% CI 0.039-0.509, P = 0.02). Both remained significant after CV risk factor adjustment. Carotid plaque displayed a similar relationship to markers of inflammation. CONCLUSION: Increased carotid artery IMT and the presence of carotid plaque are associated with markers of systemic inflammation in patients with RA and in healthy subjects. This observation is consistent with hypotheses that assign a role to systemic inflammation in atherosclerosis, and may have implications regarding RA and other chronic inflammatory diseases.     

Relationship between carotid artery intima-media thickness and brachial artery flow-mediated dilation in middle-aged healthy men

OBJECTIVES: We aimed to determine the relationship between carotid intima-media thickness (IMT) and brachial artery flow-mediated dilation (FMD) in healthy middle-age men. BACKGROUND: Carotid IMT and brachial artery FMD are frequently used as surrogate measures of subclinical atherosclerosis. Whereas carotid IMT identifies early structural abnormalities, brachial artery FMD, considered a bioassay of endothelial function, measures functional vascular integrity. The relationship between carotid IMT and brachial artery FMD has not been well studied. METHODS: We measured traditional risk factors, carotid IMT, and brachial artery FMD in 1,578 middle-aged men without known cardiovascular disease and analyzed the relationship between carotid IMT and brachial FMD. RESULTS: Carotid IMT correlated with age, systolic blood pressure, body mass index, fasting glucose, total and low-density lipoprotein (LDL) cholesterol, and with the overall Framingham risk score (p < 0.001 for all), whereas impaired brachial artery FMD correlated with systolic and diastolic blood pressure (p < 0.01). No relationship was observed between carotid IMT and brachial artery FMD for the entire cohort (r = -0.006, p = 0.82) and in subgroups defined by traditional risk factors or by quintiles of carotid IMT and brachial FMD. CONCLUSIONS: In middle-aged healthy men, there is no significant correlation between carotid IMT and brachial artery FMD. This finding suggests that these are unique, independent surrogates that measure different aspects and stages of early atherosclerosis. Further studies are needed to define their role in clinical research and in cardiovascular risk assessment.     

High prevalence of subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors

OBJECTIVE: To assess the presence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) without clinically evident atherosclerosis or its complications, and to assess whether demographic or clinical factors affect the development of atherosclerotic disease in a series of patients with PsA attended to in a community hospital. METHODS: Fifty-nine patients with PsA who fulfilled the Moll and Wright criteria were recruited from Hospital Xeral-Calde (Lugo, Spain). Patients seen during the period of recruitment who had classic cardiovascular risk factors or had experienced cardiovascular or cerebrovascular events were excluded. Fifty-nine healthy matched controls were also studied. Carotid artery intima-media thickness (IMT) and carotid plaques were measured in the right common carotid artery. The study was performed using high-resolution B-mode ultrasound. RESULTS: Patients with PsA exhibited greater carotid artery IMT than did matched controls (mean +/- SD 0.699 +/- 0.165 mm versus 0.643 +/- 0.111 mm; P = 0.031; difference of means 0.056; 95% confidence interval 0.005-0.108). Adjusted for age, the carotid IMT was correlated with age at the time of PsA diagnosis (partial correlation coefficient [r] = -0.264, P = 0.04), disease duration (r = 0.264, P = 0.04), total cholesterol (r = 0.233, P = 0.01), and low-density lipoprotein cholesterol (r = 0.243, P = 0.01). CONCLUSION: The present study demonstrates that patients with PsA without cardiovascular risk factors or clinically evident cardiovascular disease have a high prevalence of macrovascular disease in the form of increased carotid artery IMT compared with ethnically matched controls.     

代谢综合征的颈动脉粥样硬化特征

目的　观察代谢综合征患者颈动脉形态和功能的变化特点。方法　 171例住院病人分为代谢综合征组 (MS ,84例 ) ,高血压病组 (EH ,6 8例 )、糖尿病组 (DM ,19例 ) ,比较三组患者血脂改变及颈动脉超声检测结果。结果　MS组患者血浆甘油三酯 (TG)、低密度脂蛋白、载脂蛋白B水平较EH组明显升高 ( 2 5 3± 2 15比 1 72± 1 6 6 ,3 2 7± 0 99比 2 91± 0 92 ,1 0 7± 0 2 6比 0 97±0 2 0 ,P <0 0 1,0 0 5 ,0 0 1) ,MS组TG水平明显高于DM组 ( 2 5 3± 2 15比 1 6 7± 0 89,P <0 0 1) ;与EH、DM组比较 ,MS组患者颈动脉系血流阻力指数明显升高 ,颈总动脉内膜明显增厚 ( 0 88± 0 2 2比 0 80± 0 2 4 ,0 88± 0 2 2比 0 72± 0 2 9,P值均 <0 0 5 ) ;MS组颈动脉粥样斑块发生率及斑块指数明显升高。结论　代谢综合征颈动脉粥样硬化程度较单纯高血压病和糖尿病颈动脉病变更严重